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==Overview==
==Overview==
Hundred years ago, polish clinical researcher  professor W.Jaworski  was the first to describe spiral-shaped [[microorganism]]  at Cracow Jagiellonian University. Asklepios was the first to describe an association between [[GI bleeding]] and [[peptic ulcer disease]]. In 1982 Warren and B.J marshall cultured the organism and found a strong association between [[Helicobacter pylori]] and [[inflammation]] of [[gastric]] [[mucosa]] and were awarded the noble prize.


==Historical Perspective==
==Historical Perspective==
{{see also|Timeline of peptic ulcer disease and Helicobacter pylori}}
In 1997, the [[Centers for Disease Control and Prevention]], with other government agencies, academic institutions, and industry, launched a national education campaign to inform health care providers and consumers about the link between ''[[H. pylori]]'' and ulcers. This campaign reinforced the news that ulcers are a curable infection, and the fact that health can be greatly improved and money saved by disseminating information about ''H. pylori''.<ref>[http://www.cdc.gov/ulcer/history.htm Ulcer, Diagnosis and Treatment - CDC Bacterial, Mycotic Diseases]</ref>
''[[Helicobacter pylori]]'' was rediscovered in 1982 by two Australian scientists [[Robin Warren]] and [[Barry Marshall]]<ref>{{cite journal|author=Marshall BJ|title=Unidentified curved bacillus on gastric epithelium in active chronic gastritis|journal=[[The Lancet|Lancet]]|year=1983|volume=1|issue=8336|pages=1273–1275|id=PMID 6134060}}</ref>. In their original paper, Warren and Marshall contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by [[stress (medicine)|stress]] or [[spicy food]] as had been assumed before.<ref>{{cite journal|author=Marshall BJ, Warren JR|title=Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration|journal=Lancet|year=1984|volume=1|issue=8390|pages=1311–1315|id=PMID 6145023}}</ref>
The ''[[H. pylori]]'' hypothesis was poorly received, so in an act of self-experimentation Marshall drank a petri-dish containing a culture of organisms extracted from a patient and soon developed gastritis. His symptoms disappeared after two weeks, but he took antibiotics to kill the remaining bacteria at the urging of his wife, since [[halitosis]] is one of the symptoms of infection.<ref name="mja">{{cite web | url= http://www.mja.com.au/public/issues/183_11_051205/van11000_fm.html#0_i1091639| title=Research Enterprise, The 2005 Nobel Prize in Physiology or Medicine |accessdate=2007-08-26}}</ref> This experiment was published in 1984 in the Australian Medical Journal and is among the most cited articles from the journal.
In 2005, the Karolinska Institute in Stockholm awarded the [[Nobel Prize in Physiology or Medicine]] to Dr. Marshall and his long-time collaborator Dr. [[Robin Warren|Warren]] "for their discovery of the bacterium ''Helicobacter pylori'' and its role in [[gastritis]] and peptic ulcer disease". Professor Marshall continues research related to ''H. pylori'' and runs a molecular biology lab at UWA in Perth, Western Australia.
*Gastric ulcer was first discovered by Goldstein, a [nationality + occupation], in [year]/during/following [event].
*Spiral-shaped microorganism described by Polish clinical researcher  Professor W.Jaworski at Cracow Jagiellonian University 100 years ago but it was confirmed in the animal by G.Bizzazero.In late 1970, J.R Warren, a pathologist in Perth, Australia found the appearance of spiral bacteria overlying gastric mucosa.
In 1982 Warren and B.J marshall cultured the organism and demonstrate a strong association between Helicobacter pylori and inflammation of gastric mucosa ,it is not due to spicy food and stress <ref name="pmid15075463">{{cite journal |vauthors=Konturek JW |title=Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer |journal=J. Physiol. Pharmacol. |volume=54 Suppl 3 |issue= |pages=23–41 |year=2003 |pmid=15075463 |doi= |url=}}</ref><ref name="urlHome | CDC Ulcer">{{cite web |url=https://www.cdc.gov/ulcer/index.htm |title=Home &#124; CDC Ulcer |format= |work= |accessdate=}}</ref>
1994
A National Institutes of Health Consensus Development Conference concludes that there is a strong association between H. pylori and ulcer disease, and recommends that ulcer patients with H. pylori infection be treated with antibiotics.
==Overview==
==Historical Perspective==
===Discovery===
===Discovery===
*Peptic ulcer disease was first discovered by Goldstein , a [nationality + occupation], in [year]/during/following [event].
*Hundred years ago, polish clinical researcher professor W.Jaworski was the first to describe the spiral-shaped [[Microorganisms|microorganism]]  at Cracow Jagiellonian University
 
