|
|
| (33 intermediate revisions by 6 users not shown) |
| Line 1: |
Line 1: |
| __NOTOC__ | | __NOTOC__ |
| {{Syndrome of inappropriate antidiuretic hormone}}
| | [[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Syndrome_of_inappropriate_antidiuretic_hormone]] |
| {{CMG}}; {{AE}} {{Vbe}} | | {{CMG}}; {{AE}}{{Vbe}} |
|
| |
|
| ==Overview== | | ==Overview== |
| [[SIADH]] consists of[[ hyponatremia]], inappropriately elevated[[ urine]] [[osmolality]], excessive urine [[sodium]] and decreased serum [[osmolality]] in a [[euvolemic]] patient without [[edema]]. These findings should occur in the absence of [[diuretic]] treatment with normal [[cardiac, renal]], [[adrenal]], [[hepatic]] and [[thyroid]] function.[[ Hyponatremia]] occurs in about 30% of hospitalized patients and SIADH is the most frequent cause of hyponatremia. Differentiating hyponatremia due to SIADH from other causes of hyponatremia becomes essential to evaluate the treatment plan. [[Syndrome of inappropriate antidiuretic hormone]] must be differentiated from [[Cerebral salt-wasting syndrome|cerebral salt wasting]] , [[adrenal insufficiency]], [[hypopituitarism]], [[hypothyroidism]],[[psychogenic polydipsia]]
| | Syndrome of inappropriate antidiuretic hormone (SIADH) must be differentiated from other causes of [[hyponatremia]], such as [[cerebral salt wasting syndrome]], [[adrenal insufficiency]], [[hypopituitarism]], and [[psychogenic polydipsia]]. |
| | | ==Differentiating Syndrome of Inappropriate Antidiuretic Hormone from other Diseases== |
| ==Differentiating Syndrome of inappropriate antidiuretic hormone from other Diseases== | | [[SIADH]] must be differentiated from cerebral salt wasting, [[ adrenal insufficiency]], [[hypopituitarism]], [[hypothyroidism]], and [[psychogenic polydipsia]].<ref name="pmid27936532">{{cite journal |vauthors=Heidelbaugh JJ |title=Endocrinology Update: Hypopituitarism |journal=FP Essent |volume=451 |issue= |pages=25–30 |year=2016 |pmid=27936532 |doi= |url=}}</ref><ref name="pmid15241506">{{cite journal |vauthors=Hammer F, Arlt W |title=[Hypopituitarism] |language=German |journal=Internist (Berl) |volume=45 |issue=7 |pages=795–811; quiz 812–3 |year=2004 |pmid=15241506 |doi=10.1007/s00108-004-1216-5 |url=}}</ref><ref name="pmid25712898">{{cite journal |vauthors=de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E |title=The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia |journal=Endocr Connect |volume=4 |issue=2 |pages=86–91 |year=2015 |pmid=25712898 |pmc=4401105 |doi=10.1530/EC-14-0113 |url=}}</ref> |
| [[SIADH]] must be differentiated from [[cerebral salt wasting]], [[ adrenal insufficiency]], [[hypopituitarism]], [[hypothyroidism]], [[psychogenic polydipsia]]<ref name="pmid27936532">{{cite journal |vauthors=Heidelbaugh JJ |title=Endocrinology Update: Hypopituitarism |journal=FP Essent |volume=451 |issue= |pages=25–30 |year=2016 |pmid=27936532 |doi= |url=}}</ref><ref name="pmid15241506">{{cite journal |vauthors=Hammer F, Arlt W |title=[Hypopituitarism] |language=German |journal=Internist (Berl) |volume=45 |issue=7 |pages=795–811; quiz 812–3 |year=2004 |pmid=15241506 |doi=10.1007/s00108-004-1216-5 |url=}}</ref><ref name="pmid25712898">{{cite journal |vauthors=de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E |title=The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia |journal=Endocr Connect |volume=4 |issue=2 |pages=86–91 |year=2015 |pmid=25712898 |pmc=4401105 |doi=10.1530/EC-14-0113 |url=}}</ref> | |
|
| |
| {| class="wikitable"
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Causes
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Symptoms
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Diagnosis and treatment
| |
| |- Diagnostic criteria of SIADH include:
| |
| | |
| |[[SIADH]]
| |
| |[[SIADH]] is a syndrome characterized by excessive release of [[Vasopressin|antidiuretic hormone]] (ADH or vasopressin) from the [[posterior pituitary]] gland or another source. The result is [[hyponatremia]], and sometimes [[fluid]] overload.
