Rhinitis epidemiology and demographics: Difference between revisions

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==Overview==
==Overview==
Rhinitis is a very frequent and highly prevalent global disease, and it is one of the most common conditions presenting for medical care in developed countries.<ref name="Diseases of the Sinuses">{{cite book |last1=Romeo |first1=Jonathan |last2=Dykewicz |first2=Mark |title=Diseases of the Sinuses |publisher=Springer New York |date=2014 |pages=133-152 |chapter=Chapter 9:Differential Diagnosis of Rhinitis and Rhinosinusitis |isbn=978-1-4939-0265-1}}</ref> 
==Epidemiology and Demographics==
==Epidemiology and Demographics==
Rhinitis is a very common disease with significant financial impact on the society.<ref name="pmid18662584">{{cite journal| author=Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA et al.| title=The diagnosis and management of rhinitis: an updated practice parameter. | journal=J Allergy Clin Immunol | year= 2008 | volume= 122 | issue= 2 Suppl | pages= S1-84 | pmid=18662584 | doi=10.1016/j.jaci.2008.06.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18662584  }} </ref> Chronic rhinitis is one of the commonest problems seen by physicians.<ref name="Diseases of the Sinuses">{{cite book |last1=Romeo |first1=Jonathan |last2=Dykewicz |first2=Mark |title=Diseases of the Sinuses |publisher=Springer New York |date=2014 |pages=133-152 |chapter=Chapter 9:Differential Diagnosis of Rhinitis and Rhinosinusitis |isbn=978-1-4939-0265-1}}</ref>  Allergic rhinitis is estimated to affect one in every six Americans, and it is the fifth most chronic disease in the U.S.<ref name="pmid25645524">{{cite journal| author=Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR et al.| title=Clinical practice guideline: allergic rhinitis executive summary. | journal=Otolaryngol Head Neck Surg | year= 2015 | volume= 152 | issue= 2 | pages= 197-206 | pmid=25645524 | doi=10.1177/0194599814562166 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25645524  }} </ref> Allergic rhinitis is the most common chronic disease in the pediatric age group in the U.S,<ref name="pmid25645524"></ref>  and it was the most common diagnosis reported in the 2000 Otolaryngology Workforce study.<ref name="pmid25182349">{{cite journal| author=Mims JW| title=Epidemiology of allergic rhinitis. | journal=Int Forum Allergy Rhinol | year= 2014 | volume= 4 Suppl 2 | issue=  | pages= S18-20 | pmid=25182349 | doi=10.1002/alr.21385 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25182349  }} </ref> The estimated prevalence of allergic rhinitis ranges from 9-42%.<ref name="pmid17153005">{{cite journal| author=Settipane RA, Charnock DR| title=Epidemiology of rhinitis: allergic and nonallergic. | journal=Clin Allergy Immunol | year= 2007 | volume= 19 | issue=  | pages= 23-34 | pmid=17153005 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17153005  }} </ref> Annually, between 30-60 million people in the U.S suffer from allergic rhinitis, 10-30% of these individuals are adults, and up to 40% are children.<ref name="Diseases of the Sinuses"></ref> The prevalence of allergic rhinitis has been found to be increasing in countries worldwide, and factors such as  increased airborne pollution, a rise in the population of dust mite in inadequately ventilated offices/homes with central heating/air conditioning, and sedentary lifestyles, have been suggested to contribute to the rise in its prevalence.<ref name="pmid15025839">{{cite journal| author=Schoenwetter WF, Dupclay L, Appajosyula S, Botteman MF, Pashos CL| title=Economic impact and quality-of-life burden of allergic rhinitis. | journal=Curr Med Res Opin | year= 2004 | volume= 20 | issue= 3 | pages= 305-17 | pmid=15025839 | doi=10.1185/030079903125003053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15025839  }} </ref><ref name="pmid18331513">{{cite journal| author=Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al.| title=Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). | journal=Allergy | year= 2008 | volume= 63 Suppl 86 | issue=  | pages= 8-160 | pmid=18331513 | doi=10.1111/j.1398-9995.2007.01620.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18331513  }} </ref> The prevalence of allergic rhinitis has significantly increased during the past 50 years, with over 50% of adolecents in some countries reporting symptoms of allergic rhinitis.<ref name="pmid18331513"></ref> Nonallergic rhinitis is also very common, and it has been estimated to affect about 19 million people in the U.S.<ref name="pmid17153005"></ref> Nonallergic rhinitis is predominantly seen in females, and the onset is often after the age of 20 years.<ref name="pmid17153005">{{cite journal| author=Settipane RA, Charnock DR| title=Epidemiology of rhinitis: allergic and nonallergic. | journal=Clin Allergy Immunol | year= 2007 | volume= 19 | issue=  | pages= 23-34 | pmid=17153005 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17153005  }} </ref>
'''Prevalence'''
There is sometimes an overlap between allergic and nonallergic rhinitis, referred to as "mixed rhinitis", and this has been estimated to affect about 26 million individuals in the United States.<ref name="pmid17153005"></ref> Primary atrophic rhinitis is more prevalent in developing countries with warm climates, and it is seen more commonly in young to middle-aged adults.<ref name="pmid20176255">{{cite journal| author=Dykewicz MS, Hamilos DL| title=Rhinitis and sinusitis. | journal=J Allergy Clin Immunol | year= 2010 | volume= 125 | issue= 2 Suppl 2 | pages= S103-15 | pmid=20176255 | doi=10.1016/j.jaci.2009.12.989 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20176255  }} </ref>


