Acromegaly natural history, complications and prognosis: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Categories)
 
(9 intermediate revisions by 2 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Acromegaly}}
{{Acromegaly}}
{{CMG}}
{{CMG}}; {{AE}} {{AEL}}
 
==Overview==
==Overview==
If left untreated, 30% of patients with acromegaly may progress to develop [[cardiovascular]] manifestations, pulmonary dysfunction, and cerebral complications. Common complications of acromegaly include hypertension, [[arrhythmia]], [[heart failure]], [[sleep apnea]], [[dyspnea]], [[carpal tunnel syndrome]] and [[spinal cord compression]]. Prognosis of acromegaly is generally good with transsphenoidal surgery and the postoperative treatment.


==Natural History==
==Natural History, Complications, and Prognosis==
Please help WikiDoc by adding more content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing.


==Complications==
===Natural History===
*If left untreated, 30% of patients with acromegaly may progress to develop cardiovascular manifestations, pulmonary dysfunction, and cerebral complications. These comorbidities will increase the mortality rate.<ref name="pmid19884662">{{cite journal| author=Melmed S| title=Acromegaly pathogenesis and treatment. | journal=J Clin Invest | year= 2009 | volume= 119 | issue= 11 | pages= 3189-202 | pmid=19884662 | doi=10.1172/JCI39375 | pmc=2769196 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19884662  }} </ref>


* [[Arthritis]]
===Complications===
* [[Cardiovascular disease]]
*Common complications of acromegaly include:
* [[Carpal tunnel syndrome]]
**Cardivascualr complications:<ref name="pmid20463098">{{cite journal| author=Berg C, Petersenn S, Lahner H, Herrmann BL, Buchfelder M, Droste M et al.| title=Cardiovascular risk factors in patients with uncontrolled and long-term acromegaly: comparison with matched data from the general population and the effect of disease control. | journal=J Clin Endocrinol Metab | year= 2010 | volume= 95 | issue= 8 | pages= 3648-56 | pmid=20463098 | doi=10.1210/jc.2009-2570 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20463098  }} </ref>
* [[Colonic polyps]]
*** [[Cardiovascular disease]]
* [[Glucose intolerance]] or [[diabetes]]
*** [[Hypertension]]
* [[High blood pressure]]
*** [[Arrhythmias]]
* [[Hypopituitarism]]
*** [[Heart failure]]
* [[Sleep apnea]]
*** Coronary arteriosclerosis
* [[Spinal cord compression]]
**Respiratory complications:
* [[Uterine fibroids]]
***Sleep apnea
* Vision abnormalities
***Dyspnea and stridor
**Neuromuscular complications:
***[[Arthritis]]
*** [[Carpal tunnel syndrome]]
*** [[Spinal cord compression]]
*** Vision abnormalities
**Abdominal complications:
*** [[Colonic polyps]]
*** [[Uterine fibroids]] in females


==Prognosis==
===Prognosis===
Pituitary surgery is successful in most patients, depending on the size of the tumor and the experience of the surgeon. Without treatment the symptoms will get worse, and the risk of cardiovascular disease increases.  
*Prognosis of acromegaly is generally good with transsphenoidal surgery and the postoperative treatment.
*Early diagnosis and treatment of acromegaly are associated with better prognosis.<ref name="pmid26486485">{{cite journal| author=Kršek M| title=[Acromegaly: current view]. | journal=Vnitr Lek | year= 2015 | volume= 61 | issue= 10 | pages= 900-4 | pmid=26486485 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26486485  }} </ref>
*The acral features of the acromegaly in the [[face]], [[hands]], and [[feet]] usually return to normal after the surgery.


==References==
==References==

Latest revision as of 12:39, 16 August 2017

Acromegaly Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Acromegaly from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Radiation Therapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Acromegaly natural history, complications and prognosis On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Acromegaly natural history, complications and prognosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Acromegaly natural history, complications and prognosis

CDC on Acromegaly natural history, complications and prognosis

Acromegaly natural history, complications and prognosis in the news

Blogs on Acromegaly natural history, complications and prognosis

Directions to Hospitals Treating Acromegaly

Risk calculators and risk factors for Acromegaly natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

If left untreated, 30% of patients with acromegaly may progress to develop cardiovascular manifestations, pulmonary dysfunction, and cerebral complications. Common complications of acromegaly include hypertension, arrhythmia, heart failure, sleep apnea, dyspnea, carpal tunnel syndrome and spinal cord compression. Prognosis of acromegaly is generally good with transsphenoidal surgery and the postoperative treatment.

Natural History, Complications, and Prognosis

Natural History

  • If left untreated, 30% of patients with acromegaly may progress to develop cardiovascular manifestations, pulmonary dysfunction, and cerebral complications. These comorbidities will increase the mortality rate.[1]

Complications

Prognosis

  • Prognosis of acromegaly is generally good with transsphenoidal surgery and the postoperative treatment.
  • Early diagnosis and treatment of acromegaly are associated with better prognosis.[3]
  • The acral features of the acromegaly in the face, hands, and feet usually return to normal after the surgery.

References

  1. ↑ Melmed S (2009). "Acromegaly pathogenesis and treatment". J Clin Invest. 119 (11): 3189–202. doi:10.1172/JCI39375. PMC 2769196. PMID 19884662.
  2. ↑ Berg C, Petersenn S, Lahner H, Herrmann BL, Buchfelder M, Droste M; et al. (2010). "Cardiovascular risk factors in patients with uncontrolled and long-term acromegaly: comparison with matched data from the general population and the effect of disease control". J Clin Endocrinol Metab. 95 (8): 3648–56. doi:10.1210/jc.2009-2570. PMID 20463098.
  3. ↑ Kršek M (2015). "[Acromegaly: current view]". Vnitr Lek. 61 (10): 900–4. PMID 26486485.


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Acromegaly_natural_history,_complications_and_prognosis&oldid=1342001"