Glutathione S-transferase Mu 1: Difference between revisions

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{{Infobox_gene}}
'''Glutathione ''S''-transferase Mu 1''' (gene name '''GSTM1''') is a human [[glutathione S-transferase|Glutathione ''S''-transferase]].
'''Glutathione ''S''-transferase Mu 1''' (gene name '''GSTM1''') is a [[human]] [[glutathione S-transferase|Glutathione ''S''-transferase]].


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== Function ==
{{PBB_Summary
| section_title =  
| summary_text = Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of [[cancers]], likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.<ref>{{cite web | title = Entrez Gene: GSTM1 glutathione S-transferase M1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2944| accessdate = }}</ref>
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==References==
[[Cytosolic]] and [[cell membrane|membrane]]-bound forms of glutathione S-transferase are encoded by two distinct [[supergene]] families. At present, eight distinct classes of the soluble [[cytoplasm]]ic [[mammal]]ian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu [[Enzyme classification|class]]. The mu class of enzymes functions in the [[detoxification]] of [[electrophile|electrophilic]] compounds, including [[carcinogen]]s, [[therapeutic drugs]], [[environmental toxin]]s, and products of [[oxidative stress]], by [[Conjugation (genetics)|conjugation]] with [[glutathione]].
 
The genes encoding the mu class of enzymes are organized in a [[gene cluster]] on chromosome 1p13.3, and are known to be highly [[Gene polymorphism|polymorphic]]. These genetic variations can change an individual's susceptibility to carcinogens and toxins, as well as affect the [[toxicity]] and efficacy of certain [[drug]]s. [[Null mutation]]s of this class mu gene have been linked with an increase in a number of [[cancers]], likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple [[protein isoform]]s are encoded by [[Transcription (biology)|transcript]] variants of this gene.<ref>{{cite web | title = Entrez Gene: GSTM1 glutathione S-transferase M1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2944| access-date = }}</ref>
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin}}
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{{PBB_Further_reading
* {{cite journal | vauthors = Engel LS, Taioli E, Pfeiffer R, Garcia-Closas M, Marcus PM, Lan Q, Boffetta P, Vineis P, Autrup H, Bell DA, Branch RA, Brockmöller J, Daly AK, Heckbert SR, Kalina I, Kang D, Katoh T, Lafuente A, Lin HJ, Romkes M, Taylor JA, Rothman N | display-authors = 6 | title = Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review | journal = American Journal of Epidemiology | volume = 156 | issue = 2 | pages = 95–109 | date = July 2002 | pmid = 12117698 | doi = 10.1093/aje/kwf018 }}
| citations =
* {{cite journal | vauthors = Navarro SL, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW | title = Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes | journal = Cancer Epidemiology, Biomarkers & Prevention | volume = 18 | issue = 11 | pages = 2974–8 | date = November 2009 | pmid = 19900941 | pmc = 2777676 | doi = 10.1158/1055-9965.EPI-09-0701 }}
*{{cite journal   |vauthors=Engel LS, Taioli E, Pfeiffer R, etal |title=Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review. |journal=Am. J. Epidemiol. |volume=156 |issue= 2 |pages= 95–109 |year= 2002 |pmid= 12117698 |doi=10.1093/aje/kwf018 }}
*{{cite journal |vauthors=Navarro SL, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW |title=Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes. |journal=Cancer Epidemiol Biomarkers Prev. |volume=18 |issue= 11 |pages= 2974–8 |year= 2009 |pmid=19900941 |doi=10.1158/1055-9965.EPI-09-0701 | pmc=2777676 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2944}}
{{PDB Gallery|geneid=2944}}


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{{gene-1-stub}}

Latest revision as of 10:00, 9 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human Glutathione S-transferase.

Function

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione.

The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3, and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins, as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.[1]

References

  1. ↑ "Entrez Gene: GSTM1 glutathione S-transferase M1".

Further reading


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