Breast abscess pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
Following untreated [[mastitis]], breast [[abscess]] could occur. | Following untreated [[mastitis]], breast [[abscess]] could occur. | ||
[[Breast|Breas]]<nowiki/>t [[abscess]] is usually caused by [[staphylococcus aureus]] [[bacterial]] [[infection]] to an injured [[breast]] [[skin]]. [[Staphylococcus aureus]] could form [[abscess]] by secretion of several killing agents like [[enzymes]] and [[toxins]] which causes breast tissue necrosis. In a reaction to these [[bacterial]] substances, assembled [[white blood cells]] in this tissue produces anti-bacterial [[Antibodies|anti-bodies]] that help in killing the [[bacteria]]. However, these cells cause damage to the [[soft tissue]] contributing in the [[abscess]] formation. | [[Breast|Breas]]<nowiki/>t [[abscess]] is usually caused by [[staphylococcus aureus]] [[bacterial]] [[infection]] to an injured [[breast]] [[skin]]. [[Staphylococcus aureus]] could form [[abscess]] by secretion of several killing agents like [[enzymes]] and [[toxins]] which causes [[breast]] [[tissue]] [[necrosis]]. In a reaction to these [[bacterial]] substances, assembled [[white blood cells]] in this tissue produces [[Antibacterial|anti-bacterial]] [[Antibodies|anti-bodies]] that help in killing the [[bacteria]]. However, these cells cause damage to the [[soft tissue]] contributing in the [[abscess]] formation. | ||
As the [[breast]] [[abscess]] is the complicated form of [[mastitis]], the pathophysiology is mostly like the [[mastitis pathophysiology]].<ref name="pmid25749135">{{cite journal| author=Kobayashi SD, Malachowa N, DeLeo FR| title=Pathogenesis of Staphylococcus aureus abscesses. | journal=Am J Pathol | year= 2015 | volume= 185 | issue= 6 | pages= 1518-27 | pmid=25749135 | doi=10.1016/j.ajpath.2014.11.030 | pmc=4450319 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25749135 }} </ref> | As the [[breast]] [[abscess]] is the complicated form of [[mastitis]], the pathophysiology is mostly like the [[mastitis pathophysiology]].<ref name="pmid25749135">{{cite journal| author=Kobayashi SD, Malachowa N, DeLeo FR| title=Pathogenesis of Staphylococcus aureus abscesses. | journal=Am J Pathol | year= 2015 | volume= 185 | issue= 6 | pages= 1518-27 | pmid=25749135 | doi=10.1016/j.ajpath.2014.11.030 | pmc=4450319 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25749135 }} </ref> | ||
==Pathophysiology== | ==Pathophysiology== | ||
===Pathogenesis=== | ===Pathogenesis=== | ||
[[Breast abscess]] is the result of underlying [[inflammation]] ([[mastitis]]) in the breast skin. [[Injury]] may happen either during the [[lactation]] process from the infant or in the [[non-lactaion]] state of the patient as a cracking in the [[breast]] [[skin]]. This injury accelerates the entry of the causative [[bacteria]] which by its role form the [[abscess]]. <ref name="pmid24465097">{{cite journal| author=Kataria K, Srivastava A, Dhar A| title=Management of lactational mastitis and breast abscesses: review of current knowledge and practice. | journal=Indian J Surg | year= 2013 | volume= 75 | issue= 6 | pages= 430-5 | pmid=24465097 | doi=10.1007/s12262-012-0776-1 | pmc=3900741 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24465097 }} </ref><br>In neglected cases, there may be [[necrosis]] in the abscess location leads to [[fibrosis]], scarring and [[nipple retraction]]. | [[Breast abscess]] is the result of underlying [[inflammation]] ([[mastitis]]) in the [[breast]] [[skin]]. [[Injury]] may happen either during the [[lactation]] process from the infant or in the [[non-lactaion]] state of the patient as a cracking in the [[breast]] [[skin]]. This [[injury]] accelerates the entry of the causative [[bacteria]] which by its role form the [[abscess]]. <ref name="pmid24465097">{{cite journal| author=Kataria K, Srivastava A, Dhar A| title=Management of lactational mastitis and breast abscesses: review of current knowledge and practice. | journal=Indian J Surg | year= 2013 | volume= 75 | issue= 6 | pages= 430-5 | pmid=24465097 | doi=10.1007/s12262-012-0776-1 | pmc=3900741 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24465097 }} </ref><br>In neglected cases, there may be [[necrosis]] in the abscess location leads to [[fibrosis]], [[scarring]] and [[Nipple|nipple retraction]]. | ||
