Adrenocortical carcinoma physical examination: Difference between revisions
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* [[Hypotension]] occurs due to fluid contraction | * [[Hypotension]] occurs due to fluid contraction | ||
* [[Hypertension|Hypertension due to]] [[Cortisol|cortisol's]] enhancement of [[epinephrine]]'s [[vasoconstrictive]] effect | * [[Hypertension|Hypertension due to]] [[Cortisol|cortisol's]] enhancement of [[epinephrine]]'s [[vasoconstrictive]] effect | ||
* [[Tachypnea]] if [[malignant]] secondaries are found in the [[lung]] | * [[Tachypnea]] if [[malignant]] secondaries are found in the [[lung]] | ||
* [[Dyspnea]] occurs in patients with complicated [[heart failure]] and [[cardiomyopathy]] | |||
===Chest=== | ===Chest=== | ||
* [[Gynecomastia]] | * [[Gynecomastia]] | ||
===Skin=== | ===Skin=== | ||
* The skin may be fragile and thin | * The [[skin]] may be fragile and thin <ref name="pmid261569702">{{cite journal| author=Nieman LK| title=Cushing's syndrome: update on signs, symptoms and biochemical screening. | journal=Eur J Endocrinol | year= 2015 | volume= 173 | issue= 4 | pages= M33-8 | pmid=26156970 | doi=10.1530/EJE-15-0464 | pmc=4553096 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26156970 }}</ref> | ||
* [[Jaundice]] secondary to deranged [[liver]] function in case of [[metastasis]] to the [[liver]] | * [[Jaundice]] secondary to deranged [[liver]] function in case of [[metastasis]] to the [[liver]] | ||
* [[Hyperpigmentation]] - this is due to [[melanocyte-stimulating hormone]] production as a byproduct of [[Adrenocorticotropic hormone|ACTH]] synthesis from [[Proopiomelanocortin|Proopiomelanocortin (POMC)]] | * [[Hyperpigmentation]] - this is due to [[melanocyte-stimulating hormone]] production as a byproduct of [[Adrenocorticotropic hormone|ACTH]] synthesis from [[Proopiomelanocortin|Proopiomelanocortin (POMC)]] | ||
* [[Telangiectasia]] (dilation of [[capillaries]]) | * [[Telangiectasia]] (dilation of [[capillaries]]) | ||
* Thinning of the [[skin]] (which causes [[easy bruising]]) | * Thinning of the [[skin]] (which causes [[easy bruising]]) | ||
* Purple or red [[striae]] (the weight gain in [[Cushing's syndrome|Cushing's]] stretches the skin, which is thin and weakened, causing it to [[hemorrhage]]) on the trunk, buttocks, arms, legs or breasts, and proximal [[muscle weakness]] | * Purple or red [[striae]] (the weight gain in [[Cushing's syndrome|Cushing's]] stretches the skin, which is thin and weakened, causing it to [[hemorrhage|bleed]]) on the [[trunk]], [[buttocks]], arms, legs or [[breasts]], and [[proximal]] [[muscle weakness]] | ||
* [[Hirsutism]] | * [[Hirsutism]] | ||
* [[Dehydration]] caused by [[gastrointestinal]] secretion of fluid and [[Electrolyte|electrolytes]] | |||
===Head=== | ===Head=== | ||
* [[Alopecia|Facial flushing]]<ref name="pmid23285767">{{cite journal| author=Simonenko VB, Makanin MA, Dulin PA, Vasilchenko MI, Lesovik VS| title=[About the signs of malignant pheochromocytoma]. | journal=Klin Med (Mosk) | year= 2012 | volume= 90 | issue= 10 | pages= 64-8 | pmid=23285767 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23285767 }}</ref> | * [[Alopecia|Facial flushing]] <ref name="pmid23285767">{{cite journal| author=Simonenko VB, Makanin MA, Dulin PA, Vasilchenko MI, Lesovik VS| title=[About the signs of malignant pheochromocytoma]. | journal=Klin Med (Mosk) | year= 2012 | volume= 90 | issue= 10 | pages= 64-8 | pmid=23285767 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23285767 }}</ref> | ||
* [[Icterus|Scleral icterus]] in case of [[metastasis]] to the [[liver]] | * [[Icterus|Scleral icterus]] in case of [[metastasis]] to the [[liver]] | ||
* [[Moon face|Moon-face]] | * [[Moon face|Moon-face]] is often associated with [[Cushing's syndrome]], also known as [[Cushingoid appearance|Cushingoid facies]] <ref name="pmid261569702" /> | ||
* [[Alopecia]] | * [[Alopecia]] | ||
===Abdomen=== | ===Abdomen=== | ||
* A palpable [[abdominal mass]] in the lower [[abdominal]] quadrant<ref name="pmid23285767" /> | * A palpable [[abdominal mass]] in the lower [[abdominal]] quadrant <ref name="pmid23285767" /> | ||
* [[Abdominal guarding|Guarding]] may be present | * [[Abdominal guarding|Guarding]] may be present | ||
* [[Hepatomegaly]] if [[malignant]] secondaries found in [[liver]] | * [[Hepatomegaly]] if [[malignant]] secondaries found in [[liver]] | ||
* | * [[flushing]] in [[medullary thyroid cancer]] patients | ||
===Extremities=== | ===Extremities=== | ||
* [[Clubbing]] | * [[Clubbing]] | ||
* [[Cyanosis]] | * [[Cyanosis]] | ||
