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==Overview== | ==Overview== | ||
'''Acute viral nasopharyngitis | '''Acute viral nasopharyngitis''' is a highly contagious [[virus (biology)|viral]] [[infectious disease]] of the upper [[respiratory system]] primarily caused by [[rhinovirus]] and less commonly caused by [[picornavirus]]es or [[coronavirus]]es. Common symptoms are [[Pharyngitis|sore throat]], [[rhinitis|runny nose]], [[nasal congestion]], [[sneeze|sneezing]], and [[cough]] sometimes accompanied by [[myalgia|muscle aches]], [[fatigue (medical)|fatigue]], [[malaise]], [[headache]], [[muscle weakness]], or [[Anorexia (symptom)|loss of appetite]]. [[Fever]] and extreme [[fatigue (medical)|exhaustion]] are more common in [[influenza]]. The symptoms of a cold usually resolve after about one week, but can last up to 14 days. Symptoms may be more severe in infants and young children. Although the disease is generally mild and [[self-limiting]], patients with the common cold often seek professional medical help, use [[over-the-counter drug]]s, and may miss school or work days. The annual cumulative societal cost of the common cold in the United States is billions of dollars. No [[vaccine]]s are available. The primary method to prevent the [[infection]] is [[hand washing]] to minimize person-to-person [[Transmission (medicine)|transmission]] of the [[virus]]. There are no [[antiviral]] drugs approved to treat or cure the [[infection]]. Most available medications are [[palliative care|palliative]] and treat symptoms only. [[Vitamin C megadosage|Megadoses of vitamin C]], preparations from [[echinacea]], and [[zinc gluconate]] have been studied as treatments for the common cold, though none have been approved by the [[Food and Drug Administration]] or [[European Medicines Agency]]. | ||
Common symptoms are [[Pharyngitis|sore throat]], [[rhinitis|runny nose]], [[nasal congestion]], [[sneeze|sneezing]] and [[cough]] | |||
No [[vaccine]]s are available | |||
==Historical Perspective== | ==Historical Perspective== | ||
Common cold was first considered by Benjamin Franklin in the 18th century. | Common cold was first considered a distinct diagnosis by Benjamin Franklin in the 18th century. | ||
==Classification== | ==Classification== | ||
There is no established classification system for acute viral nasopharyngitis. | |||
==Pathophysiology== | ==Pathophysiology== | ||
[[Rhinovirus]] (the most common cause of common cold) is usually transmitted via aerosol generated by coughing or sneezing. Following transmission, the [[virus]] invades | [[Rhinovirus]] (the most common cause of common cold) is usually [[Transmission (medicine)|transmitted]] via [[aerosol]]<nowiki/>s generated by [[coughing]] or [[sneezing]]. The entry point is usually the nose, however viruses can enter the body through the lacrimal ducts. Following [[Transmission (medicine)|transmission]], the [[virus]] invades [[epithelial cells]] and causes a release of [[Cytokines|inflammatory cytokines]], leading to the various symptoms of the common cold. The body responds using cellular and humoral immunity in addition to the role of bacterial flora in the defense against the organism. | ||
==Causes== | ==Causes== | ||
Acute viral nasopharyngitis is most commonly caused by an infection with [[rhinovirus]]. Other common causes include [[coronavirus]], [[human parainfluenza viruses]], and [[human respiratory syncytial virus]]. | Acute viral nasopharyngitis is most commonly caused by an infection with [[rhinovirus]]. Other common causes include [[coronavirus]], [[human parainfluenza viruses]], and [[human respiratory syncytial virus]] (RSV). | ||
==Differentiating | ==Differentiating Acute Viral Nasopharyngitis from other Diseases== | ||
Acute viral nasopharyngitis should be differentiated from other diseases that cause [[runny nose]], cough and constitutional symptoms such as [[influenza]], [[allergic rhinitis]] and [[acute sinusitis]]. | Acute viral nasopharyngitis should be differentiated from other diseases that cause [[runny nose]], [[cough]], and constitutional symptoms such as [[influenza]], [[allergic rhinitis]], and [[acute sinusitis]]. | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Acute viral nasopharyngitis is the most common human infection worldwide | Acute viral nasopharyngitis is the most common human [[infection]] worldwide, responsible for about half of all family physician visits. On average, adults get 2-3 common cold bouts per year and children get 6-10 [[infections]] per year and 500 out of every 1,000 family physician visits per year are due to acute viral nasopharyngitis. Males are more likely to be affected than females and Native Americans are more prone to develop complications. | ||
==Risk Factors== | ==Risk Factors== | ||
Common risk factors | Common risk factors for acute viral nasopharyngitis include having contact with an infected patient, spending time in daycare centers, presence of [[allergic rhinitis]] or [[Immunocompromised|immunocompromisation]]. | ||
