Brucellosis natural history, complications and prognosis: Difference between revisions

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__NOTOC__
__NOTOC__
{{Brucellosis}}
{{Brucellosis}}
{{CMG}}; {{AE}} {{RT}} {{DL}}
{{CMG}}; {{AE}} {{RT}} {{DL}}{{VD}}


==Overview==
==Overview==
If left untreated, patients with brucellosis may progress to develop focal infections, relapses or chronic brucellosis.<ref name="f">Brucellosis. CDC. http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/brucellosis. Accessed on February 3, 2016</ref> Common complications of brucellosis include [[hepatitis|granulomatous hepatitis]], [[arthritis]], [[sacroiliitis]], [[meningitis]], [[orchitis]], [[epididymitis]]  [[uveitis]], and [[endocarditis]]. The prognosis of brucellosis is good with adequate treatment. Relapse may occur, and symptoms may continue for years.<ref name="f">Brucellosis. Medline Plus. https://www.nlm.nih.gov/medlineplus/ency/article/000597.htm. Accessed on February 3, 2016</ref><ref name="abc">FAO/WHO/OIE Brucellosis in humans and animals. WHO (2006). http://www.who.int/csr/resources/publications/Brucellosis.pdf Accessed on February 3, 2016  </ref><ref name="a">Brucellosis. Wikipedia. https://en.wikipedia.org/wiki/Brucellosis. Accessed on February 1, 2016</ref>
If left untreated, patients with [[brucellosis]] may progress to develop focal [[Organ (biology)|organ]] [[complications]], relapses or chronic brucellosis.<ref name="f">Brucellosis. CDC. http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/brucellosis. Accessed on February 3, 2016</ref> Common [[complications]] of brucellosis include [[hepatitis|granulomatous hepatitis]], [[arthritis]], [[sacroiliitis]], [[meningitis]], [[orchitis]], [[epididymitis]]  [[uveitis]], and [[endocarditis]]. The [[prognosis]] of brucellosis is good with adequate treatment.  


==Natural History==
==Natural History==
*Brucellosis incubation period is 2–4 weeks (range, 5 days to 5 months). If left untreated, patients with brucellosis may progress to develop focal infections, relapses or chronic brucellosis.<ref name="d">Brucellosis. CDC. http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/brucellosis. Accessed on February 3, 2016</ref>  
If left untreated, patients with [[brucellosis]] may progress to develop focal [[Organ (anatomy)|organ]] involvement, [[Relapse|relapses]] and chronic [[brucellosis]].<ref name="d">Brucellosis. CDC. http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/brucellosis. Accessed on February 3, 2016</ref>  


