Karyopherin alpha 1: Difference between revisions
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'''Importin subunit alpha-1''' is a [[protein]] that in humans is encoded by the ''KPNA1'' [[gene]].<ref name="pmid8052633">{{cite journal |vauthors=Cortes P, Ye ZS, Baltimore D | title = RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1 | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 16 | pages = 7633–7 |date=Sep 1994 | pmid = 8052633 | pmc = 44456 | doi =10.1073/pnas.91.16.7633 }}</ref> | '''Importin subunit alpha-1''' is a [[protein]] that in humans is encoded by the ''KPNA1'' [[gene]].<ref name="pmid8052633">{{cite journal |vauthors=Cortes P, Ye ZS, Baltimore D | title = RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1 | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 16 | pages = 7633–7 |date=Sep 1994 | pmid = 8052633 | pmc = 44456 | doi =10.1073/pnas.91.16.7633 | bibcode =1994PNAS...91.7633C }}</ref> | ||
==Interactions== | ==Interactions== | ||
| Line 15: | Line 15: | ||
*{{cite journal |vauthors=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138–43 |year= 1998 |pmid= 9562972 | pmc=2230352 |doi= }} | *{{cite journal |vauthors=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138–43 |year= 1998 |pmid= 9562972 | pmc=2230352 |doi= }} | ||
*{{cite journal |vauthors=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }} | *{{cite journal |vauthors=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }} | ||
*{{cite journal |vauthors=Bukrinsky MI, Sharova N, Dempsey MP, etal |title=Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 14 |pages= 6580–4 |year= 1992 |pmid= 1631159 | pmc=49545 |doi=10.1073/pnas.89.14.6580 }} | *{{cite journal |vauthors=Bukrinsky MI, Sharova N, Dempsey MP, etal |title=Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 14 |pages= 6580–4 |year= 1992 |pmid= 1631159 | pmc=49545 |doi=10.1073/pnas.89.14.6580 |bibcode=1992PNAS...89.6580B }} | ||
*{{cite journal |vauthors=Sharova N, Bukrinskaya A |title=p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells. |journal=AIDS Res. Hum. Retroviruses |volume=7 |issue= 3 |pages= 303–6 |year= 1991 |pmid= 2064827 |doi=10.1089/aid.1991.7.303 }} | *{{cite journal |vauthors=Sharova N, Bukrinskaya A |title=p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells. |journal=AIDS Res. Hum. Retroviruses |volume=7 |issue= 3 |pages= 303–6 |year= 1991 |pmid= 2064827 |doi=10.1089/aid.1991.7.303 }} | ||
*{{cite journal |vauthors=Di Marzio P, Choe S, Ebright M, etal |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909–16 |year= 1996 |pmid= 7494303 | pmc=189735 |doi= }} | *{{cite journal |vauthors=Di Marzio P, Choe S, Ebright M, etal |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909–16 |year= 1996 |pmid= 7494303 | pmc=189735 |doi= }} | ||
*{{cite journal |vauthors=Gallay P, Swingler S, Song J, etal |title=HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. |journal=Cell |volume=83 |issue= 4 |pages= 569–76 |year= 1995 |pmid= 7585960 |doi=10.1016/0092-8674(95)90097-7 }} | *{{cite journal |vauthors=Gallay P, Swingler S, Song J, etal |title=HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. |journal=Cell |volume=83 |issue= 4 |pages= 569–76 |year= 1995 |pmid= 7585960 |doi=10.1016/0092-8674(95)90097-7 }} | ||
*{{cite journal |vauthors=Moroianu J, Hijikata M, Blobel G, Radu A |title=Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 14 |pages= 6532–6 |year= 1995 |pmid= 7604027 | pmc=41552 |doi= 10.1073/pnas.92.14.6532}} | *{{cite journal |vauthors=Moroianu J, Hijikata M, Blobel G, Radu A |title=Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 14 |pages= 6532–6 |year= 1995 |pmid= 7604027 | pmc=41552 |doi= 10.1073/pnas.92.14.6532|bibcode=1995PNAS...92.6532M }} | ||
*{{cite journal |vauthors=Freed EO, Englund G, Martin MA |title=Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. |journal=J. Virol. |volume=69 |issue= 6 |pages= 3949–54 |year= 1995 |pmid= 7745752 | pmc=189124 |doi= }} | *{{cite journal |vauthors=Freed EO, Englund G, Martin MA |title=Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. |journal=J. Virol. |volume=69 |issue= 6 |pages= 3949–54 |year= 1995 |pmid= 7745752 | pmc=189124 |doi= }} | ||
*{{cite journal |vauthors=Weis K, Mattaj IW, Lamond AI |title=Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. |journal=Science |volume=268 |issue= 5213 |pages= 1049–53 |year= 1995 |pmid= 7754385 |doi=10.1126/science.7754385 }} | *{{cite journal |vauthors=Weis K, Mattaj IW, Lamond AI |title=Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. |journal=Science |volume=268 |issue= 5213 |pages= 1049–53 |year= 1995 |pmid= 7754385 |doi=10.1126/science.7754385 |bibcode=1995Sci...268.1049W }} | ||
