Cholera causes: Difference between revisions
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==Serovars== | ==Serovars== | ||
More than 200 serovars of ''[[Vibrio]]'' cholera have been identified. Two serogroups, O1 and O139, are mainly associated with major outbreaks of cholera.<ref name="pmid22748592">{{cite journal| author=Harris JB, LaRocque RC, Qadri F, Ryan ET, Calderwood SB| title=Cholera. | journal=Lancet | year= 2012 | volume= 379 | issue= 9835 | pages= 2466-76 | pmid=22748592 | doi=10.1016/S0140-6736(12)60436-X | pmc=3761070 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22748592 }} </ref> | |||
==Biotypes== | ==Biotypes== | ||
There are two main biotypes of | There are two main biotypes of ''[[Vibrio cholerae]]'': | ||
*Classic | *Classic | ||
*E1 Tor | *E1 Tor | ||
| Line 22: | Line 22: | ||
==Features of Vibrio cholera== | ==Features of Vibrio cholera== | ||
Features of Vibrio | Features of ''[[Vibrio cholerae]]'' include:<ref name="pmid9841673">{{cite journal| author=Faruque SM, Albert MJ, Mekalanos JJ| title=Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae. | journal=Microbiol Mol Biol Rev | year= 1998 | volume= 62 | issue= 4 | pages= 1301-14 | pmid=9841673 | doi= | pmc=98947 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9841673 }} </ref> | ||
*[[Gram negative]] | *[[Gram negative]] | ||
*Comma shaped organism | *Comma shaped organism | ||
*Flagellated | *Flagellated | ||
* | *Halophillic | ||
*[[Aerobic]] or [[ | *[[Aerobic]] or facultatively [[anaerobic]] | ||
*Two [[antigens]], H and O | *Two [[antigens]], H and O | ||
:*O polysaccharide antigen | :*O polysaccharide antigen | ||
:*H flagellar antigen | :*H flagellar antigen | ||
*Pathogenic factors | *Pathogenic factors | ||
:*[[Enterotoxin]] (cholera toxin) | :*[[Enterotoxin]] ([[cholera toxin]]) | ||
:*"Zona Occludans Toxin" (attacks the zona occludans or "tight" junctions joining epithelial cells) | :*"Zona Occludans Toxin" (attacks the zona occludans or "tight" junctions joining epithelial cells) | ||
:*Other [[proteases]] such as mucinases and [[chitinase|chitinases]] | :*Other [[proteases]] such as mucinases and [[chitinase|chitinases]] | ||
==Genome== | ==Genome== | ||
The genome of ''V. cholerae'' consists of two chromosomes. The following genes may be associated with pathogenesis of | The genome of ''V. cholerae'' consists of two chromosomes. The following genes may be associated with pathogenesis of ''[[Vibrio cholerae]]''.<ref name="pmid9501228">{{cite journal| author=Karaolis DK, Johnson JA, Bailey CC, Boedeker EC, Kaper JB, Reeves PR| title=A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains. | journal=Proc Natl Acad Sci U S A | year= 1998 | volume= 95 | issue= 6 | pages= 3134-9 | pmid=9501228 | doi= | pmc=19707 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9501228 }} </ref><ref name="pmid8763944">{{cite journal| author=Waldor MK, Tschäpe H, Mekalanos JJ| title=A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139. | journal=J Bacteriol | year= 1996 | volume= 178 | issue= 14 | pages= 4157-65 | pmid=8763944 | doi= | pmc=178173 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8763944 }} </ref><ref name="pmid2883655">{{cite journal| author=Taylor RK, Miller VL, Furlong DB, Mekalanos JJ| title=Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin. | journal=Proc Natl Acad Sci U S A | year= 1987 | volume= 84 | issue= 9 | pages= 2833-7 | pmid=2883655 | doi= | pmc=304754 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2883655 }} </ref><ref name="pmid8658163">{{cite journal| author=Waldor MK, Mekalanos JJ| title=Lysogenic conversion by a filamentous phage encoding cholera toxin. | journal=Science | year= 1996 | volume= 272 | issue= 5270 | pages= 1910-4 | pmid=8658163 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8658163 }} </ref> | ||
'''''CtxAB'' genes''' | '''''CtxAB'' genes''' | ||
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'''''V. cholerae'' pathogenicity island(VPI)''' | '''''V. cholerae'' pathogenicity island (VPI)''' | ||
