Glucagonoma history and symptoms: Difference between revisions
Jump to navigation
Jump to search
(/* Common symptoms of glucagonoma include:{{cite journal| author=Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV| title=The glucagonoma syndrome. Clinical and pathologic features in 21 patients. | journal=Medicine (Baltimore) | year= 1996 | volu...) |
Ahmed Younes (talk | contribs) |
||
| (9 intermediate revisions by 4 users not shown) | |||
| Line 8: | Line 8: | ||
==History== | ==History== | ||
* When evaluating a patient for glucagonoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough review of past medical history. | * When evaluating a patient for glucagonoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough review of past medical history. | ||
* Other specific areas of focus when obtaining the history include the family history of predisposing genetic disorders such as [[multiple endocrine neoplasia type 1|multiple endocrine neoplasia type 1.]] | * Other specific areas of focus when obtaining the history include the family history of predisposing [[genetic disorders]] such as [[multiple endocrine neoplasia type 1|multiple endocrine neoplasia type 1.]] | ||
==Symptoms== | ==Symptoms== | ||
| Line 14: | Line 14: | ||
===Common symptoms of glucagonoma=== | ===Common symptoms of glucagonoma=== | ||
Common symptoms of glucagonoma include:<ref name="pmid8606627">{{cite journal| author=Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV| title=The glucagonoma syndrome. Clinical and pathologic features in 21 patients. | journal=Medicine (Baltimore) | year= 1996 | volume= 75 | issue= 2 | pages= 53-63 | pmid=8606627 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8606627 }} </ref><ref name="pmid4793623">{{cite journal| author=Wilkinson DS| title=Necrolytic migratory erythema with carcinoma of the pancreas. | journal=Trans St Johns Hosp Dermatol Soc | year= 1973 | volume= 59 | issue= 2 | pages= 244-50 | pmid=4793623 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4793623 }}</ref><ref name="pmid86066272">{{cite journal| author=Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV| title=The glucagonoma syndrome. Clinical and pathologic features in 21 patients. | journal=Medicine (Baltimore) | year= 1996 | volume= 75 | issue= 2 | pages= 53-63 | pmid=8606627 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8606627 }}</ref><ref name="pmid6268399">{{cite journal| author=Stacpoole PW| title=The glucagonoma syndrome: clinical features, diagnosis, and treatment. | journal=Endocr Rev | year= 1981 | volume= 2 | issue= 3 | pages= 347-61 | pmid=6268399 | doi=10.1210/edrv-2-3-347 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6268399 }}</ref> | Common symptoms of glucagonoma include:<ref name="pmid8606627">{{cite journal| author=Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV| title=The glucagonoma syndrome. Clinical and pathologic features in 21 patients. | journal=Medicine (Baltimore) | year= 1996 | volume= 75 | issue= 2 | pages= 53-63 | pmid=8606627 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8606627 }} </ref><ref name="pmid4793623">{{cite journal| author=Wilkinson DS| title=Necrolytic migratory erythema with carcinoma of the pancreas. | journal=Trans St Johns Hosp Dermatol Soc | year= 1973 | volume= 59 | issue= 2 | pages= 244-50 | pmid=4793623 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4793623 }}</ref><ref name="pmid86066272">{{cite journal| author=Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV| title=The glucagonoma syndrome. Clinical and pathologic features in 21 patients. | journal=Medicine (Baltimore) | year= 1996 | volume= 75 | issue= 2 | pages= 53-63 | pmid=8606627 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8606627 }}</ref><ref name="pmid6268399">{{cite journal| author=Stacpoole PW| title=The glucagonoma syndrome: clinical features, diagnosis, and treatment. | journal=Endocr Rev | year= 1981 | volume= 2 | issue= 3 | pages= 347-61 | pmid=6268399 | doi=10.1210/edrv-2-3-347 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6268399 }}</ref> | ||
*[[Necrolytic migratory erythema]] (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower [[abdomen]], [[buttock]]s, [[perineum]], and [[groin]]. | *[[Necrolytic migratory erythema]] (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of [[Erythematous rash|erythematous blisters]] and swelling across areas subject to greater friction and pressure, including the lower [[abdomen]], [[buttock]]s, [[perineum]], and [[groin]]. | ||
*[[Weight loss]] | *[[Weight loss]] | ||
*[[Glucose intolerance|Glucose intolerance]] | *[[Glucose intolerance|Glucose intolerance]] | ||
=== Less common symptoms include: === | === Less common symptoms include: === | ||
Less common symptoms of glucagonoma include:<ref name="pmid62683992">{{cite journal| author=Stacpoole PW| title=The glucagonoma syndrome: clinical features, diagnosis, and treatment. | journal=Endocr Rev | year= 1981 | volume= 2 | issue= 3 | pages= 347-61 | pmid=6268399 | doi=10.1210/edrv-2-3-347 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6268399 }}</ref><ref name="pmid15201270">{{cite journal| author=Chang-Chretien K, Chew JT, Judge DP| title=Reversible dilated cardiomyopathy associated with glucagonoma. | journal=Heart | year= 2004 | volume= 90 | issue= 7 | pages= e44 | pmid=15201270 | doi=10.1136/hrt.2004.036905 | pmc=1768315 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15201270 }}</ref><ref name="pmid22350605">{{cite journal| author=Cheema A, Weber J, Strosberg JR| title=Incidental detection of pancreatic neuroendocrine tumors: an analysis of incidence and outcomes. | journal=Ann Surg Oncol | year= 2012 | volume= 19 | issue= 9 | pages= 2932-6 | pmid=22350605 | doi=10.1245/s10434-012-2285-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22350605 }}</ref> | |||
