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==Interactions==
==Interactions==
DVL3 has been shown to [[Protein-protein interaction|interact]] with [[DAB2]],<ref name=pmid12805222>{{cite journal |last=Hocevar |first=B A |author2=Mou F |author3=Rennolds J L |author4=Morris S M |author5=Cooper J A |author6=Howe P H  |date=June 2003  |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue=12 |pages=3084–94 |publisher= |location = England| issn = 0261-4189| pmid = 12805222 |doi = 10.1093/emboj/cdg286 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=162138 }}</ref> [[DVL1]]<ref name=pmid10330181>{{cite journal |last=Kishida |first=S |author2=Yamamoto H |author3=Hino S |author4=Ikeda S |author5=Kishida M |author6=Kikuchi A  |date=June 1999  |title=DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability |journal=Mol. Cell. Biol. |volume=19 |issue=6 |pages=4414–22 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10330181 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=104400 | doi=10.1128/mcb.19.6.4414}}</ref> and [[PRPF3]].<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=October 2005  |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
DVL3 has been shown to [[Protein-protein interaction|interact]] with [[DAB2]],<ref name=pmid12805222>{{cite journal |last=Hocevar |first=B A |author2=Mou F |author3=Rennolds J L |author4=Morris S M |author5=Cooper J A |author6=Howe P H  |date=June 2003  |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue=12 |pages=3084–94 |publisher= |location = England| issn = 0261-4189| pmid = 12805222 |doi = 10.1093/emboj/cdg286 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=162138 }}</ref> [[DVL1]]<ref name=pmid10330181>{{cite journal |last=Kishida |first=S |author2=Yamamoto H |author3=Hino S |author4=Ikeda S |author5=Kishida M |author6=Kikuchi A  |date=June 1999  |title=DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability |journal=Mol. Cell. Biol. |volume=19 |issue=6 |pages=4414–22 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10330181 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=104400 | doi=10.1128/mcb.19.6.4414}}</ref> and [[PRPF3]].<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=October 2005  |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode =2005Natur.437.1173R | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==See also==
==See also==
Line 26: Line 26:
*{{cite journal  | vauthors=Kishida S, Yamamoto H, Hino S |title=DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4414–22 |year= 1999 |pmid= 10330181 |doi=  10.1128/mcb.19.6.4414| pmc=104400  |display-authors=etal}}
*{{cite journal  | vauthors=Kishida S, Yamamoto H, Hino S |title=DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4414–22 |year= 1999 |pmid= 10330181 |doi=  10.1128/mcb.19.6.4414| pmc=104400  |display-authors=etal}}
*{{cite journal  | vauthors=Song DH, Sussman DJ, Seldin DC |title=Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23790–7 |year= 2000 |pmid= 10806215 |doi= 10.1074/jbc.M909107199 }}
*{{cite journal  | vauthors=Song DH, Sussman DJ, Seldin DC |title=Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23790–7 |year= 2000 |pmid= 10806215 |doi= 10.1074/jbc.M909107199 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | vauthors=Hocevar BA, Mou F, Rennolds JL |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue= 12 |pages= 3084–94 |year= 2003 |pmid= 12805222 |doi= 10.1093/emboj/cdg286  | pmc=162138 |display-authors=etal}}
*{{cite journal  | vauthors=Hocevar BA, Mou F, Rennolds JL |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue= 12 |pages= 3084–94 |year= 2003 |pmid= 12805222 |doi= 10.1093/emboj/cdg286  | pmc=162138 |display-authors=etal}}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | vauthors=Torban E, Wang HJ, Groulx N, Gros P |title=Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52703–13 |year= 2005 |pmid= 15456783 |doi= 10.1074/jbc.M408675200 }}
*{{cite journal  | vauthors=Torban E, Wang HJ, Groulx N, Gros P |title=Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52703–13 |year= 2005 |pmid= 15456783 |doi= 10.1074/jbc.M408675200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }}
*{{cite journal  | vauthors=Chan DW, Chan CY, Yam JW |title=Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer |journal=Gastroenterology |volume=131 |issue= 4 |pages= 1218–27 |year= 2006 |pmid= 17030191 |doi= 10.1053/j.gastro.2006.07.020 |display-authors=etal}}
*{{cite journal  | vauthors=Chan DW, Chan CY, Yam JW |title=Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer |journal=Gastroenterology |volume=131 |issue= 4 |pages= 1218–27 |year= 2006 |pmid= 17030191 |doi= 10.1053/j.gastro.2006.07.020 |display-authors=etal}}
}}
}}

Latest revision as of 07:31, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.[1][2]

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.[2]

Interactions

DVL3 has been shown to interact with DAB2,[3] DVL1[4] and PRPF3.[5]

See also

References

  1. Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B (January 1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum Mol Genet. 5 (7): 953–8. doi:10.1093/hmg/5.7.953. PMID 8817329.
  2. 2.0 2.1 "Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)".
  3. Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. England. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222.
  4. Kishida, S; Yamamoto H; Hino S; Ikeda S; Kishida M; Kikuchi A (June 1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. UNITED STATES. 19 (6): 4414–22. doi:10.1128/mcb.19.6.4414. ISSN 0270-7306. PMC 104400. PMID 10330181.
  5. Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

Further reading