VPI is generally only present in virulent strains and is laterally transferred. VPI was originally thought to encode a filamentous phage responsible for transfer. This theory was discredited by a study of 46 diverse ''V. cholerae'' isolates which found no evidence of VPI phage production. The generalized transduction phage CP-T1 has been shown to transduce the entire VPI, which is then integrated at the same chromosomal location. Also, VPI has been shown to excise and circularize to produce pVPI via a | VPI is generally only present in virulent strains and is laterally transferred. VPI was originally thought to encode a [[filamentous]] phage responsible for transfer. This theory was discredited by a study of 46 diverse ''V. cholerae'' isolates which found no evidence of VPI phage production. The generalized transduction phage CP-T1 has been shown to transduce the entire VPI, which is then integrated at the same chromosomal location. Also, VPI has been shown to excise and circularize to produce pVPI via a specialized mechanism involving VPI-encoded [[recombinases]]. It is not known whether pVPI is involved in CP-T1 transduction or if it is perhaps a component of an alternative VPI mobilization mechanism.<ref name="pmid9501228">{{cite journal| author=Karaolis DK, Johnson JA, Bailey CC, Boedeker EC, Kaper JB, Reeves PR| title=A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains. | journal=Proc Natl Acad Sci U S A | year= 1998 | volume= 95 | issue= 6 | pages= 3134-9 | pmid=9501228 | doi= | pmc=19707 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9501228 }} </ref> | ||
'''SXT/R391 ICE''' | '''SXT/R391 ICE''' | ||
SXT/R391 ICE is associated with the acquisition of antibiotic resistance by acquiring foreign DNA.<ref name="pmid8763944">{{cite journal| author=Waldor MK, Tschäpe H, Mekalanos JJ| title=A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139. | journal=J Bacteriol | year= 1996 | volume= 178 | issue= 14 | pages= 4157-65 | pmid=8763944 | doi= | pmc=178173 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8763944 }} </ref> | SXT/R391 ICE is associated with the acquisition of [[antibiotic resistance]] by acquiring foreign DNA.<ref name="pmid8763944">{{cite journal| author=Waldor MK, Tschäpe H, Mekalanos JJ| title=A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139. | journal=J Bacteriol | year= 1996 | volume= 178 | issue= 14 | pages= 4157-65 | pmid=8763944 | doi= | pmc=178173 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8763944 }} </ref> | ||
<gallery> | <gallery> | ||
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Latest revision as of 20:55, 29 July 2020
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Cholera Microchapters |
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Cholera causes On the Web |
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American Roentgen Ray Society Images of Cholera causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, MBBS [2], Aysha Anwar, M.B.B.S[3]
Overview
Vibrio cholerae is a gram negative bacterium with a curved-rod shape that causes cholera in humans.[1] V. cholerae and other species of the genus Vibrio belong to the gamma subdivision of the Proteobacteria. There are two major strains of V. cholerae, classic and El Tor, and numerous other serogroups.[1][2][3][4][5]
Habitat
V. cholerae occurs naturally in the plankton of fresh water, brackish water, and saltwater, attached primarily to copepods in the zooplankton. Coastal cholera outbreaks typically follow zooplankton blooms. This makes cholera a typical zoonosis.[2][6]
Serovars
More than 200 serovars of Vibrio cholera have been identified. Two serogroups, O1 and O139, are mainly associated with major outbreaks of cholera.[3]
Biotypes
There are two main biotypes of Vibrio cholerae:
- Classic
- E1 Tor
Each biotype is further associated with three serotypes based on difference in structure of O antigen:[6]
- Serotype Inaba
- Serotype Ogawa
- Serotype Hikcojima
Features of Vibrio cholera
Features of Vibrio cholerae include:[6]
- Gram negative
- Comma shaped organism
- Flagellated
- Halophillic
- Aerobic or facultatively anaerobic
- Two antigens, H and O
- O polysaccharide antigen
- H flagellar antigen
- Pathogenic factors
- Enterotoxin (cholera toxin)
- "Zona Occludans Toxin" (attacks the zona occludans or "tight" junctions joining epithelial cells)
- Other proteases such as mucinases and chitinases
Genome
The genome of V. cholerae consists of two chromosomes. The following genes may be associated with pathogenesis of Vibrio cholerae.[5][7][8][9]
CtxAB genes
CT is encoded by the ctxAB genes on a specific filamentous bacteriophage. Transduction of this phage is dependent upon bacterial expression of the Toxin Coregulated Pilus (TCP), which is encoded by the V. cholerae pathogenicity island (VPI).