*In pre-16th century:
*The association between Helicobacter pylori and peptic ulcer disease was made in 1982  by Warren and B.J marshall.Warren and Marshall contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by [[stress (medicine)|stress]] or [[spicy food]] as had been assumed before.<ref>{{cite journal|author=Marshall BJ, Warren JR|title=Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration|journal=Lancet|year=1984|volume=1|issue=8390|pages=1311–1315|id=PMID 6145023}}</ref>  
**Hippocrates  gave a detailed describtion of symptoms of [[peptic ulcer]]
<ref name="pmid15075463">{{cite journal |vauthors=Konturek JW |title=Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer |journal=J. Physiol. Pharmacol. |volume=54 Suppl 3 |issue= |pages=23–41 |year=2003 |pmid=15075463 |doi= |url=}}</ref><ref name="urlHome | CDC Ulcer">{{cite web |url=https://www.cdc.gov/ulcer/index.htm |title=Home &#124; CDC Ulcer |format= |work= |accessdate=}}</ref>  
**Avicenna described the relationship between [[abdominal pain]] and mealtimes in [[peptic ulcer]] patient<ref name="pmid9468093">{{cite journal |vauthors=Kidd M, Modlin IM |title=A century of Helicobacter pylori: paradigms lost-paradigms regained |journal=Digestion |volume=59 |issue=1 |pages=1–15 |year=1998 |pmid=9468093 |doi= |url=}}</ref>
*In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
*In 1586, Marcellus Donatus of Mantua described gastric [[ulcers]] by performing autopsies
*In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
*In 1688, Johannes von Murault gave detailed description of duodenal [[ulcers]]
*Spiral-shaped microorganism described by Polish clinical researcher  Professor W.Jaworski at Cracow Jagiellonian University 100 years ago but it was confirmed in the animal by G.Bizzazero.In late 1970, J.R Warren, a pathologist in Perth, Australia found the appearance of spiral bacteria overlying gastric mucosa.
*In 1812, Broussais found that if acute [[gastritis]] is untreated, it can lead to chronic [[gastritis]]
In 1982 Warren and B.J marshall cultured the organism and demonstrate a strong association between Helicobacter pylori and inflammation of gastric mucosa ,it is not due to spicy food and stress <ref name="pmid15075463">{{cite journal |vauthors=Konturek JW |title=Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer |journal=J. Physiol. Pharmacol. |volume=54 Suppl 3 |issue= |pages=23–41 |year=2003 |pmid=15075463 |doi= |url=}}</ref><ref name="urlHome | CDC Ulcer">{{cite web |url=https://www.cdc.gov/ulcer/index.htm |title=Home &#124; CDC Ulcer |format= |work= |accessdate=}}</ref>
*In 1821, Nepveu found a relationship between [[gastritis]] and [[gastric cancer]]
1994
*In 1857, William Brintonin described  [[ulcer]] of the [[stomach]]  and gastric cancer in his book 
A National Institutes of Health Consensus Development Conference concludes that there is a strong association between H. pylori and ulcer disease, and recommends that ulcer patients with H. pylori infection be treated with antibiotics.
*In 1875, G.Bottcher and M. Letulle hypothesize that [[ulcers]] are caused by [[bacteria]]