Despite that infection with common cold tend to have a seasonal pattern, there is no proven association between cold exposure or chilling and the occurrence of common colds. | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
If left untreated, common cold resolves completely within 7-10 days. Common complications of acute viral nasopharyngitis include [[sinusitis]], [[otitis media]], and exacerbation of [[reactive airway disease]]. Prognosis is generally excellent | If left untreated, common cold resolves completely within 7-10 days. Common complications of acute viral nasopharyngitis include [[sinusitis]], [[otitis media]], and exacerbation of [[reactive airway disease]]. [[Prognosis]] is generally excellent. 50% of patients recover completely within 7 days and 90% of patients recover within 15 days. | ||
==History and Symptoms== | ==History and Symptoms== | ||
Symptoms of acute viral nasopharyngitis include [[runny nose]], [[cough]], and [[sore throat]]. | Symptoms of acute viral nasopharyngitis include [[runny nose]], [[cough]], and [[sore throat]]. | ||
==Physical Examination== | ==Physical Examination== | ||
Patients with acute viral nasopharyngitis usually appear ill. Physical examination of patients with acute viral nasopharyngitis is usually remarkable for [[runny nose]], hyperemic nasal mucosa and mild [[Lymphadenopathy|cervical lymphadenopathy]]. | Patients with acute viral nasopharyngitis usually appear ill. Physical examination of patients with acute viral nasopharyngitis is usually remarkable for [[runny nose]], hyperemic [[nasal mucosa]], and mild [[Lymphadenopathy|cervical lymphadenopathy]]. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of acute viral nasopharyngitis include positive [[viral culture]], [[PCR|positive PCR]], and | Laboratory findings consistent with the diagnosis of acute viral nasopharyngitis include positive [[viral culture]], [[PCR|positive PCR]], and [[leucocytosis]] in [[Complete blood count|CBC]]. | ||
==Imaging Findings== | ==Imaging Findings== | ||
There are no [[x ray]], [[CT]], [[MRI]] or ultrasound findings associated with acute viral nasopharyngitis. | There are no [[x ray|X-ray]], [[CT]], [[MRI]], or [[ultrasound]] findings associated with acute viral nasopharyngitis. | ||
==Medical Therapy== | ==Medical Therapy== | ||
The mainstay of therapy for acute viral nasopharyngitis is symptomatic treatment | The mainstay of therapy for acute viral nasopharyngitis is [[symptomatic treatment]] using palliative measures like fluids, rest and throat sprays. [[Analgesics]], [[nasal decongestants]] and [[Cough suppressant|cough suppressants]] can be used to alleviate the symptoms. [[Antibiotics]] have no use in common cold as the disease is viral in origin and there is no approved [[antiviral drug]] for the common cold. Mega doses of [[vitamin C]], [[Zinc]] and steam inhalation are not proved to be of benefit in treating common cold despite the wide belief of their use. | ||
==Surgery== | ==Surgery== | ||
Surgical intervention is not recommended for the management of acute viral nasopharyngitis. | |||
==Prevention== | ==Prevention== | ||
Effective measures for the primary prevention of acute viral nasopharyngitis include avoiding close | Effective measures for the primary prevention of acute viral nasopharyngitis include avoiding close contact with patients and washing hands regularly. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Otolaryngology]] | |||
[[Category:Pediatrics]] | |||
[[Category:Disease]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | |||
Latest revision as of 20:17, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Younes M.B.B.CH [2]
Overview
Acute viral nasopharyngitis is a highly contagious viral infectious disease of the upper respiratory system primarily caused by rhinovirus and less commonly caused by picornaviruses or coronaviruses. Common symptoms are sore throat, runny nose, nasal congestion, sneezing, and cough sometimes accompanied by muscle aches, fatigue, malaise, headache, muscle weakness, or loss of appetite. Fever and extreme exhaustion are more common in influenza. The symptoms of a cold usually resolve after about one week, but can last up to 14 days. Symptoms may be more severe in infants and young children. Although the disease is generally mild and self-limiting, patients with the common cold often seek professional medical help, use over-the-counter drugs, and may miss school or work days. The annual cumulative societal cost of the common cold in the United States is billions of dollars. No vaccines are available. The primary method to prevent the infection is hand washing to minimize person-to-person transmission of the virus. There are no antiviral drugs approved to treat or cure the infection. Most available medications are palliative and treat symptoms only. Megadoses of vitamin C, preparations from echinacea, and zinc gluconate have been studied as treatments for the common cold, though none have been approved by the Food and Drug Administration or European Medicines Agency.