Rhinitis is a highly prevalent disease with significant financial impact on the society.<ref name="pmid18662584">{{cite journal| author=Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA et al.| title=The diagnosis and management of rhinitis: an updated practice parameter. | journal=J Allergy Clin Immunol | year= 2008 | volume= 122 | issue= 2 Suppl | pages= S1-84 | pmid=18662584 | doi=10.1016/j.jaci.2008.06.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18662584  }} </ref> Chronic rhinitis is one of the most common problems seen by physicians.<ref name="Diseases of the Sinuses">{{cite book |last1=Romeo |first1=Jonathan |last2=Dykewicz |first2=Mark |title=Diseases of the Sinuses |publisher=Springer New York |date=2014 |pages=133-152 |chapter=Chapter 9:Differential Diagnosis of Rhinitis and Rhinosinusitis |isbn=978-1-4939-0265-1}}</ref>  Allergic rhinitis is estimated to affect one in every six Americans, and it is the fifth most chronic disease in the U.S.<ref name="pmid25645524">{{cite journal| author=Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR et al.| title=Clinical practice guideline: allergic rhinitis executive summary. | journal=Otolaryngol Head Neck Surg | year= 2015 | volume= 152 | issue= 2 | pages= 197-206 | pmid=25645524 | doi=10.1177/0194599814562166 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25645524  }} </ref> Allergic rhinitis is the most common chronic disease in the pediatric age group in the U.S,<ref name="pmid25645524" /> and it was the most common diagnosis reported in the 2000 Otolaryngology Workforce study.<ref name="pmid25182349">{{cite journal| author=Mims JW| title=Epidemiology of allergic rhinitis. | journal=Int Forum Allergy Rhinol | year= 2014 | volume= 4 Suppl 2 | issue=  | pages= S18-20 | pmid=25182349 | doi=10.1002/alr.21385 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25182349  }} </ref> The estimated prevalence of allergic rhinitis ranges from 9-42%.<ref name="pmid17153005">{{cite journal| author=Settipane RA, Charnock DR| title=Epidemiology of rhinitis: allergic and nonallergic. | journal=Clin Allergy Immunol | year= 2007 | volume= 19 | issue=  | pages= 23-34 | pmid=17153005 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17153005  }} </ref> Annually, between 30-60 million people in the U.S suffer from allergic rhinitis, 10-30% of these individuals are adults, and up to 40% are children.<ref name="Diseases of the Sinuses" /> The prevalence of allergic rhinitis has been found to be increasing in countries worldwide, and factors such as  increased airborne pollution, a rise in the population of dust mite in inadequately ventilated offices/homes with central heating/air conditioning, and sedentary lifestyles, have been suggested to contribute to the rise in its prevalence.<ref name="pmid15025839">{{cite journal| author=Schoenwetter WF, Dupclay L, Appajosyula S, Botteman MF, Pashos CL| title=Economic impact and quality-of-life burden of allergic rhinitis. | journal=Curr Med Res Opin | year= 2004 | volume= 20 | issue= 3 | pages= 305-17 | pmid=15025839 | doi=10.1185/030079903125003053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15025839  }} </ref><ref name="pmid18331513">{{cite journal| author=Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al.| title=Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). | journal=Allergy | year= 2008 | volume= 63 Suppl 86 | issue=  | pages= 8-160 | pmid=18331513 | doi=10.1111/j.1398-9995.2007.01620.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18331513  }} </ref><ref name="pmid22092947">{{cite journal| author=Katelaris CH, Lee BW, Potter PC, Maspero JF, Cingi C, Lopatin A et al.| title=Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America. | journal=Clin Exp Allergy | year= 2012 | volume= 42 | issue= 2 | pages= 186-207 | pmid=22092947 | doi=10.1111/j.1365-2222.2011.03891.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22092947  }} </ref> The prevalence of allergic rhinitis has significantly increased during the past 50 years, with over 50% of adolecents in some countries reporting symptoms of allergic rhinitis.<ref name="pmid18331513" />  The prevalence of allergic rhinitis was noticed to have doubled in several countries over the last two decades in studies done in children between the ages 6-14years around the globe.<ref name="pmid22092947">{{cite journal| author=Katelaris CH, Lee BW, Potter PC, Maspero JF, Cingi C, Lopatin A et al.| title=Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America. | journal=Clin Exp Allergy | year= 2012 | volume= 42 | issue= 2 | pages= 186-207 | pmid=22092947 | doi=10.1111/j.1365-2222.2011.03891.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22092947  }} </ref> Nonallergic rhinitis is also very common, and it has been estimated to affect about 19 million people in the U.S.<ref name="pmid17153005" /> There is sometimes an overlap between allergic and nonallergic rhinitis, referred to as "mixed rhinitis", and this has been estimated to affect about 26 million individuals in the United States.<ref name="pmid17153005" /> The overall prevalence of occupational rhinitis is unknown but it has been estimated to affect between 23-50% of bakers in Norway.<ref name="pmid25430949">{{cite journal| author=Stevens WW, Grammer LC| title=Occupational rhinitis: an update. | journal=Curr Allergy Asthma Rep | year= 2015 | volume= 15 | issue= 1 | pages= 487 | pmid=25430949 | doi=10.1007/s11882-014-0487-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25430949  }} </ref>


