KLRA1: Difference between revisions

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'''Ly-49 receptors''' or '''killer cell lectin-like receptor subfamily A''' ('''KLRA'''), are a class of [[natural killer cell]] receptor.<ref name="pmid15593300">{{cite journal |vauthors=Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S | title = The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex | journal = Eur. J. Immunol. | volume = 35 | issue = 1 | pages = 261–72 |date=January 2005 | pmid = 15593300 | doi = 10.1002/eji.200425429  }}</ref><ref name="pmid17056508">{{cite journal |vauthors=Gays F, Aust JG, Reid DM, Falconer J, Toyama-Sorimachi N, Taylor PR, Brooks CG | title = Ly49B is expressed on multiple subpopulations of myeloid cells | journal = J. Immunol. | volume = 177 | issue = 9 | pages = 5840–51 |date=November 2006 | pmid = 17056508 | doi = 10.4049/jimmunol.177.9.5840}}</ref> Ly-49 proteins are a diverse set of C-type [[lectin]]s that are expressed on NK cells in some mammals, including rodents but not humans. Their primary function is to bind host [[MHC class I]] as a mechanism of self/health recognition. Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. In the case of cancer or virally infected cells, MHC-I will often be downregulated in order to limit [[cytotoxic T cell]] mediated killing of the cell, whereby NK cells will lack Ly-49 inhibitory signal and be able to kill infected or cancerous target cells.
'''Ly-49 receptors''' or '''killer cell lectin-like receptor subfamily A''' ('''KLRA'''), are a class of [[natural killer cell]] receptor.<ref name="pmid15593300">{{cite journal |vauthors=Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S | title = The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex | journal = Eur. J. Immunol. | volume = 35 | issue = 1 | pages = 261–72 |date=January 2005 | pmid = 15593300 | doi = 10.1002/eji.200425429  }}</ref><ref name="pmid17056508">{{cite journal |vauthors=Gays F, Aust JG, Reid DM, Falconer J, Toyama-Sorimachi N, Taylor PR, Brooks CG | title = Ly49B is expressed on multiple subpopulations of myeloid cells | journal = J. Immunol. | volume = 177 | issue = 9 | pages = 5840–51 |date=November 2006 | pmid = 17056508 | doi = 10.4049/jimmunol.177.9.5840}}</ref> Ly-49 proteins are a diverse set of C-type [[lectin]]s that are expressed on NK cells in some mammals, including rodents but not humans. Their primary function is to bind host [[MHC class I]] as a mechanism of self/health recognition. Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. In the case of cancer or virally infected cells, MHC-I will often be downregulated in order to limit [[cytotoxic T cell]] mediated killing of the cell, whereby NK cells will lack Ly-49 inhibitory signal and be able to kill infected or cancerous target cells.


The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for [[nonsense-mediated decay]] (NMD).<ref name="pmid10369937">{{cite journal |vauthors=Barten R, Trowsdale J | title = The human Ly-49L gene | journal = Immunogenetics | volume = 49 | issue = 7-8 | pages = 731–4 |date=July 1999 | pmid = 10369937 | doi = 10.1007/s002510050675}}</ref><ref name="pmid16492762">{{cite journal |vauthors=Hao L, Klein J, Nei M | title = Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 9 | pages = 3192–7 |date=February 2006 | pmid = 16492762 | pmc = 1413923 | doi = 10.1073/pnas.0511280103 }}</ref>
The homologous human KLRAP1 [[gene]] has been classified as a transcribed pseudogene because all associated transcripts are candidates for [[nonsense-mediated decay]] (NMD).<ref name="pmid10369937">{{cite journal |vauthors=Barten R, Trowsdale J | title = The human Ly-49L gene | journal = Immunogenetics | volume = 49 | issue = 7-8 | pages = 731–4 |date=July 1999 | pmid = 10369937 | doi = 10.1007/s002510050675}}</ref><ref name="pmid16492762">{{cite journal |vauthors=Hao L, Klein J, Nei M | title = Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 9 | pages = 3192–7 |date=February 2006 | pmid = 16492762 | pmc = 1413923 | doi = 10.1073/pnas.0511280103 }}</ref>


==References==
==References==

Latest revision as of 19:44, 19 February 2018

killer cell lectin-like receptor, subfamily A, member 2
Identifiers
OrganismMus musculus
SymbolKlra2
Alt. symbolsLy49b; Klra30
Entrez16633
RefSeq (mRNA)NM_008462.5
RefSeq (Prot)NP_032488.4
UniProtQ60660
Other data
Chromosome6: 131.22 - 131.25 Mb
Killer cell lectin-like receptor subfamily A pseudogene 1
Identifiers
SymbolKLRAP1
Alt. symbolsKLRA1; Ly49; LY49L; Ly-49L
Entrez10748
HUGO6372
OMIM604274
RefSeqNM_006611
UniProtO75889
Other data
LocusChr. 12 p12-p13

Ly-49 receptors or killer cell lectin-like receptor subfamily A (KLRA), are a class of natural killer cell receptor.[1][2] Ly-49 proteins are a diverse set of C-type lectins that are expressed on NK cells in some mammals, including rodents but not humans. Their primary function is to bind host MHC class I as a mechanism of self/health recognition. Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. In the case of cancer or virally infected cells, MHC-I will often be downregulated in order to limit cytotoxic T cell mediated killing of the cell, whereby NK cells will lack Ly-49 inhibitory signal and be able to kill infected or cancerous target cells.

The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD).[3][4]

References

  1. ↑ Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S (January 2005). "The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex". Eur. J. Immunol. 35 (1): 261–72. doi:10.1002/eji.200425429. PMID 15593300.
  2. ↑ Gays F, Aust JG, Reid DM, Falconer J, Toyama-Sorimachi N, Taylor PR, Brooks CG (November 2006). "Ly49B is expressed on multiple subpopulations of myeloid cells". J. Immunol. 177 (9): 5840–51. doi:10.4049/jimmunol.177.9.5840. PMID 17056508.
  3. ↑ Barten R, Trowsdale J (July 1999). "The human Ly-49L gene". Immunogenetics. 49 (7–8): 731–4. doi:10.1007/s002510050675. PMID 10369937.
  4. ↑ Hao L, Klein J, Nei M (February 2006). "Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals". Proc. Natl. Acad. Sci. U.S.A. 103 (9): 3192–7. doi:10.1073/pnas.0511280103. PMC 1413923. PMID 16492762.

External links


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