Achlorhydria causes: Difference between revisions

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==Overview==
Achlorhydria is caused by intrinsic and extrinsic changes in the [[gastrointestinal]] system, including uptake of [[antibodies]] and [[bacterial infection]]. Less commonly, it can be caused by [[cancer]], a life-threatening cause requiring prompt diagnosis and treatment.


==Overview==
==Causes<ref name="pmid9207257">{{cite journal |author=El-Omar EM, Oien K, El-Nujumi A, ''et al'' |title=Helicobacter pylori infection and chronic gastric acid hyposecretion |journal=Gastroenterology |volume=113 |issue=1 |pages=15–24 |year=1997 |pmid=9207257 |doi=}}</ref>==
<div style="-webkit-user-select: none;">
 
===Life Threatening Causes===
*[[Helicobacter pylori infection ]]
*[[Menetrier disease]]
*[[Somatostatinoma]]
*[[Stomach cancer]]
 
===Common Causes===
*[[Gastric intrinsic factor antibodies]]
*[[Atrophic gastritis]]
*[[H2-receptor antagonists]]
*[[Radiation therapy ]]
 
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| [[H2-receptor antagonists]],  [[Parietal cell antibodies]],  [[Proton pump inhibitors]]
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| [[Mucolipidosis ]],  [[Vipomas]]
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Atrophic gastritis]],  [[Gastric intrinsic factor antibodies]],  [[Menetrier disease]],  [[Somatostatinoma]],  [[Stomach cancer]]
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| [[Pernicious anemia]]
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| [[Radiation therapy ]]
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| [[Helicobacter pylori infection ]]
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| [[Somatostatinoma]],  [[Stomach cancer]],  [[Vipomas]]
|-
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| [[Autoimmune disorders ]],  [[Gastric intrinsic factor antibodies]]
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
|-
|}


==Causes==
===Causes in Alphabetical Order===
* [[Autoimmune disorder]]s where there is [[antibody]] production against [[parietal cell]]s which normally produce gastric acid.
{{columns-list|
* [[H2-receptor antagonist]]s
*[[Atrophic gastritis]]
* [[Proton pump inhibitor]]s.
*[[Autoimmune disorders ]]
* [[Mucolipidosis]] (type IV).
*[[Gastric intrinsic factor antibodies]]
* [[Helicobacter pylori]] infection which neutralizes and decreases secretion of [[gastric acid]] to aid its survival in the stomach.<ref name="pmid9207257">{{cite journal |author=El-Omar EM, Oien K, El-Nujumi A, ''et al'' |title=Helicobacter pylori infection and chronic gastric acid hyposecretion |journal=Gastroenterology |volume=113 |issue=1 |pages=15–24 |year=1997 |pmid=9207257 |doi=}}</ref>
*[[H2-receptor antagonists]]
*[[Helicobacter pylori infection ]]
*[[Menetrier disease]]
*[[Mucolipidosis ]]
*[[Parietal cell antibodies]]
*[[Pernicious anemia]]
*[[Pernicious anemia]]
* [[Atrophic gastritis]]
*[[Proton pump inhibitors]]
* [[VIPoma]]s
*[[Radiation therapy ]]
* [[Stomach cancer]].
*[[Somatostatinoma]]
* [[Radiation therapy]] involving the stomach.
*[[Stomach cancer]]
*[[Vipomas]]
}}
</div>


==References==
==References==

Latest revision as of 20:02, 10 January 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2] Luke Rusowicz-Orazem, B.S.

Overview

Achlorhydria is caused by intrinsic and extrinsic changes in the gastrointestinal system, including uptake of antibodies and bacterial infection. Less commonly, it can be caused by cancer, a life-threatening cause requiring prompt diagnosis and treatment.

Causes[1]

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect H2-receptor antagonists, Parietal cell antibodies, Proton pump inhibitors
Ear Nose Throat No underlying causes
Endocrine Mucolipidosis , Vipomas
Environmental No underlying causes
Gastroenterologic Atrophic gastritis, Gastric intrinsic factor antibodies, Menetrier disease, Somatostatinoma, Stomach cancer
Genetic No underlying causes
Hematologic Pernicious anemia
Iatrogenic Radiation therapy 
Infectious Disease Helicobacter pylori infection
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Somatostatinoma, Stomach cancer, Vipomas
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy Autoimmune disorders , Gastric intrinsic factor antibodies
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

References

  1. ↑ El-Omar EM, Oien K, El-Nujumi A; et al. (1997). "Helicobacter pylori infection and chronic gastric acid hyposecretion". Gastroenterology. 113 (1): 15–24. PMID 9207257.

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