'''Age'''


==References==  
Rhinitis affects all age groups. Allergic rhinitis is the most common chronic disease of childhood,<ref name="Allergic rhinitis-an overview of a common disease">{{cite journal |last=Rotiroti |first=Giuseppina |last2=Scadding |first2=Glenis |date=July 2016 |title=Allergic Rhinitis-an overview of a common disease |url=https://www-clinicalkey-com.ezp-prod1.hul.harvard.edu/#!/content/playContent/1-s2.0-S1751722216300063?returnurl=null&referrer=null&scrollTo=%23tbl2|journal=Paediatrics and Child Health |volume= Volume 26 |issue= Issue 7 |pages=298-303 |access-date=January 20, 2017 }} </ref> with symptoms developing in one of five children by 2-3 years of age.<ref name="pmid11449200">{{cite journal| author=Skoner DP| title=Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. | journal=J Allergy Clin Immunol | year= 2001 | volume= 108 | issue= 1 Suppl | pages= S2-8 | pmid=11449200 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11449200  }} </ref>  Up to 40% of of children have symptoms of allergic rhinitis by the age of six.<ref name="pmid11449200">{{cite journal| author=Skoner DP| title=Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. | journal=J Allergy Clin Immunol | year= 2001 | volume= 108 | issue= 1 Suppl | pages= S2-8 | pmid=11449200 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11449200  }} </ref> The onset of nonallergic (non-infectious) rhinitis is often after the age of 20 years.<ref name="pmid17153005">{{cite journal| author=Settipane RA, Charnock DR| title=Epidemiology of rhinitis: allergic and nonallergic. | journal=Clin Allergy Immunol | year= 2007 | volume= 19 | issue=  | pages= 23-34 | pmid=17153005 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17153005  }} </ref>
[[Atrophic rhinitis|Primary atrophic rhinitis]] is more commonly seen in young to middle-aged adults.<ref name="pmid20176255">{{cite journal| author=Dykewicz MS, Hamilos DL| title=Rhinitis and sinusitis. | journal=J Allergy Clin Immunol | year= 2010 | volume= 125 | issue= 2 Suppl 2 | pages= S103-15 | pmid=20176255 | doi=10.1016/j.jaci.2009.12.989 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20176255  }} </ref>
{| class="wikitable"
! colspan="3" |Pattern of Allergic and Infectious rhinitis in children<ref name="Allergic rhinitis-an overview of a common disease">{{cite journal |last=Rotiroti |first=Giuseppina |last2=Scadding |first2=Glenis |date=July 2016 |title=Allergic Rhinitis-an overview of a common disease |url=https://www-clinicalkey-com.ezp-prod1.hul.harvard.edu/#!/content/playContent/1-s2.0-S1751722216300063?returnurl=null&referrer=null&scrollTo=%23tbl2|journal=Paediatrics and Child Health |volume= Volume 26 |issue= Issue 7 |pages=298-303 |access-date=January 20, 2017 }} </ref>
 
