BPTF: Difference between revisions

Jump to navigation Jump to search
m (Bot: HTTP→HTTPS)
imported>OAbot
m (Open access bot: add pmc identifier to citation with #oabot.)
 
Line 1: Line 1:
{{Infobox_gene}}
{{Infobox_gene}}
'''Nucleosome-remodeling factor subunit BPTF''' is a [[protein]] that in humans is encoded by the ''BPTF'' [[gene]].<ref name="pmid8975731">{{cite journal | author = Bowser R | title = Assignment of the human FAC1 gene to chromosome 17q24 by fluorescence in situ hybridization | journal = Genomics | volume = 38 | issue = 3 | pages = 455–7 |date=March 1997 | pmid = 8975731 | pmc =  | doi = 10.1006/geno.1996.0657 }}</ref><ref name="pmid10662542">{{cite journal | vauthors = Jones MH, Hamana N, Shimane M | title = Identification and characterization of BPTF, a novel bromodomain transcription factor | journal = Genomics | volume = 63 | issue = 1 | pages = 35–9 |date=April 2000 | pmid = 10662542 | pmc =  | doi = 10.1006/geno.1999.6070 }}</ref><ref name="pmid16728976">{{cite journal | vauthors = Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, Wu C, Allis CD | title = A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling | journal = Nature | volume = 442 | issue = 7098 | pages = 86–90 |date=July 2006 | pmid = 16728976 | pmc =  | doi = 10.1038/nature04815 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BPTF bromodomain PHD finger transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2186| accessdate = }}</ref>
'''Nucleosome-remodeling factor subunit BPTF''' is a [[protein]] that in humans is encoded by the ''BPTF'' [[gene]].<ref name="pmid8975731">{{cite journal | author = Bowser R | title = Assignment of the human FAC1 gene to chromosome 17q24 by fluorescence in situ hybridization | journal = Genomics | volume = 38 | issue = 3 | pages = 455–7 |date=March 1997 | pmid = 8975731 | pmc =  | doi = 10.1006/geno.1996.0657 }}</ref><ref name="pmid10662542">{{cite journal | vauthors = Jones MH, Hamana N, Shimane M | title = Identification and characterization of BPTF, a novel bromodomain transcription factor | journal = Genomics | volume = 63 | issue = 1 | pages = 35–9 |date=April 2000 | pmid = 10662542 | pmc =  | doi = 10.1006/geno.1999.6070 }}</ref><ref name="pmid16728976">{{cite journal | vauthors = Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, Wu C, Allis CD | title = A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling | journal = Nature | volume = 442 | issue = 7098 | pages = 86–90 |date=July 2006 | pmid = 16728976 | pmc =  | doi = 10.1038/nature04815 | bibcode = 2006Natur.442...86W }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BPTF bromodomain PHD finger transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2186| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Line 9: Line 9:


==Interactions==
==Interactions==
BPTF has been shown to [[Protein-protein interaction|interact]] with [[MAZ (gene)|MAZ]].<ref name=pmid10727212>{{cite journal |last=Jordan-Sciutto |first=K L |author2=Dragich J M |author3=Caltagarone J |author4=Hall D J |author5=Bowser R  |date=March 2000  |title=Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity |journal=Biochemistry |volume=39 |issue=12 |pages=3206–15 |publisher= |location = UNITED STATES| issn = 0006-2960| pmid = 10727212 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1021/bi992211q }}</ref>
BPTF has been shown to [[Protein-protein interaction|interact]] with [[MAZ (gene)|MAZ]].<ref name=pmid10727212>{{cite journal |last=Jordan-Sciutto |first=K L |author2=Dragich J M |author3=Caltagarone J |author4=Hall D J |author5=Bowser R  |date=March 2000  |title=Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity |journal=Biochemistry |volume=39 |issue=12 |pages=3206–15 |publisher= |location = UNITED STATES| issn = 0006-2960| pmid = 10727212 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1021/bi992211q |pmc=3667205}}</ref>


