Hemochromatosis history and symptoms: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
No edit summary
 
(4 intermediate revisions by 2 users not shown)
Line 2: Line 2:
{{Hemochromatosis}}
{{Hemochromatosis}}
{{CMG}}; {{AE}}{{SKA}}
{{CMG}}; {{AE}}{{SKA}}
{{PleaseHelp}}


==Overview==
==Overview==
Symptoms usually begin in age of 30 years. The involvement of specific organ produces subsequent symptoms. Early symptoms are [[fatigue]] and [[weakness]]; and as the [[iron]] builds up in the body organs, [[Infection|infections]] and loss of body hair happen. After disease progression, hemochromatosis may cause the following more serious problems such as [[arthritis]], and [[Congestive heart failure|heart failure]].


==History and Symptoms==
==History and Symptoms==
<ref>[http://www.cdc.gov/ncbddd/hemochromatosis/ Iron Overload and Hemochromatosis] Centers for Disease Control and Prevention</ref><ref>[http://digestive.niddk.nih.gov/ddiseases/pubs/hemochromatosis/index.htm Hemochromatosis] National Digestive Diseases Information Clearinghouse, National Institutes of Health, U.S. Department of Health and Human Services</ref><ref>[http://www.mayoclinic.com/health/hemochromatosis/DS00455/DSECTION=2 Hemochromatosis-Signs and Symptoms] Mayo Foundation for Medical Education and Research (MFMER)</ref>
Symptoms usually begin in age of 30 years. The involvement of specific organ produces subsequent symptoms.<ref>[http://www.cdc.gov/ncbddd/hemochromatosis/ Iron Overload and Hemochromatosis] Centers for Disease Control and Prevention</ref><ref>[http://digestive.niddk.nih.gov/ddiseases/pubs/hemochromatosis/index.htm Hemochromatosis] National Digestive Diseases Information Clearinghouse, National Institutes of Health, U.S. Department of Health and Human Services</ref><ref>[http://www.mayoclinic.com/health/hemochromatosis/DS00455/DSECTION=2 Hemochromatosis-Signs and Symptoms] Mayo Foundation for Medical Education and Research (MFMER)</ref>


*'''Early indications''' of hemochromatosis are often like those of other diseases and include the following symptoms:
*'''Early indications''' of hemochromatosis are often like those of other diseases and include the following symptoms:
Line 18: Line 17:


*As '''iron builds up in the body organs''', hemochromatosis may also produce the following symptoms:
*As '''iron builds up in the body organs''', hemochromatosis may also produce the following symptoms:
:*Loss of menstrual periods or early menopause
:*Loss of menstrual periods or early [[menopause]]
:*Loss of sex drive (libido) or impotence
:*Loss of sex drive (libido) or impotence
:*Loss of body hair
:*Loss of body hair
:*[[Shortness of breath]]
:*[[Shortness of breath]]
:*[[Infection|Infections]]


*As the '''disease progresses''', hemochromatosis may cause the following more serious problems:
*As the '''disease progresses''', hemochromatosis may cause the following more serious problems:
Line 29: Line 29:
:*[[Heart failure]] symptoms
:*[[Heart failure]] symptoms
:*Gray-colored or bronze-colored skin
:*Gray-colored or bronze-colored skin
:*[[Deafness]]<ref name=Jones_1983>{{cite journal |author=Jones H, Hedley-Whyte E |title=Idiopathic hemochromatosis (IHC): dementia and ataxia as presenting signs |journal=Neurology |volume=33 |issue=11 |pages=1479-83 |year=1983 |pmid=6685241}}</ref>
:*[[Deafness]]<ref name="Jones_1983">{{cite journal |author=Jones H, Hedley-Whyte E |title=Idiopathic hemochromatosis (IHC): dementia and ataxia as presenting signs |journal=Neurology |volume=33 |issue=11 |pages=1479-83 |year=1983 |pmid=6685241}}</ref>
* A darkish color to the skin (see pigmentation, hence its name '''''Diabete bronze''''' when it was first described by [[Armand Trousseau]] in 1865)
* A darkish color to the skin (see pigmentation, hence its name '''''Diabete bronze''''' when it was first described by [[Armand Trousseau]] in 1865)
{| class="wikitable"
!System involved
!Organs
!Symptom
!Signs
!Mechanisum
|-
| rowspan="2" |Nervous system
|[[Peripheral nervous system|PNS]]
|Parastheisa
Loss of motor control
|Loss of two point discrimination
Hyporeflaxia decreased power
|[[Axonal]] sensory motor [[polyneuropathy]]
|-
|[[CNS]]
|Abnormal gait
Dementia
|Dyskinesias ([[Parkinsonism|Parkinsonian]] syndrome [[Multiple sclerosis]])
Cognitive decline
|Deposition of iron in [[basal ganglia]]
|-
| rowspan="4" |[[Endocrine]]
|[[Pituitary gland]]
|[[Menstrual cycle|Menstrual]] abnormality
Loss of [[libido]]
Loss of body hair
|[[Amenorrhea]]
Erictle dysfuntion
|Deposition of iron in [[pituitary gland]]
|-
|[[Thyroid gland]]
|[[Fatigue]]
|Signs of [[hypothyroidsm]]
|Deposition of iron in [[thyroid gland]]
|-
|[[Pancreas]]
|Polyuria polydipsia polyphagia
|Polyuria polydipsia polyphagia
|Deposition of iron in [[pancreas]]
|-
|[[Adrenal gland]]
|[[Fatigue]]
|Polyuria Hypotension
|Deposition of iron in [[adrenal gland]]
|-
|[[Dermatological]]
|[[Skin]]
|Cutaneous [[hyperpigmentation]]
|Sun exposed affected mostly with tan of melanin grey
Porphyria cutanea tarda
|iron damage skin, [[melanin]] hyperactivity responds thus color of [[melanin]]
|-
|[[Joints]]
|[[Metacarpophalangeal]], especially 2nd and 3rd MCP joints
[[Proximal interphalangeal]]
[[wrist]]
[[knee]]
|Pain
[[Stiffness]]
[[Arthritis]]
[[Joint swelling]]
|Decreased ROM
Stiffness improve with rest
|Deposition of iron in articular [[cartilage]]
Chondrocalcinosis
|-
|[[Cardiovascular]]
|Heart
Blood vessels
|Asymptomatic [[Congestive heart failure|heart failure]]
[[Palpitation]] [[Hypertension]]
|Diastolic dysfunction
Arrhythmias
Dilated cardiomyopathy
|Deposition of iron in cardiac tissue and blood vessels
|-
| rowspan="2" |[[Gastrointestinal]]
|[[Liver]]
|[[Fatigue (physical)|Fatigue]]
Fatty [[diarrhea]]
[[Itching]]
[[Jaundice]]
[[Weight loss]]
|[[Hepatomegaly]]
[[Liver failure]] ([[ascites]], [[encephalopathy]])
[[Liver tumor|Liver cancer]]
[[Splenomegaly]]


