Struma ovarii laboratory findings: Difference between revisions
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{{Struma ovarii}} | {{Struma ovarii}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{ARK}} | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of struma ovarii include [[histopathologic]] studies and elevated [[CA-125]] levels. | |||
Laboratory findings consistent with the diagnosis of [ | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
*Struma ovarii can be diagnosed only based on [[histopathologic]] <nowiki/>studies. <ref name="pmid24783110">{{cite journal |vauthors=Sinha NK |title=Struma ovarii with elevated ca-125 levels and ascites mimicking advanced ca ovary |journal=J Clin Diagn Res |volume=8 |issue=3 |pages=140–1 |year=2014 |pmid=24783110 |pmc=4003614 |doi=10.7860/JCDR/2014/8005.4138 |url=}}</ref> | |||
* | *Elevated levels of [[CA-125]] has been reported rarely in approximately only 8-10 of cases so far. <ref name="pmid18334015">{{cite journal |vauthors=Mitrou S, Manek S, Kehoe S |title=Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature |journal=Int. J. Gynecol. Cancer |volume=18 |issue=2 |pages=372–5 |year=2008 |pmid=18334015 |doi=10.1111/j.1525-1438.2007.00998.x |url=}}</ref><ref name="pmid4003614">{{cite journal |vauthors=Boselie F, Leeuwenberg E |title=Birkhoff revisited: beauty as a function of effect and means |journal=Am J Psychol |volume=98 |issue=1 |pages=1–39 |year=1985 |pmid=4003614 |doi= |url=}}</ref> | ||
*In cases of metastatic struma ovarii post total [[thyroidectomy]] along with [[radioiodine]] scanning and [[radioiodine]] ablation, the [[thyroglobulin]] levels must be monitored as a [[tumor marker]], and diagnostic [[radioiodine]] scans should be done to screen for residual or recurrent disease. <ref name="pmid19289330">{{cite journal| author=McGill JF, Sturgeon C, Angelos P| title=Metastatic struma ovarii treated with total thyroidectomy and radioiodine ablation. | journal=Endocr Pract | year= 2009 | volume= 15 | issue= 2 | pages= 167-73 | pmid=19289330 | doi=10.4158/EP.15.2.167 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19289330 }} </ref> | |||
*For follow-up as a marker of recurrence, serum [[thyroglobulin]] levels and [[Iodine-131|I-131]] scan may be used. <ref name="pmid12821363">{{cite journal |vauthors=Volpi E, Ferrero A, Nasi PG, Sismondi P |title=Malignant struma ovarii: a case report of laparoscopic management |journal=Gynecol. Oncol. |volume=90 |issue=1 |pages=191–4 |year=2003 |pmid=12821363 |doi= |url=}}</ref><ref name="pmid17168212">{{cite journal |vauthors=Zekri JM, Manifold IH, Wadsley JC |title=Metastatic struma ovarii: late presentation, unusual features and multiple radioactive iodine treatments |journal=Clin Oncol (R Coll Radiol) |volume=18 |issue=10 |pages=768–72 |year=2006 |pmid=17168212 |doi= |url=}}</ref><ref name="pmid24783110">{{cite journal |vauthors=Sinha NK |title=Struma ovarii with elevated ca-125 levels and ascites mimicking advanced ca ovary |journal=J Clin Diagn Res |volume=8 |issue=3 |pages=140–1 |year=2014 |pmid=24783110 |pmc=4003614 |doi=10.7860/JCDR/2014/8005.4138 |url=}}</ref> | |||
*[ | *The [[Iodine-131|I-131]] scan or [[thyroglobulin]] have no aid in the follow-up if [[thyroidectomy]] is not performed. <ref name="pmid15963556">{{cite journal |vauthors=Balci TA, Kabasakal L |title=Is the I-131 whole-body scanning proper for follow-up management of the patients with malignant struma ovarii without performing the thyroidectomy? |journal=Gynecol. Oncol. |volume=99 |issue=2 |pages=520 |year=2005 |pmid=15963556 |doi=10.1016/j.ygyno.2005.04.017 |url=}}</ref> | ||
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==References== | ==References== | ||
Latest revision as of 00:37, 16 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Laboratory findings consistent with the diagnosis of struma ovarii include histopathologic studies and elevated CA-125 levels.
Laboratory Findings
- Struma ovarii can be diagnosed only based on histopathologic studies. [1]
- Elevated levels of CA-125 has been reported rarely in approximately only 8-10 of cases so far. [2][3]
- In cases of metastatic struma ovarii post total thyroidectomy along with radioiodine scanning and radioiodine ablation, the thyroglobulin levels must be monitored as a tumor marker, and diagnostic radioiodine scans should be done to screen for residual or recurrent disease. [4]
- For follow-up as a marker of recurrence, serum thyroglobulin levels and I-131 scan may be used. [5][6][1]
- The I-131 scan or thyroglobulin have no aid in the follow-up if thyroidectomy is not performed. [7]
References
- ↑ 1.0 1.1 Sinha NK (2014). "Struma ovarii with elevated ca-125 levels and ascites mimicking advanced ca ovary". J Clin Diagn Res. 8 (3): 140–1. doi:10.7860/JCDR/2014/8005.4138. PMC 4003614. PMID 24783110.
- ↑ Mitrou S, Manek S, Kehoe S (2008). "Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature". Int. J. Gynecol. Cancer. 18 (2): 372–5. doi:10.1111/j.1525-1438.2007.00998.x. PMID 18334015.
- ↑ Boselie F, Leeuwenberg E (1985). "Birkhoff revisited: beauty as a function of effect and means". Am J Psychol. 98 (1): 1–39. PMID 4003614.
- ↑ McGill JF, Sturgeon C, Angelos P (2009). "Metastatic struma ovarii treated with total thyroidectomy and radioiodine ablation". Endocr Pract. 15 (2): 167–73. doi:10.4158/EP.15.2.167. PMID 19289330.
- ↑ Volpi E, Ferrero A, Nasi PG, Sismondi P (2003). "Malignant struma ovarii: a case report of laparoscopic management". Gynecol. Oncol. 90 (1): 191–4. PMID 12821363.
- ↑ Zekri JM, Manifold IH, Wadsley JC (2006). "Metastatic struma ovarii: late presentation, unusual features and multiple radioactive iodine treatments". Clin Oncol (R Coll Radiol). 18 (10): 768–72. PMID 17168212.
- ↑ Balci TA, Kabasakal L (2005). "Is the I-131 whole-body scanning proper for follow-up management of the patients with malignant struma ovarii without performing the thyroidectomy?". Gynecol. Oncol. 99 (2): 520. doi:10.1016/j.ygyno.2005.04.017. PMID 15963556.