|
|
| (One intermediate revision by one other user not shown) |
| Line 47: |
Line 47: |
|
| |
|
| * [[Pyrophosphomevalonate decarboxylase|MVD]]<ref name="urlSTRING: functional protein association networks">{{cite web | url = http://string.embl.de/ | title = STRING: functional protein association networks | author = | authorlink = | coauthors = | date = | format = | work = | publisher = EMBL.de | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2009-05-07}}</ref> MVD stands for [[pyrophosphomevalonate decarboxylase|disphosphomevalonate decarboxylase]] which is an enzyme which functions in [[cholesterol]] biosynthesis.<ref name="entrez_ MVD">{{cite web | title = Entrez Gene: MVD mevalonate (diphospho) decarboxylase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4597| accessdate = 6 May 2009}}</ref> | | * [[Pyrophosphomevalonate decarboxylase|MVD]]<ref name="urlSTRING: functional protein association networks">{{cite web | url = http://string.embl.de/ | title = STRING: functional protein association networks | author = | authorlink = | coauthors = | date = | format = | work = | publisher = EMBL.de | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2009-05-07}}</ref> MVD stands for [[pyrophosphomevalonate decarboxylase|disphosphomevalonate decarboxylase]] which is an enzyme which functions in [[cholesterol]] biosynthesis.<ref name="entrez_ MVD">{{cite web | title = Entrez Gene: MVD mevalonate (diphospho) decarboxylase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4597| accessdate = 6 May 2009}}</ref> |
| * [[BSCL2]]<ref name="Mint">{{cite web | url = http://mint.bio.uniroma2.it/mint/Welcome.do | title = mint database | author = | authorlink = | coauthors = | date = | format = | work = | publisher = | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2009-05-07}}</ref> [[BSCL2]] is the Bernardinelli-Seip congenital lipodystrophy 2, or seipin.<ref name="entrez_ BSCL2">{{cite web | title = Entrez Gene: BSCL2 Bernardinelli-Seip congenital lipodystrophy 2 (seipin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26580 | accessdate = 6 May 2009}}</ref> It located in the endoplasmic reticulum and is thought to be important in the [[lipid]] droplet morphology. | | * [[BSCL2]]<ref name="Mint">{{cite web| url =http://mint.bio.uniroma2.it/mint/Welcome.do| title =mint database| author =| authorlink =| coauthors =| date =| format =| work =| publisher =| pages =| language =| archiveurl =https://web.archive.org/web/20060506110418/http://mint.bio.uniroma2.it/mint/Welcome.do#| archivedate =2006-05-06| quote =| accessdate =2009-05-07| dead-url =yes| df =}}</ref> [[BSCL2]] is the Bernardinelli-Seip congenital lipodystrophy 2, or seipin.<ref name="entrez_ BSCL2">{{cite web | title = Entrez Gene: BSCL2 Bernardinelli-Seip congenital lipodystrophy 2 (seipin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26580 | accessdate = 6 May 2009}}</ref> It located in the endoplasmic reticulum and is thought to be important in the [[lipid]] droplet morphology. |
| * [[TSC22D4]]<ref name="Mint"/> The third interacting protein is TSC22D4, TSC22 domain family member 4, and functions as a [[leucine zipper]] translational regulation.<ref name="entrez_ TSC22D4">{{cite web | title = Entrez Gene: TSC22D4 TSC22 domain family, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81628| accessdate = 6 May 2009}}</ref> | | * [[TSC22D4]]<ref name="Mint"/> The third interacting protein is TSC22D4, TSC22 domain family member 4, and functions as a [[leucine zipper]] translational regulation.<ref name="entrez_ TSC22D4">{{cite web | title = Entrez Gene: TSC22D4 TSC22 domain family, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81628| accessdate = 6 May 2009}}</ref> |
|
| |
|
Latest revision as of 09:23, 10 January 2019
Chromosome 16 open reading frame 58, or C16orf58, also known as FLJ13638 is a protein which in humans is encoded by the C16orf58 gene.[1] The gene itself is 18892 bp long, with mRNA of 2760 bp, and a protein sequence of 468 amino acids. There is a conserved domain of unknown, DUF647. No function has been determined for this gene yet, but it is predicted that it resides in the endoplasmic reticulum in the cytoplasm.[2]
Species distribution
C16orf58 has very interesting conservation in that it has orthologs back through plants and fungi. However, it has not been found in reptiles, birds, or amphibians. The below table shows some, but not all, orthologs which were found using BLAST.[3]
Protein Interactions
Though the function is still unknown, C16orf58 has been shown to interact with three different proteins:
Structure
Although there are several sites that will give predictions on protein structure, C16orf58 does not have a known structure yet. That being said there is at least one transmembrane domain, if not more. Within the protein structure there are several extended areas with uncharged amino acids, these could be possible transmembrane domains, or hydrophobic cores.[2] The below shows the charge of each of the amino acids in the protein sequence, + for positive, - for negative and 0 for uncharged. Note the large segments of uncharged amino acids appear bolded. These stretches of uncharged amino acids are conserved back through distant orthologs.
1 00—000-00 000-00000- 0+00+000-0 0000-0000+ 00000+0000 +0-0+-00-0
61 0000000000 0000000000 000-0000-0 000000-000 0000000000 0000000000
121 0000+00000 0000000+-0 00000+0000 00+00+0-00 0+00+000-0 00-00000-0
181 0000000000 000000000+ 0000000000 +00000000+ +0000-000+ -000-00000
241 0000000000 0000000000 0000000000 000000+00+ 0000-000-0 +0+000+000
301 0+0-00-000 00+0-00000 0000000000 0000+00000 0-00000-00 0-000000-0
361 0000000000 0+000+000+ 0000000000 000-00000- 0—0+0+0+0 00++-00000
421 +-00-00-00 00+00+000- 000+0-+000 -00-0+0000 000-++00
References
External links
