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It is expressed as a [[transmembrane protein]], but a soluble form cleaved off by [[ADAM17]] is active in inhibiting [[adipogenesis]],<ref>{{cite journal |vauthors=Wang Y, Sul HS | title = Pref-1 Regulates Mesenchymal Cell Commitment and Differentiation through Sox9 | journal = Cell Metabolism | volume = 9 | issue = 3 | pages = 287–302 | year = 2009 | pmid = 19254573 | pmc = 2673480 | doi = 10.1016/j.cmet.2009.01.013 }}</ref> the differentiation of pre-adipocytes into [[adipocytes]].<ref>{{MeshName|Adipogenesis}}</ref>
It is expressed as a [[transmembrane protein]], but a soluble form cleaved off by [[ADAM17]] is active in inhibiting [[adipogenesis]],<ref>{{cite journal |vauthors=Wang Y, Sul HS | title = Pref-1 Regulates Mesenchymal Cell Commitment and Differentiation through Sox9 | journal = Cell Metabolism | volume = 9 | issue = 3 | pages = 287–302 | year = 2009 | pmid = 19254573 | pmc = 2673480 | doi = 10.1016/j.cmet.2009.01.013 }}</ref> the differentiation of pre-adipocytes into [[adipocytes]].<ref>{{MeshName|Adipogenesis}}</ref>


It is a member of the [[EGF-like domain|EGF-like]] family of [[homeosis|homeotic]] proteins.<ref>{{cite journal | author = Laborda J | title = The role of the epidermal growth factor-like protein dlk in cell differentiation | journal = Histology and histopathology | volume = 15 | issue = 1 | pages = 119–29 | year = 2000 | pmid = 10668203 }}</ref>
It is a member of the [[EGF-like domain|EGF-like]] family of [[homeosis|homeotic]] proteins.<ref>{{cite journal | author = Laborda J | title = The role of the epidermal growth factor-like protein dlk in cell differentiation | journal = Histology and Histopathology | volume = 15 | issue = 1 | pages = 119–29 | year = 2000 | pmid = 10668203 }}</ref>


