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| __NOTOC__
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| {{Suicidal ideation}}
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| {{CMG}}; {{AE}} {{Vbe}}
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| ==Overview==
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| It is thought that [[suicidal]] ideation is caused by decreased expression of serotonin transporter gene, studies have shown that there is decreased expression of 5 HTT(SLC6A4 gene) in [[Prefrontal cortex|prefronta]]<nowiki/>l and [[Cortical T ALL|cortical]] region. [[MAO-A|MAO]] and [[MAOB]] have also been implicated.
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| ==Pathophysiology==
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| Decreased cerebrospinal fluid (CSF) [[serotonin]] levels and serotonin receptor dysfunction are strong risk factors for [[suicide attempt]] and completion. Dysfunction in central [[serotonin]] systems is associated with a lowered threshold for self-directed and externally directed aggressive behavior. In 1976, As berg et al reported a bi-modal distribution of serotonin metabolites (5-HIAA) in the CSF of [[Depressed mood|depressed]] patients.In this study, significantly more of the [[Depressed mood|depressed]] patients in the "low" CSF 5-HIAA group had attempted [[suicide]] compared to the "high" CSF group. A five-year follow-up study of depressed patients concluded that patients who attempted suicide before the index admission and who reattempted suicide during the follow-up had significantly lower CSF levels of 5-HIAA.To date, more than 20 studies have reported low concentrations of CSF 5-HIAA in suicide attempters with a broad range of diagnoses, making this one of the strongest findings in biological [[psychiatry]]. The absolute reduction in the concentration of CSF 5-HIAA appears to correlate well with lethality, increased planning, and medical damage of the suicide attempt.The [[pharmacotherapy]] of suicidal patients often aims at increasing serotonin availability in the brain stem.
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| ==Genetics==
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| *[Disease name] is transmitted in [mode of genetic transmission] pattern.
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| *Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
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| *The development of [disease name] is the result of multiple genetic mutations.
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| ==Associated Conditions==
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| The following conditions are associated with increased risk of [[suicidal]] ideation:
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| **[[Major depressive disorder|Major depressive disorde]]<nowiki/>r
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| **[[Bipolar disorder]]
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| **[[Schizophrenia]]
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| **[[Post traumatic stress disorder]]
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| **[[Anxiety]]
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| **[[Personality disorders]]
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| ==References==
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| {{Reflist|2}}
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| {{WH}}
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| {{WS}}
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