*In 1880, J.Cohnheim found that [[ulcers]] may be caused by chemical factors
*In 1889, Walery Jaworski found spiral organisms in sediment washings of humans and proposed that these [[organisms]] may be involved with [[gastric]] disease
*In 1910, Moynihan wrote a book on [[duodenal ulcer]]<ref>{{cite book | last = Barry | first = J | title = Helicobacter pioneers : firsthand accounts from the scientists who discovered helicobacters, 1892-1982 | publisher = Blackwell | location = Victoria, Australia Malden, MA, USA | year = 2002 | isbn = 0867930357 }}</ref>
*In 1971, Howard Steer found [[H. pylori]] from biopsies of a patient with [[ulcers]]<ref>{{cite book | last = Barry | first = J | title = Helicobacter pioneers : firsthand accounts from the scientists who discovered helicobacters, 1892-1982 | publisher = Blackwell | location = Victoria, Australia Malden, MA, USA | year = 2002 | isbn = 0867930357 }}</ref><ref name="pmid15075463">{{cite journal |vauthors=Konturek JW |title=Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer |journal=J. Physiol. Pharmacol. |volume=54 Suppl 3 |issue= |pages=23–41 |year=2003 |pmid=15075463 |doi= |url=}}</ref>
*In late 1970, J.R Warren, a pathologist in Perth, Australia found the appearance of spiral [[bacteria]] overlying [[gastric]] mucosa<ref name="pmid15075463">{{cite journal |vauthors=Konturek JW |title=Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer |journal=J. Physiol. Pharmacol. |volume=54 Suppl 3 |issue= |pages=23–41 |year=2003 |pmid=15075463 |doi= |url=}}</ref
<nowiki>*</nowiki>In 1924, Luck and Seth discovered urease  occur naturally in the human stomach
<nowiki>*</nowiki>The association between Helicobacter pylori and peptic ulcer disease was made in 1982  by Warren and B.J marshall.They contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by <nowiki>[[stress (medicine)|stress]]</nowiki> or <nowiki>[[spicy food]]</nowiki> as had been assumed before.<nowiki><ref></nowiki>{{cite journal|author=Marshall BJ, Warren JR|title=Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration|journal=Lancet|year=1984|volume=1|issue=8390|pages=1311–1315|id=PMID 6145023}}</ref><ref name="urlHome | CDC Ulcer">{{cite web |url=https://www.cdc.gov/ulcer/index.htm |title=Home &#124; CDC Ulcer |format= |work= |accessdate=}}</ref>
*In 1982 , Warren and B.J marshall cultured the [[organism]] and found a strong association between [[Helicobacter pylori]] and [[inflammation]] of gastric mucosa<ref name="pmid15075463">{{cite journal |vauthors=Konturek JW |title=Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer |journal=J. Physiol. Pharmacol. |volume=54 Suppl 3 |issue= |pages=23–41 |year=2003 |pmid=15075463 |doi= |url=}}</ref><ref name="urlHome | CDC Ulcer">{{cite web |url=https://www.cdc.gov/ulcer/index.htm |title=Home &#124; CDC Ulcer |format= |work= |accessdate=}}</ref>
