Zollinger-Ellison syndrome causes: Difference between revisions
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==Overview== | ==Overview== | ||
The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of [[Gastrinoma|gastrinomas]], which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine | The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of [[Gastrinoma|gastrinomas]], which can cause Zollinger-Ellison syndrome, are caused by [[multiple endocrine neoplasia]] type 1 ([[MEN1]]). | ||
==Causes== | ==Causes== | ||
*The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of [[Gastrinoma|gastrinomas]], which can cause Zollinger-Ellison syndrome, are caused by | *The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of [[Gastrinoma|gastrinomas]], which can cause Zollinger-Ellison syndrome, are caused by [[multiple endocrine neoplasia type 1]] ([[MEN1]]).<ref name="NIDDK">National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes</ref> | ||
*Causes of Hypergastrinemia: <ref name="pmid21806955">{{cite journal| author=Metz DC| title=Diagnosis of the Zollinger–Ellison syndrome. | journal=Clin Gastroenterol Hepatol | year= 2012 | volume= 10 | issue= 2 | pages= 126-30 | pmid=21806955 | doi=10.1016/j.cgh.2011.07.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21806955 }} </ref> | *Hypergastrinemia (an increased fasting serum [[gastrin]] level) is the hallmark of ZES. <ref name="pmid21806955">{{cite journal |vauthors=Metz DC |title=Diagnosis of the Zollinger–Ellison syndrome |journal=Clin. Gastroenterol. Hepatol. |volume=10 |issue=2 |pages=126–30 |year=2012 |pmid=21806955 |doi=10.1016/j.cgh.2011.07.012 |url=}}</ref> | ||
:*'''Causes of Hypergastrinemia:''' <ref name="pmid21806955">{{cite journal| author=Metz DC| title=Diagnosis of the Zollinger–Ellison syndrome. | journal=Clin Gastroenterol Hepatol | year= 2012 | volume= 10 | issue= 2 | pages= 126-30 | pmid=21806955 | doi=10.1016/j.cgh.2011.07.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21806955 }} </ref> | |||
{| style="border: 0px; font-size: 90%; margin: 3px;" | {| align="center" style="border: 0px; font-size: 90%; margin: 3px;" | ||
| | | style="background: #4479BA; text-align: center;" colspan="3" | {{fontcolor|#FFF|'''Causes of Hypergastrinemia'''}} | ||
|+ | |+ | ||
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF|Appropriate | ! style="background: #4479BA; padding: 5px 5px;" rowspan="1" | {{fontcolor|#FFFFFF|Appropriate Hypergastrinemia}} | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Antisecretory therapeutic regimen (PPIs or high-dose [[histamine]] H2-receptor antagonist) | |||
*Antisecretory | *Atrophic gastritis with or without [[pernicious anemia]] | ||
* | *[[Helicobacter pylori]] pangastritis | ||
* | |||
*Vagotomy | *Vagotomy | ||
*[[Chronic renal failure |Renal failure (Chronic)]] | |||
|- | |- | ||
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF|Inappropriate | ! style="background: #4479BA; padding: 5px 5px;" rowspan="1" | {{fontcolor|#FFFFFF|Inappropriate Hypergastrinemia}} | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*ZES (sporadic or associated with MEN-1) | *Antral-predominant [[Helicobacter pylori]] infection | ||
*ZES (sporadic or associated with [[MEN-1]]) | |||
*Retained-antrum syndrome | *Retained-antrum syndrome | ||
*Gastric | *[[Gastric outlet obstruction]] | ||
*Small-bowel resection | *Small-bowel resection | ||
|- | |- | ||
! style="background: #4479BA; padding: 5px 5px;" colspan=1 | {{fontcolor|#FFFFFF|Spurious hypergastrinemia}} | ! style="background: #4479BA; padding: 5px 5px;" colspan="1" | {{fontcolor|#FFFFFF|Spurious hypergastrinemia}} | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Inaccurate assay | |||
*Nonfasting patient | *Nonfasting patient | ||
|- | |- | ||
|} | |} | ||
Latest revision as of 16:09, 11 October 2017
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Zollinger-Ellison syndrome Microchapters |
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Differentiating Zollinger-Ellison syndrome from other Diseases |
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Zollinger-Ellison syndrome causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2] Mohamad Alkateb, MBBCh [3]
Overview
The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).
Causes
- The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]
- Causes of Hypergastrinemia: [2]
| Causes of Hypergastrinemia | ||
| Appropriate Hypergastrinemia |
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|---|---|---|
| Inappropriate Hypergastrinemia |
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| Spurious hypergastrinemia |
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References
- ↑ National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes
- ↑ 2.0 2.1 Metz DC (2012). "Diagnosis of the Zollinger–Ellison syndrome". Clin. Gastroenterol. Hepatol. 10 (2): 126–30. doi:10.1016/j.cgh.2011.07.012. PMID 21806955.