Hemochromatosis: Difference between revisions

	Hemochromatosis;
ICD-10	E83.1
ICD-9	275.0
OMIM	235200
DiseasesDB	5490
MeSH	[3]

	Hemochromatosis Microchapters
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VisualWikitext

Latest revision as of 19:08, 2 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunny Kumar MD [2]

Synonyms and keywords: Haemochromatosis, Hereditary Hemochromatosis

For patient information click here

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hemochromatosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

Case Studies

Case #1

Related Chapters

Cirrhosis

References

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 ==[[Hemochromatosis overview|Overview]]==
-'''Hemochromatosis''' is a [[hereditary disease]] characterized by improper dietary [[iron]] [[metabolism]] (making it an [[iron overload disorder]]), which causes the accumulation of [[iron]] in a number of body tissues.<ref>[http://www.cdc.gov/ncbddd/hemochromatosis/ Iron Overload and Hemochromatosis] Centers for Disease Control and Prevention</ref> Iron accumulation can eventually cause end organ damage, most importantly in the [[pancreas]] manifesting as [[diabetes]], and [[liver]] failure.  It is estimated that roughly one in every 300-400 people are affected by the disease, primarily of Northern European and Anglo-English descent.
 ==[[Hemochromatosis historical perspective|Historical Perspective]]==
-The disease was first described in 1865 by [[Armand Trousseau]] in an article on [[Diabetes mellitus|diabetes]] in patients with changing skin color.<ref name=":0">name=Trousseau_1865>{{cite journal | author = Trousseau A| title = Glycosurie, diabète sucré | journal = Clinique médicale de l'Hôtel-Dieu de Paris | year = 1865 | volume = 2| pages = 663&ndash;98 | url= }}</ref> Trousseau did not connect the [[diabetes]] with [[iron]] accumulation; instead this was done by [[Friedrich Daniel von Recklinghausen]] in 1890.<ref name=":1">{{cite journal | author = von Recklinghausen FD | title = Hämochromatose | journal = Tageblatt der Naturforschenden Versammlung 1889 | year = 1890 | pages = 324 | url= }}</ref><ref>[http://www.whonamedit.com/doctor.cfm/1174.html Biography of Daniel von Recklinghausen]</ref> The mutation of human genome to increase iron absorption in people who are exposed to iron deficient diet is evolutionary stand point. Hemocromatosis is also known as Celtic Curse.
 ==[[Hemochromatosis classification|Classification]]==
-Hemochromatosis is divided on basis of it's etiology. Hereditary hemochromatosis is caused by defect in gene and secondary hemochromatosis is caused by excess absorption of iron, repeated blood transfusions, or excess oral intake, typically in patients with disorders of erythropoiesis.
 ==[[Hemochromatosis pathophysiology|Pathophysiology]]==
-Hemochromatosis is due to unchecked transfer of iron into the bloodstream in the absence of increased erythropoietic needs and its toxic effects in parenchymatous organs.
 ==[[Hemochromatosis causes|Causes]]==
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 ==Diagnosis==
-[[Hemochromatosis history and symptoms|History and Symptoms]] | [[Hemochromatosis physical examination|Physical Examination]] | [[Hemochromatosis laboratory findings|Laboratory Findings]] | [[Hemochromatosis electrocardiogram|Electrocardiogram]] | [[Hemochromatosis x ray|X Ray]] | [[Hemochromatosis CT|CT]] | [[Hemochromatosis MRI|MRI]] | [[Hemochromatosis echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Hemochromatosis other imaging findings|Other Imaging Findings]] | [[Hemochromatosis other diagnostic studies|Other Diagnostic Studies]]
+[[Hemochromatosis diagnostic study of choice|Diagnostic Study of Choice]] | [[Hemochromatosis history and symptoms|History and Symptoms]] | [[Hemochromatosis physical examination|Physical Examination]] | [[Hemochromatosis laboratory findings|Laboratory Findings]] | [[Hemochromatosis electrocardiogram|Electrocardiogram]] | [[Hemochromatosis x ray|X Ray]] | [[Hemochromatosis CT|CT]] | [[Hemochromatosis MRI|MRI]] | [[Hemochromatosis echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Hemochromatosis other imaging findings|Other Imaging Findings]] | [[Hemochromatosis other diagnostic studies|Other Diagnostic Studies]]
 ==Treatment==
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 {{Hematology}}
-[[Category:Disease]]
-[[Category:Cardiology]]
 [[Category:Gastroenterology]]
 [[Category:Hematology]]
 [[Category:Hepatology]]
-[[Category:Orthopedics]]
-[[Category:Endocrinology]]
-[[de:Hämochromatose]]
-[[es:Hemocromatosis]]
-[[fr:Hémochromatose génétique]]
-[[it:Emocromatosi]]
-[[he:המוכרומטוזיס]]
-[[nl:Hemochromatose]]
-[[no:Hemokromatose]]
-[[pl:Hemochromatoza]]
-[[pt:Hemocromatose]]
-[[fi:Hemokromatoosi]]
-[[sv:Hemakromotos]]
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Hemochromatosis
ICD-10	E83.1
ICD-9	275.0
OMIM	235200
DiseasesDB	5490
MeSH	[3]