Portal vein thrombosis laboratory findings: Difference between revisions
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Irfan Dotani (talk | contribs) (Created page with "__NOTOC__ {{Portal vein thrombosis}} {{CMG}}; {{AE}} {{PleaseHelp}} ==Overview== ==Laboratory Findings== ==References== {{reflist|2}} Category:Hepatology {{WS}} {{WH}}") |
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__NOTOC__ | __NOTOC__ | ||
{{Portal vein thrombosis}} | {{Portal vein thrombosis}} | ||
{{ | {{CMG}}; {{AE}} {{F.K}} | ||
==Overview== | ==Overview== | ||
Laboratory findings is usually normal among patients with portal vein thrombosis. In patients with cirrhosis, laboratory findings may demonstrate an elevated [[bilirubin]], low [[platelet]] count, prolonged [[international normalized ratio]] (INR), or [[renal insufficiency]]. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
*Laboratory findings of portal vein thrombosis will be normal or quite normal, unless there is coexistence of a liver disease. | |||
*Although, [[coagulation factors]] levels could be moderately decreased, while [[D-dimer]] level is usually increased. | |||
*In some patients laboratory findings may show moderate increase in serum [[aminotransferases]].<ref name="pmid20066733">{{cite journal |vauthors=Ponziani FR, Zocco MA, Campanale C, Rinninella E, Tortora A, Di Maurizio L, Bombardieri G, De Cristofaro R, De Gaetano AM, Landolfi R, Gasbarrini A |title=Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment |journal=World J. Gastroenterol. |volume=16 |issue=2 |pages=143–55 |year=2010 |pmid=20066733 |pmc=2806552 |doi= |url=}}</ref><ref name="pmid16951667">{{cite journal |vauthors=Condat B, Valla D |title=Nonmalignant portal vein thrombosis in adults |journal=Nat Clin Pract Gastroenterol Hepatol |volume=3 |issue=9 |pages=505–15 |year=2006 |pmid=16951667 |doi=10.1038/ncpgasthep0577 |url=}}</ref><ref name="pmid2806552">{{cite journal |vauthors=Zhang WW, Churchill S, Churchill P |title=Developmental regulation of D-beta-hydroxybutyrate dehydrogenase in rat liver and brain |journal=FEBS Lett. |volume=256 |issue=1-2 |pages=71–4 |year=1989 |pmid=2806552 |doi= |url=}}</ref> | |||
*In patients with [[cirrhosis]], laboratory findings may demonstrate an elevated [[bilirubin]], low [[platelet]] count, prolonged [[international normalized ratio]] (INR), or [[renal insufficiency]]. | |||
*Blood cultures of [[septic]] portal vein are often positive for [[Bacteroides fragilis|''Bacteroides fragilis'']] or [[Escherichia coli|''Escherichia coli'']], also other pathogens have been cultured.<ref name="pmid8589130">{{cite journal |vauthors=Plemmons RM, Dooley DP, Longfield RN |title=Septic thrombophlebitis of the portal vein (pylephlebitis): diagnosis and management in the modern era |journal=Clin. Infect. Dis. |volume=21 |issue=5 |pages=1114–20 |year=1995 |pmid=8589130 |doi= |url=}}</ref> | |||
==References== | ==References== | ||
{{ | {{Reflist|2}} | ||
{{WH}} | |||
{{WS}} | {{WS}} | ||
[[Category: (name of the system)]] | |||
Latest revision as of 20:16, 26 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
Laboratory findings is usually normal among patients with portal vein thrombosis. In patients with cirrhosis, laboratory findings may demonstrate an elevated bilirubin, low platelet count, prolonged international normalized ratio (INR), or renal insufficiency.
Laboratory Findings
- Laboratory findings of portal vein thrombosis will be normal or quite normal, unless there is coexistence of a liver disease.
- Although, coagulation factors levels could be moderately decreased, while D-dimer level is usually increased.
- In some patients laboratory findings may show moderate increase in serum aminotransferases.[1][2][3]
- In patients with cirrhosis, laboratory findings may demonstrate an elevated bilirubin, low platelet count, prolonged international normalized ratio (INR), or renal insufficiency.
- Blood cultures of septic portal vein are often positive for Bacteroides fragilis or Escherichia coli, also other pathogens have been cultured.[4]
References
- ↑ Ponziani FR, Zocco MA, Campanale C, Rinninella E, Tortora A, Di Maurizio L, Bombardieri G, De Cristofaro R, De Gaetano AM, Landolfi R, Gasbarrini A (2010). "Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment". World J. Gastroenterol. 16 (2): 143–55. PMC 2806552. PMID 20066733.
- ↑ Condat B, Valla D (2006). "Nonmalignant portal vein thrombosis in adults". Nat Clin Pract Gastroenterol Hepatol. 3 (9): 505–15. doi:10.1038/ncpgasthep0577. PMID 16951667.
- ↑ Zhang WW, Churchill S, Churchill P (1989). "Developmental regulation of D-beta-hydroxybutyrate dehydrogenase in rat liver and brain". FEBS Lett. 256 (1–2): 71–4. PMID 2806552.
- ↑ Plemmons RM, Dooley DP, Longfield RN (1995). "Septic thrombophlebitis of the portal vein (pylephlebitis): diagnosis and management in the modern era". Clin. Infect. Dis. 21 (5): 1114–20. PMID 8589130.