*In an act of self-experimentation Marshall drank a petri-dish containing a culture of organisms extracted from a patient and soon developed gastritis. His symptoms disappeared after two weeks, but he took [[antibiotics]] to kill the remaining [[bacteria]] at the urging of his wife.This experiment was published in 1984 in the Australian Medical Journal<ref name="mja"><nowiki>{{cite web url=</nowiki>http://www.mja.com.au/public/issues/183_11_051205/van11000_fm.html#0_i1091639<nowiki>| title=Research Enterprise, The 2005 Nobel Prize in Physiology or Medicine |accessdate=2007-08-26}}</nowiki></ref>
*In 1994, Parsonnet et al found an association between H. pylori and [[lymphomas]] of the gastrointestinal tract<ref name="pmid8145781">{{cite journal |vauthors=Parsonnet J, Hansen S, Rodriguez L, Gelb AB, Warnke RA, Jellum E, Orentreich N, Vogelman JH, Friedman GD |title=Helicobacter pylori infection and gastric lymphoma |journal=N. Engl. J. Med. |volume=330 |issue=18 |pages=1267–71 |year=1994 |pmid=8145781 |doi=10.1056/NEJM199405053301803 |url=}}</ref>
*In 1997 Tomb et al. completed sequencing of the entire 1,667,867 base pairs of the H. pylori [[genome]]. This helped in identifying new virulence factors for the infectivity of [[H. pylori]] at the molecular level<ref name="pmid9252185">{{cite journal |vauthors=Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC |title=The complete genome sequence of the gastric pathogen Helicobacter pylori |journal=Nature |volume=388 |issue=6642 |pages=539–47 |year=1997 |pmid=9252185 |doi=10.1038/41483 |url=}}</ref>
*In 2001, Chan et al. showed that eradication of [[H. pylori]]  prevents bleeding from ulcers that is caused by [[aspirin]] and [[Non-steroidal anti-inflammatory drug|non-steroidal anti-inflammatory drugs]]<ref name="pmid11274623">{{cite journal |vauthors=Chan FK, Chung SC, Suen BY, Lee YT, Leung WK, Leung VK, Wu JC, Lau JY, Hui Y, Lai MS, Chan HL, Sung JJ |title=Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen |journal=N. Engl. J. Med. |volume=344 |issue=13 |pages=967–73 |year=2001 |pmid=11274623 |doi=10.1056/NEJM200103293441304 |url=}}</ref>
*In 2002, European Helicobacter Pylori Study Group published the Maastricht 2-2000 Consensus Report, found a "test-and-treat" strategy for [[H. pylori]] in young patients without atypical symptoms. It suggests the use of noninvasive testing to evaluate for [[H. pylori]] <ref name="pmid11860399">{{cite journal |vauthors=Malfertheiner P, Mégraud F, O'Morain C, Hungin AP, Jones R, Axon A, Graham DY, Tytgat G |title=Current concepts in the management of Helicobacter pylori infection-the Maastricht 2-2000 Consensus Report |journal=Aliment. Pharmacol. Ther. |volume=16 |issue=2 |pages=167–80 |year=2002 |pmid=11860399 |doi= |url=}}</ref>
*In 2005 Warren and Marshall awarded the Nobel Prize in Physiology or Medicine by  Karolinska Institute in Stockholm for their discovery of the bacterium ''[[Helicobacter pylori]]'' and its role in [[gastritis]] and [[peptic ulcer disease]]<ref name="urlThe Nobel Prize in Physiology or Medicine 2005">{{cite web |url=https://www.nobelprize.org/nobel_prizes/medicine/laureates/2005/index.html |title=The Nobel Prize in Physiology or Medicine 2005 |format= |work= |accessdate=}}</ref>