*'''Lactational''': | *'''Lactational''': | ||
**Injured [[breast]] skin allows the entrance of the [[bacteria]] to the mammillary [[ducts]]. This [[bacteria]] can be from the infant or the mother herself. Overproduction of the breast milk with no flow to the infant forms an opportunistic field for the bacteria to cause [[infection]].<ref name="pmid11892876">{{cite journal| author=Marchant DJ| title=Inflammation of the breast. | journal=Obstet Gynecol Clin North Am | year= 2002 | volume= 29 | issue= 1 | pages= 89-102 | pmid=11892876 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11892876 }} </ref> | **Injured [[breast]] [[skin]] allows the entrance of the [[bacteria]] to the mammillary [[ducts]]. This [[bacteria]] can be from the infant or the mother herself. Overproduction of the breast milk with no flow to the infant forms an opportunistic field for the [[bacteria]] to cause [[infection]].<ref name="pmid11892876">{{cite journal| author=Marchant DJ| title=Inflammation of the breast. | journal=Obstet Gynecol Clin North Am | year= 2002 | volume= 29 | issue= 1 | pages= 89-102 | pmid=11892876 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11892876 }} </ref> | ||
**[[Duct ectasia of breast|Breast Duct Ectasia]]: [[Metaplasticity|Metaplastic]] change of the duct cells can cause [[Duct ectasia of breast|duct ectasia]]. This change causes widening of the ducts lining which leads to thickening of the ducts and obstruction. The ducts become filled with fluid which leads to [[nipple discharge]] and [[infection]] by the entrance of the bacteria and can form [[pus]] and [[abscess]] as a final result. <ref name="pmid4041720">{{cite journal| author=Bundred NJ, Dixon JM, Lumsden AB, Radford D, Hood J, Miles RS et al.| title=Are the lesions of duct ectasia sterile? | journal=Br J Surg | year= 1985 | volume= 72 | issue= 10 | pages= 844-5 | pmid=4041720 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4041720 }} </ref> | **[[Duct ectasia of breast|Breast Duct Ectasia]]: [[Metaplasticity|Metaplastic]] change of the [[duct]] cells can cause [[Duct ectasia of breast|duct ectasia]]. This change causes widening of the [[ducts]] lining which leads to thickening of the ducts and obstruction. The [[ducts]] become filled with [[fluid]] which leads to [[nipple discharge]] and [[infection]] by the entrance of the [[bacteria]] and can form [[pus]] and [[abscess]] as a final result. <ref name="pmid4041720">{{cite journal| author=Bundred NJ, Dixon JM, Lumsden AB, Radford D, Hood J, Miles RS et al.| title=Are the lesions of duct ectasia sterile? | journal=Br J Surg | year= 1985 | volume= 72 | issue= 10 | pages= 844-5 | pmid=4041720 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4041720 }} </ref> | ||
*'''Non-Lactional''': | *'''Non-Lactional''': | ||
**Non lactational breast abscess is less common than lactational form. It can be subgrouped into central, peripheral and skin associating. | **Non lactational [[breast]] [[abscess]] is less common than lactational form. It can be subgrouped into central, peripheral and [[skin]] associating. | ||
**Cracking in the skin will overtly help the bacteria to enter and form the abscess. | **Cracking in the [[skin]] will overtly help the [[bacteria]] to enter and form the [[abscess]]. | ||
===Associated diseases=== | ===Associated diseases=== | ||
There is no associated diseases with breast abscess. | There is no associated diseases with [[breast]] [[abscess]]. | ||
===Gross Pathology=== | |||
The gross findings can be confused with other malignant diseases. | |||
*Ill-defined with overlying skin thickening | |||