* Pitting/non-pitting [[edema]] of the upper/lower extremities<ref name="pmid12074769">{{cite journal| author=Brunaud L, Duh QY| title=Aldosteronoma. | journal=Curr Treat Options Oncol | year= 2002 | volume= 3 | issue= 4 | pages= 327-33 | pmid=12074769 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12074769 }}</ref> | * [[Pitting edema|Pitting]]/non-pitting [[edema]] of the upper/lower [[extremities]] <ref name="pmid12074769">{{cite journal| author=Brunaud L, Duh QY| title=Aldosteronoma. | journal=Curr Treat Options Oncol | year= 2002 | volume= 3 | issue= 4 | pages= 327-33 | pmid=12074769 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12074769 }}</ref> | ||
* [[Muscle atrophy]] | * [[Muscle atrophy]] | ||
* [[Fasciculations]] in the upper/lower extremity | * [[Fasciculations]] in the upper/lower extremity | ||
Latest revision as of 19:00, 30 October 2017
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Adrenocortical carcinoma Microchapters |
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Differentiating Adrenocortical carcinoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Study |
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Adrenocortical carcinoma physical examination On the Web |
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American Roentgen Ray Society Images of Adrenocortical carcinoma physical examination |
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Risk calculators and risk factors for Adrenocortical carcinoma physical examination |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]
Overview
Common physical examination findings of adrenocortical carcinoma include findings of Cushing's syndrome such as hypertension, weakness, gynecomastia, and acne. Hyperandrogenic cases may show findings such as clitoromegaly and hirsutism.
Physical Examination
Appearance of the patient
- Moon-like face[1]
- Buffalo hump
- Patients may appear flushed due to the associated increase in erythropoietin secretion.[2]
- Patients may appear obese due to associated type 2 diabetes mellitus and Cushing's syndrome.[3]
Vitals
- Hypotension occurs due to fluid contraction
- Hypertension due to cortisol's enhancement of epinephrine's vasoconstrictive effect
- Tachypnea if malignant secondaries are found in the lung
- Dyspnea occurs in patients with complicated heart failure and cardiomyopathy
Chest
Skin
- The skin may be fragile and thin [4]
- Jaundice secondary to deranged liver function in case of metastasis to the liver
- Hyperpigmentation - this is due to melanocyte-stimulating hormone production as a byproduct of ACTH synthesis from Proopiomelanocortin (POMC)
- Telangiectasia (dilation of capillaries)
- Thinning of the skin (which causes easy bruising)
- Purple or red striae (the weight gain in Cushing's stretches the skin, which is thin and weakened, causing it to bleed) on the trunk, buttocks, arms, legs or breasts, and proximal muscle weakness
- Hirsutism
- Dehydration caused by gastrointestinal secretion of fluid and electrolytes
Head
- Facial flushing [5]
- Scleral icterus in case of metastasis to the liver
- Moon-face is often associated with Cushing's syndrome, also known as Cushingoid facies [4]
- Alopecia
Abdomen
- A palpable abdominal mass in the lower abdominal quadrant [5]
- Guarding may be present
- Hepatomegaly if malignant secondaries found in liver
- flushing in medullary thyroid cancer patients
Extremities
- Clubbing
- Cyanosis
- Pitting/non-pitting edema of the upper/lower extremities [6]
- Muscle atrophy
- Fasciculations in the upper/lower extremity
Neurologic
Genitals
References
- ↑ Nieman LK (2015). "Cushing's syndrome: update on signs, symptoms and biochemical screening". Eur J Endocrinol. 173 (4): M33–8. doi:10.1530/EJE-15-0464. PMC 4553096. PMID 26156970.
- ↑ La Batide-Alanore A, Chatellier G, Plouin PF (2003). "Diabetes as a marker of pheochromocytoma in hypertensive patients". J Hypertens. 21 (9): 1703–7. doi:10.1097/01.hjh.0000084729.53355.ce. PMID 12923403.
- ↑ Drénou B, Le Tulzo Y, Caulet-Maugendre S, Le Guerrier A, Leclercq C, Guilhem I; et al. (1995). "Pheochromocytoma and secondary erythrocytosis: role of tumour erythropoietin secretion". Nouv Rev Fr Hematol. 37 (3): 197–9. PMID 7567437.
- ↑ 4.0 4.1 Nieman LK (2015). "Cushing's syndrome: update on signs, symptoms and biochemical screening". Eur J Endocrinol. 173 (4): M33–8. doi:10.1530/EJE-15-0464. PMC 4553096. PMID 26156970.
- ↑ 5.0 5.1 Simonenko VB, Makanin MA, Dulin PA, Vasilchenko MI, Lesovik VS (2012). "[About the signs of malignant pheochromocytoma]". Klin Med (Mosk). 90 (10): 64–8. PMID 23285767.
- ↑ Brunaud L, Duh QY (2002). "Aldosteronoma". Curr Treat Options Oncol. 3 (4): 327–33. PMID 12074769.