Norovirus infection future or investigational therapies: Difference between revisions
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== References == | ==Overview== | ||
Clinically approved vaccines are to be investigated for the norovirus infection. | |||
==Future or Investigational Therapies== | |||
A significant limitation to the event of effective control measures has been the lack of a completely permissive [[cell culture]] system and little [[animal model]] for human noroviruses. Up until now, numerous developments has taken place, yet a licensed [[vaccine]] or clinically approved antiviral remains elusive. It would be invaluable to develop an [[in vitro]] culture system and an [[animal model]] that recapitulates all aspects of the infection as it is in humans. This remains a high priority, as it gives us a much better understanding of the correlates of protection and will enable better vaccine design, eventually leading to the development of a broadly protective [[vaccine]] for at least particularly vulnerable or regularly exposed individuals. Until then, effective [[quarantine]] and deployment of [[hygiene]] measures will help control norovirus [[Outbreak|outbreaks]] and minimize its impact on human health.<ref name="pmid24199805">{{cite journal| author=Arias A, Emmott E, Vashist S, Goodfellow I| title=Progress towards the prevention and treatment of norovirus infections. | journal=Future Microbiol | year= 2013 | volume= 8 | issue= 11 | pages= 1475-87 | pmid=24199805 | doi=10.2217/fmb.13.109 | pmc=3904215 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24199805 }} </ref> | |||
==References== | |||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 15:00, 29 January 2021
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Overview
Clinically approved vaccines are to be investigated for the norovirus infection.
Future or Investigational Therapies
A significant limitation to the event of effective control measures has been the lack of a completely permissive cell culture system and little animal model for human noroviruses. Up until now, numerous developments has taken place, yet a licensed vaccine or clinically approved antiviral remains elusive. It would be invaluable to develop an in vitro culture system and an animal model that recapitulates all aspects of the infection as it is in humans. This remains a high priority, as it gives us a much better understanding of the correlates of protection and will enable better vaccine design, eventually leading to the development of a broadly protective vaccine for at least particularly vulnerable or regularly exposed individuals. Until then, effective quarantine and deployment of hygiene measures will help control norovirus outbreaks and minimize its impact on human health.[1]
References
- ↑ Arias A, Emmott E, Vashist S, Goodfellow I (2013). "Progress towards the prevention and treatment of norovirus infections". Future Microbiol. 8 (11): 1475–87. doi:10.2217/fmb.13.109. PMC 3904215. PMID 24199805.