*[[Lymphadenopathy]] | |||
*Nipple retraction | |||
===Microscopic pathology=== | |||
The following findings can be demonstrated on a pathology slide | |||
*[[Lymphocytes]] along with [[neutrophils]] are gathered around the central abscess cavity filled with [[pus]]. | |||
*Inflammatory infiltration involves gland buds and surrounding stroma along with [[lymphatic ducts]]. | |||
*Foamy [[histiocytes]] are demonstrated in the dilated ducts. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}}{{WS}} | {{WH}}{{WS}} | ||
[[Category:Disease]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Gynecology]] | |||
[[Category:Obstetrics]] | |||
[[Category:Surgery]] | |||
[[Category:Emergency medicine]] | |||
[[Category:Infectious disease]] | |||
Latest revision as of 20:42, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Following untreated mastitis, breast abscess could occur. Breast abscess is usually caused by staphylococcus aureus bacterial infection to an injured breast skin. Staphylococcus aureus could form abscess by secretion of several killing agents like enzymes and toxins which causes breast tissue necrosis. In a reaction to these bacterial substances, assembled white blood cells in this tissue produces anti-bacterial anti-bodies that help in killing the bacteria. However, these cells cause damage to the soft tissue contributing in the abscess formation. As the breast abscess is the complicated form of mastitis, the pathophysiology is mostly like the mastitis pathophysiology.[1]
Pathophysiology
Pathogenesis
Breast abscess is the result of underlying inflammation (mastitis) in the breast skin. Injury may happen either during the lactation process from the infant or in the non-lactaion state of the patient as a cracking in the breast skin. This injury accelerates the entry of the causative bacteria which by its role form the abscess. [2]
In neglected cases, there may be necrosis in the abscess location leads to fibrosis, scarring and nipple retraction.
- Lactational:
- Injured breast skin allows the entrance of the bacteria to the mammillary ducts. This bacteria can be from the infant or the mother herself. Overproduction of the breast milk with no flow to the infant forms an opportunistic field for the bacteria to cause infection.[3]
- Breast Duct Ectasia: Metaplastic change of the duct cells can cause duct ectasia. This change causes widening of the ducts lining which leads to thickening of the ducts and obstruction. The ducts become filled with fluid which leads to nipple discharge and infection by the entrance of the bacteria and can form pus and abscess as a final result. [4]
- Non-Lactional:
Associated diseases
There is no associated diseases with breast abscess.
Gross Pathology
The gross findings can be confused with other malignant diseases.
- Ill-defined with overlying skin thickening
- Lymphadenopathy
- Nipple retraction
Microscopic pathology
The following findings can be demonstrated on a pathology slide
- Lymphocytes along with neutrophils are gathered around the central abscess cavity filled with pus.
- Inflammatory infiltration involves gland buds and surrounding stroma along with lymphatic ducts.
- Foamy histiocytes are demonstrated in the dilated ducts.
References
- ↑ Kobayashi SD, Malachowa N, DeLeo FR (2015). "Pathogenesis of Staphylococcus aureus abscesses". Am J Pathol. 185 (6): 1518–27. doi:10.1016/j.ajpath.2014.11.030. PMC 4450319. PMID 25749135.
- ↑ Kataria K, Srivastava A, Dhar A (2013). "Management of lactational mastitis and breast abscesses: review of current knowledge and practice". Indian J Surg. 75 (6): 430–5. doi:10.1007/s12262-012-0776-1. PMC 3900741. PMID 24465097.
- ↑ Marchant DJ (2002). "Inflammation of the breast". Obstet Gynecol Clin North Am. 29 (1): 89–102. PMID 11892876.
- ↑ Bundred NJ, Dixon JM, Lumsden AB, Radford D, Hood J, Miles RS; et al. (1985). "Are the lesions of duct ectasia sterile?". Br J Surg. 72 (10): 844–5. PMID 4041720.