Mucin 7: Difference between revisions
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:''For the MUC-7 conference, see [[Message Understanding Conference]].'' | :''For the MUC-7 conference, see [[Message Understanding Conference]].'' | ||
{{Infobox_gene}} | {{Infobox_gene}} | ||
'''Mucin-7''' is a [[protein]] that in humans is encoded by the ''MUC7'' [[gene]].<ref name="pmid8838308">{{cite journal |vauthors=Bobek LA, Liu J, Sait SN, Shows TB, Bobek YA, Levine MJ | title = Structure and chromosomal localization of the human salivary mucin gene, MUC7 | journal = Genomics | volume = 31 | issue = 3 | pages = 277–82 |date= | '''Mucin-7''' is a [[protein]] that in humans is encoded by the ''MUC7'' [[gene]].<ref name="pmid8838308">{{cite journal | vauthors = Bobek LA, Liu J, Sait SN, Shows TB, Bobek YA, Levine MJ | title = Structure and chromosomal localization of the human salivary mucin gene, MUC7 | journal = Genomics | volume = 31 | issue = 3 | pages = 277–82 | date = February 1996 | pmid = 8838308 | pmc = | doi = 10.1006/geno.1996.0049 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MUC7 mucin 7, secreted| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4589| access-date = }}</ref> In animals, the MUC7 gene is found in most [[placental mammal]]s, but not [[marsupial]]s.<ref name="Xu Pavlidis Thamadilok Redwood 2016"/> | ||
==Human variations== | |||
{{ | Humans carry either a five or six [[tandem repeat]] version of the gene. In other primates, the number of repeats found is 4-5 for [[gorilla]]s, 5 for [[chimpanzee]]s, 6-7 for [[orangutan]]s, 8-10 for [[macaques]], 10-11 for [[baboon]]s and 11-12 for [[green monkey]]s.<ref name="Xu Pavlidis Thamadilok Redwood 2016">{{cite journal | vauthors = Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O | title = Recent evolution of the salivary mucin MUC7 | journal = Scientific Reports | volume = 6 | pages = 31791 | date = August 2016 | pmid = 27558399 | doi = 10.1038/srep31791 | url = https://www.nature.com/articles/srep31791 | access-date = 2018-03-20 }} [[File:CC-BY icon.svg|50px]] This article contains quotations from this source, which is available under the [https://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0)] license.</ref> | ||
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== | Some modern people from [[Sub-Saharan Africa]] were found to carry a five tandem repeat variation of the MUC7 gene that is highly divergent from other, modern humans. The estimated [[Coalescent theory|coalescence age]] for the human variations of the MUC7 gene is estimated to be around 4.5 million years ago, which predates the human-Neanderthal split. [[Neanderthal]]s and [[Denisovan]]s also carry variants that are much closer to those of other, modern humans; thus, researcers postulate that this divergent Sub-Saharan variant most likely [[introgression|introgressed]] from a currently yet-unknown archaic human [[ghost population]].<ref name="Xu Pavlidis Taskent Alachiotis 2017">{{cite journal | vauthors = Xu D, Pavlidis P, Taskent RO, Alachiotis N, Flanagan C, DeGiorgio M, Blekhman R, Ruhl S, Gokcumen O | title = Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation | journal = Molecular Biology and Evolution | volume = 34 | issue = 10 | pages = 2704–2715 | date = October 2017 | pmid = 28957509 | doi = 10.1093/molbev/msx206 | url = https://academic.oup.com/mbe/article/34/10/2704/3988100 | publisher = Oxford University Press (OUP) }} [[File:CC-BY icon.svg|50px]] This article contains quotations from this source, which is available under the [https://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0)] license.</ref> | ||
==Further reading== | == References == | ||
{{reflist|30em}} | |||
== Further reading == | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Zalewska A, Zwierz K, Zółkowski K, Gindzieński A | title = Structure and biosynthesis of human salivary mucins | journal = Acta Biochimica Polonica | volume = 47 | issue = 4 | pages = 1067–79 | year = 2002 | pmid = 11996097 | doi = }} | |||
* {{cite journal | vauthors = Bobek LA, Tsai H, Biesbrock AR, Levine MJ | title = Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7) | journal = The Journal of Biological Chemistry | volume = 268 | issue = 27 | pages = 20563–9 | date = September 1993 | pmid = 7690757 | doi = }} | |||
*{{cite journal | * {{cite journal | vauthors = Troxler RF, Iontcheva I, Oppenheim FG, Nunes DP, Offner GD | title = Molecular characterization of a major high molecular weight mucin from human sublingual gland | journal = Glycobiology | volume = 7 | issue = 7 | pages = 965–73 | date = October 1997 | pmid = 9363439 | doi = 10.1093/glycob/7.7.965 }} | ||
*{{cite journal | * {{cite journal | vauthors = Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ | title = Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity | journal = Biochemistry | volume = 37 | issue = 14 | pages = 4916–27 | date = April 1998 | pmid = 9538010 | doi = 10.1021/bi972612a }} | ||