==Outbreaks==
*In 1992,Covacci discovered CagA [[gene]], which encodes for a cytotoxin-associated surface protein, related  with strains of [[H. pylori]] that caused duodenal [[ulcers]] and was discovered by molecular techniques were first involved in the pathogenesis of [[peptic ulcer disease]] <ref name="pmid8516329">{{cite journal |vauthors=Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, Massone A, Papini E, Xiang Z, Figura N |title=Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue=12 |pages=5791–5 |year=1993 |pmid=8516329 |pmc=46808 |doi= |url=}}</ref>
*There have been several outbreaks of [disease name], which are summarized below:


==Landmark Events in the Development of Treatment Strategies==
==Landmark Events in the Development of Treatment Strategies==
*In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].
*In 1868, Kussmaul discovered that an [[antibacterial]] agent containing [[bismuth]] used to treat [[Peptic ulcer|peptic ulcers]]
 
*In 1915, [[Antacids]] are first suggested for the treatment of [[Peptic ulcer disease]]<ref name="pmid9604426">{{cite journal |vauthors=Buckley MJ, O'Morain CA |title=Helicobacter biology--discovery |journal=Br. Med. Bull. |volume=54 |issue=1 |pages=7–16 |year=1998 |pmid=9604426 |doi= |url=}}</ref>
==Impact on Cultural History==
*In 1951, J. Allende wrote a book explaining the treatment of gastric [[ulcers]] with penicillin<ref>{{cite book | last = Barry | first = J | title = Helicobacter pioneers : firsthand accounts from the scientists who discovered helicobacters, 1892-1982 | publisher = Blackwell | location = Victoria, Australia Malden, MA, USA | year = 2002 | isbn = 0867930357 }}</ref>
 
*1953, Dintzis and Hastings suggested a relationship between [[urease]] and a bacterial infection,by stopping [[urease]] production in mice with [[antibiotics]]<ref name="pmid16589306">{{cite journal |vauthors=Dintzis RZ, Hastings AB |title=The Effect of Antibiotics on Urea Breakdown in Mice |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=39 |issue=7 |pages=571–8 |year=1953 |pmid=16589306 |pmc=1063826 |doi= |url=}}</ref>
*1957, Charles Lieber and Andre Lefèvre explained that [[antibiotics]] decreases the production of [[urea]] to [[ammonia]] in [[stomach]]<ref name="pmid13500735">{{cite journal |vauthors=LIEBER CS, LEFEVRE A |title=[Effect of oxytetracycline on acidity, ammonia, and urea in gastric juice in normal and uremic subjects] |language=French |journal=C. R. Seances Soc. Biol. Fil. |volume=151 |issue=5 |pages=1038–42 |year=1957 |pmid=13500735 |doi= |url=}}</ref>
*In 1990
**Borody's triple therapy became commercialized under the product name Helidac in the United States<ref name="urlHELIDAC® Therapy">{{cite web |url=https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=11128 |title=HELIDAC® Therapy |format= |work= |accessdate=}}</ref>
**Rauws and Tytgat described treatment of [[duodenal ulcer]] by eradication of [[H. pylori]] using Borody's triple therapy that is combination of [[proton pump inhibitor]] and two [[antibiotics]], becomes first-line therapy for eradication<ref name="pmid1971318">{{cite journal |vauthors=Rauws EA, Tytgat GN |title=Cure of duodenal ulcer associated with eradication of Helicobacter pylori |journal=Lancet |volume=335 |issue=8700 |pages=1233–5 |year=1990 |pmid=1971318 |doi= |url=}}</ref>
**World Congress of Gastroenterology suggested eradicating [[H. pylori]] to treatment of duodenal [[ulcers]]
**First report of resistance of [[H. pylori]] to the antibiotic [[metronidazole]] was found<ref name="pmid1968548">{{cite journal |vauthors=Becx MC, Janssen AJ, Clasener HA, de Koning RW |title=Metronidazole-resistant Helicobacter pylori |journal=Lancet |volume=335 |issue=8688 |pages=539–40 |year=1990 |pmid=1968548 |doi= |url=}}</ref>
**The resistance of [[H. pylori]] to treatment leads to the development of new regimen which includes many different [[antibiotic]] and [[proton pump inhibitor]] regimens for eradication<ref name="pmid11860399">{{cite journal |vauthors=Malfertheiner P, Mégraud F, O'Morain C, Hungin AP, Jones R, Axon A, Graham DY, Tytgat G |title=Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Report |journal=Aliment. Pharmacol. Ther. |volume=16 |issue=2 |pages=167–80 |year=2002 |pmid=11860399 |doi= |url=}}</ref>
*In 1996 first [[antibiotic]] was developed by the Food and Drug Administration to treat [[peptic ulcer disease]]<ref>[http://www.cdc.gov/ulcer/history.htm Ulcer, Diagnosis and Treatment - CDC Bacterial, Mycotic Diseases]</ref>