==Complications==
==Complications==
Complications of Brucellosis include the following:<ref>Colmenero JD, Reguera JM, Martos F, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 1996; 75:195.</ref><ref>Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007; 25:188.</ref><ref>Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352:2325.</ref><ref>Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7:173.</ref><ref>Young EJ. Brucellosis: current epidemiology, diagnosis, and management. Curr Clin Top Infect Dis 1995; 15:115.</ref><ref>Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.</ref><ref>Geyik MF, Gür A, Nas K, et al. Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases. Swiss Med Wkly 2002; 132:98.</ref><ref>Mousa AM, Bahar RH, Araj GF, et al. Neurological complications of brucella spondylitis. Acta Neurol Scand 1990; 81:16.</ref><ref>Pappas G, Bosilkovski M, Akritidis N, et al. Brucellosis and the respiratory system. Clin Infect Dis 2003; 37:e95.</ref><ref>Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.</ref>
Complications of [[brucellosis]] include the following:<ref name="pmid8699960">{{cite journal| author=Colmenero JD, Reguera JM, Martos F, Sánchez-De-Mora D, Delgado M, Causse M et al.| title=Complications associated with Brucella melitensis infection: a study of 530 cases. | journal=Medicine (Baltimore) | year= 1996 | volume= 75 | issue= 4 | pages= 195-211 | pmid=8699960 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8699960  }}</ref><ref name="pmid17901634">{{cite journal| author=Mantur BG, Amarnath SK, Shinde RS| title=Review of clinical and laboratory features of human brucellosis. | journal=Indian J Med Microbiol | year= 2007 | volume= 25 | issue= 3 | pages= 188-202 | pmid=17901634 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17901634  }}</ref><ref name="pmid159304">{{cite journal| author=Overturf ML, Druihet RE, Fitz A| title=The effects of kallikrein, plasmin, and thrombin on hog kidney renin. | journal=J Biol Chem | year= 1979 | volume= 254 | issue= 23 | pages= 12078-83 | pmid=159304 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=159304  }}</ref><ref>Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7:173.</ref><ref name="pmid7546364">{{cite journal| author=Young EJ| title=Brucellosis: current epidemiology, diagnosis, and management. | journal=Curr Clin Top Infect Dis | year= 1995 | volume= 15 | issue=  | pages= 115-28 | pmid=7546364 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7546364  }}</ref><ref name="pmid21623056">{{cite journal| author=Zamani A, Kooraki S, Mohazab RA, Zamani N, Matloob R, Hayatbakhsh MR et al.| title=Epidemiological and clinical features of Brucella arthritis in 24 children. | journal=Ann Saudi Med | year= 2011 | volume= 31 | issue= 3 | pages= 270-3 | pmid=21623056 | doi=10.4103/0256-4947.81543 | pmc=3119967 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21623056  }}</ref><ref name="pmid2330811">{{cite journal| author=Mousa AM, Bahar RH, Araj GF, Koshy TS, Muhtaseb SA, al-Mudallal DS et al.| title=Neurological complications of brucella spondylitis. | journal=Acta Neurol Scand | year= 1990 | volume= 81 | issue= 1 | pages= 16-23 | pmid=2330811 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2330811  }}</ref><ref name="pmid13130417">{{cite journal| author=Pappas G, Bosilkovski M, Akritidis N, Mastora M, Krteva L, Tsianos E| title=Brucellosis and the respiratory system. | journal=Clin Infect Dis | year= 2003 | volume= 37 | issue= 7 | pages= e95-9 | pmid=13130417 | doi=10.1086/378125 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13130417  }}</ref><ref name="pmid24480149">{{cite journal| author=Herrick JA, Lederman RJ, Sullivan B, Powers JH, Palmore TN| title=Brucella arteritis: clinical manifestations, treatment, and prognosis. | journal=Lancet Infect Dis | year= 2014 | volume= 14 | issue= 6 | pages= 520-6 | pmid=24480149 | doi=10.1016/S1473-3099(13)70270-6 | pmc=4498663 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24480149  }}</ref>
{| class="wikitable"
{| class="wikitable"
! colspan="2" |Complications of Brucellosis  
! colspan="2" |Complications of Brucellosis  
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*[[Spondylitis]]
*[[Spondylitis]]
|-
|-
|'''Cardiovascular'''
|'''[[Cardiovascular]]'''
|
|
*[[Infective endocarditis]]
*[[Infective endocarditis]]
**Common cardiovascular complication
**Common [[cardiovascular]] complication
**Frequent cause of death
**Frequent cause of death
**It has been reported in approximately 2% of cases
**It has been reported in approximately 2% of cases
Line 35: Line 35:
**[[Valve]] replacement [[surgery]] is usually needed apart from the medical therapy
**[[Valve]] replacement [[surgery]] is usually needed apart from the medical therapy
*[[Aneurysm of sinus of valsalva]]  
*[[Aneurysm of sinus of valsalva]]  
**Common complication when [[infection]] is due to ''B. suis''
**Common complication when [[infection]] is due to ''B.suis''
|-
|-
|'''Hepatobiliary complications'''
|'''[[Hepatobiliary system|Hepatobiliary complications]]'''
|
|
*[[Granulomatous hepatitis]]
*[[Granulomatous hepatitis]]
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**Due to B. suis
**Due to B. suis
|-
|-
|'''Genitourinary'''
|'''[[Genitourinary]]'''
|[[Orchitis]] and [[epididymitis]]
|[[Orchitis]] and [[epididymitis]]
*Frequent [[Genitourinary system|genitourinary]] complications within men
*Frequent [[Genitourinary system|genitourinary]] complications within men
|-
|-
|'''Neurological'''
|'''[[Neurology|Neurological]]'''
|
|
*[[Meningitis]] or [[meningoencephalitis]]
*[[Meningitis]] or [[meningoencephalitis]]
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*[[Poliomyelitis]]-like syndrome
*[[Poliomyelitis]]-like syndrome
|-
|-
|'''Gastrointestinal'''
|'''[[Gastrointestinal]]'''
|[[Colitis]], [[ileitis]], and [[spontaneous bacterial peritonitis]].
|[[Colitis]], [[ileitis]], and [[spontaneous bacterial peritonitis]].
*Rare cases have been reported.
*Rare cases have been reported.
|-
|-
|'''Respiratory tract'''
|'''[[Respiratory tract]]'''
|
|
*[[Bronchopneumonia]]  
*[[Bronchopneumonia]]  
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*[[Pleural effusions]]
*[[Pleural effusions]]
|-
|-
|'''Pregnancy'''
|'''[[Pregnancy]]'''
|[[Spontaneous abortion]]
|[[Spontaneous abortion]]
|-
|-
|'''Cutaneous'''
|'''[[Cutaneous]]'''
|   
|   
*[[Erythema nodosum]]
*[[Erythema nodosum]]
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|'''Opthalmic'''
|'''Opthalmic'''
|[[Uveitis]]
|[[Uveitis]]
*Most frequent ophtalmic complications<ref name="abc" />
*Most frequent ophtalmic complications<ref name="abc">FAO/WHO/OIE Brucellosis in humans and animals. WHO (2006). http://www.who.int/csr/resources/publications/Brucellosis.pdf Accessed on February 3, 2016  </ref>
|}
|}
 