==References==
==References==
Line 12: Line 12:
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal |doi=10.1093/nar/18.3.685 |title=The sequence of an adrenal specific human cDNA, pG2 |year=1990 |last1=Helamn |first1=Lee J. |last2=Sack |first2=Nancy |last3=Plon |first3=Sharon E. |last4=Israel |first4=Mark A. |journal=Nucleic Acids Research |volume=18 |issue=3 |pages=685–685}}
*{{cite journal |doi=10.1093/nar/18.3.685 |pmid=2308864 |pmc=333507 |title=The sequence of an adrenal specific human cDNA, pG2 |year=1990 |last1=Helamn |first1=Lee J. |last2=Sack |first2=Nancy |last3=Plon |first3=Sharon E. |last4=Israel |first4=Mark A. |journal=Nucleic Acids Research |volume=18 |issue=3 |pages=685}}
*{{cite journal |pages=2336–9 |doi=10.1073/pnas.84.8.2336 |title=Molecular Markers of Neuroendocrine Development and Evidence of Environmental Regulation |year=1987 |last1=Helman |first1=L. J. |journal=Proceedings of the National Academy of Sciences |volume=84 |issue=8}}
*{{cite journal |pages=2336–9 |doi=10.1073/pnas.84.8.2336 |pmid=3470797 |title=Molecular Markers of Neuroendocrine Development and Evidence of Environmental Regulation |year=1987 |last1=Helman |first1=L. J. |journal=Proceedings of the National Academy of Sciences |volume=84 |issue=8|pmc=304645 |bibcode=1987PNAS...84.2336H }}
*{{cite journal |vauthors=Lee YL, Helman L, Hoffman T, Laborda J | title = Dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA | journal = Biochimica et Biophysica Acta | volume = 1261 | issue = 2 | pages = 223–32 | year = 1995 | pmid = 7711066 | doi = 10.1016/0167-4781(95)00007-4 }}
*{{cite journal |vauthors=Lee YL, Helman L, Hoffman T, Laborda J | title = Dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA | journal = Biochimica et Biophysica Acta | volume = 1261 | issue = 2 | pages = 223–32 | year = 1995 | pmid = 7711066 | doi = 10.1016/0167-4781(95)00007-4 }}
*{{cite journal |vauthors=Smas CM, Sul HS | title = Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation | journal = Cell | volume = 73 | issue = 4 | pages = 725–34 | year = 1993 | pmid = 8500166 | doi = 10.1016/0092-8674(93)90252-L }}
*{{cite journal |vauthors=Smas CM, Sul HS | title = Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation | journal = Cell | volume = 73 | issue = 4 | pages = 725–34 | year = 1993 | pmid = 8500166 | doi = 10.1016/0092-8674(93)90252-L }}
*{{cite journal |vauthors=Jensen CH, Teisner B, Højrup P, Rasmussen HB, Madsen OD, Nielsen B, Skjødt K | title = Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2 | journal = Human Reproduction | volume = 8 | issue = 4 | pages = 635–41 | year = 1993 | pmid = 8501199 }}
*{{cite journal |vauthors=Jensen CH, Teisner B, Højrup P, Rasmussen HB, Madsen OD, Nielsen B, Skjødt K | title = Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2 | journal = Human Reproduction | volume = 8 | issue = 4 | pages = 635–41 | year = 1993 | pmid = 8501199 | doi=10.1093/oxfordjournals.humrep.a138110}}
*{{cite journal |vauthors=Tornehave D, Jensen CH, Teisner B, Larsson LI | title = FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression | journal = Histochemistry and Cell Biology | volume = 106 | issue = 6 | pages = 535–42 | year = 1996 | pmid = 8985741 | doi = 10.1007/BF02473268 }}
*{{cite journal |vauthors=Tornehave D, Jensen CH, Teisner B, Larsson LI | title = FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression | journal = Histochemistry and Cell Biology | volume = 106 | issue = 6 | pages = 535–42 | year = 1996 | pmid = 8985741 | doi = 10.1007/BF02473268 }}
*{{cite journal |vauthors=Jensen CH, Schroder HD, Teisner B, Laursen I, Brandrup F, Rasmussen HB | title = Fetal antigen 1, a member of the epidermal growth factor superfamily, in neurofibromas and serum from patients with neurofibromatosis type 1 | journal = British Journal of Dermatology | volume = 140 | issue = 6 | pages = 1054–9 | year = 1999 | pmid = 10354070 | doi = 10.1046/j.1365-2133.1999.02906.x }}
*{{cite journal |vauthors=Jensen CH, Schroder HD, Teisner B, Laursen I, Brandrup F, Rasmussen HB | title = Fetal antigen 1, a member of the epidermal growth factor superfamily, in neurofibromas and serum from patients with neurofibromatosis type 1 | journal = British Journal of Dermatology | volume = 140 | issue = 6 | pages = 1054–9 | year = 1999 | pmid = 10354070 | doi = 10.1046/j.1365-2133.1999.02906.x }}
*{{cite journal |pages=206–7 |doi=10.1159/000015259 |title=Assignment of DLK1 to human chromosome band 14q32 by in situ hybridization |year=1999 |last1=Gubina |first1=E. |last2=Ruiz-Hidalgo |first2=M.J. |last3=Baladr&oacute;n |first3=V. |last4=Laborda |first4=J. |journal=Cytogenetic and Genome Research |volume=84 |issue=3–4}}