| |
| |
| |
| *[[Nausea/vomiting]]
| |
| *[[Cramps]]
| |
| *[[Depressed mood]]
| |
| *[[Irritability]]
| |
| *[[Confusion]]
| |
| *[[ Hallucinations]].
| |
| *[[Seizures]] ,[[stupor]] or [[coma ]]
| |
| |
| |
| *[[Hyponatremia ]] <135 mmol/l
| |
| | |
| *[[Decreased effective serum osmolalit]]y<275mosm
| |
| | |
| *[[Urine sodium concentration]]>40mmol/litre
| |
| | |
| *[[Plasma uric acid]] <200;FeUrate>12%
| |
| | |
| *Absence of edematous disease like[[ cardiac failure]], [[liver cirrhosis]],[[ nephrotic syndrome]].
| |
| | |
| *Normal [[adrenal]] and thyroid function
| |
|
| |
|
| | {| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px" align="center" |
| | | valign="top" | |
| | |+ |
| | ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Differential Diagnosis}} |
| | ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Similar Features}} |
| | ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Differentiating Features}} |
| | |- |
| | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |[[SIADH]] |
| | | style="padding: 5px 5px; background: #F5F5F5;" | |
| | *Excessive release of [[Vasopressin|antidiuretic hormone (ADH or vasopressin)]] from the [[posterior pituitary]] gland or another source. |
| | *[[Hyponatremia]] |
| | *[[Fluid]] overload |
| | *[[Hyponatremia]] <135 mmol/l |
| | *Effective serum [[osmolality]] < 275 mOsm |
| | *Urine [[sodium]] concentration > 40 mMol/l |
| | *Plasma [[uric acid]] < 200 |
| | *Absence of [[edema]]-inducing diseases, such as [[heart failure]], [[liver cirrhosis]], and [[nephrotic syndrome]] |
| | *Normal [[adrenal]] and [[thyroid]] function |
| | | style="padding: 5px 5px; background: #F5F5F5;" | |
| | * [[Weight loss]] (in case of [[malignancy]]) |
| | * History of head [[trauma]] |
| | * History of medication intake |
| | * Positive [[family history]] |
| |- | | |- |
| |[[Cerebral salt wasting syndrome]] | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |[[Cerebral salt wasting syndrome]] |
| | | | style="padding: 5px 5px; background: #F5F5F5;" | |
| |[[ Cerebral salt wasting syndrome]] is defined as the[[ renal]] loss of [[sodium]] during intracranial disease leading to [[hyponatremia]] and a decrease in extracellular fluid volume. | | *[[Hyponatremia]] |
| | | *Urine [[sodium]] concentration > 40 mMol/l |
| *[[Trauma]] | |
| *[[Tumor]] | |
| *[[Hematoma]]
| |
|
| |
|
| |The patient is | | | style="padding: 5px 5px; background: #F5F5F5;" | |
| *[[Hypovolemic]] | | *[[Hypovolemia]] |
| *[[Hyponatremic]]. | | *Intracranial [[diseases]], such as: |
| | | **[[Tumor]] |
| |Treatment is with adequate
| | **[[Trauma]] |
| *[[Hydration]] and | | **[[Hematoma]] |
| *[[Sodium]] replacement. | |
| |- | | |- |
| |[[Adrenal insufficiency]] | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |[[Adrenal insufficiency]] |
| | | | style="padding: 5px 5px; background: #F5F5F5;" | |
| |[[Adrenal insufficiency]] ranges from mild nonspecific symptoms to life-threatening [[shock]] like condition. | | *[[Hyponatremia]] |
| An important distinction in these patients is the presence of[[ mineralocorticoid deficiency]]. Those with [[secondary]] or [[tertiary adrenal insufficiency]] will typically have preserved[[ mineralocorticoid]] function due to the separate feedback systems.
| |
| Adrenal insufficiency can be
| |
| *[[Primary]]
| |
| *[[Secondary]]
| |
| [[Tertiary]]
| |
| Common causes of primary adrenal insufficiency:
| |
| *[[Autoimmune]]
| |
| *[[Iatrogenic]]
| |
| *[[Drugs]]
| |
| * [[Adrenal hemorrhage]]
| |
| *[[Cancer]]
| |
| *[[Infection]]
| |
| *[[Congenital]].
| |
| *Secondary adrenal insufficiency refers to decreased [[adrenocorticotropic hormone]] (ACTH) stimulation of the [[adrenal cortex]] and therefore does not affect [[aldosterone levels]].
| |
| *Most common causes are:
| |
| *[[Traumatic brain injury (TBI) ]]
| |
| *[[Panhypopituitarism]]
| |
| *Tertiary adrenal insufficiency refers to decreased [[hypothalamic]] stimulation of the pituitary to secrete [[ACTH]].