*{{cite journal | * {{cite journal | vauthors = Kirkbride HJ, Bolscher JG, Nazmi K, Vinall LE, Nash MW, Moss FM, Mitchell DM, Swallow DM | title = Genetic polymorphism of MUC7: allele frequencies and association with asthma | journal = European Journal of Human Genetics | volume = 9 | issue = 5 | pages = 347–54 | date = May 2001 | pmid = 11378823 | doi = 10.1038/sj.ejhg.5200642 }} | ||
*{{cite journal | * {{cite journal | vauthors = Guo JM, Zhang Y, Cheng L, Iwasaki H, Wang H, Kubota T, Tachibana K, Narimatsu H | title = Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12 | journal = FEBS Letters | volume = 524 | issue = 1-3 | pages = 211–8 | date = July 2002 | pmid = 12135769 | doi = 10.1016/S0014-5793(02)03007-7 }} | ||
*{{cite journal | * {{cite journal | vauthors = Cheng L, Tachibana K, Zhang Y, Guo J, Kahori Tachibana K, Kameyama A, Wang H, Hiruma T, Iwasaki H, Togayachi A, Kudo T, Narimatsu H | title = Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10 | journal = FEBS Letters | volume = 531 | issue = 2 | pages = 115–21 | date = November 2002 | pmid = 12417297 | doi = 10.1016/S0014-5793(02)03399-9 }} | ||
*{{cite journal | * {{cite journal | vauthors = Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R, Aceves-Luna E, González-Begné M | title = Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students | journal = Archives of Medical Research | volume = 33 | issue = 5 | pages = 499–505 | year = 2003 | pmid = 12459324 | doi = 10.1016/S0188-4409(02)00395-8 }} | ||
*{{cite journal | * {{cite journal | vauthors = Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H | title = Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14 | journal = Biochemical and Biophysical Research Communications | volume = 300 | issue = 3 | pages = 738–44 | date = January 2003 | pmid = 12507512 | doi = 10.1016/S0006-291X(02)02908-X }} | ||
*{{cite journal | * {{cite journal | vauthors = Soares RV, Siqueira CC, Bruno LS, Oppenheim FG, Offner GD, Troxler RF | title = MG2 and lactoferrin form a heterotypic complex in salivary secretions | journal = Journal of Dental Research | volume = 82 | issue = 6 | pages = 471–5 | date = June 2003 | pmid = 12766201 | doi = 10.1177/154405910308200613 }} | ||
*{{cite journal | * {{cite journal | vauthors = Ge J, Catt DM, Gregory RL | title = Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen | journal = Infection and Immunity | volume = 72 | issue = 11 | pages = 6748–52 | date = November 2004 | pmid = 15501816 | pmc = 523000 | doi = 10.1128/IAI.72.11.6748-6752.2004 }} | ||
* {{cite journal | vauthors = Grys TE, Siegel MB, Lathem WW, Welch RA | title = The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells | journal = Infection and Immunity | volume = 73 | issue = 3 | pages = 1295–303 | date = March 2005 | pmid = 15731026 | pmc = 1064933 | doi = 10.1128/IAI.73.3.1295-1303.2005 }} | |||
*{{cite journal | * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }} | ||
*{{cite journal | * {{cite journal | vauthors = Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD | title = Two-hybrid analysis of human salivary mucin MUC7 interactions | journal = Biochimica et Biophysica Acta | volume = 1746 | issue = 1 | pages = 65–72 | date = October 2005 | pmid = 16203048 | doi = 10.1016/j.bbamcr.2005.08.007 }} | ||
* {{cite journal | vauthors = Li S, Intini G, Bobek LA | title = Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 35 | issue = 1 | pages = 95–102 | date = July 2006 | pmid = 16514118 | pmc = 2658701 | doi = 10.1165/rcmb.2005-0305OC }} | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
{{Mucoproteins}} | {{Mucoproteins}} | ||
Latest revision as of 12:04, 10 January 2019
- For the MUC-7 conference, see Message Understanding Conference.
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Mucin-7 is a protein that in humans is encoded by the MUC7 gene.[1][2] In animals, the MUC7 gene is found in most placental mammals, but not marsupials.[3]
Human variations
Humans carry either a five or six tandem repeat version of the gene. In other primates, the number of repeats found is 4-5 for gorillas, 5 for chimpanzees, 6-7 for orangutans, 8-10 for macaques, 10-11 for baboons and 11-12 for green monkeys.[3]
Some modern people from Sub-Saharan Africa were found to carry a five tandem repeat variation of the MUC7 gene that is highly divergent from other, modern humans. The estimated coalescence age for the human variations of the MUC7 gene is estimated to be around 4.5 million years ago, which predates the human-Neanderthal split. Neanderthals and Denisovans also carry variants that are much closer to those of other, modern humans; thus, researcers postulate that this divergent Sub-Saharan variant most likely introgressed from a currently yet-unknown archaic human ghost population.[4]
References
- ↑ Bobek LA, Liu J, Sait SN, Shows TB, Bobek YA, Levine MJ (February 1996). "Structure and chromosomal localization of the human salivary mucin gene, MUC7". Genomics. 31 (3): 277–82. doi:10.1006/geno.1996.0049. PMID 8838308.