*{{cite journal |pages=206–7 |doi=10.1159/000015259 |pmid=10393432 |title=Assignment of DLK1 to human chromosome band 14q32 by in situ hybridization |year=1999 |last1=Gubina |first1=E. |last2=Ruiz-Hidalgo |first2=M.J. |last3=Baladr&oacute;n |first3=V. |last4=Laborda |first4=J. |journal=Cytogenetic and Genome Research |volume=84 |issue=3–4}}
*{{cite journal |vauthors=Jensen CH, Erb K, Westergaard LG, Kliem A, Teisner B | title = Fetal antigen 1, an EGF multidomain protein in the sex hormone-producing cells of the gonads and the microenvironment of germ cells | journal = Molecular Human Reproduction | volume = 5 | issue = 10 | pages = 908–13 | year = 1999 | pmid = 10508217 | doi = 10.1093/molehr/5.10.908 }}
*{{cite journal |vauthors=Jensen CH, Erb K, Westergaard LG, Kliem A, Teisner B | title = Fetal antigen 1, an EGF multidomain protein in the sex hormone-producing cells of the gonads and the microenvironment of germ cells | journal = Molecular Human Reproduction | volume = 5 | issue = 10 | pages = 908–13 | year = 1999 | pmid = 10508217 | doi = 10.1093/molehr/5.10.908 }}
*{{cite journal |vauthors=Aguan K, Carvajal JA, Thompson LP, Weiner CP | title = Application of a functional genomics approach to identify differentially expressed genes in human myometrium during pregnancy and labour | journal = Molecular Human Reproduction | volume = 6 | issue = 12 | pages = 1141–5 | year = 2000 | pmid = 11101697 | doi = 10.1093/molehr/6.12.1141 }}
*{{cite journal |vauthors=Aguan K, Carvajal JA, Thompson LP, Weiner CP | title = Application of a functional genomics approach to identify differentially expressed genes in human myometrium during pregnancy and labour | journal = Molecular Human Reproduction | volume = 6 | issue = 12 | pages = 1141–5 | year = 2000 | pmid = 11101697 | doi = 10.1093/molehr/6.12.1141 }}
Line 27: Line 27:
*{{cite journal |vauthors=Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS | title = Notch Ligands Are Substrates for Protein O-Fucosyltransferase-1 and Fringe | journal = Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29945–52 | year = 2002 | pmid = 12036964 | doi = 10.1074/jbc.M204445200 }}
*{{cite journal |vauthors=Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS | title = Notch Ligands Are Substrates for Protein O-Fucosyltransferase-1 and Fringe | journal = Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29945–52 | year = 2002 | pmid = 12036964 | doi = 10.1074/jbc.M204445200 }}
*{{cite journal |vauthors=Doggett KL, Briggs JA, Linton MF, Fazio S, Head DR, Xie J, Hashimoto Y, Laborda J, Briggs RC | title = Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulatesDlk1 expression | journal = Journal of Cellular Biochemistry | volume = 86 | issue = 1 | pages = 56–66 | year = 2002 | pmid = 12112016 | doi = 10.1002/jcb.10190  }}
*{{cite journal |vauthors=Doggett KL, Briggs JA, Linton MF, Fazio S, Head DR, Xie J, Hashimoto Y, Laborda J, Briggs RC | title = Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulatesDlk1 expression | journal = Journal of Cellular Biochemistry | volume = 86 | issue = 1 | pages = 56–66 | year = 2002 | pmid = 12112016 | doi = 10.1002/jcb.10190  }}
*{{cite journal |vauthors=Van Limpt VA, Chan AJ, Van Sluis PG, Caron HN, Van Noesel CJ, Versteeg R | title = High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type | journal = International Journal of Cancer | volume = 105 | pages = 61–9 | year = 2003 | pmid = 12672031 | doi = 10.1002/ijc.11047 }}
*{{cite journal |vauthors=Van Limpt VA, Chan AJ, Van Sluis PG, Caron HN, Van Noesel CJ, Versteeg R | title = High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type | journal = International Journal of Cancer | volume = 105 | issue = 1 | pages = 61–9 | year = 2003 | pmid = 12672031 | doi = 10.1002/ijc.11047 }}
*{{cite journal |vauthors=Abdallah BM, Jensen CH, Gutierrez G, Leslie RG, Jensen TG, Kassem M | title = Regulation of Human Skeletal Stem Cells Differentiation by Dlk1/Pref-1 | journal = Journal of Bone and Mineral Research | volume = 19 | issue = 5 | pages = 841–52 | year = 2004 | pmid = 15068508 | doi = 10.1359/JBMR.040118 }}
*{{cite journal |vauthors=Abdallah BM, Jensen CH, Gutierrez G, Leslie RG, Jensen TG, Kassem M | title = Regulation of Human Skeletal Stem Cells Differentiation by Dlk1/Pref-1 | journal = Journal of Bone and Mineral Research | volume = 19 | issue = 5 | pages = 841–52 | year = 2004 | pmid = 15068508 | doi = 10.1359/JBMR.040118 }}
{{refend}}
{{refend}}