Cutaneous stigmata of [[chronic liver disease]]
|Deposition of [[iron]] in [[liver]]
|-
|[[Gallbladder]]
|Right [[upper abdominal pain]]
|Tender [[hepatomegaly]]
|Multiple blood transfusion leading to hemochromatosis
|}
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Latest revision as of 18:08, 1 January 2019

Hemochromatosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hemochromatosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hemochromatosis history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Hemochromatosis history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hemochromatosis history and symptoms

CDC on Hemochromatosis history and symptoms

Hemochromatosis history and symptoms in the news

Blogs on Hemochromatosis history and symptoms

Directions to Hospitals Treating Hemochromatosis

Risk calculators and risk factors for Hemochromatosis history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunny Kumar MD [2]

Overview

Symptoms usually begin in age of 30 years. The involvement of specific organ produces subsequent symptoms. Early symptoms are fatigue and weakness; and as the iron builds up in the body organs, infections and loss of body hair happen. After disease progression, hemochromatosis may cause the following more serious problems such as arthritis, and heart failure.

History and Symptoms

Symptoms usually begin in age of 30 years. The involvement of specific organ produces subsequent symptoms.[1][2][3]

  • Early indications of hemochromatosis are often like those of other diseases and include the following symptoms:
  • As iron builds up in the body organs, hemochromatosis may also produce the following symptoms:
  • As the disease progresses, hemochromatosis may cause the following more serious problems:
  • Arthritis
  • Abdominal pain that does not go away
  • Severe fatigue (feeling extremely tired and having a lack of energy)
  • Heart failure symptoms
  • Gray-colored or bronze-colored skin
  • Deafness[4]
  • A darkish color to the skin (see pigmentation, hence its name Diabete bronze when it was first described by Armand Trousseau in 1865)
System involved Organs Symptom Signs Mechanisum
Nervous system PNS Parastheisa

Loss of motor control

Loss of two point discrimination

Hyporeflaxia decreased power

Axonal sensory motor polyneuropathy
CNS Abnormal gait

Dementia

Dyskinesias (Parkinsonian syndrome Multiple sclerosis)

Cognitive decline

Deposition of iron in basal ganglia
Endocrine Pituitary gland Menstrual abnormality

Loss of libido

Loss of body hair

Amenorrhea

Erictle dysfuntion

Deposition of iron in pituitary gland
Thyroid gland Fatigue Signs of hypothyroidsm Deposition of iron in thyroid gland
Pancreas Polyuria polydipsia polyphagia Polyuria polydipsia polyphagia Deposition of iron in pancreas
Adrenal gland Fatigue Polyuria Hypotension Deposition of iron in adrenal gland
Dermatological Skin Cutaneous hyperpigmentation Sun exposed affected mostly with tan of melanin grey

Porphyria cutanea tarda

iron damage skin, melanin hyperactivity responds thus color of melanin
Joints Metacarpophalangeal, especially 2nd and 3rd MCP joints

Proximal interphalangeal

wrist

knee

Pain

Stiffness

Arthritis

Joint swelling

Decreased ROM

Stiffness improve with rest

Deposition of iron in articular cartilage

Chondrocalcinosis

Cardiovascular Heart

Blood vessels

Asymptomatic heart failure

Palpitation Hypertension

Diastolic dysfunction

Arrhythmias

Dilated cardiomyopathy

Deposition of iron in cardiac tissue and blood vessels
Gastrointestinal Liver Fatigue

Fatty diarrhea

Itching

Jaundice

Weight loss

Hepatomegaly

Liver failure (ascites, encephalopathy)

Liver cancer

Splenomegaly

Cutaneous stigmata of chronic liver disease

Deposition of iron in liver
Gallbladder Right upper abdominal pain Tender hepatomegaly Multiple blood transfusion leading to hemochromatosis

References

  1. ↑ Iron Overload and Hemochromatosis Centers for Disease Control and Prevention
  2. ↑ Hemochromatosis National Digestive Diseases Information Clearinghouse, National Institutes of Health, U.S. Department of Health and Human Services
  3. ↑ Hemochromatosis-Signs and Symptoms Mayo Foundation for Medical Education and Research (MFMER)
  4. ↑ Jones H, Hedley-Whyte E (1983). "Idiopathic hemochromatosis (IHC): dementia and ataxia as presenting signs". Neurology. 33 (11): 1479–83. PMID 6685241.

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Hemochromatosis_history_and_symptoms&oldid=1513213"