Psoriasis future or investigational therapies: Difference between revisions
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==Future or Investigational Therapies== | ==Future or Investigational Therapies== | ||
Historically, agents used to treat psoriasis were discovered by experimentation or by accident. In contrast, current novel therapeutic agents are designed from a better understanding of the immune processes involved in psoriasis and by the specific targeting of molecular mediators. Examples can be seen in the use of biologics | Historically, agents used to treat psoriasis were discovered by experimentation or by accident. In contrast, current novel therapeutic agents are designed from a better understanding of the immune processes involved in psoriasis and by the specific targeting of molecular mediators. Examples can be seen in the use of biologics that target [[T cells]] and [[Tumor necrosis factors|TNF]] inhibitors. | ||
It has been suggested that [[cannabis (drug)|marijuana]] might treat psoriasis | It has been suggested that [[cannabis (drug)|marijuana]] might treat psoriasis due to the anti-inflammatory properties of its [[cannabinoids]] and the regulatory effects of [[Tetrahydrocannabinol|THC]] on the immune system.<ref name="pmid15857457">{{cite journal |author=Namazi MR |title=Cannabinoids, loratadine and allopurinol as novel additions to the antipsoriatic ammunition |journal=Journal of the European Academy of Dermatology and Venereology : JEADV |volume=19 |issue=3 |pages=319-22 |year=2005 |pmid=15857457 |doi=10.1111/j.1468-3083.2004.01184.x}}</ref> The adverse effects of [[marijuana]] might be overcome by the use of more specific cannabinoid receptor medications to inhibit [[keratinocyte]] proliferation.<ref name="pmid16375686">{{cite journal |author=Fowler CJ |title=Pharmacological properties and therapeutic possibilities for drugs acting upon endocannabinoid receptors |journal=Current drug targets. CNS and neurological disorders |volume=4 |issue=6 |pages=685-96 |year=2005 |pmid=16375686 |doi=}}</ref><ref name="pmid17157480">{{cite journal |author=Wilkinson JD, Williamson EM |title=Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis |journal=J. Dermatol. Sci. |volume=45 |issue=2 |pages=87-92 |year=2007 |pmid=17157480 |doi=10.1016/j.jdermsci.2006.10.009}}</ref> | ||
Future innovation | Future innovation will likely involve the creation of additional drugs that refine the targeting of immune-mediators further.<!-- | ||
--><ref name="Nickoloff">{{cite journal |author=Nickoloff BJ, Nestle FO |title=Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities |journal=J. Clin. Invest. |volume=113 |issue=12 |pages=1664-75 |year=2004 |pmid=15199399 |doi=10.1172/JCI200422147}}</ref> | --><ref name="Nickoloff">{{cite journal |author=Nickoloff BJ, Nestle FO |title=Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities |journal=J. Clin. Invest. |volume=113 |issue=12 |pages=1664-75 |year=2004 |pmid=15199399 |doi=10.1172/JCI200422147}}</ref> | ||
Research into [[oligonucleotide|antisense oligonucleotide]]s carries the potential to provide novel therapeutic strategies for | Research into [[oligonucleotide|antisense oligonucleotide]]s carries the potential to provide novel therapeutic strategies for the treatment of psoriasis.<!-- | ||
--><ref name="White">{{cite journal |author=White PJ, Atley LM, Wraight CJ |title=Antisense oligonucleotide treatments for psoriasis |journal=Expert opinion on biological therapy |volume=4 |issue=1 |pages=75-81 |year=2004 |pmid=14680470 |doi=10.1517/14712598.4.1.75}}</ref> | --><ref name="White">{{cite journal |author=White PJ, Atley LM, Wraight CJ |title=Antisense oligonucleotide treatments for psoriasis |journal=Expert opinion on biological therapy |volume=4 |issue=1 |pages=75-81 |year=2004 |pmid=14680470 |doi=10.1517/14712598.4.1.75}}</ref> | ||
===Pseudoceramides=== | ===Pseudoceramides=== | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Needs overview]] | [[Category:Needs overview]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Latest revision as of 23:52, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Historically, agents used to treat psoriasis were discovered by experimentation or by accident. In contrast, current novel therapeutic agents are designed from a better understanding of the immune processes involved in psoriasis and by the specific targeting of molecular mediators.
Future or Investigational Therapies
Historically, agents used to treat psoriasis were discovered by experimentation or by accident. In contrast, current novel therapeutic agents are designed from a better understanding of the immune processes involved in psoriasis and by the specific targeting of molecular mediators. Examples can be seen in the use of biologics that target T cells and TNF inhibitors.
It has been suggested that marijuana might treat psoriasis due to the anti-inflammatory properties of its cannabinoids and the regulatory effects of THC on the immune system.[1] The adverse effects of marijuana might be overcome by the use of more specific cannabinoid receptor medications to inhibit keratinocyte proliferation.[2][3]
Future innovation will likely involve the creation of additional drugs that refine the targeting of immune-mediators further.[4]
Research into antisense oligonucleotides carries the potential to provide novel therapeutic strategies for the treatment of psoriasis.[5]
Pseudoceramides
On August 27, 2006, scientists led by Jeung-Hoon Lee created in the laboratory synthetic lipids called pseudoceramides which are involved in skin cell growth and could be used in treating skin diseases such as atopic dermatitis, a form of eczema characterized by red, flaky, and very itchy skin, psoriasis, a disease that causes red scaly patches on the skin, and glucocorticoid-induced epidermal atrophy, in which the skin shrinks due to skin cell loss.[6]
References
- ↑ Namazi MR (2005). "Cannabinoids, loratadine and allopurinol as novel additions to the antipsoriatic ammunition". Journal of the European Academy of Dermatology and Venereology : JEADV. 19 (3): 319–22. doi:10.1111/j.1468-3083.2004.01184.x. PMID 15857457.
- ↑ Fowler CJ (2005). "Pharmacological properties and therapeutic possibilities for drugs acting upon endocannabinoid receptors". Current drug targets. CNS and neurological disorders. 4 (6): 685–96. PMID 16375686.
- ↑ Wilkinson JD, Williamson EM (2007). "Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis". J. Dermatol. Sci. 45 (2): 87–92. doi:10.1016/j.jdermsci.2006.10.009. PMID 17157480.
- ↑ Nickoloff BJ, Nestle FO (2004). "Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities". J. Clin. Invest. 113 (12): 1664–75. doi:10.1172/JCI200422147. PMID 15199399.
- ↑ White PJ, Atley LM, Wraight CJ (2004). "Antisense oligonucleotide treatments for psoriasis". Expert opinion on biological therapy. 4 (1): 75–81. doi:10.1517/14712598.4.1.75. PMID 14680470.
- ↑ Science Daily, New Skin-healing Chemicals