Diabetes insipidus risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
The [[risk factors]] | The [[risk factors]] for the development of diabetes insipidus vary among different types of DI. [[risk factors]] for the development of [[Central diabetes insipidus|central DI]] include [[genetic mutations]], [[Pituitary disease|pituitary disorders]], [[hypothalamic]] injury, and head [[tumors]]. The most potent [[risk factor]] for the development of [[nephrogenic diabetes insipidus]] is [[lithium]] use, as [[lithium]] has a very narrow [[therapeutic index]] of 0.4-0.8 mmol/L. Excessive water intake has been identified as the only [[risk factor]] associated with psychogenic DI, as [[pregnancy]] is the only risk factor for gestational DI. | ||
==Risk Factors== | ==Risk Factors== | ||
===Common Risk Factors=== | ===Common Risk Factors=== | ||
The following are some of the common [[risk factors]] associated with the development of diabetes insipidus:<ref name="pmid15806465">{{cite journal |vauthors=Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF |title=Causes of reversible nephrogenic diabetes insipidus: a systematic review |journal=Am. J. Kidney Dis. |volume=45 |issue=4 |pages=626–37 |year=2005 |pmid=15806465 |doi= | The following are some of the common [[risk factors]] associated with the development of diabetes insipidus:<ref name="pmid15806465">{{cite journal |vauthors=Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF |title=Causes of reversible nephrogenic diabetes insipidus: a systematic review |journal=Am. J. Kidney Dis. |volume=45 |issue=4 |pages=626–37 |year=2005 |pmid=15806465 |doi= |url=}}</ref><ref name="pmid15153548">{{cite journal |vauthors=Devonald MA, Karet FE |title=Renal epithelial traffic jams and one-way streets |journal=J. Am. Soc. Nephrol. |volume=15 |issue=6 |pages=1370–81 |year=2004 |pmid=15153548 |doi= |url=}}</ref><ref name="pmid16713495">{{cite journal |vauthors=Bichet DG |title=Hereditary polyuric disorders: new concepts and differential diagnosis |journal=Semin. Nephrol. |volume=26 |issue=3 |pages=224–33 |year=2006 |pmid=16713495 |doi=10.1016/j.semnephrol.2006.02.004 |url=}}</ref><ref name="pmid26077742">{{cite journal |vauthors=Bockenhauer D, Bichet DG |title=Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus |journal=Nat Rev Nephrol |volume=11 |issue=10 |pages=576–88 |year=2015 |pmid=26077742 |doi=10.1038/nrneph.2015.89 |url=}}</ref> | ||
*[[Genetics]] | *[[Genetics]] | ||
| Line 21: | Line 21: | ||
*[[Lithium]] use | *[[Lithium]] use | ||
===Less Common Risk Factors=== | ===Less Common Risk Factors=== | ||
Less common [[risk factors]] include:<ref name="pmid10477148">{{cite journal |vauthors=van Lieburg AF, Knoers NV, Monnens LA |title=Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus |journal=J. Am. Soc. Nephrol. |volume=10 |issue=9 |pages=1958–64 |year=1999 |pmid=10477148 |doi= |url=}}</ref><ref name="pmid10749568">{{cite journal |vauthors=Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M |title=Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants |journal=J. Clin. Invest. |volume=105 |issue=7 |pages=887–95 |year=2000 |pmid=10749568 |pmc=377482 |doi=10.1172/JCI8688 |url=}}</ref> | |||
*Male | *Male gender | ||
*[[Family history]] of [[nephrogenic diabetes insipidus]] | *[[Family history]] of [[nephrogenic diabetes insipidus]] | ||
*Excessive water consumption | *Excessive water consumption | ||
| Line 32: | Line 32: | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Nephrology]] | [[Category:Nephrology]] | ||
Latest revision as of 21:17, 27 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]
Overview
The risk factors for the development of diabetes insipidus vary among different types of DI. risk factors for the development of central DI include genetic mutations, pituitary disorders, hypothalamic injury, and head tumors. The most potent risk factor for the development of nephrogenic diabetes insipidus is lithium use, as lithium has a very narrow therapeutic index of 0.4-0.8 mmol/L. Excessive water intake has been identified as the only risk factor associated with psychogenic DI, as pregnancy is the only risk factor for gestational DI.
Risk Factors
Common Risk Factors
The following are some of the common risk factors associated with the development of diabetes insipidus:[1][2][3][4]
- Genetics
- Polycystic kidney disease
- Pituitary disorders
- Hypothalamic injury
- Hypercalcemia
- Head tumors
- Pregnancy
- Sickle cell disease
- Amyloidosis
- Lithium use
Less Common Risk Factors
Less common risk factors include:[5][6]
- Male gender
- Family history of nephrogenic diabetes insipidus
- Excessive water consumption
- Pregnancy
- Drugs like phenothiazine
References
- ↑ Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF (2005). "Causes of reversible nephrogenic diabetes insipidus: a systematic review". Am. J. Kidney Dis. 45 (4): 626–37. PMID 15806465.
- ↑ Devonald MA, Karet FE (2004). "Renal epithelial traffic jams and one-way streets". J. Am. Soc. Nephrol. 15 (6): 1370–81. PMID 15153548.
- ↑ Bichet DG (2006). "Hereditary polyuric disorders: new concepts and differential diagnosis". Semin. Nephrol. 26 (3): 224–33. doi:10.1016/j.semnephrol.2006.02.004. PMID 16713495.
- ↑ Bockenhauer D, Bichet DG (2015). "Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus". Nat Rev Nephrol. 11 (10): 576–88. doi:10.1038/nrneph.2015.89. PMID 26077742.
- ↑ van Lieburg AF, Knoers NV, Monnens LA (1999). "Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus". J. Am. Soc. Nephrol. 10 (9): 1958–64. PMID 10477148.
- ↑ Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M (2000). "Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants". J. Clin. Invest. 105 (7): 887–95. doi:10.1172/JCI8688. PMC 377482. PMID 10749568.