V. cholerae pathogenicity island (VPI)
VPI is generally only present in virulent strains and is laterally transferred. VPI was originally thought to encode a filamentous phage responsible for transfer. This theory was discredited by a study of 46 diverse V. cholerae isolates which found no evidence of VPI phage production. The generalized transduction phage CP-T1 has been shown to transduce the entire VPI, which is then integrated at the same chromosomal location. Also, VPI has been shown to excise and circularize to produce pVPI via a specialized mechanism involving VPI-encoded recombinases. It is not known whether pVPI is involved in CP-T1 transduction or if it is perhaps a component of an alternative VPI mobilization mechanism.[5]
SXT/R391 ICE
SXT/R391 ICE is associated with the acquisition of antibiotic resistance by acquiring foreign DNA.[7]
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![Crabs have been a repeated source of cholera in the United States and elsewhere, even though they are rarely eaten raw. From Public Health Image Library (PHIL). [10]](/images/2/26/Cholera10.jpeg)
Crabs have been a repeated source of cholera in the United States and elsewhere, even though they are rarely eaten raw. From Public Health Image Library (PHIL). [10]
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![Typical Vibrio cholera contaminated water supply. From Public Health Image Library (PHIL). [10]](/images/d/d2/Cholera16.jpeg)
Typical Vibrio cholera contaminated water supply. From Public Health Image Library (PHIL). [10]
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![Scanning electron micrograph (SEM) depicts a number of Vibrio parahaemolyticus bacteria; Mag. 19058x. From Public Health Image Library (PHIL). [10]](/images/3/36/Cholera07.jpeg)
Scanning electron micrograph (SEM) depicts a number of Vibrio parahaemolyticus bacteria; Mag. 19058x. From Public Health Image Library (PHIL). [10]
-
![Scanning electron micrograph (SEM) depicts a grouping of Vibrio vulnificus bacteria; Mag. 13184x. From Public Health Image Library (PHIL). [10]](/images/0/0d/Cholera06.jpeg)
Scanning electron micrograph (SEM) depicts a grouping of Vibrio vulnificus bacteria; Mag. 13184x. From Public Health Image Library (PHIL). [10]
-
![Scanning electron micrograph (SEM) depicts a flagellated Vibrio vulnificus bacterium; Mag. 26367x. From Public Health Image Library (PHIL). [10]](/images/b/b9/Cholera05.jpeg)
Scanning electron micrograph (SEM) depicts a flagellated Vibrio vulnificus bacterium; Mag. 26367x. From Public Health Image Library (PHIL). [10]
-
![Scanning electron micrograph (SEM) depicts a grouping of Vibrio vulnificus bacteria; Mag. 13184x. From Public Health Image Library (PHIL). [10]](/images/2/2c/Cholera04.jpeg)
Scanning electron micrograph (SEM) depicts a grouping of Vibrio vulnificus bacteria; Mag. 13184x. From Public Health Image Library (PHIL). [10]
-
![Scanning electron micrograph (SEM) depicts a number of Vibrio cholerae bacteria of the serogroup 01; Magnified 22371x. From Public Health Image Library (PHIL). [10]](/images/c/c8/Cholera03.jpeg)
