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| {{CMG}}
| | __NOTC__ |
| {{Renal cell carcinoma}} | | {{Renal cell carcinoma}} |
| | {{CMG}} {{AE}} {{F.K}} |
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| ==Overview== | | ==Overview== |
| A needle biopsy should always be performed when the finding of a renal mass is detected on imaging.
| | There are no other diagnostic studies associated with renal cell carcinoma. |
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| ==Needle Biopsy== | | ==Other diagnostic studies== |
| Needle biopsy should always be performed when the finding of a renal mass is detected on imaging. CT or MRI guided needle biopsy distinguishes between different subgroups of renal cell carcinoma and identifies management: active surveillance, surgery, or medical therapy.<ref name="pmid23665399">{{cite journal| author=Donat SM, Diaz M, Bishoff JT, Coleman JA, Dahm P, Derweesh IH et al.| title=Follow-up for Clinically Localized Renal Neoplasms: AUA Guideline. | journal=J Urol | year= 2013 | volume= 190 | issue= 2 | pages= 407-16 | pmid=23665399 | doi=10.1016/j.juro.2013.04.121 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23665399 }} </ref> The sensitivity and specificity of needle biopsy are very high. The rate of biopsy-related complications, including biopsy-associated seeding, is considered very low.<ref name="pmid23665399">{{cite journal| author=Donat SM, Diaz M, Bishoff JT, Coleman JA, Dahm P, Derweesh IH et al.| title=Follow-up for Clinically Localized Renal Neoplasms: AUA Guideline. | journal=J Urol | year= 2013 | volume= 190 | issue= 2 | pages= 407-16 | pmid=23665399 | doi=10.1016/j.juro.2013.04.121 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23665399 }} </ref>
| | There are no other diagnostic studies associated with renal cell carcinoma. |
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| {| border="1" style="border-collapse:collapse; text-align:left;" cellpadding="5" align="center"
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| |+ '''''Histopathological Findings in Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal| author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. |journal=N Engl J Med | year= 2005 | volume= 353 | issue= 23 | pages= 2477-90 | pmid=16339096 |doi=10.1056/NEJMra043172 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096 }} </ref><ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>'''''
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| | bgcolor="#d9ff54"|'''Type''' || bgcolor="#d9ff54"|'''Characteristic Features'''
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| | bgcolor="#ececec"|'''Conventional (Clear Cell)''' ||*Nests of tumor cells that are compacted near each other<br>*Clear cytoplasm<br>*Delicate vasculature that separates the cytoplasm<br>*Varying architectural patterns, such as solid, alveolar, or acinar
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| | bgcolor="#ececec"|'''Papillary''' || *Papillae, tubulopapillae, and tubules that are present in differing percentages<br>*Type I generally has papillae lined with only 1 layer of cancer cells, pale cytoplasm, and small oval nuclei<br>*Type II generally are more heterogeneous tumors that have pseudostratification with large, spherical nuclei and distinct nucleoli
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| | bgcolor="#ececec"|'''Chromophobe''' || *Large polygonal cells<br>*Finely reticulated cytoplasm that may be eosinophilic<br>*Distinct cell borders<br>*Atypical nuclei with perinuclear halo
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| <sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90 & Rini BI, Campbell SC, Escudier B. Renal cell carcinoma. ''Lancet''. 2009; 373(9669):1119-32</center></sup>
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| ==References== | | ==References== |