Latest revision as of 06:23, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein delta homolog 1 is a protein that in humans is encoded by the DLK1 gene.[1][2][3]

It is expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis,[4] the differentiation of pre-adipocytes into adipocytes.[5]

It is a member of the EGF-like family of homeotic proteins.[6]

References

  1. ↑ Laborda J, Sausville EA, Hoffman T, Notario V (1993). "dlk, a Putative Mammalian Homeotic Gene Differentially Expressed in Small Cell Lung Carcinoma and Neuroendocrine Tumor Cell Line". The Journal of Biological Chemistry. 268 (6): 3817–20. PMID 8095043.
  2. ↑ Jensen CH, Krogh TN, Højrup P, Clausen PP, Skjødt K, Larsson LI, Enghild JJ, Teisner B (1994). "Protein Structure of Fetal Antigen 1 (FA1). A Novel Circulating Human Epidermal-Growth-Factor-Like Protein Expressed in Neuroendocrine Tumors and its Relation to the Gene Products of Dlk and pG2". European Journal of Biochemistry. 225 (1): 83–92. doi:10.1111/j.1432-1033.1994.00083.x. PMID 7925474.
  3. ↑ EntrezGene 8788
  4. ↑ Wang Y, Sul HS (2009). "Pref-1 Regulates Mesenchymal Cell Commitment and Differentiation through Sox9". Cell Metabolism. 9 (3): 287–302. doi:10.1016/j.cmet.2009.01.013. PMC 2673480. PMID 19254573.
  5. ↑ Adipogenesis at the US National Library of Medicine Medical Subject Headings (MeSH)
  6. ↑ Laborda J (2000). "The role of the epidermal growth factor-like protein dlk in cell differentiation". Histology and Histopathology. 15 (1): 119–29. PMID 10668203.

