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==Overview== | ==Overview== | ||
Other diagnostic studies for mesothelioma include [[laparoscopy]], [[thoracoscopy]], [[pleuroscopy]], [[biopsy]], [[PET|position emission tomography scan]], and [[FISH|fluorescence in situ hybridization]]. | Other diagnostic studies for mesothelioma include [[laparoscopy]], [[thoracoscopy]], [[pleuroscopy]], [[biopsy]], [[PET|position emission tomography scan]], and [[FISH|fluorescence in situ hybridization]]. | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Laparoscopy, Thoracoscopy, and Pleuroscopy=== | ===Laparoscopy, Thoracoscopy, and Pleuroscopy=== | ||
*[[Thoracoscopy]] or [[ | *[[Thoracoscopy]] or pleuroscopy may help in the [[diagnosis]] of [[mesothelioma]].<ref name="pmid19878170">{{cite journal| author=Alvarez JM, Hasani A, Segal A, Sterret G, Millward M, Nowak A et al.| title=Bilateral thoracoscopy, mediastinoscopy and laparoscopy, in addition to CT, MRI and PET imaging, are essential to correctly stage and treat patients with mesothelioma prior to trimodality therapy. | journal=ANZ J Surg | year= 2009 | volume= 79 | issue= 10 | pages= 734-8 | pmid=19878170 | doi=10.1111/j.1445-2197.2009.05060.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19878170 }} </ref><ref name="biopsyofmesothelioma1">Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016</ref><ref name="MRimesothelioma1">Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015</ref><ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227 }} </ref><ref name="pmid19878170">{{cite journal| author=Alvarez JM, Hasani A, Segal A, Sterret G, Millward M, Nowak A et al.| title=Bilateral thoracoscopy, mediastinoscopy and laparoscopy, in addition to CT, MRI and PET imaging, are essential to correctly stage and treat patients with mesothelioma prior to trimodality therapy. | journal=ANZ J Surg | year= 2009 | volume= 79 | issue= 10 | pages= 734-8 | pmid=19878170 | doi=10.1111/j.1445-2197.2009.05060.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19878170 }} </ref> | ||
*[[Laparoscopy]] may be used to diagnose and treat selected cases of well-differentiated papillary mesothelioma associated with [[endometriosis|pelvic endometriosis]].<ref name="pmid20728825">{{cite journal| author=Nezhat FR, DeNoble SM, Brown DN, Shamshirsaz A, Hoehn D| title=Laparoscopic management of peritoneal mesothelioma associated with pelvic endometriosis. | journal=J Minim Invasive Gynecol | year= 2010 | volume= 17 | issue= 5 | pages= 646-50 | pmid=20728825 | doi=10.1016/j.jmig.2010.03.025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20728825 }} </ref> | *[[Laparoscopy]] may be used to diagnose and treat selected cases of well-differentiated papillary [[mesothelioma]] associated with [[endometriosis|pelvic endometriosis]].<ref name="pmid20728825">{{cite journal| author=Nezhat FR, DeNoble SM, Brown DN, Shamshirsaz A, Hoehn D| title=Laparoscopic management of peritoneal mesothelioma associated with pelvic endometriosis. | journal=J Minim Invasive Gynecol | year= 2010 | volume= 17 | issue= 5 | pages= 646-50 | pmid=20728825 | doi=10.1016/j.jmig.2010.03.025 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20728825 }} </ref> | ||
===Biopsy=== | ===Biopsy=== | ||
*[[Biopsy]] is helpful in the diagnosis of mesothelioma.<ref name=biopsyofmesothelioma1>Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016</ref> | *[[Biopsy]] is helpful in the [[diagnosis]] of [[mesothelioma]].<ref name="biopsyofmesothelioma1">Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016</ref> | ||
*Procedures performed for biopsy may include:<ref name=biopsyofmesothelioma1>Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016</ref> | *Procedures performed for [[biopsy]] may include:<ref name="biopsyofmesothelioma1">Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016</ref> | ||
:*[[Needle aspiration biopsy|Fine-needle (FNA) aspiration biopsy of the lung]] | :*[[Needle aspiration biopsy|Fine-needle (FNA) aspiration biopsy of the lung]] | ||
:*[[Thoracoscopy]] | :*[[Thoracoscopy]] | ||
:*[[Thoracotomy]] | :*[[Thoracotomy]] | ||
:*Peritoneoscopy | :*Peritoneoscopy | ||
:*Open biopsy | :*[[Biopsy|Open biopsy]] | ||
===Position Emission Tomography=== | ===Position Emission Tomography=== | ||
*Positron emission tomography is becoming useful in two clinical settings:<ref name=MRimesothelioma1>Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015</ref> | *[[Positron emission tomography]] is becoming useful in two [[clinical]] settings:<ref name="MRimesothelioma1">Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015</ref> | ||
:*Differentiating between benign and malignant asbestos-related pleural thickening | :*Differentiating between [[benign]] and [[malignant]] [[asbestos]]-related [[pleural]] thickening | ||
