De Quervain's thyroiditis medical therapy: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{De Quervain's thyroiditis }} | {{De Quervain's thyroiditis }} | ||
{{CMG}} {{MMF}} | {{CMG}}; {{AE}} {{MMF}} | ||
==Overview== | ==Overview== | ||
The mainstay of therapy for [[de Quervain's thyroiditis]] is [[aspirin]] or [[Non-steroidal anti-inflammatory drug|non-steroidal anti-inflammatory]] drugs for pain control. [[Beta adrenergic-blocking agents|Beta-adrenergic blockers]] are recommended for the patients who develop [[Thyrotoxicosis|thyrotoxic symptoms]]. [[Corticosteroids]] are usually used in severely ill patients. [[Levothyroxine]] is required if the patient develops [[hypothyroidism]] following the resolution of the [[hyperthyroid]] state. | |||
==Medical Therapy== | ==Medical Therapy== | ||
===De Quervain's thyroiditis=== | |||
The drugs used in the treatment of [[de Quervain's thyroiditis]] are:<ref name="pmid20886353">{{cite journal |vauthors=Engkakul P, Mahachoklertwattana P, Poomthavorn P |title=Eponym : de Quervain thyroiditis |journal=Eur. J. Pediatr. |volume=170 |issue=4 |pages=427–31 |year=2011 |pmid=20886353 |doi=10.1007/s00431-010-1306-4 |url=}}</ref><ref name="pmid3427792">{{cite journal |vauthors=Yamamoto M, Saito S, Sakurada T, Fukazawa H, Yoshida K, Kaise K, Kaise N, Nomura T, Itagaki Y, Yonemitsu K |title=Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis |journal=Clin. Endocrinol. (Oxf) |volume=27 |issue=3 |pages=339–44 |year=1987 |pmid=3427792 |doi= |url=}}</ref><ref name="pmid8257868">{{cite journal |vauthors=Volpé R |title=The management of subacute (DeQuervain's) thyroiditis |journal=Thyroid |volume=3 |issue=3 |pages=253–5 |year=1993 |pmid=8257868 |doi= |url=}}</ref><ref name="pmid6144501">{{cite journal |vauthors=Feely J, Peden N |title=Use of beta-adrenoceptor blocking drugs in hyperthyroidism |journal=Drugs |volume=27 |issue=5 |pages=425–46 |year=1984 |pmid=6144501 |doi= |url=}}</ref> | |||
* '''For pain''' | |||
**Preferred regimen (1): [[Naproxen]]: 500 to 1000 mg per day in two divided doses | |||
**Preferred regimen (2): [[Ibuprofen]]: 1200 to 3200 mg per day in three or four divided doses | |||
* '''For severe condition''' | |||
**Preferred regimen (1): [[Prednisone]]: 40 mg per day orally | |||
* '''For hypothyroidism''' | |||
*Preferred regimen (1): [[Levothyroxine (oral)|Synthetic levothyroxine]] (L-T4): 1.6–1.8 μg/kg per day orally | |||
* '''For thyrotoxic symptoms''' | |||
**Preferred regimen (1): [[atenolol]]: 25-200mg per day orally | |||
**Preferred regimen (2): [[metoprolol]]: 25-200mg per day orally | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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[[Category:Medicine]] | |||
[[Category:Endocrinology]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 21:14, 29 July 2020
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De Quervain's thyroiditis Microchapters |
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Differentiating De Quervain's thyroiditis from other Diseases |
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Diagnosis |
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Treatment |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
The mainstay of therapy for de Quervain's thyroiditis is aspirin or non-steroidal anti-inflammatory drugs for pain control. Beta-adrenergic blockers are recommended for the patients who develop thyrotoxic symptoms. Corticosteroids are usually used in severely ill patients. Levothyroxine is required if the patient develops hypothyroidism following the resolution of the hyperthyroid state.
Medical Therapy
De Quervain's thyroiditis
The drugs used in the treatment of de Quervain's thyroiditis are:[1][2][3][4]
- For pain
- For severe condition
- Preferred regimen (1): Prednisone: 40 mg per day orally
- For hypothyroidism
- Preferred regimen (1): Synthetic levothyroxine (L-T4): 1.6–1.8 μg/kg per day orally
- For thyrotoxic symptoms
- Preferred regimen (1): atenolol: 25-200mg per day orally
- Preferred regimen (2): metoprolol: 25-200mg per day orally
References
- ↑ Engkakul P, Mahachoklertwattana P, Poomthavorn P (2011). "Eponym : de Quervain thyroiditis". Eur. J. Pediatr. 170 (4): 427–31. doi:10.1007/s00431-010-1306-4. PMID 20886353.
- ↑ Yamamoto M, Saito S, Sakurada T, Fukazawa H, Yoshida K, Kaise K, Kaise N, Nomura T, Itagaki Y, Yonemitsu K (1987). "Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis". Clin. Endocrinol. (Oxf). 27 (3): 339–44. PMID 3427792.
- ↑ Volpé R (1993). "The management of subacute (DeQuervain's) thyroiditis". Thyroid. 3 (3): 253–5. PMID 8257868.
- ↑ Feely J, Peden N (1984). "Use of beta-adrenoceptor blocking drugs in hyperthyroidism". Drugs. 27 (5): 425–46. PMID 6144501.