Perianal abscess

WikiDoc Resources for Perianal abscess
Articles
Most recent articles on Perianal abscess Most cited articles on Perianal abscess Review articles on Perianal abscess Articles on Perianal abscess in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Perianal abscess Images of Perianal abscess Photos of Perianal abscess Podcasts & MP3s on Perianal abscess Videos on Perianal abscess
Evidence Based Medicine
Cochrane Collaboration on Perianal abscess Bandolier on Perianal abscess TRIP on Perianal abscess
Clinical Trials
Ongoing Trials on Perianal abscess at Clinical Trials.gov Trial results on Perianal abscess Clinical Trials on Perianal abscess at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Perianal abscess NICE Guidance on Perianal abscess NHS PRODIGY Guidance FDA on Perianal abscess CDC on Perianal abscess
Books
Books on Perianal abscess
News
Perianal abscess in the news Be alerted to news on Perianal abscess News trends on Perianal abscess
Commentary
Blogs on Perianal abscess
Definitions
Definitions of Perianal abscess
Patient Resources / Community
Patient resources on Perianal abscess Discussion groups on Perianal abscess Patient Handouts on Perianal abscess Directions to Hospitals Treating Perianal abscess Risk calculators and risk factors for Perianal abscess
Healthcare Provider Resources
Symptoms of Perianal abscess Causes & Risk Factors for Perianal abscess Diagnostic studies for Perianal abscess Treatment of Perianal abscess
Continuing Medical Education (CME)
CME Programs on Perianal abscess
International
Perianal abscess en Espanol Perianal abscess en Francais
Business
Perianal abscess in the Marketplace Patents on Perianal abscess
Experimental / Informatics
List of terms related to Perianal abscess

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Kuchkuntla, M.B.B.S[2]

Synonyms and keywords: Anorectal abscess, Ischiorectal abscess, Supralevator abscess, Horse shoe abscess
To return to abscess main page, click here.

Overview

Anorectal abscess is secondary to blockade of the anal gland ducts, resulting in a infection of the gland. The anatomical position of the anal glands in relation to the anal canal is responsible for the variation in the location of the abscess. Initial infection occurs in the anal gland duct and it takes the path of least resistance. The anorectal abscess are classified into low abscess and high based on the location of the abscess. Patients with low abscess present with anal pain associated with bowel movement, and patients with high abscess present systemic manifestations such as fever and malaise in addition to anal pain. On examination tenderness and flactulance suggest anorectal abscess. It is an emergency condition and must be treated promptly within 24 hours of presentation as spread of infection can result in perineal cellulitis and sepsis. Incision and drainage is the definitive treatment and should be performed under local or general anesthesia based on the location of the abscess. With treatment prognosis is good but a risk of recurrence and formation of a fistula is high in patients with improper drainage and failure to identify existing fistula. Antibiotic therapy does not help with treatment of the infection and wound healing.

Historical Perspective

• In 1880, Herman and Desfosses described the anal glands within the internal sphincter, sub-mucosa and their opening into the anal crypts and demonstrated that the infection of these glands and the spread of the infection through the intersphincteric space can result in the formation of a anorectal abscess.
• Tucker and Hellwig, provided evidence that the initial infection occurs in the anal ducts allowing the infection to spread from the anal lumen into the anal canal wall.
• In 1950, Goligher described the treatment for anorectal abscess with incision and curettage with antibiotic bath and primary closure.

Classification

Based on the location of the abscess in relation to the anal canal and the spread of infection to the surrounding structures, anorectal abscess can be classified into

• Perianal abscess: When the infection reaches the anal verge passing between the internal sphincter and external sphincter, it results in the formation of a perianal abscess.
• Ischiorectal abscess: If the infection ruptures through the external sphincter it results in a formation of a ischiorectal abscess.
• Supralevator abscess: If the infection extends superiorly, it can form a supralevator abscess.
• Horseshoe abscess: Extension of the abscess to both the ischiorectal fossa results in the formation of a horseshoe abscess.

Based on the location the abscesses can also be classified into:

• High anorectal abscess: These include intersphincteric, perianal, and ischiorectal abscesses.
• Low anorectal abscess: These incude submucosal, supralevator abscesses.

Pathophysiology

Pathogenesis

• Anal canal is a 2 to 4cm in length, starts at the anorectal junction to the end of anal verge.
• It is divided into a upper and a lower part by transition zone that is seen at the dentate line or pectinate line which is surrounded by longitudinal mucosal folds, called columns of morgagni.
• Each of this fold contains anal crypts, each of which contains 3 to 12 anal glands, the distribution of these glands is not uniform with most of the glands present anterior to the position of the anal canal and fewer in the posterior position.
• The initial infection occurs in the ducts of the anal glands and the spread of infection results in the formation of the abscess, various theories were put forward to describe the pathogenesis and the most accepted one is the cryptoglandular theory.
• The crytoglandular theory states that obstruction of anal gland duct results in a infection and due to the presence of these glands deep in relation to the anal canal and sphincter, the infection follows the path of least resistance resulting in abscess formation at the termination of the gland.

