Pyogenic liver abscess laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory tests consistent with diagnosis of pyogenic liver abscess include [[complete blood picture]], [[ESR]], [[C-reactive protein]], [[liver function tests]], [[pus]] | Laboratory tests consistent with diagnosis of pyogenic liver abscess include [[CBC|complete blood picture]], [[ESR]], [[C-reactive protein]], [[liver function tests]], [[pus]] culture, and [[blood culture]].<ref name="pmid15578367">{{cite journal| author=Rahimian J, Wilson T, Oram V, Holzman RS| title=Pyogenic liver abscess: recent trends in etiology and mortality. | journal=Clin Infect Dis | year= 2004 | volume= 39 | issue= 11 | pages= 1654-9 | pmid=15578367 | doi=10.1086/425616 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15578367 }} </ref> | ||
==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
Diagnostic criteria for pyogenic liver abscess are: | Diagnostic criteria for pyogenic liver abscess are:<ref name="pmid15578367">{{cite journal| author=Rahimian J, Wilson T, Oram V, Holzman RS| title=Pyogenic liver abscess: recent trends in etiology and mortality. | journal=Clin Infect Dis | year= 2004 | volume= 39 | issue= 11 | pages= 1654-9 | pmid=15578367 | doi=10.1086/425616 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15578367 }} </ref> | ||
*Liver aspirate or surgical tissue culture positive from a discrete liver abscess | *[[aspirate|Liver aspirate]] or [[tissue culture|surgical tissue culture]] positive from a discrete [[liver abscess]] | ||
*Diagnostic imaging consistent with liver abscess with a concurrent positive blood culture | *Diagnostic imaging consistent with [[liver abscess]] with a concurrent positive [[blood culture]] | ||
*Diagnostic imaging consistent with liver abscess and a defined radiologic and clinical response to antimicrobial management even if cultures were negative or not performed. | *Diagnostic imaging consistent with [[liver abscess]] and a defined radiologic and clinical response to [[antimicrobial]] management even if cultures were negative or not performed. | ||
==Laboratory findings== | ==Laboratory findings== | ||
*Laboratory tests consistent with diagnosis of | *Laboratory tests consistent with diagnosis of pyogenic liver abscess include:<ref name="pmid15578367">{{cite journal| author=Rahimian J, Wilson T, Oram V, Holzman RS| title=Pyogenic liver abscess: recent trends in etiology and mortality. | journal=Clin Infect Dis | year= 2004 | volume= 39 | issue= 11 | pages= 1654-9 | pmid=15578367 | doi=10.1086/425616 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15578367 }} </ref><ref name="pmid8651751">{{cite journal| author=Huang CJ, Pitt HA, Lipsett PA, Osterman FA, Lillemoe KD, Cameron JL et al.| title=Pyogenic hepatic abscess. Changing trends over 42 years. | journal=Ann Surg | year= 1996 | volume= 223 | issue= 5 | pages= 600-7; discussion 607-9 | pmid=8651751 | doi= | pmc=1235191 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8651751 }} </ref><ref name="pmid4372883">{{cite journal| author=Rubin RH, Swartz MN, Malt R| title=Hepatic abscess: changes in clinical, bacteriologic and therapeutic aspects. | journal=Am J Med | year= 1974 | volume= 57 | issue= 4 | pages= 601-10 | pmid=4372883 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4372883 }} </ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
!Lab Test | !Lab Test | ||
!Findings | !Findings | ||
|- | |- | ||
! Complete Blood | ! [[Complete blood count|Complete Blood count]] | ||
| | | | ||
*[[Hemoglobin]] <10g/dl | *[[Hemoglobin]] <10g/dl | ||
| Line 24: | Line 24: | ||
*[[Neutrophilia]] | *[[Neutrophilia]] | ||
|- | |- | ||
! ESR and CRP | ! [[ESR]] and [[CRP]] | ||
| | | | ||
Elevated ESR and C reactive protein | Elevated [[ESR]] and [[C-reactive protein]] | ||
|- | |- | ||
! Liver function tests | ! [[Liver function tests]] | ||
| | | | ||
* Elevated alkaline phosphatase | * Elevated [[alkaline phosphatase]] | ||
* Elevated serum aspartate aminotransferase | * Elevated serum [[AST|aspartate aminotransferase (AST)]] | ||
* Elevated serum alanine | * Elevated serum [[Alanine aminotransferase|alanine aminotransferase (ALT)]] | ||
* Elevated | * Elevated [[bilirubin]] | ||
* Decreased albumin and increased globulin | * Decreased [[albumin]] and increased [[globulin]] | ||
|- | |- | ||
!Pus culture | ![[Pus]] [[culture]] | ||
|Pus drained from abscess is used for culture and sensitivity | |[[Pus]] drained from [[abscess]] is used for culture and sensitivity | ||
|- | |- | ||
!Blood culture | ![[Blood culture]] | ||
| | | | ||
Culture of blood for bacteria | [[Culture]] of [[blood]] for [[bacteria]] | ||
|} | |} | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Emergency mdicine]] | |||
[[Category:Disease]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Hepatology]] | |||
Latest revision as of 23:55, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]
Overview
Laboratory tests consistent with diagnosis of pyogenic liver abscess include complete blood picture, ESR, C-reactive protein, liver function tests, pus culture, and blood culture.[1]
Diagnostic Criteria
Diagnostic criteria for pyogenic liver abscess are:[1]
- Liver aspirate or surgical tissue culture positive from a discrete liver abscess
- Diagnostic imaging consistent with liver abscess with a concurrent positive blood culture
- Diagnostic imaging consistent with liver abscess and a defined radiologic and clinical response to antimicrobial management even if cultures were negative or not performed.
Laboratory findings
| Lab Test | Findings |
|---|---|
| Complete Blood count |
|
| ESR and CRP |
Elevated ESR and C-reactive protein |
| Liver function tests |
|
| Pus culture | Pus drained from abscess is used for culture and sensitivity |
| Blood culture |
References
- ↑ 1.0 1.1 1.2 Rahimian J, Wilson T, Oram V, Holzman RS (2004). "Pyogenic liver abscess: recent trends in etiology and mortality". Clin Infect Dis. 39 (11): 1654–9. doi:10.1086/425616. PMID 15578367.
- ↑ Huang CJ, Pitt HA, Lipsett PA, Osterman FA, Lillemoe KD, Cameron JL; et al. (1996). "Pyogenic hepatic abscess. Changing trends over 42 years". Ann Surg. 223 (5): 600–7, discussion 607-9. PMC 1235191. PMID 8651751.
- ↑ Rubin RH, Swartz MN, Malt R (1974). "Hepatic abscess: changes in clinical, bacteriologic and therapeutic aspects". Am J Med. 57 (4): 601–10. PMID 4372883.