WFDC1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
 
Matt Pijoan (talk | contribs)
Bots, Bureaucrats, bureaucrats, Interface administrators, interwiki, nocaptcha, smwadministrator, staff, Administrators, Widget editors
7,579 edits
m 1 revision imported
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
{{Multiple issues|
{{Orphan|date=January 2019}}
{{Underlinked|date=June 2016}}
{{Underlinked|date=June 2016}}
}}
{{Infobox_gene}}
{{Infobox_gene}}
'''WAP four-disulfide core domain protein 1''' is a [[protein]] that in humans is encoded by the ''WFDC1'' [[gene]].<ref name="pmid10967136">{{cite journal | vauthors = Larsen M, Ressler SJ, Gerdes MJ, Lu B, Byron M, Lawrence JB, Rowley DR | title = The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers | journal = Mamm Genome | volume = 11 | issue = 9 | pages = 767–73 |date=Sep 2000 | pmid = 10967136 | pmc =  | doi =10.1007/s003350010135  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WFDC1 WAP four-disulfide core domain 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=58189| accessdate = }}</ref>
'''WAP four-disulfide core domain protein 1''' is a [[protein]] that in humans is encoded by the ''WFDC1'' [[gene]].<ref name="pmid10967136">{{cite journal | vauthors = Larsen M, Ressler SJ, Gerdes MJ, Lu B, Byron M, Lawrence JB, Rowley DR | title = The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers | journal = Mamm Genome | volume = 11 | issue = 9 | pages = 767–73 |date=Sep 2000 | pmid = 10967136 | pmc =  | doi =10.1007/s003350010135  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WFDC1 WAP four-disulfide core domain 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=58189| accessdate = }}</ref>
Line 6: Line 10:
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.<ref name="entrez" />
| summary_text = This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight [[cysteine]]s forming four [[disulfide bonds]] at the core of the protein, and functions as a [[Protease inhibitor (biology)|protease inhibitor]] in many family members. The encoded protein shares 81% [[amino acid]] identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and [[Wilms' tumor]]. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a [[tumor suppressor gene]].<ref name="entrez" />
}}
}}


Latest revision as of 09:22, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

WAP four-disulfide core domain protein 1 is a protein that in humans is encoded by the WFDC1 gene.[1][2]

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.[2]

References

  1. ↑ Larsen M, Ressler SJ, Gerdes MJ, Lu B, Byron M, Lawrence JB, Rowley DR (Sep 2000). "The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers". Mamm Genome. 11 (9): 767–73. doi:10.1007/s003350010135. PMID 10967136.
  2. ↑ 2.0 2.1 "Entrez Gene: WFDC1 WAP four-disulfide core domain 1".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=WFDC1&oldid=1524697"