Causes

Source of Infection

• Supralevator abscess can be caused by the spread of infection from abdominal infections such as appendicitis, diverticulitis, or gynecologic sepsis.
• Spread of infection of ano-rectal Crohn's disease.
• Trauma to the anal canal
• Cancer of the anal canal or the anal glands

Microbial Causes

Organisms commonly causing anorectal abscess include:

• E.coli
• Staphylococcus aureus
• MRSA

Epidemiology and Demographics

Incidence

• The incidence of anorectal abscess is estimated to be around 68,000 to 96,000 cases per year in the United States.

Gender

• Anorectal abscesses are two times more frequently seen in men than women.

Age

• Patients with anorectal abscess present between ages of 20 to 60 years with a mean age of 40 in both sexes.

Race

• There are limited epidemiological studies which studied the frequency of anorectal abscess with race differences, however a study in Chicago reported a 92% of the patients presented with anorectal abscess were of African-American origin.

Risk Factors

Risk factors for the development of recurrent of anal abscesses include:

• Crohn's disease
• Diabetes mellitus
• History of abscess in the ischiorectal location
• HIV infection
• Receptive anal sex

Differential Diagnosis

Anorectal abscess must be differentiated from other causes of anal pain including anal fissure, thrombosed hemorrhoids, levator spasm, sexually transmitted disease, proctitis, hidradenitis suppurativa, infected skin furuncles, herpes simplex virus, tuberculosis, syphilis, actinomycosis and cancer.

Disease	Definition	Causes	Clinical Features	Diagnosis
Fistula in ano	A epithelialized track formed between the anorectum and the perianal skin secondary to rupture of anorectal abscess Chronic manifestation of anorectal abscess	Anorectal abscess Crohn's Disease Radiation Proctitis Lymphogranuloma venereum Actinomycosis	Anal pain with bowel movement and sitting Perianal discharge Perianal pruritus Presence of exteral opening on examination Perianal inflammation	Endoanal ultrasound Fistulography Computed tomography
Anal Fissure	Tear in the anoderm distal to the dentate line	Anal Trauma Receptive anal sex Inflammatory bowel disease	Pain with passing of stools Minimal bright red rectal bleeding on the toilet paper or stool On examination acute fissure appears as a fresh laceration Chronic fissure has raised edges with anal skin tag	Clinical diagnosis
Thrombosed External Hemorrhoids	Engorged fibrovascular cushions lining the anal canal	Constipation Prolonged straining	Anal pain Anal pruritus Rectal bleeding with bowel movement Tenderness on examination with a palpable thrombus	Clinical diagnosis
Levator spasm	Severe, intermittent episodes of rectal pain	Seen in patients with perfectionistic, anxious somatic, and/or neurotic tendencies	Severe anal pain lasting for seconds to 5 minutes	Diagnosis is by Rome IV criteria It is diagnosis of exlusion
Proctatitis	Epithelial damage to the rectum secondary to radiation, associated with minimal or no inflammation	Radiation therapy	Diarrhea within six weeks of radiation therapy Urgency Tenesmus Rectal bleeding	Biopsy
Hidradenitis suppurativa	Suppurative disorder of sweat glands	Causes unidentified	Anal pain Anal mass Recurrent and relapsing symptoms Nodules and scarring is demonstrated on examination	Clinical Diagnosis Biopsy should be done to rule out cancer
Infected skin furuncle	Well-circumscribed, painful, suppurative inflammatory nodule involving hair follicles	Staphylococcus aureus	Anal pain Inflammed and red, tender elevated pustular lesion on examination	Clinical diagnosis
Bartholin's abscess	Obstruction of the bartholin's ducts, results in abscess formation	E.coli	Vulvar pain Palpable bartholin gland on examination	Clinical diagnosis Incision and drainage

Perianal absscess must be differentiated from other diseases that cause anal discomfort and pain with defecation such as hemorrhoids, anal fissure and anal cancer.