*{{cite journal |vauthors=O'Neill RE, Palese P |title=NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. |journal=Virology |volume=206 |issue= 1 |pages= 116–25 |year= 1995 |pmid= 7831767 |doi=10.1016/S0042-6822(95)80026-3 }} | *{{cite journal |vauthors=O'Neill RE, Palese P |title=NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. |journal=Virology |volume=206 |issue= 1 |pages= 116–25 |year= 1995 |pmid= 7831767 |doi=10.1016/S0042-6822(95)80026-3 }} | ||
*{{cite journal |vauthors=Gallay P, Swingler S, Aiken C, Trono D |title=HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. |journal=Cell |volume=80 |issue= 3 |pages= 379–88 |year= 1995 |pmid= 7859280 |doi=10.1016/0092-8674(95)90488-3 }} | *{{cite journal |vauthors=Gallay P, Swingler S, Aiken C, Trono D |title=HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. |journal=Cell |volume=80 |issue= 3 |pages= 379–88 |year= 1995 |pmid= 7859280 |doi=10.1016/0092-8674(95)90488-3 }} | ||
*{{cite journal |vauthors=Moroianu J, Blobel G, Radu A |title=Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 2008–11 |year= 1995 |pmid= 7892216 | pmc=42412 |doi=10.1073/pnas.92.6.2008 }} | *{{cite journal |vauthors=Moroianu J, Blobel G, Radu A |title=Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 2008–11 |year= 1995 |pmid= 7892216 | pmc=42412 |doi=10.1073/pnas.92.6.2008 |bibcode=1995PNAS...92.2008M }} | ||
*{{cite journal |vauthors=von Schwedler U, Kornbluth RS, Trono D |title=The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 6992–6 |year= 1994 |pmid= 8041734 | pmc=44324 |doi=10.1073/pnas.91.15.6992 }} | *{{cite journal |vauthors=von Schwedler U, Kornbluth RS, Trono D |title=The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 6992–6 |year= 1994 |pmid= 8041734 | pmc=44324 |doi=10.1073/pnas.91.15.6992 |bibcode=1994PNAS...91.6992V }} | ||
*{{cite journal |vauthors=Heinzinger NK, Bukinsky MI, Haggerty SA, etal |title=The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 7311–5 |year= 1994 |pmid= 8041786 | pmc=44389 |doi=10.1073/pnas.91.15.7311 }} | *{{cite journal |vauthors=Heinzinger NK, Bukinsky MI, Haggerty SA, etal |title=The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 7311–5 |year= 1994 |pmid= 8041786 | pmc=44389 |doi=10.1073/pnas.91.15.7311 |bibcode=1994PNAS...91.7311H }} | ||
*{{cite journal |vauthors=Bukrinsky MI, Haggerty S, Dempsey MP, etal |title=A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. |journal=Nature |volume=365 |issue= 6447 |pages= 666–9 |year= 1993 |pmid= 8105392 |doi= 10.1038/365666a0 }} | *{{cite journal |vauthors=Bukrinsky MI, Haggerty S, Dempsey MP, etal |title=A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. |journal=Nature |volume=365 |issue= 6447 |pages= 666–9 |year= 1993 |pmid= 8105392 |doi= 10.1038/365666a0 |bibcode=1993Natur.365..666B }} | ||
*{{cite journal |vauthors=Dubrovsky L, Ulrich P, Nuovo GJ, etal |title=Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. |journal=Mol. Med. |volume=1 |issue= 2 |pages= 217–30 |year= 1996 |pmid= 8529100 | pmc=2229944 |doi= }} | *{{cite journal |vauthors=Dubrovsky L, Ulrich P, Nuovo GJ, etal |title=Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. |journal=Mol. Med. |volume=1 |issue= 2 |pages= 217–30 |year= 1996 |pmid= 8529100 | pmc=2229944 |doi= }} | ||
*{{cite journal |vauthors=Gallay P, Stitt V, Mundy C, etal |title=Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. |journal=J. Virol. |volume=70 |issue= 2 |pages= 1027–32 |year= 1996 |pmid= 8551560 | pmc=189908 |doi= }} | *{{cite journal |vauthors=Gallay P, Stitt V, Mundy C, etal |title=Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. |journal=J. Virol. |volume=70 |issue= 2 |pages= 1027–32 |year= 1996 |pmid= 8551560 | pmc=189908 |doi= }} | ||
*{{cite journal |vauthors=Bukrinskaya AG, Ghorpade A, Heinzinger NK, etal |title=Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 367–71 |year= 1996 |pmid= 8552640 | pmc=40239 |doi=10.1073/pnas.93.1.367 }} | *{{cite journal |vauthors=Bukrinskaya AG, Ghorpade A, Heinzinger NK, etal |title=Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 367–71 |year= 1996 |pmid= 8552640 | pmc=40239 |doi=10.1073/pnas.93.1.367 |bibcode=1996PNAS...93..367B }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
Latest revision as of 17:55, 24 June 2018
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Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene.[1]
Interactions
Karyopherin alpha 1 has been shown to interact with KPNB1[2][3] and UBR5.[4]
References
- ↑ Cortes P, Ye ZS, Baltimore D (Sep 1994). "RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1". Proc Natl Acad Sci U S A. 91 (16): 7633–7. Bibcode:1994PNAS...91.7633C. doi:10.1073/pnas.91.16.7633. PMC 44456. PMID 8052633.