|-
|Age
|Allergic rhinitis
|Infectious rhinitis
|-
|Neonates and Infants
| +/-
| ++
|-
|Pre-school age
| ++
| ++
|-
|School age
| +++
| ++
|-
|Pre-adolescent
| +++
| +
|}
 
'''Sex'''
 
* Allergic rhinitis appears to be more common in boys during childhood, but males and females are equally affected during adulthood.<ref name="pmid11449200">{{cite journal| author=Skoner DP| title=Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. | journal=J Allergy Clin Immunol | year= 2001 | volume= 108 | issue= 1 Suppl | pages= S2-8 | pmid=11449200 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11449200  }} </ref>
 
* Nonallergic (non-infectious) rhinitis is predominantly seen in females.<ref name="pmid17153005">{{cite journal| author=Settipane RA, Charnock DR| title=Epidemiology of rhinitis: allergic and nonallergic. | journal=Clin Allergy Immunol | year= 2007 | volume= 19 | issue=  | pages= 23-34 | pmid=17153005 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17153005  }} </ref>
 
* [[Atrophic rhinitis|Primary atrophic rhinitis]] is more common in females, with a female:male ratio of 5.6:1.<ref name="pmid23762613">{{cite journal| author=Bist SS, Bisht M, Purohit JP| title=Primary atrophic rhinitis: a clinical profile, microbiological and radiological study. | journal=ISRN Otolaryngol | year= 2012 | volume= 2012 | issue=  | pages= 404075 | pmid=23762613 | doi=10.5402/2012/404075 | pmc=3671697 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23762613  }} </ref>
 
'''Geographical Distribution'''
 
Rhinitis is a global disease with wide inter-regional and intra-regional variations in its prevalence.<ref name="pmid22092947">{{cite journal| author=Katelaris CH, Lee BW, Potter PC, Maspero JF, Cingi C, Lopatin A et al.| title=Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America. | journal=Clin Exp Allergy | year= 2012 | volume= 42 | issue= 2 | pages= 186-207 | pmid=22092947 | doi=10.1111/j.1365-2222.2011.03891.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22092947  }} </ref>  A study on the prevalence and diversity of allergic rhinitis in regions of the world (several countries in Africa, the Asia-Pacific region, Australia, Eastern Europe, Latin America, Middle East and Turkey), showed wide variations in the prevalence of allergic rhinitis, ranging from 2.9% to 54.1%.<ref name="pmid22092947">{{cite journal| author=Katelaris CH, Lee BW, Potter PC, Maspero JF, Cingi C, Lopatin A et al.| title=Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America. | journal=Clin Exp Allergy | year= 2012 | volume= 42 | issue= 2 | pages= 186-207 | pmid=22092947 | doi=10.1111/j.1365-2222.2011.03891.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22092947  }} </ref> [[Atrophic rhinitis|Primary atrophic rhinitis]] is more prevalent in developing countries with warm climates.<ref name="pmid20176255">{{cite journal| author=Dykewicz MS, Hamilos DL| title=Rhinitis and sinusitis. | journal=J Allergy Clin Immunol | year= 2010 | volume= 125 | issue= 2 Suppl 2 | pages= S103-15 | pmid=20176255 | doi=10.1016/j.jaci.2009.12.989 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20176255  }} </ref> The prevalence of [[Atrophic rhinitis|primary atrophic rhinitis]] varies in different parts of the world, affecting about 0.3-1% of the population in countries where it is highly prevalent.<ref name="pmid23762613">{{cite journal| author=Bist SS, Bisht M, Purohit JP| title=Primary atrophic rhinitis: a clinical profile, microbiological and radiological study. | journal=ISRN Otolaryngol | year= 2012 | volume= 2012 | issue=  | pages= 404075 | pmid=23762613 | doi=10.5402/2012/404075 | pmc=3671697 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23762613  }} </ref> It has been found to be a common condition in tropical countries like India.<ref name="pmid23762613">{{cite journal| author=Bist SS, Bisht M, Purohit JP| title=Primary atrophic rhinitis: a clinical profile, microbiological and radiological study. | journal=ISRN Otolaryngol | year= 2012 | volume= 2012 | issue=  | pages= 404075 | pmid=23762613 | doi=10.5402/2012/404075 | pmc=3671697 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23762613  }} </ref>
 