==References==
==References==
Line 26: Line 26:
*{{cite journal  | vauthors=Mu X, Springer JE, Bowser R |title=FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord |journal=Exp. Neurol. |volume=146 |issue= 1 |pages= 17–24 |year= 1997 |pmid= 9225734 |doi= 10.1006/exnr.1997.6508 }}
*{{cite journal  | vauthors=Mu X, Springer JE, Bowser R |title=FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord |journal=Exp. Neurol. |volume=146 |issue= 1 |pages= 17–24 |year= 1997 |pmid= 9225734 |doi= 10.1006/exnr.1997.6508 }}
*{{cite journal  | vauthors=Jordan-Sciutto KL, Dragich JM, Bowser R |title=DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 3 |pages= 785–9 |year= 1999 |pmid= 10403843 |doi= 10.1006/bbrc.1999.0986 }}
*{{cite journal  | vauthors=Jordan-Sciutto KL, Dragich JM, Bowser R |title=DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 3 |pages= 785–9 |year= 1999 |pmid= 10403843 |doi= 10.1006/bbrc.1999.0986 }}
*{{cite journal  | vauthors=Jordan-Sciutto KL, Dragich JM, Rhodes JL, Bowser R |title=Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 35262–8 |year= 2000 |pmid= 10575013 |doi=10.1074/jbc.274.49.35262  }}
*{{cite journal  | vauthors=Jordan-Sciutto KL, Dragich JM, Rhodes JL, Bowser R |title=Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 35262–8 |year= 2000 |pmid= 10575013 |doi=10.1074/jbc.274.49.35262  |pmc=3670955 }}
*{{cite journal  | author=Jordan-Sciutto KL |title=Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity |journal=Biochemistry |volume=39 |issue= 12 |pages= 3206–15 |year= 2000 |pmid= 10727212 |doi=10.1021/bi992211q  |name-list-format=vanc| author2=Dragich JM  | author3=Caltagarone J  | display-authors=3  | last4=Hall  | first4=D. J.  | last5=Bowser  | first5=R.  }}
*{{cite journal  | author=Jordan-Sciutto KL |title=Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity |journal=Biochemistry |volume=39 |issue= 12 |pages= 3206–15 |year= 2000 |pmid= 10727212 |doi=10.1021/bi992211q  |name-list-format=vanc| author2=Dragich JM  | author3=Caltagarone J  | display-authors=3  | last4=Hall  | first4=D. J.  | last5=Bowser  | first5=R.  |pmc=3667205}}
*{{cite journal  | vauthors=Jordan-Sciutto K, Rhodes J, Bowser R |title=Altered subcellular distribution of transcriptional regulators in response to Abeta peptide and during Alzheimer's disease |journal=Mech. Ageing Dev. |volume=123 |issue= 1 |pages= 11–20 |year= 2002 |pmid= 11640947 |doi=10.1016/S0047-6374(01)00334-7  }}
*{{cite journal  | vauthors=Jordan-Sciutto K, Rhodes J, Bowser R |title=Altered subcellular distribution of transcriptional regulators in response to Abeta peptide and during Alzheimer's disease |journal=Mech. Ageing Dev. |volume=123 |issue= 1 |pages= 11–20 |year= 2002 |pmid= 11640947 |doi=10.1016/S0047-6374(01)00334-7  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal  | vauthors=Rhodes J, Lutka FA, Jordan-Sciutto KL, Bowser R |title=Altered expression and distribution of FAC1 during NGF-induced neurite outgrowth of PC12 cells |journal=NeuroReport |volume=14 |issue= 3 |pages= 449–52 |year= 2003 |pmid= 12634501 |doi= 10.1097/01.wnr.0000059782.23521.35 }}
*{{cite journal  | vauthors=Rhodes J, Lutka FA, Jordan-Sciutto KL, Bowser R |title=Altered expression and distribution of FAC1 during NGF-induced neurite outgrowth of PC12 cells |journal=NeuroReport |volume=14 |issue= 3 |pages= 449–52 |year= 2003 |pmid= 12634501 |doi= 10.1097/01.wnr.0000059782.23521.35 }}
*{{cite journal  | author=Barak O |title=Isolation of human NURF: a regulator of Engrailed gene expression |journal=EMBO J. |volume=22 |issue= 22 |pages= 6089–100 |year= 2004 |pmid= 14609955 |doi= 10.1093/emboj/cdg582  | pmc=275440  |name-list-format=vanc| author2=Lazzaro MA  | author3=Lane WS  | display-authors=3  | last4=Speicher  | first4=DW  | last5=Picketts  | first5=DJ  | last6=Shiekhattar  | first6=R }}
*{{cite journal  | author=Barak O |title=Isolation of human NURF: a regulator of Engrailed gene expression |journal=EMBO J. |volume=22 |issue= 22 |pages= 6089–100 |year= 2004 |pmid= 14609955 |doi= 10.1093/emboj/cdg582  | pmc=275440  |name-list-format=vanc| author2=Lazzaro MA  | author3=Lane WS  | display-authors=3  | last4=Speicher  | first4=DW  | last5=Picketts  | first5=DJ  | last6=Shiekhattar  | first6=R }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP |bibcode=2004PNAS..10112130B}}
*{{cite journal  | author=Strachan GD |title=Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein |journal=Biochemistry |volume=43 |issue= 38 |pages= 12113–22 |year= 2004 |pmid= 15379550 |doi= 10.1021/bi0494166  |name-list-format=vanc| author2=Morgan KL  | author3=Otis LL  | display-authors=3  | last4=Caltagarone  | first4=John  | last5=Gittis  | first5=Aryn  | last6=Bowser  | first6=Robert  | last7=Jordan-Sciutto  | first7=Kelly L. }}
*{{cite journal  | author=Strachan GD |title=Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein |journal=Biochemistry |volume=43 |issue= 38 |pages= 12113–22 |year= 2004 |pmid= 15379550 |doi= 10.1021/bi0494166  |name-list-format=vanc| author2=Morgan KL  | author3=Otis LL  | display-authors=3  | last4=Caltagarone  | first4=John  | last5=Gittis  | first5=Aryn  | last6=Bowser  | first6=Robert  | last7=Jordan-Sciutto  | first7=Kelly L. |pmc=3670950}}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | vauthors=Strachan GD, Ostrow LA, Jordan-Sciutto KL |title=Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death |journal=Biochem. Biophys. Res. Commun. |volume=336 |issue= 2 |pages= 490–5 |year= 2005 |pmid= 16137655 |doi= 10.1016/j.bbrc.2005.08.127 }}
*{{cite journal  | vauthors=Strachan GD, Ostrow LA, Jordan-Sciutto KL |title=Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death |journal=Biochem. Biophys. Res. Commun. |volume=336 |issue= 2 |pages= 490–5 |year= 2005 |pmid= 16137655 |doi= 10.1016/j.bbrc.2005.08.127 }}
*{{cite journal  | author=Li H |title=Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF |journal=Nature |volume=442 |issue= 7098 |pages= 91–5 |year= 2006 |pmid= 16728978 |doi= 10.1038/nature04802  |name-list-format=vanc| author2=Ilin S  | author3=Wang W  | display-authors=3  | last4=Duncan  | first4=Elizabeth M.  | last5=Wysocka  | first5=Joanna  | last6=Allis  | first6=C. David  | last7=Patel  | first7=Dinshaw J. }}
*{{cite journal  | author=Li H |title=Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF |journal=Nature |volume=442 |issue= 7098 |pages= 91–5 |year= 2006 |pmid= 16728978 |doi= 10.1038/nature04802  |name-list-format=vanc| author2=Ilin S  | author3=Wang W  | display-authors=3  | last4=Duncan  | first4=Elizabeth M.  | last5=Wysocka  | first5=Joanna  | last6=Allis  | first6=C. David  | last7=Patel  | first7=Dinshaw J. |bibcode=2006Natur.442...91L|pmc=4690523}}
}}
}}
{{refend}}
{{refend}}

