Marburg hemorrhagic fever historical perspective: Difference between revisions
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==Overview== | ==Overview== | ||
Marburg hemorrhagic fever was first detected in 1967 in Marburg after which there has been reports of several sporadic outbreaks all over the world. | Marburg hemorrhagic fever was first detected in 1967 in Marburg after which there has been reports of several sporadic outbreaks all over the world. Subsequently, outbreaks and sporadic cases were reported in Angola, Democratic Republic of the Congo, Kenya, South Africa, and Uganda | ||
==Historical Perspective== | ==Historical Perspective== | ||
* Marburg hemorrhagic fever was initially detected in 1967 after simultaneous outbreaks in Marburg, from which the disease takes its name, Frankfurt, and Belgrade. | * Marburg hemorrhagic fever was initially detected in 1967 after simultaneous outbreaks in Marburg, from which the disease takes its name, Frankfurt, and Belgrade. | ||
* Subsequently, outbreaks and sporadic cases were reported in Angola, Democratic Republic of the Congo, Kenya, South Africa, and Uganda. | * Subsequently, outbreaks and sporadic cases were reported in Angola, Democratic Republic of the Congo, Kenya, South Africa, and Uganda. | ||
{| style="border: 0px; font-size: 90%; margin: 3px;" align="center" | |||
|+'''''Chronology of Marburg Hemorrhagic Fever Outbreaks''''' ({{cite web |url=http://www.cdc.gov/vhf/marburg/resources/outbreak-table.html |title= Marburg Hemorrhagic Fever |website= Center for Disease Control and Prevention|publisher= Center for Disease Control and Prevention (CDC)}}) | |||
! style="background: #4479BA; width: 120px;" | {{fontcolor|#FFF|Years}} | |||
! style="background: #4479BA; width: 550px;" | {{fontcolor|#FFF|Country}} | |||
! style="background: #4479BA; width: 550px;" | {{fontcolor|#FFF|Apparent or suspected origin}} | |||
! style="background: #4479BA; width: 120px;" | {{fontcolor|#FFF|Reported number of human cases}} | |||
! style="background: #4479BA; width: 120px;" | {{fontcolor|#FFF|Reported number (%) of deaths among cases}} | |||
! style="background: #4479BA; width: 650px;" | {{fontcolor|#FFF|Situation}} | |||
|- | |||
! style="background: #DCDCDC;" |2014 | |||
! style="background: #F5F5F5;" |Uganda | |||
! style="background: #F5F5F5;" |Kampala | |||
! style="background: #F5F5F5;" |1 | |||
! style="background: #F5F5F5;" |1 (100%) | |||
! style="background: #F5F5F5;" |Ninety-nine individuals were [[Quarantine|quarantined]] after a 30-year-old male health-worker died of Marburg hemorrhagic fever on the 28th of September. | |||
|- | |||
! style="background: #DCDCDC;" |2012 | |||
! style="background: #F5F5F5;" |Uganda | |||
! style="background: #F5F5F5;" |Kabale | |||
! style="background: #F5F5F5;" |15 | |||
! style="background: #F5F5F5;" |4 (27%) | |||
! style="background: #F5F5F5;" |Testing at CDC/UVRI identified a [[Marburg virus]] disease outbreak in the districts of Kabale, Ibanda, Mbarara, and Kampala over a 3 week time period<ref name="pmid23001720">{{cite journal| author=Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR et al.| title=Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae. | journal=Arch Virol | year= 2013 | volume= 158 | issue= 1 | pages= 301-11 | pmid=23001720 | doi=10.1007/s00705-012-1454-0 | pmc=PMC3535543 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23001720 }} </ref> | |||
|- | |||
! style="background: #DCDCDC;" |2008 | |||
! style="background: #F5F5F5;" |Netherlands ex Uganda | |||
! style="background: #F5F5F5;" |Cave in Maramagambo forest in Uganda, at the southern edge of Queen Elizabeth National Park | |||
! style="background: #F5F5F5;" |1 | |||
