Mitochondrial translational release factor 1: Difference between revisions
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*{{cite journal |vauthors=Young DJ, Edgar CD, Murphy J, etal | title= Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. | journal=RNA |volume= 16 |pages= 1146–55 |year= 2010 |pmid= 20421313 |doi=10.1261/rna.1970310 |issue=6 |pmc=2874167}} | *{{cite journal |vauthors=Young DJ, Edgar CD, Murphy J, etal | title= Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. | journal=RNA |volume= 16 |pages= 1146–55 |year= 2010 |pmid= 20421313 |doi=10.1261/rna.1970310 |issue=6 |pmc=2874167}} | ||
*{{cite journal|last=Huynen, MA|first=Martijn|author2=Duarte I |author3=Chrzanowska-Lightowlers ZM |author4=Nabuurs SB. |title=Structure based hypothesis of a mitochondrial ribosome rescue mechanism.|journal=Biology Direct|date=8 May 2012|volume=7|issue=1|pages=14|doi=10.1186/1745-6150-7-14|pmid=22569235|pmc=3418547}} | *{{cite journal|last=Huynen, MA|first=Martijn|author2=Duarte I |author3=Chrzanowska-Lightowlers ZM |author4=Nabuurs SB. |title=Structure based hypothesis of a mitochondrial ribosome rescue mechanism.|journal=Biology Direct|date=8 May 2012|volume=7|issue=1|pages=14|doi=10.1186/1745-6150-7-14|pmid=22569235|pmc=3418547}} | ||
*{{cite journal|last=Lind |first=C |author2=Sund J| author3=Åqvist J| title=Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons.|journal=Nature Communications |year=2013|doi=10.1038/ncomms3940|volume=4}} | |||
{{refend}} | {{refend}} | ||
Latest revision as of 11:26, 9 January 2019
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Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.[1][2]
The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.
References
- ↑ Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta. 1443 (1–2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.
- ↑ Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 91–2. doi:10.1159/000015494. PMID 10773675.
Further reading
- Nozaki Y, Matsunaga N, Ishizawa T, et al. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG". Genes Cells. 13 (5): 429–38. doi:10.1111/j.1365-2443.2008.01181.x. PMID 18429816.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Soleimanpour-Lichaei HR, Kühl I, Gaisne M, et al. (2007). "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG". Molecular Cell. 27 (5): 745–57. doi:10.1016/j.molcel.2007.06.031. PMC 1976341. PMID 17803939.
- Young DJ, Edgar CD, Murphy J, et al. (2010). "Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria". RNA. 16 (6): 1146–55. doi:10.1261/rna.1970310. PMC 2874167. PMID 20421313.
- Huynen, MA, Martijn; Duarte I; Chrzanowska-Lightowlers ZM; Nabuurs SB. (8 May 2012). "Structure based hypothesis of a mitochondrial ribosome rescue mechanism". Biology Direct. 7 (1): 14. doi:10.1186/1745-6150-7-14. PMC 3418547. PMID 22569235.
- Lind, C; Sund J; Åqvist J (2013). "Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons". Nature Communications. 4. doi:10.1038/ncomms3940.
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