- ↑ "Entrez Gene: MUC7 mucin 7, secreted".
- ↑ 3.0 3.1 Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O (August 2016). "Recent evolution of the salivary mucin MUC7". Scientific Reports. 6: 31791. doi:10.1038/srep31791. PMID 27558399. Retrieved 2018-03-20. File:CC-BY icon.svg This article contains quotations from this source, which is available under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.
- ↑ Xu D, Pavlidis P, Taskent RO, Alachiotis N, Flanagan C, DeGiorgio M, Blekhman R, Ruhl S, Gokcumen O (October 2017). "Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation". Molecular Biology and Evolution. Oxford University Press (OUP). 34 (10): 2704–2715. doi:10.1093/molbev/msx206. PMID 28957509. File:CC-BY icon.svg This article contains quotations from this source, which is available under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.
Further reading
- Zalewska A, Zwierz K, Zółkowski K, Gindzieński A (2002). "Structure and biosynthesis of human salivary mucins". Acta Biochimica Polonica. 47 (4): 1067–79. PMID 11996097.
- Bobek LA, Tsai H, Biesbrock AR, Levine MJ (September 1993). "Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7)". The Journal of Biological Chemistry. 268 (27): 20563–9. PMID 7690757.
- Troxler RF, Iontcheva I, Oppenheim FG, Nunes DP, Offner GD (October 1997). "Molecular characterization of a major high molecular weight mucin from human sublingual gland". Glycobiology. 7 (7): 965–73. doi:10.1093/glycob/7.7.965. PMID 9363439.
- Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ (April 1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity". Biochemistry. 37 (14): 4916–27. doi:10.1021/bi972612a. PMID 9538010.
- Kirkbride HJ, Bolscher JG, Nazmi K, Vinall LE, Nash MW, Moss FM, Mitchell DM, Swallow DM (May 2001). "Genetic polymorphism of MUC7: allele frequencies and association with asthma". European Journal of Human Genetics. 9 (5): 347–54. doi:10.1038/sj.ejhg.5200642. PMID 11378823.
- Guo JM, Zhang Y, Cheng L, Iwasaki H, Wang H, Kubota T, Tachibana K, Narimatsu H (July 2002). "Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12". FEBS Letters. 524 (1–3): 211–8. doi:10.1016/S0014-5793(02)03007-7. PMID 12135769.
- Cheng L, Tachibana K, Zhang Y, Guo J, Kahori Tachibana K, Kameyama A, Wang H, Hiruma T, Iwasaki H, Togayachi A, Kudo T, Narimatsu H (November 2002). "Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10". FEBS Letters. 531 (2): 115–21. doi:10.1016/S0014-5793(02)03399-9. PMID 12417297.
- Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R, Aceves-Luna E, González-Begné M (2003). "Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students". Archives of Medical Research. 33 (5): 499–505. doi:10.1016/S0188-4409(02)00395-8. PMID 12459324.
- Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H (January 2003). "Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14". Biochemical and Biophysical Research Communications. 300 (3): 738–44. doi:10.1016/S0006-291X(02)02908-X. PMID 12507512.
- Soares RV, Siqueira CC, Bruno LS, Oppenheim FG, Offner GD, Troxler RF (June 2003). "MG2 and lactoferrin form a heterotypic complex in salivary secretions". Journal of Dental Research. 82 (6): 471–5. doi:10.1177/154405910308200613. PMID 12766201.
- Ge J, Catt DM, Gregory RL (November 2004). "Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen". Infection and Immunity. 72 (11): 6748–52. doi:10.1128/IAI.72.11.6748-6752.2004. PMC 523000. PMID 15501816.
- Grys TE, Siegel MB, Lathem WW, Welch RA (March 2005). "The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells". Infection and Immunity. 73 (3): 1295–303. doi:10.1128/IAI.73.3.1295-1303.2005. PMC 1064933. PMID 15731026.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD (October 2005). "Two-hybrid analysis of human salivary mucin MUC7 interactions". Biochimica et Biophysica Acta. 1746 (1): 65–72. doi:10.1016/j.bbamcr.2005.08.007. PMID 16203048.
- Li S, Intini G, Bobek LA (July 2006). "Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo". American Journal of Respiratory Cell and Molecular Biology. 35 (1): 95–102. doi:10.1165/rcmb.2005-0305OC. PMC 2658701. PMID 16514118.
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