! style="background: #F5F5F5;" |1 (100%) | |||
! style="background: #F5F5F5;" |A 40-year-old Dutch woman with a recent history of travel to Uganda was admitted to hospital in the Netherlands. Three days prior to hospitalization, the first symptoms ([[fever]], [[chills]]) occurred, followed by rapid clinical deterioration. The woman died on the 10th day of the illness. | |||
|- | |||
! style="background: #DCDCDC;" |2007 | |||
! style="background: #F5F5F5;" |Uganda | |||
! style="background: #F5F5F5;" |Lead and gold mine in Kamwenge District, Uganda | |||
! style="background: #F5F5F5;" |4 | |||
! style="background: #F5F5F5;" |1 (25%) | |||
! style="background: #F5F5F5;" |Small outbreak, with 4 cases in young males working in a mine. To date, there have been no additional cases identified<ref name="Marburg">{{cite web | title =Outbreak of Marburg Hemorrhagic Fever Among Miners in Kamwenge and Ibanda Districts, Uganda, 2007|http://jid.oxfordjournals.org/content/204/suppl_3/S796.full =}}</ref> | |||
|- | |||
! style="background: #DCDCDC;" |2004-2005 | |||
! style="background: #F5F5F5;" |Angola | |||
! style="background: #F5F5F5;" |Uige Province, Angola | |||
! style="background: #F5F5F5;" |252 | |||
! style="background: #F5F5F5;" |227 (90%) | |||
! style="background: #F5F5F5;" |Outbreak believed to have begun in Uige Province in October 2004. Most cases detected in other provinces have been linked directly to the outbreak in Uige<ref name="pmid16775337">{{cite journal| author=Towner JS, Khristova ML, Sealy TK, Vincent MJ, Erickson BR, Bawiec DA et al.| title=Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola. | journal=J Virol | year= 2006 | volume= 80 | issue= 13 | pages= 6497-516 | pmid=16775337 | doi=10.1128/JVI.00069-06 | pmc=PMC1488971 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16775337 }} </ref> | |||
|- | |||
! style="background: #DCDCDC;" |1998-2000 | |||
! style="background: #F5F5F5;" |Democratic Republic of Congo (DRC) | |||
! style="background: #F5F5F5;" |Durba, DRC | |||
! style="background: #F5F5F5;" |154 | |||
! style="background: #F5F5F5;" |128 (83%) | |||
! style="background: #F5F5F5;" |Most cases occurred in young male workers at a gold mine in Durba, in the north-eastern part of the country, which proved to be the epicenter of the outbreak. Cases were subsequently detected in the neighboring village of Watsa.<ref name="Marburg">{{cite web | title =Marburg Hemorrhagic Fever Associated with Multiple Genetic Lineages of Virus|http://www.nejm.org/doi/full/10.1056/NEJMoa051465 =}}</ref> | |||
|- | |||
! style="background: #DCDCDC;" |1990 | |||
! style="background: #F5F5F5;" |Russia | |||
! style="background: #F5F5F5;" |Russia | |||
! style="background: #F5F5F5;" |1 | |||
! style="background: #F5F5F5;" |1 (100%) | |||
! style="background: #F5F5F5;" |[[Laboratory]] [[contamination]].<ref name="Marburg">{{cite web | title =Marburg |http://core.kmi.open.ac.uk/download/pdf/9417733.pdf =}}</ref> | |||
|- | |||
! style="background: #DCDCDC;" |1987 | |||
! style="background: #F5F5F5;" |Kenya | |||
! style="background: #F5F5F5;" |Kenya | |||
! style="background: #F5F5F5;" |1 | |||
! style="background: #F5F5F5;" |1 (100%) | |||
! style="background: #F5F5F5;" |A 15-year-old Danish boy was hospitalized with a 3-day history of [[headache]], [[malaise]], [[fever]], and [[vomiting]]. Nine days prior to symptom onset, he had visited Kitum Cave in Mount Elgon National Park. Despite aggressive supportive therapy, the patient died on the 11th day of illness. No further cases were detected<ref name="pmid22046196">{{cite journal| author=Mehedi M, Groseth A, Feldmann H, Ebihara H| title=Clinical aspects of Marburg hemorrhagic fever. | journal=Future Virol | year= 2011 | volume= 6 | issue= 9 | pages= 1091-1106 | pmid=22046196 | doi=10.2217/fvl.11.79 | pmc=PMC3201746 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22046196 }} </ref> | |||