Further reading

  • Helamn, Lee J.; Sack, Nancy; Plon, Sharon E.; Israel, Mark A. (1990). "The sequence of an adrenal specific human cDNA, pG2". Nucleic Acids Research. 18 (3): 685. doi:10.1093/nar/18.3.685. PMC 333507. PMID 2308864.
  • Helman, L. J. (1987). "Molecular Markers of Neuroendocrine Development and Evidence of Environmental Regulation". Proceedings of the National Academy of Sciences. 84 (8): 2336–9. Bibcode:1987PNAS...84.2336H. doi:10.1073/pnas.84.8.2336. PMC 304645. PMID 3470797.
  • Lee YL, Helman L, Hoffman T, Laborda J (1995). "Dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA". Biochimica et Biophysica Acta. 1261 (2): 223–32. doi:10.1016/0167-4781(95)00007-4. PMID 7711066.
  • Smas CM, Sul HS (1993). "Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation". Cell. 73 (4): 725–34. doi:10.1016/0092-8674(93)90252-L. PMID 8500166.
  • Jensen CH, Teisner B, Højrup P, Rasmussen HB, Madsen OD, Nielsen B, Skjødt K (1993). "Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2". Human Reproduction. 8 (4): 635–41. doi:10.1093/oxfordjournals.humrep.a138110. PMID 8501199.
  • Tornehave D, Jensen CH, Teisner B, Larsson LI (1996). "FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression". Histochemistry and Cell Biology. 106 (6): 535–42. doi:10.1007/BF02473268. PMID 8985741.
  • Jensen CH, Schroder HD, Teisner B, Laursen I, Brandrup F, Rasmussen HB (1999). "Fetal antigen 1, a member of the epidermal growth factor superfamily, in neurofibromas and serum from patients with neurofibromatosis type 1". British Journal of Dermatology. 140 (6): 1054–9. doi:10.1046/j.1365-2133.1999.02906.x. PMID 10354070.
  • Gubina, E.; Ruiz-Hidalgo, M.J.; Baladrón, V.; Laborda, J. (1999). "Assignment of DLK1 to human chromosome band 14q32 by in situ hybridization". Cytogenetic and Genome Research. 84 (3–4): 206–7. doi:10.1159/000015259. PMID 10393432.
  • Jensen CH, Erb K, Westergaard LG, Kliem A, Teisner B (1999). "Fetal antigen 1, an EGF multidomain protein in the sex hormone-producing cells of the gonads and the microenvironment of germ cells". Molecular Human Reproduction. 5 (10): 908–13. doi:10.1093/molehr/5.10.908. PMID 10508217.
  • Aguan K, Carvajal JA, Thompson LP, Weiner CP (2000). "Application of a functional genomics approach to identify differentially expressed genes in human myometrium during pregnancy and labour". Molecular Human Reproduction. 6 (12): 1141–5. doi:10.1093/molehr/6.12.1141. PMID 11101697.
  • Andersen, M. (2001). "Fetal Antigen 1 in Healthy Adults and Patients with Pituitary Disease: Relation to Physiological, Pathological, and Pharmacological GH Levels". Journal of Clinical Endocrinology & Metabolism. 86 (11): 5465–70. doi:10.1210/jc.86.11.5465.
  • Jensen CH, Meyer M, Schroder HD, Kliem A, Zimmer J, Teisner B (2001). "Neurons in the monoaminergic nuclei of the rat and human central nervous system express FA1/dlk". NeuroReport. 12 (18): 3959–63. doi:10.1097/00001756-200112210-00021. PMID 11742219.
  • Baladrón V, Ruiz-Hidalgo MJ, Bonvini E, Gubina E, Notario V, Laborda J (2002). "The EGF-like Homeotic Protein dlk Affects Cell Growth and Interacts with Growth-Modulating Molecules in the Yeast Two-Hybrid System". Biochemical and Biophysical Research Communications. 291 (2): 193–204. doi:10.1006/bbrc.2002.6431. PMID 11846389.
  • Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS (2002). "Notch Ligands Are Substrates for Protein O-Fucosyltransferase-1 and Fringe". Journal of Biological Chemistry. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.
  • Doggett KL, Briggs JA, Linton MF, Fazio S, Head DR, Xie J, Hashimoto Y, Laborda J, Briggs RC (2002). "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulatesDlk1 expression". Journal of Cellular Biochemistry. 86 (1): 56–66. doi:10.1002/jcb.10190. PMID 12112016.
  • Van Limpt VA, Chan AJ, Van Sluis PG, Caron HN, Van Noesel CJ, Versteeg R (2003). "High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type". International Journal of Cancer. 105 (1): 61–9. doi:10.1002/ijc.11047. PMID 12672031.
  • Abdallah BM, Jensen CH, Gutierrez G, Leslie RG, Jensen TG, Kassem M (2004). "Regulation of Human Skeletal Stem Cells Differentiation by Dlk1/Pref-1". Journal of Bone and Mineral Research. 19 (5): 841–52. doi:10.1359/JBMR.040118. PMID 15068508.


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