'''Cost'''
 
Chronic rhinitis constitute a huge financial burden to the society.<ref name="pmid18662584" /> Allergic rhinitis generates between $1.6-$4.9 billion in direct healthcare expenditure in the United States,  and an indirect cost of about $0.1-$9.7 billion due to lost productivity annually.<ref name="pmid25182349">{{cite journal| author=Mims JW| title=Epidemiology of allergic rhinitis. | journal=Int Forum Allergy Rhinol | year= 2014 | volume= 4 Suppl 2 | issue=  | pages= S18-20 | pmid=25182349 | doi=10.1002/alr.21385 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25182349  }} </ref>
 
==References==
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[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Infectious disease]]
[[Category:Otolaryngology]]
[[Category:Immunology]]

Latest revision as of 00:00, 30 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Fatimo Biobaku M.B.B.S [2]

Overview

Rhinitis is a very frequent and highly prevalent global disease, and it is one of the most common conditions presenting for medical care in developed countries.[1]

Epidemiology and Demographics

Prevalence

Rhinitis is a highly prevalent disease with significant financial impact on the society.[2] Chronic rhinitis is one of the most common problems seen by physicians.[1] Allergic rhinitis is estimated to affect one in every six Americans, and it is the fifth most chronic disease in the U.S.[3] Allergic rhinitis is the most common chronic disease in the pediatric age group in the U.S,[3] and it was the most common diagnosis reported in the 2000 Otolaryngology Workforce study.[4] The estimated prevalence of allergic rhinitis ranges from 9-42%.[5] Annually, between 30-60 million people in the U.S suffer from allergic rhinitis, 10-30% of these individuals are adults, and up to 40% are children.[1] The prevalence of allergic rhinitis has been found to be increasing in countries worldwide, and factors such as increased airborne pollution, a rise in the population of dust mite in inadequately ventilated offices/homes with central heating/air conditioning, and sedentary lifestyles, have been suggested to contribute to the rise in its prevalence.[6][7][8] The prevalence of allergic rhinitis has significantly increased during the past 50 years, with over 50% of adolecents in some countries reporting symptoms of allergic rhinitis.[7] The prevalence of allergic rhinitis was noticed to have doubled in several countries over the last two decades in studies done in children between the ages 6-14years around the globe.[8] Nonallergic rhinitis is also very common, and it has been estimated to affect about 19 million people in the U.S.[5] There is sometimes an overlap between allergic and nonallergic rhinitis, referred to as "mixed rhinitis", and this has been estimated to affect about 26 million individuals in the United States.[5] The overall prevalence of occupational rhinitis is unknown but it has been estimated to affect between 23-50% of bakers in Norway.[9]

Age

Rhinitis affects all age groups. Allergic rhinitis is the most common chronic disease of childhood,[10] with symptoms developing in one of five children by 2-3 years of age.[11] Up to 40% of of children have symptoms of allergic rhinitis by the age of six.[11] The onset of nonallergic (non-infectious) rhinitis is often after the age of 20 years.[5] Primary atrophic rhinitis is more commonly seen in young to middle-aged adults.[12]

Pattern of Allergic and Infectious rhinitis in children[10]
Age Allergic rhinitis Infectious rhinitis
Neonates and Infants +/- ++
Pre-school age ++ ++
School age +++ ++
Pre-adolescent +++ +

Sex

  • Allergic rhinitis appears to be more common in boys during childhood, but males and females are equally affected during adulthood.[11]
  • Nonallergic (non-infectious) rhinitis is predominantly seen in females.[5]

