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{{Spondyloarthropathy}}
{{CMG}} {{AE}}[[User:Arash Azhideh|Arash Azhideh]]


== [[Spondyloarthropathy overview|Overview]] ==


'''Spondyloarthropathies''' are inflammatory joint diseases associated with the [[Major_histocompatibility_complex|MHC]] class I molecule [[HLA-B27]]. The term '''seronegative spondylarthropathy''' is used by medical practitioners because this set of conditions may mimic rheumatoid diseases such as [[rheumatoid arthritis]], but [[serological]] (blood) tests are typically negative for [[rheumatoid factor|rheumatoid factor (RhF)]].
== [[Spondyloarthropathy historical perspective|Historical Perspective]] ==


Subgroups (with increased HLA-B27 frequency) are:
== [[Spondyloarthropathy classification|Classification]] ==
*[[ankylosing spondylitis]] Caucasians (AS, 92%),
*[[ankylosing spondylitis]] African-Americans (AS, 50%),
*[[reactive arthritis]] (Reiter's syndrome) (RS, 60-80%),
*[[enteropathic]] arthritis associated with [[inflammatory bowel disease]] (IBD, 60%),
*[[Psoriatic arthritis]] (60%),
*isolated acute anterior uveitis (AAU, iritis or iridocyclitis, 50%), and
*undifferentiated SpA (USpA, 20-25%).


[[Whipple disease]] and [[Behçet disease]] may also be linked to HLA-B27, as may undifferentiated spondyloarthropathy.
== [[Spondyloarthropathy pathophysiology|Pathophysiology]] ==


*Note: One of the causes of erosive or destructive spondyloarthropathy is [[Hyperparathyroidism|tertiary hyperparathyroidism]].<ref name="pmid2712794">{{cite journal |vauthors=Adler JS, Cameron DC |title=Erosive spondylo-arthropathy and tertiary hyperparathyroidism |journal=Australas Radiol |volume=33 |issue=1 |pages=90–2 |year=1989 |pmid=2712794 |doi= |url=}}</ref>
== [[Spondyloarthropathy causes|Causes]] ==
[[Category:Musculoskeletal disorders]]
 
== [[Spondyloarthropathies differential diagnosis|Differentiating Spondyloarthropathies from other Disease]] ==
 
== [[Spondyloarthropathy epidemiology and demographics|Epidemiology and Demographics]] ==
 
== [[Spondyloarthropathy risk factors|Risk Factors]] ==
 
== [[Spondyloarthropathy screening|Screening]] ==
 
== [[Spondyloarthropathy natural history, complications and prognosis|Natural History, Complications and Prognosis]] ==
 
== Diagnosis ==
[[Spondyloarthropathy diagnostic study of choice|Diagnostic Study of Choice]] | [[Spondyloarthropathy history and symptoms|History and symptoms]] | [[Spondyloarthropathy physical examination|Physical Examination]] | [[Spondyloarthropathy laboratory findings|Laboratory Findings]] | [[Spondyloarthropathy electrocardiogram|Electrocardiogram]] | [[Spondyloarthropathy x ray|X-Ray]] | [[Spondyloarthropathy echocardiography and ultrasound|Echocardiography and Ultrasound]] | [[Spondyloarthropathy CT scan|CT Scan]] | [[Spondyloarthropathy MRI|MRI]] | [[Spondyloarthropathy other imaging findings|Other Imaging Findings]] | [[Spondyloarthropathy other diagnostic studies|Other diagnostic Studies]]
 
== Treatment ==
[[Spondyloarthropathy medical therapy|Medical Therapy]] | [[Spondyloarthropathy interventions|Interventions]] | [[Spondyloarthropathy surgery|Surgery]] | [[Spondyloarthropathy primary prevention|Primary Prevention]] | [[Spondyloarthropathy secondary prevention|Secondary Prevention]] | [[Spondyloarthropathy cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | Future or Investigational Therapies


==References==
==References==

Latest revision as of 14:25, 1 June 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Arash Azhideh

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Spondyloarthropathies from other Disease

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice | History and symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray | Echocardiography and Ultrasound | CT Scan | MRI | Other Imaging Findings | Other diagnostic Studies

Treatment

Medical Therapy | Interventions | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

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