Red man syndrome: Difference between revisions
Usama Talib (talk | contribs) No edit summary |
Usama Talib (talk | contribs) |
||
| (9 intermediate revisions by the same user not shown) | |||
| Line 6: | Line 6: | ||
Red man syndrome is characterized by symptoms consistent with anaphylactoid reactions. These symptoms may include dyspnea, hypotension, urticaria, pain and spasm of chest and back muscles, wheezing, pruritus, and upper body flushing giving the typical appearance and thus the name '''"Red man syndrome”'''. On discontinuation of the offending agent, these symptoms can resolve as early as 20 minutes but in some cases may require several hours. [[Vancomycin]] is the most common agent responsible for Red man syndrome.<ref name="pmid9743397">{{cite journal |vauthors=Renz CL, Laroche D, Thurn JD, Finn HA, Lynch JP, Thisted R, Moss J |title=Tryptase levels are not increased during vancomycin-induced anaphylactoid reactions |journal=Anesthesiology |volume=89 |issue=3 |pages=620–5 |year=1998 |pmid=9743397 |doi= |url=}}</ref> | Red man syndrome is characterized by symptoms consistent with anaphylactoid reactions. These symptoms may include dyspnea, hypotension, urticaria, pain and spasm of chest and back muscles, wheezing, pruritus, and upper body flushing giving the typical appearance and thus the name '''"Red man syndrome”'''. On discontinuation of the offending agent, these symptoms can resolve as early as 20 minutes but in some cases may require several hours. [[Vancomycin]] is the most common agent responsible for Red man syndrome.<ref name="pmid9743397">{{cite journal |vauthors=Renz CL, Laroche D, Thurn JD, Finn HA, Lynch JP, Thisted R, Moss J |title=Tryptase levels are not increased during vancomycin-induced anaphylactoid reactions |journal=Anesthesiology |volume=89 |issue=3 |pages=620–5 |year=1998 |pmid=9743397 |doi= |url=}}</ref> | ||
== | ==Causes== | ||
The most common cause of red man syndrome is:<ref name="pmid9743397">{{cite journal |vauthors=Renz CL, Laroche D, Thurn JD, Finn HA, Lynch JP, Thisted R, Moss J |title=Tryptase levels are not increased during vancomycin-induced anaphylactoid reactions |journal=Anesthesiology |volume=89 |issue=3 |pages=620–5 |year=1998 |pmid=9743397 |doi= |url=}}</ref><ref name="pmid1955716">{{cite journal |vauthors=Wallace MR, Mascola JR, Oldfield EC |title=Red man syndrome: incidence, etiology, and prophylaxis |journal=J. Infect. Dis. |volume=164 |issue=6 |pages=1180–5 |year=1991 |pmid=1955716 |doi= |url=}}</ref> | |||
=== | *[[Vancomycin]] infusion for less than 1 hour in patients who are not pre-treated with [[diphenhydramine]] | ||
===Other Antibiotics=== | |||
Red man syndrome can result as a result of hypersensitivity to:<ref name="pmid1955716">{{cite journal |vauthors=Wallace MR, Mascola JR, Oldfield EC |title=Red man syndrome: incidence, etiology, and prophylaxis |journal=J. Infect. Dis. |volume=164 |issue=6 |pages=1180–5 |year=1991 |pmid=1955716 |doi= |url=}}</ref> | |||
* [[Ciprofloxacin]] | * [[Ciprofloxacin]] | ||
* [[Amphotericin B]] | * [[Amphotericin B]] | ||
| Line 18: | Line 17: | ||
==Symptoms== | ==Symptoms== | ||
Some associated symptoms of red man syndrome include: | Some associated symptoms of red man syndrome include:<ref name="pmid1955716">{{cite journal |vauthors=Wallace MR, Mascola JR, Oldfield EC |title=Red man syndrome: incidence, etiology, and prophylaxis |journal=J. Infect. Dis. |volume=164 |issue=6 |pages=1180–5 |year=1991 |pmid=1955716 |doi= |url=}}</ref> | ||
* [[Headache]] | * [[Headache]] | ||
* [[Chills]] | * [[Chills]] | ||
* [[ | * [[Hypotension]] | ||
* [[Dizziness]] | |||
* [[Chest pain]] | * [[Chest pain]] | ||
* [[Dyspnea]] | * [[Dyspnea]] | ||
* [[Pruritis]] | * [[Pruritis]], [[urticaria]] | ||
* [[Rash]] | * [[Rash]] | ||
** [[Erythematous]] rash that involves the | ** [[Erythematous]] rash that involves the | ||
| Line 30: | Line 30: | ||
**Neck and | **Neck and | ||
**Upper [[torso]] | **Upper [[torso]] | ||
*Spasm of chest and back muscles | |||
*Wheezing | |||
*Upper body flushing giving the typical appearance of "red man" | |||
== | ==Anaphylactoid Reaction== | ||
Red man syndrome | Red man syndrome has similar features to [[anaphylactoid reaction]]. This is as a result of: | ||
*Absence of elevation in tryptase levels | *Absence of elevation in tryptase levels | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 19:34, 31 May 2017
|
WikiDoc Resources for Red man syndrome |
|
Articles |
|---|
|
Most recent articles on Red man syndrome Most cited articles on Red man syndrome |
|
Media |
|
Powerpoint slides on Red man syndrome |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Red man syndrome at Clinical Trials.gov Trial results on Red man syndrome Clinical Trials on Red man syndrome at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Red man syndrome NICE Guidance on Red man syndrome
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Red man syndrome Discussion groups on Red man syndrome Patient Handouts on Red man syndrome Directions to Hospitals Treating Red man syndrome Risk calculators and risk factors for Red man syndrome
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Red man syndrome |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Usama Talib, BSc, MD [2]
Overview
Red man syndrome is characterized by symptoms consistent with anaphylactoid reactions. These symptoms may include dyspnea, hypotension, urticaria, pain and spasm of chest and back muscles, wheezing, pruritus, and upper body flushing giving the typical appearance and thus the name "Red man syndrome”. On discontinuation of the offending agent, these symptoms can resolve as early as 20 minutes but in some cases may require several hours. Vancomycin is the most common agent responsible for Red man syndrome.[1]
Causes
The most common cause of red man syndrome is:[1][2]
- Vancomycin infusion for less than 1 hour in patients who are not pre-treated with diphenhydramine
Other Antibiotics
Red man syndrome can result as a result of hypersensitivity to:[2]
Symptoms
Some associated symptoms of red man syndrome include:[2]
- Headache
- Chills
- Hypotension
- Dizziness
- Chest pain
- Dyspnea
- Pruritis, urticaria
- Rash
- Erythematous rash that involves the
- Face
- Neck and
- Upper torso
- Spasm of chest and back muscles
- Wheezing
- Upper body flushing giving the typical appearance of "red man"
Anaphylactoid Reaction
Red man syndrome has similar features to anaphylactoid reaction. This is as a result of:
- Absence of elevation in tryptase levels
References
- ↑ 1.0 1.1 Renz CL, Laroche D, Thurn JD, Finn HA, Lynch JP, Thisted R, Moss J (1998). "Tryptase levels are not increased during vancomycin-induced anaphylactoid reactions". Anesthesiology. 89 (3): 620–5. PMID 9743397.
- ↑ 2.0 2.1 2.2 Wallace MR, Mascola JR, Oldfield EC (1991). "Red man syndrome: incidence, etiology, and prophylaxis". J. Infect. Dis. 164 (6): 1180–5. PMID 1955716.