*[[Cheilosis]] | *[[Cheilosis]] | ||
*[[Hemorrhage retroperitoneal| | *[[Hemorrhage retroperitoneal|Intraabdominal hemorrhage]] | ||
*[[Venous thrombosis]] | *[[Venous thrombosis]] | ||
*[[Stomatitis]] | *[[Stomatitis]] | ||
*[[Diarrhea]] | *[[Diarrhea]] | ||
| Line 28: | Line 29: | ||
*[[Polyphagia]] | *[[Polyphagia]] | ||
*[[Blurred vision]] | *[[Blurred vision]] | ||
*Neuropsychiatric manifestations include [[depression]], [[dementia]], [[psychosis]], and [[agitation]] | *[[Neuropsychiatric|Neuropsychiatric manifestations]] include [[depression]], [[dementia]], [[psychosis]], and [[agitation]] | ||
*[[Dilated cardiomyopathy]] | *[[Dilated cardiomyopathy]] | ||
* Some patients do not present with hormonal symptoms but present with metastatic symptoms in other organs and mainly the liver. | * Some patients do not present with [[Hormonal|hormonal symptoms]] but present with [[Metastasis|metastatic symptoms]] in other [[organs]] and mainly the [[liver]]. | ||
**These symptoms include [[jaundice]], [[edema]], and [[abdominal pain]]. | **These symptoms include [[jaundice]], [[edema]], and [[abdominal pain]]. | ||
**There is usually high level of substances such as chromogranins, enolase, pancreatic polypeptide, and ghrelin in patients with | **There is usually high level of substances such as [[Chromogranin|chromogranins]], [[enolase]], [[pancreatic polypeptide]], and [[ghrelin]] in patients with [[Metastasis|metastases]]. | ||
* Some tumors can develop additional syndromes subsequently due to secretion of more than one hormone. | * Some [[tumors]] can develop additional syndromes subsequently due to secretion of more than one [[hormone]]. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
[[Category:Medicine]] | |||
[[Category:Endocrinology]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 22:31, 30 May 2019
|
Glucagonoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Glucagonoma history and symptoms On the Web |
|
American Roentgen Ray Society Images of Glucagonoma history and symptoms |
|
Risk calculators and risk factors for Glucagonoma history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2], Mohammed Abdelwahed M.D[3]
Overview
Symptoms of glucagonoma include necrolytic migratory erythema, weight loss, glucose intolerance, cheilosis, stomatitis, diarrhea, polyuria, and polydipsia. A positive family history of multiple endocrine neoplasia type 1 may be present.
History
- When evaluating a patient for glucagonoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough review of past medical history.
- Other specific areas of focus when obtaining the history include the family history of predisposing genetic disorders such as multiple endocrine neoplasia type 1.
Symptoms
Common symptoms of glucagonoma
Common symptoms of glucagonoma include:[1][2][3][4]
- Necrolytic migratory erythema (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower abdomen, buttocks, perineum, and groin.
- Weight loss
- Glucose intolerance
Less common symptoms include:
Less common symptoms of glucagonoma include:[5][6][7]
- Cheilosis
- Intraabdominal hemorrhage
- Venous thrombosis
- Stomatitis
- Diarrhea
- Polyuria
- Polydipsia
- Polyphagia
- Blurred vision
- Neuropsychiatric manifestations include depression, dementia, psychosis, and agitation
- Dilated cardiomyopathy
- Some patients do not present with hormonal symptoms but present with metastatic symptoms in other organs and mainly the liver.
- These symptoms include jaundice, edema, and abdominal pain.
- There is usually high level of substances such as chromogranins, enolase, pancreatic polypeptide, and ghrelin in patients with metastases.
- Some tumors can develop additional syndromes subsequently due to secretion of more than one hormone.
References
- ↑ Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV (1996). "The glucagonoma syndrome. Clinical and pathologic features in 21 patients". Medicine (Baltimore). 75 (2): 53–63. PMID 8606627.
- ↑ Wilkinson DS (1973). "Necrolytic migratory erythema with carcinoma of the pancreas". Trans St Johns Hosp Dermatol Soc. 59 (2): 244–50. PMID 4793623.
- ↑ Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV (1996). "The glucagonoma syndrome. Clinical and pathologic features in 21 patients". Medicine (Baltimore). 75 (2): 53–63. PMID 8606627.
- ↑ Stacpoole PW (1981). "The glucagonoma syndrome: clinical features, diagnosis, and treatment". Endocr Rev. 2 (3): 347–61. doi:10.1210/edrv-2-3-347. PMID 6268399.
- ↑ Stacpoole PW (1981). "The glucagonoma syndrome: clinical features, diagnosis, and treatment". Endocr Rev. 2 (3): 347–61. doi:10.1210/edrv-2-3-347. PMID 6268399.
- ↑ Chang-Chretien K, Chew JT, Judge DP (2004). "Reversible dilated cardiomyopathy associated with glucagonoma". Heart. 90 (7): e44. doi:10.1136/hrt.2004.036905. PMC 1768315. PMID 15201270.
- ↑ Cheema A, Weber J, Strosberg JR (2012). "Incidental detection of pancreatic neuroendocrine tumors: an analysis of incidence and outcomes". Ann Surg Oncol. 19 (9): 2932–6. doi:10.1245/s10434-012-2285-7. PMID 22350605.