==Famous Cases==
*The following are a few famous cases of [[disease name]]:
==References==
==References==
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Latest revision as of 23:37, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

Hundred years ago, polish clinical researcher professor W.Jaworski was the first to describe spiral-shaped microorganism at Cracow Jagiellonian University. Asklepios was the first to describe an association between GI bleeding and peptic ulcer disease. In 1982 Warren and B.J marshall cultured the organism and found a strong association between Helicobacter pylori and inflammation of gastric mucosa and were awarded the noble prize.

Historical Perspective

Discovery

  • Hundred years ago, polish clinical researcher professor W.Jaworski was the first to describe the spiral-shaped microorganism at Cracow Jagiellonian University
  • In pre-16th century:
  • In 1586, Marcellus Donatus of Mantua described gastric ulcers by performing autopsies
  • In 1688, Johannes von Murault gave detailed description of duodenal ulcers
  • In 1812, Broussais found that if acute gastritis is untreated, it can lead to chronic gastritis
  • In 1821, Nepveu found a relationship between gastritis and gastric cancer
  • In 1857, William Brintonin described ulcer of the stomach and gastric cancer in his book
  • In 1875, G.Bottcher and M. Letulle hypothesize that ulcers are caused by bacteria
  • In 1880, J.Cohnheim found that ulcers may be caused by chemical factors
  • In 1889, Walery Jaworski found spiral organisms in sediment washings of humans and proposed that these organisms may be involved with gastric disease
  • In 1910, Moynihan wrote a book on duodenal ulcer[2]
  • In 1971, Howard Steer found H. pylori from biopsies of a patient with ulcers[3][4]
  • In late 1970, J.R Warren, a pathologist in Perth, Australia found the appearance of spiral bacteria overlying gastric mucosa[4][5]
  • In 1982 , Warren and B.J marshall cultured the organism and found a strong association between Helicobacter pylori and inflammation of gastric mucosa[4][5]
  • In an act of self-experimentation Marshall drank a petri-dish containing a culture of organisms extracted from a patient and soon developed gastritis. His symptoms disappeared after two weeks, but he took antibiotics to kill the remaining bacteria at the urging of his wife.This experiment was published in 1984 in the Australian Medical Journal[6]
  • In 1994, Parsonnet et al found an association between H. pylori and lymphomas of the gastrointestinal tract[7]
  • In 1997 Tomb et al. completed sequencing of the entire 1,667,867 base pairs of the H. pylori genome. This helped in identifying new virulence factors for the infectivity of H. pylori at the molecular level[8]
  • In 2001, Chan et al. showed that eradication of H. pylori prevents bleeding from ulcers that is caused by aspirin and non-steroidal anti-inflammatory drugs[9]
  • In 2002, European Helicobacter Pylori Study Group published the Maastricht 2-2000 Consensus Report, found a "test-and-treat" strategy for H. pylori in young patients without atypical symptoms. It suggests the use of noninvasive testing to evaluate for H. pylori [10]
  • In 2005 Warren and Marshall awarded the Nobel Prize in Physiology or Medicine by Karolinska Institute in Stockholm for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease[11]
  • In 1992,Covacci discovered CagA gene, which encodes for a cytotoxin-associated surface protein, related with strains of H. pylori that caused duodenal ulcers and was discovered by molecular techniques were first involved in the pathogenesis of peptic ulcer disease [12]