Disease	History	Physical exam findings	Sample image
Hemorrhoids	External hemorrhoids External hemorrhoids are painful as the skin below the punctate line is sensitive to pain.[1] Blood clots may form in external hemorrhoids. Thrombosed external hemorrhoids cause bleeding, painful swelling, or a hard lump around the anus. When the blood clot dissolves, extra skin is left behind. This skin can become irritated or itch. Excessive straining, rubbing, or cleaning around the anus may make symptoms, such as itching and irritation, worse. Internal hemorrhoids The most common symptom of internal hemorrhoids is bright red blood on stool, on toilet paper, or in the toilet bowl after a bowel movement. Internal hemorrhoids that are not prolapsed are usually not painful. Prolapsed hemorrhoids often cause pain, discomfort, and anal itching	Skin examination Inspection of the anal verge may show scratch marks and skin tags. Inspection also may reveal external hemorrhoids or prolapsed internal hemorrhoids. Digital rectal examination Digital rectal examination reveals the size and location of hemorrhoids. Thrombosed hemorrhoids are tender to palpation. Internal hemorrhoids are not palpable by digital rectal examination and the use of anoscope is mandatory.	External hemorrhoids - By Dr. Joachim Guntau - www.Endoskopiebilder.de, CC BY-SA 3.0, httpscommons.wikimedia.orgwindex.phpcurid=18660115
Anal fissure	Anal fissure usually presents with tearing pain with every bowel movement. Pain usually lasts for minutes to hours after every bowel movement. Patient is typically afraid of going to the bathroom to avoid the pain, which leads to a viscious cycle. The fissure worsens the constipation and the constipation (hard stool) aggravates the fissure. About two-thirds of the patients present with bright red blood streaks on toilet papers or on the surface of stools. May be accompanied by pruritis and discharge.	Most fissures occur in the posterior midline of the anal canal. Skin tags in the perianal area may accompany chronic anal fissures.	Anal fissure - Own work, Public Domain, httpscommons.wikimedia.orgwindex.phpcurid=8885750
Rectal prolapse	Rectal prolapse most commonly occurs in multiparous females over 40 years old. Appears as a progressive mass protrusion from the anus. The protrusion first appears with straining and defecation, then progresses to the degree when it is no longer replaced back. It presents with abdominal discomfort and incomplete defecation. Fecal incontinence and anal discharge. Pain is not usually present.	Mass protruding from the anus. Concentric mucosal rings are characteristic of rectal prolapse.	Rectal prolapse - By Dr. K.-H. Günther, Klinikum Main Spessart, Lohr am Main - Dr. K.-H. Günther, Klinikum Main Spessart, Lohr am Main, CC BY 3.0, httpscommons.wikimedia.orgwindex.phpcurid=20649968
Perianal abscess	Perianal abscess presents with severe, continuous, dull, aching pain in the perianal area. Pain is exacerbated with bowel movements, but is not exclusive to it. Constipation due to fear of bowel movements. Fever, headache, and chills may accompany the pain. If the abscess starts to drain, discharge of purulent or bloody fluid may be noticed.	Flatulent, erythematous, and tender area of skin overlying the abscess. If abscess is deep, tenderness is elicited with digital rectal examination.
Anal cancer	Rectal bleeding is the most common presentation. Mass sensation in the anus. Mucoid discharge may occur. Patient may give a history of anal condyloma (especially homosexual men). Fecal incontinence.	On digital rectal examination, solid hemorrhagic mass that is firmly fixed to the surrounding structures is noted. Femoral and inguinal lymph nodes may show lymphadenopathy secondary to spread of cancer.	Anal Cancer - By Internet Archive Book Images - httpswww.flickr.comphotosinternetarchivebookimages14598073128Source book page httpsarchive.orgstreamdiseasesofrectum00gantdiseasesofrectum00gant-pagen653mode1up, No restrictions, httpsc
Condylomata acuminata	Patient may give a history of unprotected anal sex with an infected partner. Having multiple sexual partners is a risk factor and should be investigated. Condyloma acuminata presents with painless warts that vary in size, shape, and color. Pruritis and discharge may accompany the warts.	Anal condyloma acuminata may be accompanied by cervical, vaginal, or even ororpharyngeal warts, so the patient should be examined thoroughly.

Natural History, Prognosis, Complications

Natural History

If left untreated, anorectal abscess can spread to the surrounding tissue and can cause perineal cellulitis and sepsis. Perianal abscess is the most common type followed by ischiorectal abscess.

Prognosis

Prognosis of patients is good with incision and drainage and most patients do not require any antibiotic therapy after the procedure, except for patients with HIV infection, Crohn's disease. Majority of patients have relief of pain after abscess drainage and healing takes time as it heals by secondary intention.

Complications

• Recurrence usually to incomplete drainage of the abscess
• Sepsis
• Fistula formation
• Scarring

Diagnosis

History and Symptoms

• Patients with low abscess typically present with anal pain. Other findings include:
  • Anal pain
  • Pain associated with bowel movement: It is worse when the person sits down and right before a bowel movement. After the individual has a bowel movement, the pain usually lessens.
  • Swelling
  • Chills
  • Constipation
  • Discharge of pus from the rectum
  • Fever
• Patients with high abscess present with :
  • Fever
  • Malaise
  • Anal pain

Physical Examination

General Appearance

• Patients with high abscess present with fever, elevated body temperature can be noticed.

