Pancreatic insufficiency: Difference between revisions
Jump to navigation
Jump to search
m (Bot: Automated text replacement (-{{columns-list|3| +{{columns-list|)) |
|||
| (31 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
{{ | __NOTOC__ | ||
{{CMG}} | {{SI}} | ||
{{CMG}}; {{AE}} {{VSKP}} | |||
{{SK}} Exocrine pancreatic insufficiency | |||
== Overview == | == Overview == | ||
Pancreatic insufficiency is characterized by deficiency of the exocrine [[pancreatic juice|pancreatic enzymes]], resulting in the inability to digest food properly, or maldigestion. | |||
== Causes == | == Causes == | ||
===Common Causes=== | |||
*[[Chronic alcoholism]] | |||
*[[Chronic pancreatitis]] | |||
*[[Cystic fibrosis]] | |||
*[[Gall stones]] | |||
*[[Gastrectomy]] | |||
*[[Shwachman-Diamond syndrome]] | |||
*[[Zollinger-Ellison syndrome]] | |||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
| Line 44: | Line 53: | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Gastroenterologic''' | | '''Gastroenterologic''' | ||
|bgcolor="Beige"| [[Chronic pancreatitis]], [[Cystic fibrosis]], [[Diabetic gastroparesis]], [[Gallstones]], [[Hemochromatosis]] | |bgcolor="Beige"| [[Bowel resection]], [[Celiac disease]], [[Chronic pancreatitis]], [[Cystic fibrosis]], [[Diabetic gastroparesis]], [[Gallstones]], [[Hemochromatosis]] , [[Short bowel syndrome]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Genetic''' | | '''Genetic''' | ||
|bgcolor="Beige"| [[Alpha 1-antitrypsin deficiency]], [[Annular pancreas]], [[Ataxia telangiectasia]], [[Congenital lipomatosis of pancreas]], [[Congenital pancreatic dysfunction]], [[Congenital partial lipodystrophy]], [[Cystic fibrosis]], [[Havlikova syndrome]], [[Hemochromatosis]], [[Hereditary pancreatitis]], [[Homocystinuria]], [[Johanson- | |bgcolor="Beige"| [[Alpha 1-antitrypsin deficiency]], [[Annular pancreas]], [[Ataxia telangiectasia]], [[Congenital lipomatosis of pancreas]], [[Congenital pancreatic dysfunction]], [[Congenital partial lipodystrophy]], [[Cystic fibrosis]], [[Havlikova syndrome]], [[Hemochromatosis]], [[Hereditary pancreatitis]], [[Homocystinuria]], [[Johanson-Blizzard syndrome]], [[Juvenile tropical pancreatitis syndrome]], [[Pancreatic agenesis]], [[Pearson syndrome]], [[Shwachman-Diamond syndrome]], [[Situs inversus totalis with cystic dysplasia of pancreas]], [[Wolfram's disease]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| Line 56: | Line 65: | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Iatrogenic''' | | '''Iatrogenic''' | ||
|bgcolor="Beige"| [[ | |bgcolor="Beige"| [[Bowel resection]], [[Gastrectomy]] , [[Pancreatectomy]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| Line 72: | Line 81: | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Nutritional/Metabolic''' | | '''Nutritional/Metabolic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Malnutrition]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| Line 104: | Line 113: | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Rheumatology/Immunology/Allergy''' | | '''Rheumatology/Immunology/Allergy''' | ||
|bgcolor="Beige"| [[Autoimmune lymphoproliferative syndrome]], [[Lupus]], [[Polyglandular autoimmune syndrome]], [[Sjogren's syndrome]] | |bgcolor="Beige"| [[Autoimmune lymphoproliferative syndrome]], [[Lupus]], [[Polyglandular autoimmune syndrome]], [[Sjogren's syndrome]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| Line 120: | Line 129: | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Miscellaneous''' | | '''Miscellaneous''' | ||
|bgcolor="Beige"| [[Chronic alcoholism]], [[Pancreatic cyst]], [[Pancreatic duct]] | |bgcolor="Beige"| [[Chronic alcoholism]], [[Pancreatic cyst]], [[Cholestasis|Pancreatic duct obstruction]], [[Pancreatic pseudocyst]] | ||
|- | |- | ||
|} | |} | ||
===Causes in Alphabetical Order=== | ===Causes in Alphabetical Order=== | ||
{{columns-list | {{columns-list| | ||
*[[Acute intermittent porphyria]] | *[[Acute intermittent porphyria]] | ||
| Line 133: | Line 142: | ||
*[[Ataxia telangiectasia]] | *[[Ataxia telangiectasia]] | ||
*[[Autoimmune lymphoproliferative syndrome]] | *[[Autoimmune lymphoproliferative syndrome]] | ||
*[[Bowel resection]] | |||
*[[Celiac disease]] | |||
*[[Chronic alcoholism]] | *[[Chronic alcoholism]] | ||
*[[Chronic pancreatitis]] | *[[Chronic pancreatitis]] | ||
| Line 141: | Line 152: | ||
*[[Diabetic gastroparesis]] | *[[Diabetic gastroparesis]] | ||
*[[Gallstones]] | *[[Gallstones]] | ||
*[[Gastrectomy]] | |||
