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| *'''Historical Perspective'''[ Postpartum ischemic pituitary necrosis was first reported about a century ago in Przeglad Lekarski by Leon Konrad Gliński, though it was named after Harold Sheehan. Postpartum ischemic pituitary necrosis is still one of the most common causes of hypopituitarism in developing countries but it's prevalence is decreased in developed countries because of improved obstetrical care. Mostly, PPH leading to severe hypotension or shock results in Sheehan's syndrome.<ref name="pmid26817341">{{cite journal |vauthors=Krysiak R, Okopień B |title=[Sheehan's syndrome--a forgotten disease with 100 years' history] |language=Polish |journal=Prz. Lek. |volume=72 |issue=6 |pages=313–20 |year=2015 |pmid=26817341 |doi= |url=}}</ref>
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| *Pathophysiology[Apart from pituitary gland enlargement during and before parturition, vasospasm, thrombosis and compression of the hypophyseal arteries, autoimmunity, DIC and smaller size of sella are thought to play a contributing role in pathogenesis of sheehan Syndrome.<ref name="pmid15237929">{{cite journal |vauthors=Keleştimur F |title=Sheehan's syndrome |journal=Pituitary |volume=6 |issue=4 |pages=181–8 |year=2003 |pmid=15237929 |doi= |url=}}</ref>. It is thought that tissue necrosis results in release of sequestered antigens, precipitating autoimmunity of the pituitary gland and hypopituitarism in Sheehan's syndrome.<ref name="pmid12213861">{{cite journal |vauthors=Goswami R, Kochupillai N, Crock PA, Jaleel A, Gupta N |title=Pituitary autoimmunity in patients with Sheehan's syndrome |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue=9 |pages=4137–41 |year=2002 |pmid=12213861 |doi=10.1210/jc.2001-020242 |url=}}</ref>. Type 1 diabetes, pre-existinfg vascular diseases and known/unknown pituitary masses are associated with increased risk of developing Sheehan syndrome in pregnancy <ref name="Abourawi2006">{{cite journal|last1=Abourawi|first1=F|title=Diabetes Mellitus and Pregnancy|journal=Libyan Journal of Medicine|volume=1|issue=1|year=2006|pages=28–41|issn=19932820|doi=10.4176/060617}}</ref>]
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