- ↑ Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H; Görlich D; Hartmann E (Nov 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Mol. Cell. Biol. UNITED STATES. 19 (11): 7782–91. doi:10.1128/mcb.19.11.7782. ISSN 0270-7306. PMC 84838. PMID 10523667.
- ↑ Percipalle, P; Clarkson W D; Kent H M; Rhodes D; Stewart M (Mar 1997). "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import". J. Mol. Biol. ENGLAND. 266 (4): 722–32. doi:10.1006/jmbi.1996.0801. ISSN 0022-2836. PMID 9102465.
- ↑ Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A; Sutherland Robert L; Watts Colin K W (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. United States. 277 (29): 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095.
Further reading
- Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear import: in search of a leader". Front. Biosci. 2: d578–87. doi:10.2741/A213. PMID 9366553.
- Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr". Mol. Med. 4 (3): 138–43. PMC 2230352. PMID 9562972.
- Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
- Bukrinsky MI, Sharova N, Dempsey MP, et al. (1992). "Active nuclear import of human immunodeficiency virus type 1 preintegration complexes". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6580–4. Bibcode:1992PNAS...89.6580B. doi:10.1073/pnas.89.14.6580. PMC 49545. PMID 1631159.
- Sharova N, Bukrinskaya A (1991). "p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells". AIDS Res. Hum. Retroviruses. 7 (3): 303–6. doi:10.1089/aid.1991.7.303. PMID 2064827.
- Di Marzio P, Choe S, Ebright M, et al. (1996). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr". J. Virol. 69 (12): 7909–16. PMC 189735. PMID 7494303.
- Gallay P, Swingler S, Song J, et al. (1995). "HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase". Cell. 83 (4): 569–76. doi:10.1016/0092-8674(95)90097-7. PMID 7585960.
- Moroianu J, Hijikata M, Blobel G, Radu A (1995). "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6532–6. Bibcode:1995PNAS...92.6532M. doi:10.1073/pnas.92.14.6532. PMC 41552. PMID 7604027.
- Freed EO, Englund G, Martin MA (1995). "Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection". J. Virol. 69 (6): 3949–54. PMC 189124. PMID 7745752.
- Weis K, Mattaj IW, Lamond AI (1995). "Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences". Science. 268 (5213): 1049–53. Bibcode:1995Sci...268.1049W. doi:10.1126/science.7754385. PMID 7754385.
- O'Neill RE, Palese P (1995). "NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein". Virology. 206 (1): 116–25. doi:10.1016/S0042-6822(95)80026-3. PMID 7831767.
- Gallay P, Swingler S, Aiken C, Trono D (1995). "HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator". Cell. 80 (3): 379–88. doi:10.1016/0092-8674(95)90488-3. PMID 7859280.
- Moroianu J, Blobel G, Radu A (1995). "Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2008–11. Bibcode:1995PNAS...92.2008M. doi:10.1073/pnas.92.6.2008. PMC 42412. PMID 7892216.
- von Schwedler U, Kornbluth RS, Trono D (1994). "The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 6992–6. Bibcode:1994PNAS...91.6992V. doi:10.1073/pnas.91.15.6992. PMC 44324. PMID 8041734.
- Heinzinger NK, Bukinsky MI, Haggerty SA, et al. (1994). "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 7311–5. Bibcode:1994PNAS...91.7311H. doi:10.1073/pnas.91.15.7311. PMC 44389. PMID 8041786.
- Bukrinsky MI, Haggerty S, Dempsey MP, et al. (1993). "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells". Nature. 365 (6447): 666–9. Bibcode:1993Natur.365..666B. doi:10.1038/365666a0. PMID 8105392.
- Dubrovsky L, Ulrich P, Nuovo GJ, et al. (1996). "Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention". Mol. Med. 1 (2): 217–30. PMC 2229944. PMID 8529100.
- Gallay P, Stitt V, Mundy C, et al. (1996). "Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import". J. Virol. 70 (2): 1027–32. PMC 189908. PMID 8551560.
- Bukrinskaya AG, Ghorpade A, Heinzinger NK, et al. (1996). "Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 367–71. Bibcode:1996PNAS...93..367B. doi:10.1073/pnas.93.1.367. PMC 40239. PMID 8552640.
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