==Prognosis==
==Prognosis==
The prognosis of brucellosis is good with treatment. Mortality is less then 1%, usually a consequence of cardiac involvement or severe neurologic disease. General well-being and the body weight of the patient are useful guide to estimating the prognosis or chance of relapse.
The [[prognosis]] of [[brucellosis]] is good with treatment. [[Mortality]] is less then 1%, usually due to consequence of [[cardiac]] involvement or severe [[Neurology|neurologic]] disease.<ref>Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9th, 2017</ref>


==Reference==
==Reference==
{{reflist|2}}
{{reflist|2}}
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Latest revision as of 20:44, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Danitza LukacVishal Devarkonda, M.B.B.S[3]

Overview

If left untreated, patients with brucellosis may progress to develop focal organ complications, relapses or chronic brucellosis.[1] Common complications of brucellosis include granulomatous hepatitis, arthritis, sacroiliitis, meningitis, orchitis, epididymitis uveitis, and endocarditis. The prognosis of brucellosis is good with adequate treatment.

Natural History

If left untreated, patients with brucellosis may progress to develop focal organ involvement, relapses and chronic brucellosis.[2]

Complications

Complications of brucellosis include the following:[3][4][5][6][7][8][9][10][11]

Complications of Brucellosis
Osteoarticular
Cardiovascular
Hepatobiliary complications
Genitourinary Orchitis and epididymitis
Neurological
Gastrointestinal Colitis, ileitis, and spontaneous bacterial peritonitis.
  • Rare cases have been reported.
Respiratory tract
Pregnancy Spontaneous abortion
Cutaneous
Opthalmic Uveitis
  • Most frequent ophtalmic complications[12]

Prognosis

The prognosis of brucellosis is good with treatment. Mortality is less then 1%, usually due to consequence of cardiac involvement or severe neurologic disease.[13]

Reference

  1. ↑ Brucellosis. CDC. http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/brucellosis. Accessed on February 3, 2016
  2. ↑ Brucellosis. CDC. http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/brucellosis. Accessed on February 3, 2016
  3. ↑ Colmenero JD, Reguera JM, Martos F, Sánchez-De-Mora D, Delgado M, Causse M; et al. (1996). "Complications associated with Brucella melitensis infection: a study of 530 cases". Medicine (Baltimore). 75 (4): 195–211. PMID 8699960.
  4. ↑ Mantur BG, Amarnath SK, Shinde RS (2007). "Review of clinical and laboratory features of human brucellosis". Indian J Med Microbiol. 25 (3): 188–202. PMID 17901634.
  5. ↑ Overturf ML, Druihet RE, Fitz A (1979). "The effects of kallikrein, plasmin, and thrombin on hog kidney renin". J Biol Chem. 254 (23): 12078–83. PMID 159304.
  6. ↑ Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7:173.
  7. ↑ Young EJ (1995). "Brucellosis: current epidemiology, diagnosis, and management". Curr Clin Top Infect Dis. 15: 115–28. PMID 7546364.
  8. ↑ Zamani A, Kooraki S, Mohazab RA, Zamani N, Matloob R, Hayatbakhsh MR; et al. (2011). "Epidemiological and clinical features of Brucella arthritis in 24 children". Ann Saudi Med. 31 (3): 270–3. doi:10.4103/0256-4947.81543. PMC 3119967. PMID 21623056.
  9. ↑ Mousa AM, Bahar RH, Araj GF, Koshy TS, Muhtaseb SA, al-Mudallal DS; et al. (1990). "Neurological complications of brucella spondylitis". Acta Neurol Scand. 81 (1): 16–23. PMID 2330811.
  10. ↑ Pappas G, Bosilkovski M, Akritidis N, Mastora M, Krteva L, Tsianos E (2003). "Brucellosis and the respiratory system". Clin Infect Dis. 37 (7): e95–9. doi:10.1086/378125. PMID 13130417.
  11. ↑ Herrick JA, Lederman RJ, Sullivan B, Powers JH, Palmore TN (2014). "Brucella arteritis: clinical manifestations, treatment, and prognosis". Lancet Infect Dis. 14 (6): 520–6. doi:10.1016/S1473-3099(13)70270-6. PMC 4498663. PMID 24480149.
  12. ↑ FAO/WHO/OIE Brucellosis in humans and animals. WHO (2006). http://www.who.int/csr/resources/publications/Brucellosis.pdf Accessed on February 3, 2016
  13. ↑ Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9th, 2017
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