Thrombophilia risk factors: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Thrombophilia}} | {{Thrombophilia}} | ||
{{CMG}} {{AE}} {{asiri}} | {{CMG}} {{AE}} {{asiri}} {{JK}} | ||
==Overview== | ==Overview== | ||
Common risk factors in the development of acquired thrombophlias are [[trauma]], [[surgery]], [[immobility]], [[pregnancy]], [[oral contraceptives]], [[hormone replacement therapy]], and [[age]]. Common risk factors for the development of inherited thrombophilias are a family history of [[thrombosis]] at an early age or a family history of inherited thrombophilia. Common genetic risk factors in the development of inherited thrombophilias are mutations in [[Factor_V_Leiden|factor V leiden]] and [[prothrombin]] G20210A. | |||
==Risk Factors== | ==Risk Factors== | ||
* | *Risk factors for '''inherited thrombophilias''' are as follows:<ref name="pmid24421360">{{cite journal| author=Cohoon KP, Heit JA| title=Inherited and secondary thrombophilia. | journal=Circulation | year= 2014 | volume= 129 | issue= 2 | pages= 254-7 | pmid=24421360 | doi=10.1161/CIRCULATIONAHA.113.001943 | pmc=3979345 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24421360 }} </ref><ref name="pmid11309638">{{cite journal| author=Seligsohn U, Lubetsky A| title=Genetic susceptibility to venous thrombosis. | journal=N Engl J Med | year= 2001 | volume= 344 | issue= 16 | pages= 1222-31 | pmid=11309638 | doi=10.1056/NEJM200104193441607 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11309638 }} </ref><ref name="pmid21340752">{{cite journal| author=Middeldorp S| title=Evidence-based approach to thrombophilia testing. | journal=J Thromb Thrombolysis | year= 2011 | volume= 31 | issue= 3 | pages= 275-81 | pmid=21340752 | doi=10.1007/s11239-011-0572-y | pmc=3056012 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21340752 }} </ref> | ||
** | **Family history of thrombosis at an early age | ||
** | **Family history of inherited thrombophilia | ||
*Risk factors in the development of '''acquired thrombophlias''' are enlisted in the following '''Table 1''': <ref name="urlAcute Pulmonary Embolism Article">{{cite web |url=https://www.statpearls.com/ArticleLibrary/viewarticle/42576 |title=Acute Pulmonary Embolism Article |format= |work= |accessdate=}}</ref> | |||
{| class="wikitable" | |||
|- | |||
! '''Acquired risk factors''' !! '''Acquired risk factors''' | |||
|- | |||
| | |||
*Advancing [[Age]] | |||
*[[Pregnancy]] | |||
*[[Oral_contraceptive|Oral contraceptive pills]] | |||
*[[Hormone_replacement_therapy|Hormone therapy]] | |||
*Postpartum period | |||
*[[Infection]] (specifically pneumonia, urinary tract infection, and HIV) | |||
*[[Cancer]] (highest risk in metastatic disease) | |||
*Bed rest greater than three days | |||
*[[Obesity]] | |||
|| | |||
*[[Immobility]] | |||
*[[Fracture]] of [[lower limb]] | |||
*Hospitalization for [[heart failure]] or [[atrial fibrillation]]/flutter within the previous three months | |||
*Hip or knee replacement | |||
*Major trauma | |||
*History of previous venous thromboembolism | |||
*Central venous lines | |||
*Chemotherapy | |||
*[[Congestive heart failure]] or respiratory failure | |||
|} | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:FinalQCRequired]] | |||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Latest revision as of 17:54, 5 April 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Asiri Ediriwickrema, M.D., M.H.S. [2] Jaspinder Kaur, MBBS[3]
Overview
Common risk factors in the development of acquired thrombophlias are trauma, surgery, immobility, pregnancy, oral contraceptives, hormone replacement therapy, and age. Common risk factors for the development of inherited thrombophilias are a family history of thrombosis at an early age or a family history of inherited thrombophilia. Common genetic risk factors in the development of inherited thrombophilias are mutations in factor V leiden and prothrombin G20210A.
Risk Factors
- Risk factors for inherited thrombophilias are as follows:[1][2][3]
- Family history of thrombosis at an early age
- Family history of inherited thrombophilia
- Risk factors in the development of acquired thrombophlias are enlisted in the following Table 1: [4]
| Acquired risk factors | Acquired risk factors |
|---|---|
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References
- ↑ Cohoon KP, Heit JA (2014). "Inherited and secondary thrombophilia". Circulation. 129 (2): 254–7. doi:10.1161/CIRCULATIONAHA.113.001943. PMC 3979345. PMID 24421360.
- ↑ Seligsohn U, Lubetsky A (2001). "Genetic susceptibility to venous thrombosis". N Engl J Med. 344 (16): 1222–31. doi:10.1056/NEJM200104193441607. PMID 11309638.
- ↑ Middeldorp S (2011). "Evidence-based approach to thrombophilia testing". J Thromb Thrombolysis. 31 (3): 275–81. doi:10.1007/s11239-011-0572-y. PMC 3056012. PMID 21340752.
- ↑ "Acute Pulmonary Embolism Article".