POLR2C: Difference between revisions

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POLR2C has been shown to [[Protein-protein interaction|interact]] with:
POLR2C has been shown to [[Protein-protein interaction|interact]] with:
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* [[ATF4]],<ref name = pmid12860379>{{cite journal | vauthors = De Angelis R, Iezzi S, Bruno T, Corbi N, Di Padova M, Floridi A, Fanciulli M, Passananti C | title = Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4) | journal = FEBS Lett. | volume = 547 | issue = 1-3 | pages = 15–9 | date = Jul 2003 | pmid = 12860379 | doi =  10.1016/s0014-5793(03)00659-8}}</ref>  
* [[ATF4]],<ref name = pmid12860379>{{cite journal | vauthors = De Angelis R, Iezzi S, Bruno T, Corbi N, Di Padova M, Floridi A, Fanciulli M, Passananti C | title = Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4) | journal = FEBS Lett. | volume = 547 | issue = 1–3 | pages = 15–9 | date = Jul 2003 | pmid = 12860379 | doi =  10.1016/s0014-5793(03)00659-8}}</ref>  
* [[CCHCR1]],<ref name = pmid16141233>{{cite journal | vauthors = Corbi N, Bruno T, De Angelis R, Di Padova M, Libri V, Di Certo MG, Spinardi L, Floridi A, Fanciulli M, Passananti C | title = RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product | journal = J. Cell Sci. | volume = 118 | issue = Pt 18 | pages = 4253–60 | date = Sep 2005 | pmid = 16141233 | doi = 10.1242/jcs.02545 }}</ref>  
* [[CCHCR1]],<ref name = pmid16141233>{{cite journal | vauthors = Corbi N, Bruno T, De Angelis R, Di Padova M, Libri V, Di Certo MG, Spinardi L, Floridi A, Fanciulli M, Passananti C | title = RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product | journal = J. Cell Sci. | volume = 118 | issue = Pt 18 | pages = 4253–60 | date = Sep 2005 | pmid = 16141233 | doi = 10.1242/jcs.02545 }}</ref>  
* [[Myogenin]],<ref name = pmid12207009/>
* [[Myogenin]],<ref name = pmid12207009/>
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* [[POLR2K]],<ref name = pmid9201987/>  
* [[POLR2K]],<ref name = pmid9201987/>  
* [[POLR2L]],<ref name = pmid9201987/>  and
* [[POLR2L]],<ref name = pmid9201987/>  and
* [[TAF15]].<ref name = pmid9488465>{{cite journal | vauthors = Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L | title = EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes | journal = Mol. Cell. Biol. | volume = 18 | issue = 3 | pages = 1489–97 | date = Mar 1998 | pmid = 9488465 | pmc = 108863 | doi =  }}</ref>  
* [[TAF15]].<ref name = pmid9488465>{{cite journal | vauthors = Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L | title = EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes | journal = Mol. Cell. Biol. | volume = 18 | issue = 3 | pages = 1489–97 | date = Mar 1998 | pmid = 9488465 | pmc = 108863 | doi =  10.1128/mcb.18.3.1489}}</ref>  
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Latest revision as of 09:14, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA-directed RNA polymerase II subunit RPB3 is an enzyme that in humans is encoded by the POLR2C gene.[1]

Function

This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21.[2]

Interactions

POLR2C has been shown to interact with:

References

  1. Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326.
  2. "Entrez Gene: POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa".
  3. De Angelis R, Iezzi S, Bruno T, Corbi N, Di Padova M, Floridi A, Fanciulli M, Passananti C (Jul 2003). "Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4)". FEBS Lett. 547 (1–3): 15–9. doi:10.1016/s0014-5793(03)00659-8. PMID 12860379.
  4. Corbi N, Bruno T, De Angelis R, Di Padova M, Libri V, Di Certo MG, Spinardi L, Floridi A, Fanciulli M, Passananti C (Sep 2005). "RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product". J. Cell Sci. 118 (Pt 18): 4253–60. doi:10.1242/jcs.02545. PMID 16141233.
  5. 5.0 5.1 Corbi N, Di Padova M, De Angelis R, Bruno T, Libri V, Iezzi S, Floridi A, Fanciulli M, Passananti C (Oct 2002). "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin". FASEB J. 16 (12): 1639–41. doi:10.1096/fj.02-0123fje. PMID 12207009.
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (Jul 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. PMID 9201987.
  7. Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L (Mar 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. 18 (3): 1489–97. doi:10.1128/mcb.18.3.1489. PMC 108863. PMID 9488465.

Further reading