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{{CMG}}
__NOTOC__
{{Teratoma}}
{{Teratoma}}
__NOTOC__
 
===Natural history===
{{CMG}}; {{AE}} {{G.D.}}
 
==Overview==
==Overview==
The prognosis of teratoma depends on the type of tumor and malignant transformation. Mature teratoma is begnin and has an excellent prognosis compared to immature teratoma which has a favorable prognosis.The 6 year survival rate of patients with mature teratoma is approximately 96%. The overall 5 years survival rate of patient with immature teratoma is 90% and 75% for stage II-IV.Common complications are malignant transformation, rupture, torsion, and hemolytic anemia.
==Natural History, Complications, and Prognosis==


==Complications==
===Natural History===
*The symptoms of teratoma depends on the locations of the tumors.


Teratomas are not dangerous for the fetus unless there is either a [[mass effect (medicine)|mass effect]] or a large amount of blood flow through the tumor (known as ''vascular steal''). The mass effect frequently consists of obstruction of normal passage of fluids from surrounding organs.  The vascular steal can place a strain on the growing heart of the fetus, even resulting in heart failure, and thus must be monitored by fetal [[echocardiography]].


After surgery, there is a risk of regrowth in place, or in nearby organs.<ref>[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=14532748 ''A recurred case of a mature ovarian teratoma presenting as a rectal mass'' (in Korean, abstract in English)]</ref>
===Complications===
*Common complications of teratoma specially ovarian teratoma include:<ref name="pmid18635624">{{cite journal| author=Park SB, Kim JK, Kim KR, Cho KS| title=Imaging findings of complications and unusual manifestations of ovarian teratomas. | journal=Radiographics | year= 2008 | volume= 28 | issue= 4 | pages= 969-83 | pmid=18635624 | doi=10.1148/rg.284075069 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18635624  }} </ref><ref name="pmid8008317">Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL (1994) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=8008317 Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature.] ''Obstet Gynecol'' 84 (1):22-8. PMID: [https://pubmed.gov/8008317 8008317]</ref><ref name="pmid2841767">{{cite journal| author=Singh P, Yordan EL, Wilbanks GD, Miller AW, Wee A| title=Malignancy associated with benign cystic teratomas (dermoid cysts) of the ovary. | journal=Singapore Med J | year= 1988 | volume= 29 | issue= 1 | pages= 30-4 | pmid=2841767 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2841767  }} </ref>
**Torsion
**Rupture
**Malignant transformation
**Infections
**Autoimmune hemolytic anemia


==Prognosis==
===Prognosis===
The prognosis of teratoma depends on the following:
*Mature teratoma has an excellent prognosis.<ref name="pmid25631333">{{cite journal| author=Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL et al.| title=Mature and immature teratoma: A report from the second Italian pediatric study. | journal=Pediatr Blood Cancer | year= 2015 | volume= 62 | issue= 7 | pages= 1202-8 | pmid=25631333 | doi=10.1002/pbc.25423 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25631333  }} </ref>
*The 6 year survival rate of patients with mature teratoma is approximately 96%.<ref name="pmid9607423">{{cite journal| author=Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP et al.| title=Teratomas in infancy and childhood. | journal=Med Pediatr Oncol | year= 1998 | volume= 31 | issue= 1 | pages= 8-15 | pmid=9607423 | doi=10.1002/(sici)1096-911x(199807)31:1<8::aid-mpo2>3.0.co;2-h | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9607423  }} </ref>
*Immature teratoma has favorable prognosis for stage I and poor for advance stages.<ref name="pmid18541896">Mann JR, Gray ES, Thornton C, Raafat F, Robinson K, Collins GS et al. (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18541896 Mature and immature extracranial teratomas in children: the UK Children's Cancer Study Group Experience.] ''J Clin Oncol'' 26 (21):3590-7. [http://dx.doi.org/10.1200/JCO.2008.16.0622 DOI:10.1200/JCO.2008.16.0622] PMID: [https://pubmed.gov/18541896 18541896]</ref>
*Immature teratoma has 90%-95% of 5 years of survival rate for stage I and 75 % for stage II-IV.<ref name="pmid18541896">Mann JR, Gray ES, Thornton C, Raafat F, Robinson K, Collins GS et al. (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18541896 Mature and immature extracranial teratomas in children: the UK Children's Cancer Study Group Experience.] ''J Clin Oncol'' 26 (21):3590-7. [http://dx.doi.org/10.1200/JCO.2008.16.0622 DOI:10.1200/JCO.2008.16.0622] PMID: [https://pubmed.gov/18541896 18541896]</ref>


:*Whether or not the tumor can be removed by surgery.
==References==
:*The size and location of the tumor
{{Reflist|2}}
:*The patient’s general health


==References==
{{WH}}
{{Reflist}}
{{WS}}
<references/> 


[[Category:Disease]]
[[Category:Disease]]

Latest revision as of 20:35, 25 November 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2]

Overview

The prognosis of teratoma depends on the type of tumor and malignant transformation. Mature teratoma is begnin and has an excellent prognosis compared to immature teratoma which has a favorable prognosis.The 6 year survival rate of patients with mature teratoma is approximately 96%. The overall 5 years survival rate of patient with immature teratoma is 90% and 75% for stage II-IV.Common complications are malignant transformation, rupture, torsion, and hemolytic anemia.

Natural History, Complications, and Prognosis

Natural History

  • The symptoms of teratoma depends on the locations of the tumors.


Complications

  • Common complications of teratoma specially ovarian teratoma include:[1][2][3]
    • Torsion
    • Rupture
    • Malignant transformation
    • Infections
    • Autoimmune hemolytic anemia

Prognosis

  • Mature teratoma has an excellent prognosis.[4]
  • The 6 year survival rate of patients with mature teratoma is approximately 96%.[5]
  • Immature teratoma has favorable prognosis for stage I and poor for advance stages.[6]
  • Immature teratoma has 90%-95% of 5 years of survival rate for stage I and 75 % for stage II-IV.[6]

References

  1. ↑ Park SB, Kim JK, Kim KR, Cho KS (2008). "Imaging findings of complications and unusual manifestations of ovarian teratomas". Radiographics. 28 (4): 969–83. doi:10.1148/rg.284075069. PMID 18635624.
  2. ↑ Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL (1994) Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. Obstet Gynecol 84 (1):22-8. PMID: 8008317
  3. ↑ Singh P, Yordan EL, Wilbanks GD, Miller AW, Wee A (1988). "Malignancy associated with benign cystic teratomas (dermoid cysts) of the ovary". Singapore Med J. 29 (1): 30–4. PMID 2841767.
  4. ↑ Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL; et al. (2015). "Mature and immature teratoma: A report from the second Italian pediatric study". Pediatr Blood Cancer. 62 (7): 1202–8. doi:10.1002/pbc.25423. PMID 25631333.
  5. ↑ Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP; et al. (1998). "Teratomas in infancy and childhood". Med Pediatr Oncol. 31 (1): 8–15. doi:10.1002/(sici)1096-911x(199807)31:1<8::aid-mpo2>3.0.co;2-h. PMID 9607423.
  6. ↑ 6.0 6.1 Mann JR, Gray ES, Thornton C, Raafat F, Robinson K, Collins GS et al. (2008) Mature and immature extracranial teratomas in children: the UK Children's Cancer Study Group Experience. J Clin Oncol 26 (21):3590-7. DOI:10.1200/JCO.2008.16.0622 PMID: 18541896

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