Scanning electron micrograph (SEM) depicts a number of Vibrio cholerae bacteria of the serogroup 01; Magnified 22371x. From Public Health Image Library (PHIL). [10]
![Crabs have been a repeated source of cholera in the United States and elsewhere, even though they are rarely eaten raw. From Public Health Image Library (PHIL). [10]](/index.php/File:Cholera10.jpeg)
![Typical Vibrio cholera contaminated water supply. From Public Health Image Library (PHIL). [10]](/index.php/File:Cholera16.jpeg)
![Scanning electron micrograph (SEM) depicts a number of Vibrio parahaemolyticus bacteria; Mag. 19058x. From Public Health Image Library (PHIL). [10]](/index.php/File:Cholera07.jpeg)
![Scanning electron micrograph (SEM) depicts a grouping of Vibrio vulnificus bacteria; Mag. 13184x. From Public Health Image Library (PHIL). [10]](/index.php/File:Cholera06.jpeg)
![Scanning electron micrograph (SEM) depicts a flagellated Vibrio vulnificus bacterium; Mag. 26367x. From Public Health Image Library (PHIL). [10]](/index.php/File:Cholera05.jpeg)
![Scanning electron micrograph (SEM) depicts a grouping of Vibrio vulnificus bacteria; Mag. 13184x. From Public Health Image Library (PHIL). [10]](/index.php/File:Cholera04.jpeg)
![Scanning electron micrograph (SEM) depicts a number of Vibrio cholerae bacteria of the serogroup 01; Magnified 22371x. From Public Health Image Library (PHIL). [10]](/index.php/File:Cholera03.jpeg)
References
- ↑ 1.0 1.1 Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed. ed.). McGraw Hill. ISBN 0838585299.
- ↑ 2.0 2.1 Wilcox, Bruce A., and Rita R. Colwell. "Emerging and reemerging infectious diseases: biocomplexity as an interdisciplinary paradigm." EcoHealth 2.4 (2005): 244-257.
- ↑ 3.0 3.1 Harris JB, LaRocque RC, Qadri F, Ryan ET, Calderwood SB (2012). "Cholera". Lancet. 379 (9835): 2466–76. doi:10.1016/S0140-6736(12)60436-X. PMC 3761070. PMID 22748592.
- ↑ Huq A, Sack RB, Nizam A, Longini IM, Nair GB, Ali A; et al. (2005). "Critical factors influencing the occurrence of Vibrio cholerae in the environment of Bangladesh". Appl Environ Microbiol. 71 (8): 4645–54. doi:10.1128/AEM.71.8.4645-4654.2005. PMC 1183289. PMID 16085859.
- ↑ 5.0 5.1 5.2 Karaolis DK, Johnson JA, Bailey CC, Boedeker EC, Kaper JB, Reeves PR (1998). "A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains". Proc Natl Acad Sci U S A. 95 (6): 3134–9. PMC 19707. PMID 9501228.
- ↑ 6.0 6.1 6.2 Faruque SM, Albert MJ, Mekalanos JJ (1998). "Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae". Microbiol Mol Biol Rev. 62 (4): 1301–14. PMC 98947. PMID 9841673.
- ↑ 7.0 7.1 Waldor MK, Tschäpe H, Mekalanos JJ (1996). "A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139". J Bacteriol. 178 (14): 4157–65. PMC 178173. PMID 8763944.
- ↑ Taylor RK, Miller VL, Furlong DB, Mekalanos JJ (1987). "Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin". Proc Natl Acad Sci U S A. 84 (9): 2833–7. PMC 304754. PMID 2883655.
- ↑ Waldor MK, Mekalanos JJ (1996). "Lysogenic conversion by a filamentous phage encoding cholera toxin". Science. 272 (5270): 1910–4. PMID 8658163.
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 "Public Health Image Library (PHIL)".