Geographical Distribution

Rhinitis is a global disease with wide inter-regional and intra-regional variations in its prevalence.[8] A study on the prevalence and diversity of allergic rhinitis in regions of the world (several countries in Africa, the Asia-Pacific region, Australia, Eastern Europe, Latin America, Middle East and Turkey), showed wide variations in the prevalence of allergic rhinitis, ranging from 2.9% to 54.1%.[8] Primary atrophic rhinitis is more prevalent in developing countries with warm climates.[12] The prevalence of primary atrophic rhinitis varies in different parts of the world, affecting about 0.3-1% of the population in countries where it is highly prevalent.[13] It has been found to be a common condition in tropical countries like India.[13]

Cost

Chronic rhinitis constitute a huge financial burden to the society.[2] Allergic rhinitis generates between $1.6-$4.9 billion in direct healthcare expenditure in the United States, and an indirect cost of about $0.1-$9.7 billion due to lost productivity annually.[4]

References

  1. ↑ 1.0 1.1 1.2 Romeo, Jonathan; Dykewicz, Mark (2014). "Chapter 9:Differential Diagnosis of Rhinitis and Rhinosinusitis". Diseases of the Sinuses. Springer New York. pp. 133–152. ISBN 978-1-4939-0265-1.
  2. ↑ 2.0 2.1 Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA; et al. (2008). "The diagnosis and management of rhinitis: an updated practice parameter". J Allergy Clin Immunol. 122 (2 Suppl): S1–84. doi:10.1016/j.jaci.2008.06.003. PMID 18662584.
  3. ↑ 3.0 3.1 Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR; et al. (2015). "Clinical practice guideline: allergic rhinitis executive summary". Otolaryngol Head Neck Surg. 152 (2): 197–206. doi:10.1177/0194599814562166. PMID 25645524.
  4. ↑ 4.0 4.1 Mims JW (2014). "Epidemiology of allergic rhinitis". Int Forum Allergy Rhinol. 4 Suppl 2: S18–20. doi:10.1002/alr.21385. PMID 25182349.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Settipane RA, Charnock DR (2007). "Epidemiology of rhinitis: allergic and nonallergic". Clin Allergy Immunol. 19: 23–34. PMID 17153005.
  6. ↑ Schoenwetter WF, Dupclay L, Appajosyula S, Botteman MF, Pashos CL (2004). "Economic impact and quality-of-life burden of allergic rhinitis". Curr Med Res Opin. 20 (3): 305–17. doi:10.1185/030079903125003053. PMID 15025839.
  7. ↑ 7.0 7.1 Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A; et al. (2008). "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)". Allergy. 63 Suppl 86: 8–160. doi:10.1111/j.1398-9995.2007.01620.x. PMID 18331513.
  8. ↑ 8.0 8.1 8.2 8.3 Katelaris CH, Lee BW, Potter PC, Maspero JF, Cingi C, Lopatin A; et al. (2012). "Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America". Clin Exp Allergy. 42 (2): 186–207. doi:10.1111/j.1365-2222.2011.03891.x. PMID 22092947.
  9. ↑ Stevens WW, Grammer LC (2015). "Occupational rhinitis: an update". Curr Allergy Asthma Rep. 15 (1): 487. doi:10.1007/s11882-014-0487-8. PMID 25430949.
  10. ↑ 10.0 10.1 Rotiroti, Giuseppina; Scadding, Glenis (July 2016). "Allergic Rhinitis-an overview of a common disease". Paediatrics and Child Health. Volume 26 (Issue 7): 298–303. Retrieved January 20, 2017.
  11. ↑ 11.0 11.1 11.2 Skoner DP (2001). "Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis". J Allergy Clin Immunol. 108 (1 Suppl): S2–8. PMID 11449200.
  12. ↑ 12.0 12.1 Dykewicz MS, Hamilos DL (2010). "Rhinitis and sinusitis". J Allergy Clin Immunol. 125 (2 Suppl 2): S103–15. doi:10.1016/j.jaci.2009.12.989. PMID 20176255.
  13. ↑ 13.0 13.1 13.2 Bist SS, Bisht M, Purohit JP (2012). "Primary atrophic rhinitis: a clinical profile, microbiological and radiological study". ISRN Otolaryngol. 2012: 404075. doi:10.5402/2012/404075. PMC 3671697. PMID 23762613.

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