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*{{cite journal | author=Shamay M |title=Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9982–8 |year= 2002 |pmid= 11788598 |doi= 10.1074/jbc.M111354200 |name-list-format=vanc| author2=Barak O | author3=Doitsh G | display-authors=3 | last4=Ben-Dor | first4=I | last5=Shaul | first5=Y }} | *{{cite journal | author=Shamay M |title=Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9982–8 |year= 2002 |pmid= 11788598 |doi= 10.1074/jbc.M111354200 |name-list-format=vanc| author2=Barak O | author3=Doitsh G | display-authors=3 | last4=Ben-Dor | first4=I | last5=Shaul | first5=Y }} | ||
*{{cite journal |vauthors=Li Y, Lu YY |title=Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells |journal=World J. Gastroenterol. |volume=8 |issue= 2 |pages= 213–6 |year= 2002 |pmid= 11925594 |doi= }} | *{{cite journal |vauthors=Li Y, Lu YY |title=Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells |journal=World J. Gastroenterol. |volume=8 |issue= 2 |pages= 213–6 |year= 2002 |pmid= 11925594 |doi= }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}} | ||
*{{cite journal | author=Marusawa H |title=HBXIP functions as a cofactor of survivin in apoptosis suppression |journal=EMBO J. |volume=22 |issue= 11 |pages= 2729–40 |year= 2003 |pmid= 12773388 |doi= 10.1093/emboj/cdg263 | pmc=156760 |name-list-format=vanc| author2=Matsuzawa S | author3=Welsh K | display-authors=3 | last4=Zou | first4=H | last5=Armstrong | first5=R | last6=Tamm | first6=I | last7=Reed | first7=JC }} | *{{cite journal | author=Marusawa H |title=HBXIP functions as a cofactor of survivin in apoptosis suppression |journal=EMBO J. |volume=22 |issue= 11 |pages= 2729–40 |year= 2003 |pmid= 12773388 |doi= 10.1093/emboj/cdg263 | pmc=156760 |name-list-format=vanc| author2=Matsuzawa S | author3=Welsh K | display-authors=3 | last4=Zou | first4=H | last5=Armstrong | first5=R | last6=Tamm | first6=I | last7=Reed | first7=JC }} | ||
*{{cite journal | author=Kong HJ |title=Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2 |journal=Hepatology |volume=38 |issue= 5 |pages= 1258–66 |year= 2003 |pmid= 14578865 |doi= 10.1053/jhep.2003.50451 |name-list-format=vanc| author2=Park MJ | author3=Hong S | display-authors=3 | last4=Yu | first4=HJ | last5=Lee | first5=YC | last6=Choi | first6=YH | last7=Cheong | first7=J }} | *{{cite journal | author=Kong HJ |title=Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2 |journal=Hepatology |volume=38 |issue= 5 |pages= 1258–66 |year= 2003 |pmid= 14578865 |doi= 10.1053/jhep.2003.50451 |name-list-format=vanc| author2=Park MJ | author3=Hong S | display-authors=3 | last4=Yu | first4=HJ | last5=Lee | first5=YC | last6=Choi | first6=YH | last7=Cheong | first7=J }} | ||
Latest revision as of 19:40, 23 June 2018
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Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.[1][2]
This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.[2]
Interactions
HBXIP has been shown to interact with NCOA6.[3]
References
- ↑ Melegari M, Scaglioni PP, Wands JR (Mar 1998). "Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication". J Virol. 72 (3): 1737–43. PMC 109461. PMID 9499022.
- ↑ 2.0 2.1 "Entrez Gene: HBXIP hepatitis B virus x interacting protein".
- ↑ Kong, Hee Jeong; Park Min Jung; Hong SunHwa; Yu Hyun Jung; Lee Young Chul; Choi Young Hyun; Cheong JaeHun (Nov 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. United States. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. ISSN 0270-9139. PMID 14578865.
Further reading
- Shamay M, Barak O, Doitsh G, et al. (2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J. Biol. Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
- Li Y, Lu YY (2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 213–6. PMID 11925594.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Marusawa H, Matsuzawa S, Welsh K, et al. (2003). "HBXIP functions as a cofactor of survivin in apoptosis suppression". EMBO J. 22 (11): 2729–40. doi:10.1093/emboj/cdg263. PMC 156760. PMID 12773388.
- Kong HJ, Park MJ, Hong S, et al. (2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Lee SH, Park SG, Lim SO, Jung G (2005). "The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes". Biochim. Biophys. Acta. 1741 (1–2): 75–84. doi:10.1016/j.bbadis.2004.10.004. PMID 15955450.
- Lee AT, Ren J, Wong ET, et al. (2005). "The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage". J. Biol. Chem. 280 (39): 33525–35. doi:10.1074/jbc.M506628200. PMID 16055925.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Minczuk M, Mroczek S, Pawlak SD, Stepien PP (2005). "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP". FEBS J. 272 (19): 5008–19. doi:10.1111/j.1742-4658.2005.04910.x. PMID 16176273.
- Muroyama R, Kato N, Yoshida H, et al. (2007). "Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma". J. Hepatol. 45 (6): 805–12. doi:10.1016/j.jhep.2006.07.025. PMID 17050029.
- Chen J, Siddiqui A (2007). "Hepatitis B Virus X Protein Stimulates the Mitochondrial Translocation of Raf-1 via Oxidative Stress". J. Virol. 81 (12): 6757–60. doi:10.1128/JVI.00172-07. PMC 1900104. PMID 17428866.
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