*[[Gestational diabetes]] | *[[Gestational diabetes]] | ||
*[[Havlikova syndrome]] | *[[Havlikova syndrome]] | ||
| Line 149: | Line 161: | ||
*[[Hypertriglyceridemia]] | *[[Hypertriglyceridemia]] | ||
*[[Idiopathic pancreatitis]] | *[[Idiopathic pancreatitis]] | ||
*[[Johanson- | *[[Johanson-Blizzard syndrome]] | ||
*[[Juvenile tropical pancreatitis syndrome]] | *[[Juvenile tropical pancreatitis syndrome]] | ||
*[[Lupus]] | *[[Lupus]] | ||
*[[Malnutrition]] | |||
*[[Mumps]] | *[[Mumps]] | ||
*[[Pancreatectomy]] | *[[Pancreatectomy]] | ||
* [[Pancreas divisum]] | |||
*[[Pancreatic agenesis]] | *[[Pancreatic agenesis]] | ||
*[[Pancreatic cancer]] | *[[Pancreatic cancer]] | ||
*[[Pancreatic cyst]] | *[[Pancreatic cyst]] | ||
*[[Pancreatic duct]] | *[[Cholestasis|Pancreatic duct obstruction]] | ||
*[[Pancreatic pseudocyst]] | *[[Pancreatic pseudocyst]] | ||
*[[Pearson syndrome]] | *[[Pearson syndrome]] | ||
*[[Polyglandular autoimmune syndrome]] | *[[Polyglandular autoimmune syndrome]] | ||
*[[Short bowel syndrome]] | |||
*[[Shwachman-Diamond syndrome]] | *[[Shwachman-Diamond syndrome]] | ||
*[[Situs inversus totalis with cystic dysplasia of pancreas]] | *[[Situs inversus totalis with cystic dysplasia of pancreas]] | ||
| Line 171: | Line 185: | ||
== Diagnosis == | == Diagnosis == | ||
=== History and Symptoms === | === History and Symptoms === | ||
*[[Fatty stools]] | *[[Fatty stools]] | ||
| Line 180: | Line 193: | ||
== Differential Diagnosis of Causes of {{PAGENAME}}== | == Differential Diagnosis of Causes of {{PAGENAME}}== | ||
{{columns-list| | {{columns-list| | ||
*[[Chronic alcoholism]] | *[[Chronic alcoholism]] | ||
*[[Congenital pancreatic dysfunction]] | *[[Congenital pancreatic dysfunction]] | ||
| Line 194: | Line 206: | ||
*[[Trauma]] | *[[Trauma]] | ||
*[[Zollinger-Ellison syndrome]] | *[[Zollinger-Ellison syndrome]] | ||
}} | |||
==Treatment== | |||
Often pancreatic insufficiency is treated with Pancreatic Enzyme Products (PEPs), such as [[pancrelipase]], that are used to breakdown fats ([[lipases]]), proteins ([[proteases]]) and carbohydrates ([[amylases]]) into units that can be digested by those with pancreatic insufficiency. <ref>[http://www.fda.gov/cder/otcmonographs/category_sort/pancreatic_insufficiency.htm FDA rulemaking history of OTC EPI drug products]</ref> | |||
== References == | == References == | ||
{{Reflist}} | {{Reflist}} | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
Latest revision as of 22:18, 10 January 2020
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Venkata Sivakrishna Kumar Pulivarthi M.B.B.S [2]
Synonyms and keywords: Exocrine pancreatic insufficiency
Overview
Pancreatic insufficiency is characterized by deficiency of the exocrine pancreatic enzymes, resulting in the inability to digest food properly, or maldigestion.
Causes
Common Causes
- Chronic alcoholism
- Chronic pancreatitis
- Cystic fibrosis
- Gall stones
- Gastrectomy
- Shwachman-Diamond syndrome
- Zollinger-Ellison syndrome
Causes by Organ System
Causes in Alphabetical Order
- Acute intermittent porphyria
- Alagille syndrome
- Alpha-1 antitrypsin deficiency
- Annular pancreas
- Ataxia telangiectasia
- Autoimmune lymphoproliferative syndrome
- Bowel resection
- Celiac disease
- Chronic alcoholism
- Chronic pancreatitis
- Congenital lipomatosis of pancreas
- Congenital pancreatic dysfunction
- Congenital partial lipodystrophy
- Cystic fibrosis
- Diabetic gastroparesis
- Gallstones
- Gastrectomy
- Gestational diabetes
- Havlikova syndrome
- Hemochromatosis
- Hereditary pancreatitis
- Homocystinuria
- Hyperparathyroidism
- Hypertriglyceridemia
- Idiopathic pancreatitis
- Johanson-Blizzard syndrome
- Juvenile tropical pancreatitis syndrome
- Lupus
- Malnutrition
- Mumps
- Pancreatectomy
- Pancreas divisum
- Pancreatic agenesis
- Pancreatic cancer
- Pancreatic cyst
- Pancreatic duct obstruction
- Pancreatic pseudocyst
- Pearson syndrome
- Polyglandular autoimmune syndrome
- Short bowel syndrome
- Shwachman-Diamond syndrome
- Situs inversus totalis with cystic dysplasia of pancreas
- Sjogren's syndrome
- Trauma
- Wolfram's disease
- Zollinger-Ellison syndrome
Diagnosis
History and Symptoms
Differential Diagnosis of Causes of Pancreatic insufficiency
Treatment
Often pancreatic insufficiency is treated with Pancreatic Enzyme Products (PEPs), such as pancrelipase, that are used to breakdown fats (lipases), proteins (proteases) and carbohydrates (amylases) into units that can be digested by those with pancreatic insufficiency. [1]
References