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{{Infobox_gene}}
{{Infobox_gene}}
'''Target of rapamycin complex subunit LST8''', also known as '''mammalian lethal with SEC13 protein 8''' (mLST8) or '''TORC subunit LST8''' or '''G protein beta subunit-like''' (GβL or Gable), is a [[protein]] that in humans is encoded by the ''MLST8'' (MTOR associated protein, LST8 homolog) [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTOR associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64223| accessdate = }}</ref> It is a subunit of both [[mTORC1]] and [[mTORC2]], complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.<ref>{{cite web | title = UniProtKB – Q9BVC4 (LST8_HUMAN) | url = http://www.uniprot.org/uniprot/Q9BVC4 | accessdate = }}</ref> It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.<ref>{{cite journal | vauthors = Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C | title = mLST8 Promotes mTOR-Mediated Tumor Progression | journal = PLOS ONE | date = 23 Apr 2015 | doi = 10.1371/journal.pone.0119015 | url = http://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0119015}}</ref>
'''Target of rapamycin complex subunit LST8''', also known as '''mammalian lethal with SEC13 protein 8''' (mLST8) or '''TORC subunit LST8''' or '''G protein beta subunit-like''' (GβL or Gable), is a [[protein]] that in humans is encoded by the ''MLST8'' (MTOR associated protein, LST8 homolog) [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTOR associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64223| accessdate = }}</ref> It is a subunit of both [[mTORC1]] and [[mTORC2]], complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.<ref>{{cite web | title = UniProtKB – Q9BVC4 (LST8_HUMAN) | url = https://www.uniprot.org/uniprot/Q9BVC4 | accessdate = }}</ref> It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.<ref>{{cite journal | vauthors = Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C | title = mLST8 Promotes mTOR-Mediated Tumor Progression | journal = PLOS ONE | date = 23 Apr 2015 | doi = 10.1371/journal.pone.0119015 | url = http://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0119015}}</ref>
Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene.[1] It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.[2] It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.[3]
Ali SM, Sabatini DM (2005). "Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site". J. Biol. Chem. 280 (20): 19445–8. doi:10.1074/jbc.C500125200. PMID15809305.
Rodgers BD, Levine MA, Bernier M, Montrose-Rafizadeh C (2001). "Insulin regulation of a novel WD-40 repeat protein in adipocytes". J. Endocrinol. 168 (2): 325–32. doi:10.1677/joe.0.1680325. PMID11182770.
Long X, Lin Y, Ortiz-Vega S, et al. (2005). "Rheb binds and regulates the mTOR kinase". Curr. Biol. 15 (8): 702–13. doi:10.1016/j.cub.2005.02.053. PMID15854902.
Loewith R, Jacinto E, Wullschleger S, et al. (2002). "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control". Mol. Cell. 10 (3): 457–68. doi:10.1016/S1097-2765(02)00636-6. PMID12408816.
Sarbassov DD, Sabatini DM (2005). "Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex". J. Biol. Chem. 280 (47): 39505–9. doi:10.1074/jbc.M506096200. PMID16183647.
Oshiro N, Yoshino K, Hidayat S, et al. (2004). "Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function". Genes Cells. 9 (4): 359–66. doi:10.1111/j.1356-9597.2004.00727.x. PMID15066126.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Kawai S, Enzan H, Hayashi Y, et al. (2003). "Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers". Virchows Arch. 443 (1): 78–86. doi:10.1007/s00428-003-0804-4. PMID12719976.
Kim DH, Sarbassov DD, Ali SM, et al. (2003). "GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR". Mol. Cell. 11 (4): 895–904. doi:10.1016/S1097-2765(03)00114-X. PMID12718876.
Jacinto E, Loewith R, Schmidt A, et al. (2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive". Nat. Cell Biol. 6 (11): 1122–8. doi:10.1038/ncb1183. PMID15467718.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex". Science. 307 (5712): 1098–101. doi:10.1126/science.1106148. PMID15718470.