Historical Perspective
Common cold was first considered a distinct diagnosis by Benjamin Franklin in the 18th century.
Classification
There is no established classification system for acute viral nasopharyngitis.
Pathophysiology
Rhinovirus (the most common cause of common cold) is usually transmitted via aerosols generated by coughing or sneezing. The entry point is usually the nose, however viruses can enter the body through the lacrimal ducts. Following transmission, the virus invades epithelial cells and causes a release of inflammatory cytokines, leading to the various symptoms of the common cold. The body responds using cellular and humoral immunity in addition to the role of bacterial flora in the defense against the organism.
Causes
Acute viral nasopharyngitis is most commonly caused by an infection with rhinovirus. Other common causes include coronavirus, human parainfluenza viruses, and human respiratory syncytial virus (RSV).
Differentiating Acute Viral Nasopharyngitis from other Diseases
Acute viral nasopharyngitis should be differentiated from other diseases that cause runny nose, cough, and constitutional symptoms such as influenza, allergic rhinitis, and acute sinusitis.
Epidemiology and Demographics
Acute viral nasopharyngitis is the most common human infection worldwide, responsible for about half of all family physician visits. On average, adults get 2-3 common cold bouts per year and children get 6-10 infections per year and 500 out of every 1,000 family physician visits per year are due to acute viral nasopharyngitis. Males are more likely to be affected than females and Native Americans are more prone to develop complications.
Risk Factors
Common risk factors for acute viral nasopharyngitis include having contact with an infected patient, spending time in daycare centers, presence of allergic rhinitis or immunocompromisation.
Despite that infection with common cold tend to have a seasonal pattern, there is no proven association between cold exposure or chilling and the occurrence of common colds.
Natural History, Complications, and Prognosis
If left untreated, common cold resolves completely within 7-10 days. Common complications of acute viral nasopharyngitis include sinusitis, otitis media, and exacerbation of reactive airway disease. Prognosis is generally excellent. 50% of patients recover completely within 7 days and 90% of patients recover within 15 days.
History and Symptoms
Symptoms of acute viral nasopharyngitis include runny nose, cough, and sore throat.
Physical Examination
Patients with acute viral nasopharyngitis usually appear ill. Physical examination of patients with acute viral nasopharyngitis is usually remarkable for runny nose, hyperemic nasal mucosa, and mild cervical lymphadenopathy.
Laboratory Findings
Laboratory findings consistent with the diagnosis of acute viral nasopharyngitis include positive viral culture, positive PCR, and leucocytosis in CBC.
Imaging Findings
There are no X-ray, CT, MRI, or ultrasound findings associated with acute viral nasopharyngitis.
Medical Therapy
The mainstay of therapy for acute viral nasopharyngitis is symptomatic treatment using palliative measures like fluids, rest and throat sprays. Analgesics, nasal decongestants and cough suppressants can be used to alleviate the symptoms. Antibiotics have no use in common cold as the disease is viral in origin and there is no approved antiviral drug for the common cold. Mega doses of vitamin C, Zinc and steam inhalation are not proved to be of benefit in treating common cold despite the wide belief of their use.
Surgery
Surgical intervention is not recommended for the management of acute viral nasopharyngitis.
Prevention
Effective measures for the primary prevention of acute viral nasopharyngitis include avoiding close contact with patients and washing hands regularly.