Digital Rectal Examination

• It is difficult to perform digital rectal examination due to the severe pain, therefore patient should be examined under local anesthesia to identify the location of the abscess and also if suspicion of a high abscess (Supralevator abscess) is present.
• Anoscopy should not be performed.
• Anorectal abscess is a clinical diagnosis and presence of induration, tenderness and fluctulance are diagnostic of perianal and ishciorectal abscess. In patients with intersphincteric or supralevator abscesses external findings are minimal only pelvic or rectal tenderness or fluctulance on digital rectal examination can be demonstrated.

Physical examination findings demonstrated in anorectal abscess include:

• Erythema
• Warmth
• Tenderness
• Induration
• Fluctulance

• 

  Perianal abscess

• 

  Perianal abscess

(Images courtesy of Charlie Goldberg, M.D., UCSD School of Medicine and VA Medical Center, San Diego, CA)

Laboratory Findings

• Anorectal abscess is a clinical diagnosis and physical examination is sufficient to make the diagnosis, therefore complete laboratory testing is not done in most of the patients.
• Complete blood count will demonstrate a neutrophilia and elevated ESR.
• Bleeding time and clotting time and routine pre-operative evaluation must be performed.
• Culture and gram staining of the necrotic tissue is done to establish cause of infection.

Imaging

Ultrasound

• Endoanal ultrasound is useful in detecting horse-shoe abscesses extension and presence of fistula tracts with high sensitivity.
• Three dimensional ultrasound is useful in patients to identify the anatomical locations of complex perianal abscesses and fistula tracts.

CT Scan

• CT scan is useful in patients with complex suppurative anorectal conditions such as supralevator abscess and to identify other etiologies causing anorectal abscess such as pelvic infections, appendicitis, Crohn's disease and diverticulitis.

Treatment

Medical Therapy

• Medical therapy is not recommended in patients with anal abscess as the antibiotics have poor penetration in to the abscess cavity and are not helpful to in treatment of the infection or wound healing.
• Antibiotics may be considered in patients with extensive cellulitis, HIV infection and diabetes mellitus.
• Patients with low neutrophil count (500-1000/mm³) and also in patients with no fluctulance medical therapy can be helpful in resolution of the abscess, however in patients with neutrophil count of >1000/mm³ and with fluctulance surgical drainage is a better option for treatment.
• Prophylactic antibiotics prior to incision and drainage is recommended by American Heart Association, in patients with prosthetic valves, previous bacterial endocarditis, congenital heart disease, and heart transplant recipients with valve pathology.

Surgical Therapy

• Management of anal abscess should be prompt as the risk of involving the surrounding tissue resulting in perineal cellulitis and sepsis is high.
• Primary treatment for anorectal abscess is incision and drainage and it should be performed within 24 hours of presentation.
• Patients with perianal abscess and ischiorectal abscess can be treated in a outpatient setting under local anesthesia using 1% lidocaine or bupivacaine with epinephrine is injected subcutaneously into the area affected by the abscess to provide adequate infilteration into the skin.
• Patients with loculations or large ischiorectal, intersphincteric, supralevator, or horseshoe abscesses should be admitted to the hospital and the procedure should be performed under anesthesia.

Procedure

• Under aseptic precautions a scalpel is used to make a cruciate or elliptical incision over the area of flactulance. The incision should be close to the anal verge to minimize the length of a potential fistula.
• After incision is made the necrotic tissue is removed and loculations are broken using a hemostat or a finger.
• After the procedure the wound is packed with a gauze sponge which is removed after 24 hours.
• Regular sitz bath is recommended after the surgery, it will help in local cleansing and wound healing.
• A variation in the incision and drainage is using a small latex catheter (Pezzer catheter). After a small incision is made the catheter is inserted into the cavity and is left in place for a duration of 3 to 10 days till the abscess cavity is drained and the cavity closes around the catheter.

Complications

• Recurrence of the abscess: The recurrence rate depends on the location of the abscess and the duration of follow-up, the rate ranges from 3% to 44%. Other factors influencing the recurrence rate include incomplete initial drainage, failure to break up loculations within the abscess, missed abscess undiagnosed fistula. Recurrence rates are high in horseshoe abscess with a range from 18% to 50% which require multiple surgeries.
• Urinary retention
• Postoperative bleeding

Prevention

Primary Prevention

• Abstain from anal intercourse
• Adequate treatment of Crohn's disease and HIV infection
• Maintaining proper hygiene

Secondary Prevention

• Early incision and drainage, with regular sitz bath is adviced in all patients.
• Identification of pre-existing fistula tract and fistulotomy during incision and drainage decreases the risk of recurrence and fistula formation.