Latest revision as of 18:29, 21 August 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nucleosome-remodeling factor subunit BPTF is a protein that in humans is encoded by the BPTF gene.[1][2][3][4]

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.[4]

Interactions

BPTF has been shown to interact with MAZ.[5]

References

  1. Bowser R (March 1997). "Assignment of the human FAC1 gene to chromosome 17q24 by fluorescence in situ hybridization". Genomics. 38 (3): 455–7. doi:10.1006/geno.1996.0657. PMID 8975731.
  2. Jones MH, Hamana N, Shimane M (April 2000). "Identification and characterization of BPTF, a novel bromodomain transcription factor". Genomics. 63 (1): 35–9. doi:10.1006/geno.1999.6070. PMID 10662542.
  3. Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, Wu C, Allis CD (July 2006). "A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling". Nature. 442 (7098): 86–90. Bibcode:2006Natur.442...86W. doi:10.1038/nature04815. PMID 16728976.
  4. 4.0 4.1 "Entrez Gene: BPTF bromodomain PHD finger transcription factor".
  5. Jordan-Sciutto, K L; Dragich J M; Caltagarone J; Hall D J; Bowser R (March 2000). "Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity". Biochemistry. UNITED STATES. 39 (12): 3206–15. doi:10.1021/bi992211q. ISSN 0006-2960. PMC 3667205. PMID 10727212.

External links

Further reading