| |
| *Exogenous[[ steroid]] administration is the most common cause of tertiary [[adrenal]] insufficiency.
| |
| | | |
| * [[Fatigue]] | |
| *[[ Muscle weakness]]
| |
| * [[Loss of appetite]]
| |
| *[[ Weight loss]]
| |
| * [[Abdominal pain]]
| |
| *[[Diarrhea]]
| |
| *[[Vomiting]]
| |
|
| |
|
| Chronic disease is characterized by
| | | style="padding: 5px 5px; background: #F5F5F5;" | |
| *[[Weight loss]] | | *[[Weight loss]] |
| *[[Sparse axillary hair]] | | *Sparse [[axillary]] hair |
| *[[Hyperpigmentation]] | | *[[Hyperpigmentation]] |
| *[[Orthostatic hypotension]]. | | *[[Orthostatic hypotension]] |
| | |
| Acute [[addisonian]] crisis is characterized by :
| |
| *[[Fever]] | | *[[Fever]] |
| *[[ Hypotension]]. | | *[[Hypotension]] |
| |The diagnosis of [[Addisons]] disease is made through rapid [[ACTH]] administration and measurement of [[cortisol]].
| | *[[Eosinophilia]] |
| *Lab findings include:
| | *[[Hyperkalemia]] |
| *[[White blood cell]] count with moderate [[neutropenia]]
| | *[[Hypoglycemia]] |
| *[[lymphocytosis]]
| | *Morning low plasma [[cortisol]] |
| *[[ eosinophilia]]
| |
| *Elevated serum[[ potassium]] and [[urea nitrogen]] | |
| *Low [[sodium]] | |
| *Low blood[[ glucose]] | |
| * Morning low plasma [[cortisol]]. | |
| The definitive diagnosis is the [[cosyntropin]] or [[ACTH]] stimulation test. A[[ cortisol]] level is obtained before and after administering [[ACTH]]. A normal person should show a brisk rise in [[cortisol]] level after [[ACTH]] administration.
| |
| | |
| | |
| Management: The management of Addison disease involves:
| |
| *Gluocorticoid
| |
| *Mineralocorticoid
| |
| *Sodium chloride replacement.
| |
| Adrenal crisis:
| |
| *In adrenal crisis,measure cortisol level,then rapidly administer
| |
| * Fluids
| |
| * Hydrocortisone
| |
|
| |
| |- | | |- |
| |[[Hypopituitarism]]: | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |[[Hypopituitarism]] |
| |Hypopituitarism is defined as the partial or complete loss of [[anterior pituitary]] function that can result from acquired or [[congenital]] causes. | | | style="padding: 5px 5px; background: #F5F5F5;" | |
| Etiology is as follows:
| | *[[Hyponatremia]] |
| *[[Pituitary]] [[tumors]] | | | style="padding: 5px 5px; background: #F5F5F5;" | |
| *[[Sellar tumors]]
| |
| *[[Head trauma]]
| |
| *[[Infection]]
| |
| *[[Empty sella]]
| |
| *[[Infiltration]]
| |
| *Idiopathic
| |
| *[[Congenital]]
| |
| | | |
| Signs and symptoms of[[ hypopituitarism]] vary, depending on the deficient
| |
| | |
| [[hormone ]] and severity of the disorder,some of the [[symptoms]] may be as follows:
| |
| * [[Fatigue]] | | * [[Fatigue]] |
| * [[Weight loss]] | | * [[Weight loss]] |
| Line 140: |
Line 71: |
| * [[Anemia]] | | * [[Anemia]] |
| * [[Infertility]] | | * [[Infertility]] |
| *[[ Cold insensitivity]]. | | * [[Cold intolerance]] |
| * [[Amenorrha]] | | * [[Amenorrhea]] |
| *[[Inability to lactate]] in [[breast feeding]] women | | * Inability to lactate in [[breast feeding]] women |
| * Decreased [[facial]] or[[ body hair]] in men | | * Decreased [[facial]] or [[body hair]] in men |
| * [[Short stature]] in children | | * [[Short stature]] in children |
| |The diagnosis is based on detailed investigation of symptoms of target endocrine gland function relative to the corresponding pituitary[[ hormone]] deficiency. The clinical manifestations of[[ hypopituitarism]] result from the degree of the specific hormone [[deficiency]].
| |
| A thorough and longitudinal [[history]] and[[ physical examination]], including [[visual field]] testing, are important.
