Addison's disease natural history, complications and prognosis: Difference between revisions
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{{Addison's disease}} | {{Addison's disease}} | ||
{{CMG}} | {{CMG}} ; {{AE}} {{ADG}} | ||
==Overview== | |||
If left untreated, Addison's disease can be life-threatening. Complications of Addison's disease include [[hypoglycemia]], [[addisonian crisis]], [[hypoxia]], [[hypovolemic shock]], [[cardiac arrest]], [[stroke]]. Prognosis is generally good in patients with Addison's disease as long as they are on life time [[hormone replacement therapy]]. | |||
==Natural History== | ==Natural History== | ||
If left untreated, Addison's disease can be life-threatening. Any stressful event or illness can cause a sudden worsening of symptoms, which can lead to severe dehydration and fatally low blood pressure and eventually death. | If left untreated, Addison's disease can be life-threatening. Any stressful event or illness can cause a sudden worsening of [[symptoms]], which can lead to severe [[dehydration]] and fatally low [[blood pressure]] and eventually death. | ||
==Complications== | ==Complications== | ||
Complications of Addison's disease include | Complications of Addison's disease include:<ref name="pmid22907517">{{cite journal |vauthors=Quinkler M |title=[Addison's disease] |language=German |journal=Med Klin Intensivmed Notfmed |volume=107 |issue=6 |pages=454–9 |year=2012 |pmid=22907517 |doi=10.1007/s00063-012-0112-3 |url=}}</ref> | ||
* [[Hypoglycemia]] | * [[Hypoglycemia]] | ||
* [[Addisonian crisis]] | * [[Addisonian crisis]] | ||
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==Prognosis== | ==Prognosis== | ||
*[[Prognosis]] is generally good in patients with Addison's disease as long as they are on life-time [[hormonal]] therapy.<ref name="pmid19011006">{{cite journal |vauthors=Erichsen MM, Løvås K, Fougner KJ, Svartberg J, Hauge ER, Bollerslev J, Berg JP, Mella B, Husebye ES |title=Normal overall mortality rate in Addison's disease, but young patients are at risk of premature death |journal=Eur. J. Endocrinol. |volume=160 |issue=2 |pages=233–7 |year=2009 |pmid=19011006 |doi=10.1530/EJE-08-0550 |url=}}</ref><ref name="pmid16968806">{{cite journal |vauthors=Bergthorsdottir R, Leonsson-Zachrisson M, Odén A, Johannsson G |title=Premature mortality in patients with Addison's disease: a population-based study |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue=12 |pages=4849–53 |year=2006 |pmid=16968806 |doi=10.1210/jc.2006-0076 |url=}}</ref> | |||
*Patients with Addison's disease must be closely monitored for [[Compliance (medicine)|compliance]] with medications as acute cases can be life-threating and the [[Mortality rate|mortality rates]] can go up to 95% in acute crisis. | |||
==References== | ==References== | ||
Latest revision as of 16:46, 11 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
If left untreated, Addison's disease can be life-threatening. Complications of Addison's disease include hypoglycemia, addisonian crisis, hypoxia, hypovolemic shock, cardiac arrest, stroke. Prognosis is generally good in patients with Addison's disease as long as they are on life time hormone replacement therapy.
Natural History
If left untreated, Addison's disease can be life-threatening. Any stressful event or illness can cause a sudden worsening of symptoms, which can lead to severe dehydration and fatally low blood pressure and eventually death.
Complications
Complications of Addison's disease include:[1]
Prognosis
- Prognosis is generally good in patients with Addison's disease as long as they are on life-time hormonal therapy.[2][3]
- Patients with Addison's disease must be closely monitored for compliance with medications as acute cases can be life-threating and the mortality rates can go up to 95% in acute crisis.
References
- ↑ Quinkler M (2012). "[Addison's disease]". Med Klin Intensivmed Notfmed (in German). 107 (6): 454–9. doi:10.1007/s00063-012-0112-3. PMID 22907517.
- ↑ Erichsen MM, Løvås K, Fougner KJ, Svartberg J, Hauge ER, Bollerslev J, Berg JP, Mella B, Husebye ES (2009). "Normal overall mortality rate in Addison's disease, but young patients are at risk of premature death". Eur. J. Endocrinol. 160 (2): 233–7. doi:10.1530/EJE-08-0550. PMID 19011006.
- ↑ Bergthorsdottir R, Leonsson-Zachrisson M, Odén A, Johannsson G (2006). "Premature mortality in patients with Addison's disease: a population-based study". J. Clin. Endocrinol. Metab. 91 (12): 4849–53. doi:10.1210/jc.2006-0076. PMID 16968806.