|- | |||
! style="background: #DCDCDC;" |1980 | |||
! style="background: #F5F5F5;" |Kenya | |||
! style="background: #F5F5F5;" |Kenya | |||
! style="background: #F5F5F5;" |2 | |||
! style="background: #F5F5F5;" |1 (50%) | |||
! style="background: #F5F5F5;" |A man with a recent travel history to Kitum Cave in Kenya's Mount Elgon National Park. Despite specialized care in Nairobi, the male patient died. A doctor who attempted resuscitation developed symptoms 9 days later but recovered<ref name="pmid6122054">{{cite journal| author=Smith DH, Johnson BK, Isaacson M, Swanapoel R, Johnson KM, Killey M et al.| title=Marburg-virus disease in Kenya. | journal=Lancet | year= 1982 | volume= 1 | issue= 8276 | pages= 816-20 | pmid=6122054| doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6122054 }} </ref> | |||
|- | |||
! style="background: #DCDCDC;" |1975 | |||
! style="background: #F5F5F5;" |Johannesburg, South Africa | |||
! style="background: #F5F5F5;" |Zimbabwe | |||
! style="background: #F5F5F5;" |3 | |||
! style="background: #F5F5F5;" |1 (33%) | |||
! style="background: #F5F5F5;" |A man with a recent travel history to Zimbabwe was admitted to hospital in South Africa. [[Infection]] spread from the man to his traveling companion and a nurse at the hospital. The man died, but both women were given vigorous supportive treatment and eventually recovered.<ref name="AO">{{cite web | title = WHO |http://whqlibdoc.who.int/wer/WHO_WER_1975/WER1975_50_121-128%20%28N%C2%B012%29.pdf url =}}</ref> | |||
|- | |||
! style="background: #DCDCDC;" |1967 | |||
! style="background: #F5F5F5;" |Germany and Yugoslavia | |||
! style="background: #F5F5F5;" |Uganda | |||
! style="background: #F5F5F5;" |31 | |||
! style="background: #F5F5F5;" |7 (23%) | |||
! style="background: #F5F5F5;" |Simultaneous outbreaks occurred in laboratory workers handling African green monkeys imported from Uganda. In addition to the 31 reported cases, an additional primary case was retrospectively diagnosed by serology. <ref name="pmid8800808">{{cite journal| author=Feldmann H, Slenczka W, Klenk HD| title=Emerging and reemerging of filoviruses. | journal=Arch Virol Suppl | year= 1996 | volume= 11 | issue= | pages= 77-100 | pmid=8800808 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8800808 }} </ref> | |||
|- | |||
|} | |||
<br> | <br> | ||
[[File:Distribution map of Marburg Hemorrhagic Fever.png |thumb|center|500px| <SMALL><SMALL> ''[(http://www.cdc.gov/vhf/marburg/<nowiki>)]</nowiki>''<ref name="CDC">{{Cite web | title = The Centers for Disease Control and Prevention | url =http://www.cdc.gov/vhf/marburg/ }}</ref></SMALL></SMALL>]] | |||
[[File:Distribution map of Marburg Hemorrhagic Fever.png |thumb|center|500px| <SMALL><SMALL> ''[(http://www.cdc.gov/vhf/marburg/)]''<ref name="CDC">{{Cite web | title = The Centers for Disease Control and Prevention | url =http://www.cdc.gov/vhf/marburg/ }}</ref></SMALL></SMALL>]] | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Latest revision as of 18:57, 20 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Marburg hemorrhagic fever was first detected in 1967 in Marburg after which there has been reports of several sporadic outbreaks all over the world. Subsequently, outbreaks and sporadic cases were reported in Angola, Democratic Republic of the Congo, Kenya, South Africa, and Uganda
Historical Perspective
- Marburg hemorrhagic fever was initially detected in 1967 after simultaneous outbreaks in Marburg, from which the disease takes its name, Frankfurt, and Belgrade.
