Osteomalacia causes: Difference between revisions
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{{Osteomalacia}} | {{Osteomalacia}} | ||
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==Overview== | ==Overview== | ||
'''Osteomalacia''' is the softening of the [[bone]]s caused by deactivated [[bone mineralization]] primarily due to inadequate levels of available [[phosphate]] and [[calcium]], or because of [[bone resorption|resorption]] of calcium. Osteomalacia in children is known as [[rickets]], and because of this, use of the term "osteomalacia" is often restricted to the milder, adult form of the disease. Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones. | '''Osteomalacia''' is the softening of the [[bone]]s caused by deactivated [[bone mineralization]] primarily due to inadequate levels of available [[phosphate]] and [[calcium]], or because of [[bone resorption|resorption]] of calcium. Osteomalacia in children is known as [[rickets]], and because of this, use of the term "osteomalacia" is often restricted to the milder, adult form of the disease. Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones. | ||
==Causes== | |||
==Causes== | |||
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===Common Causes=== | ===Common Causes=== | ||
*Insufficient nutritional quantities or faulty metabolism of [[vitamin D]] or [[phosphorus]] | *Insufficient nutritional quantities or faulty metabolism of [[vitamin D]] or [[phosphorus]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Endocrine''' | | '''Endocrine''' | ||
|bgcolor="Beige"| [[Cystinosis]], [[Hyperparathyroidism]], [[Hypocalcemia]], [[Nephropathic early-onset cystinosis]] | |bgcolor="Beige"| [[Cystinosis]], [[Hyperparathyroidism]], [[Hypocalcemia]], [[Nephropathic early-onset cystinosis]], [[Hyperparathyroidism|primary hyperparathyroidism]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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===Causes in Alphabetical Order=== | ===Causes in Alphabetical Order=== | ||
{{columns-list | {{columns-list| | ||
*[[Acid phosphatase deficiency]] | *[[Acid phosphatase deficiency]] | ||
*[[Acid-base imbalance]] | *[[Acid-base imbalance]] | ||
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*[[Phenytoin]] | *[[Phenytoin]] | ||
*[[Primary biliary cirrhosis]] | *[[Primary biliary cirrhosis]] | ||
*[[Hyperparathyroidism|Primary hyperparathyroidism]] | |||
*[[Primary renal phosphate wasting syndromes]] | *[[Primary renal phosphate wasting syndromes]] | ||
*[[Proximal renal tubular acidosis]] | *[[Proximal renal tubular acidosis]] | ||
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*[[X-linked hypophosphataemia]] | *[[X-linked hypophosphataemia]] | ||
}} | }} | ||
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==References== | ==References== | ||
Latest revision as of 22:15, 10 January 2020
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Osteomalacia Microchapters |
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Case Studies |
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Osteomalacia causes On the Web |
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American Roentgen Ray Society Images of Osteomalacia causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Osteomalacia is the softening of the bones caused by deactivated bone mineralization primarily due to inadequate levels of available phosphate and calcium, or because of resorption of calcium. Osteomalacia in children is known as rickets, and because of this, use of the term "osteomalacia" is often restricted to the milder, adult form of the disease. Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones.
Causes
Common Causes
- Insufficient nutritional quantities or faulty metabolism of vitamin D or phosphorus
- Renal tubular acidosis
- Malnutrition during pregnancy
- Malabsorption syndrome
- Hypophosphatemia[1]
- Chronic kidney failure
- Tumor-induced osteomalacia
- Long-term anticonvulsant therapy[2]
- Celiac disease[3]
- Cadmium poisoning, Itai-itai disease
Causes by Organ System
Causes in Alphabetical Order
- Acid phosphatase deficiency
- Acid-base imbalance
- Adefovir
- Adult hypophosphatasia
- Aluminium toxicity
- Autosomal dominant hypophosphatemic rickets
- Axial osteomalacia
- Bisphosphonates
- Cadmium poisoning
- Celiac disease
- Cholestasis
- Chronic kidney failure
- Cystinosis
- Dent disease
- Ethotoin
- Etidronate
- Fanconi renotubular syndrome
- Fibrogenesis imperfecta
- Fluoride
- Glutethimide
- Hyperparathyroidism
- Hypocalcemia
- Hypokalaemic distal renal tubular acidosis
- Hypophosphatasia
- Hypophosphatemia
- Inadequate sunlight exposure
- Insufficient vitamin d
- Itai-itai disease
- Long-term anticonvulsant therapy
- Malabsorption
- Malnutrition during pregnancy
- Mesenchymal tumors
- Metabolic acidosis
- Nephropathic early-onset cystinosis
- Phenytoin
- Primary biliary cirrhosis
- Primary hyperparathyroidism
- Primary renal phosphate wasting syndromes
- Proximal renal tubular acidosis
- Renal failure
- Renal tubular acidosis
- Tenofovir
- Tumor-induced osteomalacia
- Vitamin d deficiency
- Wilson disease
- X-linked hypophosphataemia
References
- ↑ "Autoimmunity research foundation, Science behind Vitamin D". Retrieved 2011-07-19.
- ↑ Pack, Alison (2008). "Bone health in people with epilepsy: is it impaired and what are the risk factors". Seizure. 17 (2): 181–6. doi:10.1016/j.seizure.2007.11.020. PMID 18187347.
- ↑ Albany, Costantine; Servetnyk, Zhanna (2009). "Disabling osteomalacia and myopathy as the only presenting features of celiac disease: a case report". Cases Journal. 2 (1): 20. doi:10.1186/1757-1626-2-20. PMC 2626577. PMID 19128487.