| |
| Hypopituitarism may involve from one to all endocrine axes regulated by the pituitary
| |
| In order of frequency: [[growth hormone]] deficiency>[[secondary hypogonadism]]>[[secondary hypothyroidism]]>[[secondary adrenal failure]]).
| |
| The treatment of permanent hypopituitarism consists of replacement of the peripheral hormones
| |
| *[[Hydrocortisone]]
| |
| *[[DHEA]]
| |
| *[[Thyroxine]]
| |
| *[[Testosterone]] or [[oestradiol]]
| |
| *[[ Growth hormone]]
| |
| *[[Surgery]] and/or
| |
| *[[ Radiotherapy]] to restore normal [[endocrine]] function and quality of life.
| |
| *Patients with hypopituitarism require lifelong monitoring of serum hormone levels and symptoms of hormone deficiency or excess.
| |
| *Long-term care and monitoring of patients with hypopituitarism requires a experienced [[endocrinologist]].
| |
| |- | | |- |
| |[[Hypothyroidism]] | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |[[Psychogenic polydipsia]] |
| |Hypofunctioning of the thyroid gland due to multifactorial etiology ranging from congenital to [[autoimmune]] causes described below: | | | style="padding: 5px 5px; background: #F5F5F5;" | |
| *[[Congenital]]
| | *[[Fluid]] overload |
| *[[Autoimmune]]
| | *[[Hyponatremia]] |
| *[[Drugs]]
| | | style="padding: 5px 5px; background: #F5F5F5;" | |
| *[[Post surgery]]
| | *Defect in the [[hypothalamus]] |
| *[[Post radiation]]
| |
| *[[Infiltrative]] e.g., amyloid
| |
| | | |
| *[[ Fatigue]] | |
| * [[Constipation]]
| |
| *[[ Dry skin]]
| |
| *[[ Weight gain]]
| |
| * [[Cold intolerance]]
| |
| *[[ Puffy face]]
| |
| *[[ Hoarseness]]
| |
| *[[ Muscle weakness]]
| |
| * Elevated blood [[cholesterol]] level
| |
| * [[Bradycardia]]
| |
| *[[ Myopathy]]
| |
| *[[ Depression]]
| |
| * Impaired [[memory]] | |
| | Diagnosis of [[hypothyroidism]] is based on [[blood]] tests: | |
| *T3(triiodothyronine)
| |
| *T4(Thyroxine) and
| |
| *TSH (thyroid stimulating hormone).
| |
| *Signs and symptoms are neither [[sensitive]] nor [[specific]] for the diagnosis.
| |
| *TSH is the most sensitive tool for screening,diagnosis and treatment follow up, when[[ pituitary]] is normal.
| |
| *The drug of choice for treatment is [[Levothyroxine]].
| |
| |-
| |
| |[[Psychogenic polydipsia]]
| |
| | Also called as[[ primary polydipsia]] is characterized by[[ polyuria]] and [[polydipsia]]. Causes are: | |
| * Defect in the [[hypothalamus]] | |
| *Adverse effect of a [[medication]]
| |
| *Traumatic[[ brain]] injury
| |
| *[[Psychiatric]] disorders such as [[schizophrenia]]
| |
| |
| |
| *[[Polyuria]] | | *[[Polyuria]] |
| *[[Polydipsia]] | | *[[Polydipsia]] |
| Line 202: |
Line 88: |
| *[[Lethargy]] | | *[[Lethargy]] |
| *[[Psychosis]] | | *[[Psychosis]] |
| *[[Seizures]] and | | *[[Seizures]] |
| *Sometimes, even [[Death]].
| |
| |Evaluation of[[ psychiatric]] patients with polydipsia warrants a comprehensive evaluation for other medical causes of polydipsia, polyuria,[[ hyponatremia]], and the syndrome of inappropriate secretion of antidiuretic hormone.
| |
| *The management strategy in[[ psychiatric]] patients should include:
| |
| | |
| *[[Fluid]] restriction and[[ behavioral]] and [[pharmacologic]] modalities.
| |
| *The water deprivation test is the [[gold standard]] test.
| |
| |} | | |} |
|
| |
| ==References== | | ==References== |
| {{Reflist|2}} | | {{Reflist|2}} |
|
| |
|
| [[Category:Needs content]] | | [[Category:Medicine]] |
| [[Category:Endocrinology]] | | [[Category:Endocrinology]] |
| | [[Category:Nephrology]] |
| [[Category:Neurology]] | | [[Category:Neurology]] |
| [[Category:Nephrology]] | | [[Category:Up-To-Date]] |
| | |
| {{WikiDoc Help Menu}}
| |
| {{WikiDoc Sources}}
| |