- Subsequently, outbreaks and sporadic cases were reported in Angola, Democratic Republic of the Congo, Kenya, South Africa, and Uganda.
| Years | Country | Apparent or suspected origin | Reported number of human cases | Reported number (%) of deaths among cases | Situation |
|---|---|---|---|---|---|
| 2014 | Uganda | Kampala | 1 | 1 (100%) | Ninety-nine individuals were quarantined after a 30-year-old male health-worker died of Marburg hemorrhagic fever on the 28th of September. |
| 2012 | Uganda | Kabale | 15 | 4 (27%) | Testing at CDC/UVRI identified a Marburg virus disease outbreak in the districts of Kabale, Ibanda, Mbarara, and Kampala over a 3 week time period[1] |
| 2008 | Netherlands ex Uganda | Cave in Maramagambo forest in Uganda, at the southern edge of Queen Elizabeth National Park | 1 | 1 (100%) | A 40-year-old Dutch woman with a recent history of travel to Uganda was admitted to hospital in the Netherlands. Three days prior to hospitalization, the first symptoms (fever, chills) occurred, followed by rapid clinical deterioration. The woman died on the 10th day of the illness. |
| 2007 | Uganda | Lead and gold mine in Kamwenge District, Uganda | 4 | 1 (25%) | Small outbreak, with 4 cases in young males working in a mine. To date, there have been no additional cases identified[2] |
| 2004-2005 | Angola | Uige Province, Angola | 252 | 227 (90%) | Outbreak believed to have begun in Uige Province in October 2004. Most cases detected in other provinces have been linked directly to the outbreak in Uige[3] |
| 1998-2000 | Democratic Republic of Congo (DRC) | Durba, DRC | 154 | 128 (83%) | Most cases occurred in young male workers at a gold mine in Durba, in the north-eastern part of the country, which proved to be the epicenter of the outbreak. Cases were subsequently detected in the neighboring village of Watsa.[2] |
| 1990 | Russia | Russia | 1 | 1 (100%) | Laboratory contamination.[2] |
| 1987 | Kenya | Kenya | 1 | 1 (100%) | A 15-year-old Danish boy was hospitalized with a 3-day history of headache, malaise, fever, and vomiting. Nine days prior to symptom onset, he had visited Kitum Cave in Mount Elgon National Park. Despite aggressive supportive therapy, the patient died on the 11th day of illness. No further cases were detected[4] |
| 1980 | Kenya | Kenya | 2 | 1 (50%) | A man with a recent travel history to Kitum Cave in Kenya's Mount Elgon National Park. Despite specialized care in Nairobi, the male patient died. A doctor who attempted resuscitation developed symptoms 9 days later but recovered[5] |
| 1975 | Johannesburg, South Africa | Zimbabwe | 3 | 1 (33%) | A man with a recent travel history to Zimbabwe was admitted to hospital in South Africa. Infection spread from the man to his traveling companion and a nurse at the hospital. The man died, but both women were given vigorous supportive treatment and eventually recovered.[6] |
| 1967 | Germany and Yugoslavia | Uganda | 31 | 7 (23%) | Simultaneous outbreaks occurred in laboratory workers handling African green monkeys imported from Uganda. In addition to the 31 reported cases, an additional primary case was retrospectively diagnosed by serology. [7] |
References
- ↑ Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR; et al. (2013). "Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae". Arch Virol. 158 (1): 301–11. doi:10.1007/s00705-012-1454-0. PMC 3535543. PMID 23001720.
- ↑ 2.0 2.1 2.2 "Outbreak of Marburg Hemorrhagic Fever Among Miners in Kamwenge and Ibanda Districts, Uganda, 2007". Missing or empty
|url=(help) - ↑ Towner JS, Khristova ML, Sealy TK, Vincent MJ, Erickson BR, Bawiec DA; et al. (2006). "Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola". J Virol. 80 (13): 6497–516. doi:10.1128/JVI.00069-06. PMC 1488971. PMID 16775337.
- ↑ Mehedi M, Groseth A, Feldmann H, Ebihara H (2011). "Clinical aspects of Marburg hemorrhagic fever". Future Virol. 6 (9): 1091–1106. doi:10.2217/fvl.11.79. PMC 3201746. PMID 22046196.
- ↑ Smith DH, Johnson BK, Isaacson M, Swanapoel R, Johnson KM, Killey M; et al. (1982). "Marburg-virus disease in Kenya". Lancet. 1 (8276): 816–20. PMID 6122054.
- ↑ "WHO". Missing or empty
|url=(help) - ↑ Feldmann H, Slenczka W, Klenk HD (1996). "Emerging and reemerging of filoviruses". Arch Virol Suppl. 11: 77–100. PMID 8800808.
- ↑ "The Centers for Disease Control and Prevention".