Brucellosis diagnostic criteria

Brucellosis Microchapters
Home
Patient Information
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating Brucellosis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Principles of diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
X-Ray
CT Scan
MRI
Other Diagnostic Studies
Treatment
Medical Therapy
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Brucellosis diagnostic criteria On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Brucellosis diagnostic criteria All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Brucellosis diagnostic criteria
CDC on Brucellosis diagnostic criteria
Brucellosis diagnostic criteria in the news
Blogs on Brucellosis diagnostic criteria
Directions to Hospitals Treating Brucellosis
Risk calculators and risk factors for Brucellosis diagnostic criteria

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Danitza Lukac Vishal Devarkonda, M.B.B.S[2]

Overview

There is no specific diagnostic criteria for Brucellosis, diagnosis is based on history of potential exposure, presentation consistent with the disease, supporting laboratory findings.

Diagnostic Criteria

There is no specific diagnostic criteria for Brucellosis, diagnosis is based on:

• History of potential exposure
• Presentation consistent with the disease
• Supporting laboratory findings

Diagnosis of brucellosis
History of potential exposure	Living or travelling to Brucellosis endemic countries Consuming unpasteurized dairy products or raw meat products Unsafe hunting practices Occupational risks such as slaughther house workers, meat-packing employees, and veterinarian
presentation consistent with the disease	An illness characterized by acute or insidious onset of fever and one or more of the following: Night sweats Arthralgia Headache Fatigue Anorexia Myalgia Weight loss Arthritis/spondylitis Meningitis Focal organ involvement (endocarditis, orchitis/epididymitis, hepatomegaly, splenomegaly)
Supporting laboratory findings	Definitive: Culture and identification of Brucella spp. from clinical specimens Evidence of a fourfold or greater rise in Brucella antibody titer between acute- and convalescent-phase serum specimens obtained greater than or equal to 2 weeks apart Presumptive: Brucella total antibody titer of greater than or equal to 160 by standard tube agglutination test (SAT) or Brucella microagglutination test (BMAT) in one or more serum specimens obtained after onset of symptoms Detection of Brucella DNA in a clinical specimen by PCR assay Other non-specific findings may include: Complete blood count: Normal or low with relative lymphocytosis. Low platelets may be reported Hemoglobin: Mild anemia is documented Normal or elevated ESR Normal or elevated C-reactive protein levels Normal or raised fibrinogen degraded products
Relapse
Relapse	Relapse is usually suspected in patients with established diagnosis of Brucellosis, when general well being and body weight(loss of body weight) are affected. Pcr assay of pheripheral blood is recommended in diagnosis of relapse.
Chronic Brucellosis
Chronic Brucellosis	Chronic Brucellosis is diagnosis of exclusion. Chronic Brucellosis, should be considered in patients who present with chronic complains of fatigue, arthralgia, malaise, myalgia, and difficulty in vision for more then one year after established diagnosis of brucellosis. Pcr assay of pheripheral blood is recommended in diagnosis of Chronic Brucellosis.