Thyroid nodule causes: Difference between revisions
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{{CMG}} ; {{AE}} {{MIR}} | {{CMG}} ; {{AE}} {{MIR}} | ||
==Overview== | ==Overview== | ||
The major causes of thyroid nodule development include, [[Multinodular goiter|multinodular (sporadic) goiter]], [[Hashimoto's thyroiditis]], [[cysts]], macrofollicular/microfollicular adenomas, childhood [[radioiodine]] exposure, [[familial history]], and [[gene]] [[mutations]] include N&H [[Ras oncogene|ras]], [[RET gene|RET]], Gsp, [[C-MET]] (α and β subunit), [[TRK]], EGF / [[EGFR|EGF-R]], and [[P53]] [[mutation]]. | |||
== Causes == | == Causes == | ||
* Causes of benign thyroid nodule: | The most important causes of thyroid nodule development include:<ref name="pmid20510711">{{cite journal |vauthors=Bomeli SR, LeBeau SO, Ferris RL |title=Evaluation of a thyroid nodule |journal=Otolaryngol. Clin. North Am. |volume=43 |issue=2 |pages=229–38, vii |year=2010 |pmid=20510711 |pmc=2879398 |doi=10.1016/j.otc.2010.01.002 |url=}}</ref><ref name="pmid26180765">{{cite journal |vauthors=Jena A, Patnayak R, Prakash J, Sachan A, Suresh V, Lakshmi AY |title=Malignancy in solitary thyroid nodule: A clinicoradiopathological evaluation |journal=Indian J Endocrinol Metab |volume=19 |issue=4 |pages=498–503 |year=2015 |pmid=26180765 |pmc=4481656 |doi=10.4103/2230-8210.159056 |url=}}</ref><ref name="pmid20693948">{{cite journal |vauthors=Chibishev A, Simonovska N, Shikole A |title=Post-corrosive injuries of upper gastrointestinal tract |journal=Prilozi |volume=31 |issue=1 |pages=297–316 |year=2010 |pmid=20693948 |doi= |url=}}</ref> | ||
** Multinodular (sporadic) goiter ("colloid adenoma") | * Causes of [[benign]] thyroid nodule: | ||
** Hashimoto's (chronic lymphocytic) thyroiditis | ** [[Goiter|Multinodular (sporadic) goiter ("colloid adenoma")]] | ||
** Cysts (colloid, simple, or hemorrhagic) | ** [[Hashimoto thyroiditis| Hashimoto's (chronic lymphocytic) thyroiditis]] | ||
** Follicular adenomas | ** [[Cysts]] (colloid, simple, or [[hemorrhagic]]) | ||
** Macrofollicular adenomas | ** Follicular [[adenomas]] | ||
** Microfollicular or cellular adenomas | ** Macrofollicular [[adenomas]] | ||
** Hürthle cell (oxyphil cell) adenomas | ** Microfollicular or cellular [[adenomas]] | ||
** [[Hurthle cells|Hürthle cell]] ([[oxyphil cell]]) [[adenomas]] | |||
** Macro- or microfollicular patterns | ** Macro- or microfollicular patterns | ||
* Causes of malignant nodule mutations: | * Causes of [[malignant]] nodule [[mutations]]: | ||
** Childhood radioiodine exposure | ** Childhood [[radioiodine]] exposure | ||
** Familial history | ** [[Family history|Familial history]] | ||
The most important [[genes]] which can lead to [[thyroid cancer]] include:<ref name="pmid20510711">{{cite journal |vauthors=Bomeli SR, LeBeau SO, Ferris RL |title=Evaluation of a thyroid nodule |journal=Otolaryngol. Clin. North Am. |volume=43 |issue=2 |pages=229–38, vii |year=2010 |pmid=20510711 |pmc=2879398 |doi=10.1016/j.otc.2010.01.002 |url=}}</ref><ref name="pmid26180765">{{cite journal |vauthors=Jena A, Patnayak R, Prakash J, Sachan A, Suresh V, Lakshmi AY |title=Malignancy in solitary thyroid nodule: A clinicoradiopathological evaluation |journal=Indian J Endocrinol Metab |volume=19 |issue=4 |pages=498–503 |year=2015 |pmid=26180765 |pmc=4481656 |doi=10.4103/2230-8210.159056 |url=}}</ref><ref name="pmid20693948">{{cite journal |vauthors=Chibishev A, Simonovska N, Shikole A |title=Post-corrosive injuries of upper gastrointestinal tract |journal=Prilozi |volume=31 |issue=1 |pages=297–316 |year=2010 |pmid=20693948 |doi= |url=}}</ref> | |||
* | * N&H [[Ras oncogene|ras]] | ||
* | * [[RET gene|RET]] | ||
* Gsp | |||
* | * [[C-MET]] (α and β subunit) | ||
* | * [[TRK]] | ||
* EGF / [[EGFR|EGF-R]] | |||
* | * [[P53]] | ||
==References== | ==References== | ||
Latest revision as of 01:22, 20 November 2017
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Thyroid nodule causes On the Web |
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American Roentgen Ray Society Images of Thyroid nodule causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]
Overview
The major causes of thyroid nodule development include, multinodular (sporadic) goiter, Hashimoto's thyroiditis, cysts, macrofollicular/microfollicular adenomas, childhood radioiodine exposure, familial history, and gene mutations include N&H ras, RET, Gsp, C-MET (α and β subunit), TRK, EGF / EGF-R, and P53 mutation.
Causes
The most important causes of thyroid nodule development include:[1][2][3]
- Causes of benign thyroid nodule:
- Multinodular (sporadic) goiter ("colloid adenoma")
- Hashimoto's (chronic lymphocytic) thyroiditis
- Cysts (colloid, simple, or hemorrhagic)
- Follicular adenomas
- Macrofollicular adenomas
- Microfollicular or cellular adenomas
- Hürthle cell (oxyphil cell) adenomas
- Macro- or microfollicular patterns
- Causes of malignant nodule mutations:
- Childhood radioiodine exposure
- Familial history
The most important genes which can lead to thyroid cancer include:[1][2][3]
References
- ↑ 1.0 1.1 Bomeli SR, LeBeau SO, Ferris RL (2010). "Evaluation of a thyroid nodule". Otolaryngol. Clin. North Am. 43 (2): 229–38, vii. doi:10.1016/j.otc.2010.01.002. PMC 2879398. PMID 20510711.
- ↑ 2.0 2.1 Jena A, Patnayak R, Prakash J, Sachan A, Suresh V, Lakshmi AY (2015). "Malignancy in solitary thyroid nodule: A clinicoradiopathological evaluation". Indian J Endocrinol Metab. 19 (4): 498–503. doi:10.4103/2230-8210.159056. PMC 4481656. PMID 26180765.
- ↑ 3.0 3.1 Chibishev A, Simonovska N, Shikole A (2010). "Post-corrosive injuries of upper gastrointestinal tract". Prilozi. 31 (1): 297–316. PMID 20693948.