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{{SI}}
{{Gonadoblastoma}}
{{CMG}} {{AE}} {{Ammu}}
{{CMG}}; {{AE}} {{Sahar}}
 
{{SK}} [[Gonadoblastomas]]; [[Gonadoblastomata]]
 
 
 
==[[Gonadoblastoma overview|Overview]]==
 
==[[Gonadoblastoma historical perspective|Historical Perspective]]==
 
==[[Gonadoblastoma classification|Classification]]==
 
==[[Gonadoblastoma pathophysiology|Pathophysiology]]==
 
==[[Gonadoblastoma causes|Causes]]==
 
==[[Gonadoblastoma differential diagnosis|Differentiating Gonadoblastoma from other Diseases]]==
 
==[[Gonadoblastoma epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Gonadoblastoma risk factors|Risk Factors]]==
 
==[[Gonadoblastoma screening|Screening]]==
 
==[[Gonadoblastoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
[[Gonadoblastoma diagnostic study of choice|Diagnostic study of choice]] | [[Gonadoblastoma history and symptoms|History and Symptoms]] | [[Gonadoblastoma physical examination|Physical Examination]] | [[Gonadoblastoma laboratory findings|Laboratory Findings]] | [[Gonadoblastoma electrocardiogram|Electrocardiogram]] | [[Gonadoblastoma x ray|X-Ray Findings]] | [[Gonadoblastoma echocardiography and ultrasound|Echocardiography and Ultrasound]] | [[Gonadoblastoma CT scan|CT-Scan Findings]] | [[Gonadoblastoma MRI|MRI Findings]] | [[Gonadoblastoma other imaging findings|Other Imaging Findings]] | [[Gonadoblastoma other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Gonadoblastoma medical therapy|Medical Therapy]] | [[Gonadoblastoma surgery|Surgery]] | [[Gonadoblastoma primary prevention|Primary Prevention]] | [[Gonadoblastoma secondary prevention|Secondary Prevention]] | [[Gonadoblastoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Gonadoblastoma future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Gonadoblastoma case study one|Case #1]]
 
 
[[Category:Medicine]]


{{SK}} Gonadoblastomas; Gonadoblastomata
==Overview==
Gonadoblastoma was first discovered by Scully, in 1953. A gonadoblastoma is a complex [[neoplasm]] composed of a mixture of [[gonad]]al elements, such as large primordial [[germ cell]]s, immature [[Sertoli cell]]s or [[granulosa cell]]s of the [[sex cord]], and gonadal [[stromal cell]]s. Gonadoblastoma may be caused by either complete androgen insensitivity, pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis, Frasier syndrome, Denys-Drash syndrome, and 9p Partial monosomy. Gonadoblastoma must be differentiated from other diseases that cause ovarian tumors, such as 17-hydroxylase deficiency syndrome, 5-alpha-reductase deficiency, amenorrhea, congenital adrenal hyperplasia, hypospadias, and Meigs syndrome. Gonadoblastoma may also be diagnosed using chromosomal analysis. Surgery is the mainstay of therapy for gonadoblastoma.
==Historical Perspective==
*Gonadoblastoma was first discovered by Scully, in 1953.
==Pathophysiology==
*A gonadoblastoma is a complex [[neoplasm]] composed of a mixture of [[gonad]]al elements, such as large primordial [[germ cell]]s, immature [[Sertoli cell]]s or [[granulosa cell]]s of the [[sex cord]], and gonadal [[stromal cell]]s.<ref> Gonadoblstoma. Wikipedia (2016). https://en.wikipedia.org/wiki/Gonadoblastoma  Accessed on April 15, 2016</ref>
*Abnormal chromosomal [[karyotype]], gonadal [[dysgenesis]], and the presence of a [[Y chromosome]] has been associated with the development of gonadoblastoma.
==Causes==
* Gonadoblastoma may be caused by either complete androgen insensitivity, pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis, Frasier syndrome, Denys-Drash syndrome, and 9p Partial monosomy.
==Differentiating Gonadoblastoma from other Diseases==
*Gonadoblastoma must be differentiated from other diseases such as:
:*17-Hydroxylase Deficiency Syndrome
:*5-Alpha-Reductase Deficiency
:*Amenorrhea
:*Congenital Adrenal Hyperplasia
:*Genital Anomalies
:*Hypospadias
:*Pediatric Seminoma
:*Turner Syndrome
:*Meigs syndrome
=== Other Diagnostic Studies ===
*Gonadoblastoma may also be diagnosed using chromosomal analysis.
== Treatment ==
=== Surgery ===
*Surgery is the mainstay of therapy for gonadoblastoma.
*Surgical exploration via laparotomy and bilateral salpingo-oophorectomy (BSO) is the most common approach to the treatment of gonadoblastoma.
==References==
{{Reflist|2}}
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Gynecology]]
[[Category:Up-To-Date]]

Latest revision as of 06:33, 28 July 2020

Gonadoblastoma Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gonadoblastoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

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Treatment

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Synonyms and keywords: Gonadoblastomas; Gonadoblastomata


Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gonadoblastoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray Findings | Echocardiography and Ultrasound | CT-Scan Findings | MRI Findings | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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