Landmark Events in the Development of Treatment Strategies

References

  1. ↑ Kidd M, Modlin IM (1998). "A century of Helicobacter pylori: paradigms lost-paradigms regained". Digestion. 59 (1): 1–15. PMID 9468093.
  2. ↑ Barry, J (2002). Helicobacter pioneers : firsthand accounts from the scientists who discovered helicobacters, 1892-1982. Victoria, Australia Malden, MA, USA: Blackwell. ISBN 0867930357.
  3. ↑ Barry, J (2002). Helicobacter pioneers : firsthand accounts from the scientists who discovered helicobacters, 1892-1982. Victoria, Australia Malden, MA, USA: Blackwell. ISBN 0867930357.
  4. ↑ 4.0 4.1 4.2 Konturek JW (2003). "Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer". J. Physiol. Pharmacol. 54 Suppl 3: 23–41. PMID 15075463.
  5. ↑ 5.0 5.1 "Home | CDC Ulcer".
  6. ↑ {{cite web url=http://www.mja.com.au/public/issues/183_11_051205/van11000_fm.html#0_i1091639| title=Research Enterprise, The 2005 Nobel Prize in Physiology or Medicine |accessdate=2007-08-26}}
  7. ↑ Parsonnet J, Hansen S, Rodriguez L, Gelb AB, Warnke RA, Jellum E, Orentreich N, Vogelman JH, Friedman GD (1994). "Helicobacter pylori infection and gastric lymphoma". N. Engl. J. Med. 330 (18): 1267–71. doi:10.1056/NEJM199405053301803. PMID 8145781.
  8. ↑ Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC (1997). "The complete genome sequence of the gastric pathogen Helicobacter pylori". Nature. 388 (6642): 539–47. doi:10.1038/41483. PMID 9252185.
  9. ↑ Chan FK, Chung SC, Suen BY, Lee YT, Leung WK, Leung VK, Wu JC, Lau JY, Hui Y, Lai MS, Chan HL, Sung JJ (2001). "Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen". N. Engl. J. Med. 344 (13): 967–73. doi:10.1056/NEJM200103293441304. PMID 11274623.
  10. ↑ 10.0 10.1 Malfertheiner P, Mégraud F, O'Morain C, Hungin AP, Jones R, Axon A, Graham DY, Tytgat G (2002). "Current concepts in the management of Helicobacter pylori infection-the Maastricht 2-2000 Consensus Report". Aliment. Pharmacol. Ther. 16 (2): 167–80. PMID 11860399.
  11. ↑ "The Nobel Prize in Physiology or Medicine 2005".
  12. ↑ Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, Massone A, Papini E, Xiang Z, Figura N (1993). "Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5791–5. PMC 46808. PMID 8516329.
  13. ↑ Buckley MJ, O'Morain CA (1998). "Helicobacter biology--discovery". Br. Med. Bull. 54 (1): 7–16. PMID 9604426.
  14. ↑ Barry, J (2002). Helicobacter pioneers : firsthand accounts from the scientists who discovered helicobacters, 1892-1982. Victoria, Australia Malden, MA, USA: Blackwell. ISBN 0867930357.
  15. ↑ Dintzis RZ, Hastings AB (1953). "The Effect of Antibiotics on Urea Breakdown in Mice". Proc. Natl. Acad. Sci. U.S.A. 39 (7): 571–8. PMC 1063826. PMID 16589306.
  16. ↑ LIEBER CS, LEFEVRE A (1957). "[Effect of oxytetracycline on acidity, ammonia, and urea in gastric juice in normal and uremic subjects]". C. R. Seances Soc. Biol. Fil. (in French). 151 (5): 1038–42. PMID 13500735.
  17. ↑ "HELIDAC® Therapy".
  18. ↑ Rauws EA, Tytgat GN (1990). "Cure of duodenal ulcer associated with eradication of Helicobacter pylori". Lancet. 335 (8700): 1233–5. PMID 1971318.
  19. ↑ Becx MC, Janssen AJ, Clasener HA, de Koning RW (1990). "Metronidazole-resistant Helicobacter pylori". Lancet. 335 (8688): 539–40. PMID 1968548.
  20. ↑ Ulcer, Diagnosis and Treatment - CDC Bacterial, Mycotic Diseases

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