:*Assessing for nodal metastases | :*Assessing for [[Nodal (protein)|nodal]] [[metastases]] | ||
*In addition, there appears to be a correlation between the degree of [[Fludeoxyglucose F 18|FDG uptake]] and the biological aggressiveness of the tumor, which may help to guide treatment.<ref name=MRimesothelioma1>Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015</ref> | *In addition, there appears to be a correlation between the degree of [[Fludeoxyglucose F 18|FDG uptake]] and the biological aggressiveness of the [[tumor]], which may help to guide treatment.<ref name="MRimesothelioma1">Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015</ref> | ||
===Fluorescence In Situ Hybridization (FISH)=== | ===Fluorescence In Situ Hybridization (FISH)=== | ||
*[[FISH]] may be helpful in the diagnosis of mesothelioma. It helps in distinguishing malignant mesothelioma from reactive mesothelial cells in effusions.<ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227 }} </ref> | *[[FISH]] may be helpful in the [[diagnosis]] of [[mesothelioma]]. It helps in distinguishing [[malignant]] [[mesothelioma]] from reactive [[mesothelial]] [[cells]] in effusions.<ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227 }} </ref> | ||
*Mutlitarget FISH assay may be used to detect chromosomal abberations ([[chromosome 3|chromosomes 3]], [[chromosome 7|7]], [[chromosome 17|17]], and [[chromosome 9|9p21]]). | *Mutlitarget [[Fluorescence in situ hybridization|FISH]] [[Assays|assay]] may be used to detect [[chromosomal]] abberations ([[chromosome 3|chromosomes 3]], [[chromosome 7|7]], [[chromosome 17|17]], and [[chromosome 9|9p21]]). | ||
*FISH technique may also be used to explore the alternative mechanism of [[tumor suppressor gene]] inactivation by methylation of ''[[p16]]'', ''p14'', and ''p15'' gene in the pathogenesis of mesothelioma.<ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227 }} </ref> | *[[Fluorescence in situ hybridization|FISH]] technique may also be used to explore the alternative [[Mechanism (biology)|mechanism]] of [[tumor suppressor gene]] inactivation by [[methylation]] of ''[[p16]]'', ''p14'', and ''p15'' [[gene]] in the [[pathogenesis]] of mesothelioma.<ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227 }} </ref> | ||
==References== | ==References== | ||
Latest revision as of 15:49, 11 March 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Other diagnostic studies for mesothelioma include laparoscopy, thoracoscopy, pleuroscopy, biopsy, position emission tomography scan, and fluorescence in situ hybridization.
Other Diagnostic Studies
Laparoscopy, Thoracoscopy, and Pleuroscopy
- Thoracoscopy or pleuroscopy may help in the diagnosis of mesothelioma.[1][2][3][4][1]
- Laparoscopy may be used to diagnose and treat selected cases of well-differentiated papillary mesothelioma associated with pelvic endometriosis.[5]
Biopsy
- Biopsy is helpful in the diagnosis of mesothelioma.[2]
- Procedures performed for biopsy may include:[2]
Position Emission Tomography
- Positron emission tomography is becoming useful in two clinical settings:[3]
- In addition, there appears to be a correlation between the degree of FDG uptake and the biological aggressiveness of the tumor, which may help to guide treatment.[3]
Fluorescence In Situ Hybridization (FISH)
- FISH may be helpful in the diagnosis of mesothelioma. It helps in distinguishing malignant mesothelioma from reactive mesothelial cells in effusions.[4]
- Mutlitarget FISH assay may be used to detect chromosomal abberations (chromosomes 3, 7, 17, and 9p21).
- FISH technique may also be used to explore the alternative mechanism of tumor suppressor gene inactivation by methylation of p16, p14, and p15 gene in the pathogenesis of mesothelioma.[4]
References
- ↑ 1.0 1.1 Alvarez JM, Hasani A, Segal A, Sterret G, Millward M, Nowak A; et al. (2009). "Bilateral thoracoscopy, mediastinoscopy and laparoscopy, in addition to CT, MRI and PET imaging, are essential to correctly stage and treat patients with mesothelioma prior to trimodality therapy". ANZ J Surg. 79 (10): 734–8. doi:10.1111/j.1445-2197.2009.05060.x. PMID 19878170.
- ↑ 2.0 2.1 2.2 Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016
- ↑ 3.0 3.1 3.2 Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015
- ↑ 4.0 4.1 4.2 Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B; et al. (2010). "Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology". Chest. 138 (1): 137–44. doi:10.1378/chest.09-1951. PMID 20139227.
- ↑ Nezhat FR, DeNoble SM, Brown DN, Shamshirsaz A, Hoehn D (2010). "Laparoscopic management of peritoneal mesothelioma associated with pelvic endometriosis". J Minim Invasive Gynecol. 17 (5): 646–50. doi:10.1016/j.jmig.2010.03.025. PMID 20728825.